Feature Channels: Aging

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Pharmacology graduate student Kaitlan Smith was recently awarded a diversity supplement from the National Institute on Aging (NIA) to study the effects of aging and necroptosis. She shares her resilient journey into scientific research while reflecting on her Lumbee roots.

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Although genetic mutations in BRCA1 or BRCA2 are associated with a younger onset of breast and ovarian cancer, women with these genetic mutations continue to face a high risk of cancer incidence after age 50, even if they have not been previously diagnosed with cancer.

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Less than one year after stepping away from acting due to a diagnosis of aphasia, Bruce Willis has been diagnosed with frontotemporal dementia. Here, a neurologist answers key questions about FTD.

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The New England Journal of Medicine (NEJM) Catalyst recently published an article by Ochsner Health neuropsychologist and a team of researchers discussing the critical need for value-based care models for patients with dementia.

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Of all the known genetic risk factors for late-onset Alzheimer’s disease, the strongest is a gene for the protein called ApoE4.

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Below are some of the latest articles that have been added to the Chemistry news channel on Newswise.

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Leqembi, Recientemente Aprobado por la FDA, Muestra un Beneficio Potencial para los Pacientes con Enfermedad en Etapa Temprana, pero la Disponibilidad Llevará tiempo, Comenta Experta de Cedars-Sinai

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Reporting in the PNAS, UNC School of Medicine researchers made the stunning discovery that telomeres contain genetic information to produce two small proteins, one of which they found is elevated in some human cancer cells, as well as cells from patients suffering from telomere-related defects.

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Um grupo de trabalho de especialistas reformulou o que é considerado clinicamente significativo para desacelerar a progressão da doença de Alzheimer durante ensaios clínicos, incluindo o impacto do tratamento ao longo do tempo e a necessidade de terapias combinadas.

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Un grupo de trabajo de expertos ha replanteado qué es importante a nivel clínico para retrasar el avance de la enfermedad de Alzheimer durante los ensayos clínicos, incluidas la repercusión del tratamiento a lo largo del tiempo y la necesidad de terapias combinadas.

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Social cohesion and connection decline in an ageing population, according to a new study of one of humanity’s closest relatives.

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Researchers at the University of South Australia are calling for the Federal Government to mandate financial support for pets in aged care ¬¬¬to help improve the mental health and wellbeing of thousands of residents.

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Delray Medical Center is the first hospital in Florida to treat an Alzheimer’s disease patient using non-invasive focused ultrasound technology as part of a groundbreaking study being conducted in collaboration with FAU’s Institute for Human Health and Disease Intervention (I-Health). In the FDA-approved clinical trial, focused ultrasound technology is used to disrupt the blood-brain barrier in participating Alzheimer’s patients.

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Researchers discover a mechanism used by neurons to repair damage that occurs during neuronal activity

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“A potential pathway between obesity and these stressors could be related to weight bias and stigma; there was extensive media coverage highlighting obesity as a potential risk factor for COVID-19 mortality which may have increased weight stigma,” the researchers wrote. The study examined data from nearly 24,000 participants enrolled in the Canadian Longitudinal Study on Aging (CLSA), who were between the ages of 50 and 96 during the first year of the pandemic. The participants completed the CLSA COVID-19 Questionnaire Study, which collected longitudinal data from April to December 2020. The researchers also used data collected before the pandemic to examine if childhood adversity, such as abuse and neglect, was a factor that modified the relationship between obesity and stress.

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Volunteering not only fulfills a sense of purpose for older adults by helping others, it also can alleviate loneliness, especially when volunteering more than 100 hours per year, according to a University of Michigan study.

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A first-of-its-kind study finds a natural coconut sugar may help reduce the risk of cardiovascular disease by improving blood vessel health and managing high blood pressure. The study is published ahead of print in the Journal of Applied Physiology.

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Scientists at St. Jude Children’s Research Hospital used deep sequencing data from childhood cancer survivors and found the mutational fingerprint of a toxic chemotherapy associated with a marker of accelerated aging.

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An expert work group has reframed what is clinically meaningful to slow Alzheimer's disease progression during clinical trials, including treatment impact over time and the need for combination therapies.

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Researchers at Tel Aviv University identified a new genetic risk factor for the complex eye disease AMD (Age-related Macular Degeneration), a leading cause for loss of eyesight at an advanced age.

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A study conducted by Florida State University Psychology Professor Chris Martin and a team of researchers at the University of Toronto, shows that a smart phone application can enhance memory function in older adults.

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The prevalence of disabilities among American adults aged 65 and older is much lower than it was for the same age group a decade earlier, according to a nationally representative study published online in the International Journal of Environmental Research and Public Health (IJERPH) .

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The human body runs on a finely tuned clock synchronized to the 24-hour cycle of Earth’s rotation, known as the circadian clock, which controls various physiological processes such as the sleep-wake cycle, hormone production, and metabolism.

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Adults ages 50 and older who lived near dense fast food and unhealthy food environments known as “food swamps” had a higher risk of stroke compared to those who lived in areas with fewer retail and fast food choices, according to preliminary research to be presented at the American Stroke Association’s International Stroke Conference 2023.

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For the more than 6 million Americans living with Alzheimer’s disease, related dementias, or mild cognitive impairment, anxiety is often an accompanying challenge. A Florida State University psychologist has received a five-year, $3.7 million grant from the National Institute on Aging to study intervention techniques that aim to combat anxiety in these groups and improve quality of life.

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Investigadores y colaboradores de Mayo Clinic han descubierto hallazgos clínicos clave que pueden ayudar a los médicos clínicos a reconocer causas que podrían tratar la demencia rápidamente progresiva en pacientes que, de lo contrario, podrían recibir un diagnóstico de enfermedad de Creutzfeldt-Jakob. Su estudio se publicó en la versión en línea de Neurology Clinical Practice, la revista médica oficial de la Academia Americana de Neurología.

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Slipping on ice or tripping over a curb can result in broken bones or more serious injuries. To avoid taking an unexpected tumble, it’s important to be aware of your surroundings and watch where you’re walking, a UT Southwestern Medical Center orthopedist advises.

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Os pesquisadores e colaboradores da Mayo Clinic identificaram achados clínicos importantes que podem ajudar os médicos a reconhecer pacientes com causas potencialmente tratáveis de demência rapidamente progressiva e que seriam diagnosticados erroneamente com a doença de Creutzfeldt-Jakob. O estudo foi publicado on-line na Neurology Clinical Practice, uma revista médica oficial da American Academy of Neurology.

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The American Macular Degeneration Foundation will be hosting multiple, awareness-spreading activities throughout February, which is AMD Awareness Month, including new films on living well with AMD.

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Rutgers Biomedical and Health Sciences (RBHS) is launching the Herbert and Jacqueline Krieger Klein Alzheimer’s and Dementia Clinical Research and Treatment Center. Based at the Rutgers Brain Health Institute and scheduled to open in fall 2023, the center will offer research expertise from the institute, Rutgers Robert Wood Johnson Medical School, Rutgers New Jersey Medical School and the Rutgers Institute for Health, Health Care Policy and Aging Research as well as facilitate clinical research in Alzheimer’s disease that could result in new medical treatments.

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The study analyzed data from 1,445 participants aged 45 to 85 years from the Canadian Longitudinal Study on Aging. The participants provided blood samples for DNA methylation analysis and completed a self-report questionnaire on ACEs. These experiences include childhood exposure to physical, emotional or sexual abuse, neglect, as well as exposure to parental intimate partner violence or poor parental mental health. The data was analyzed to determine if there was an association between early childhood adversity and accelerated biological aging.

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A roundup of the latest medical discoveries and faculty news at Cedars-Sinai.

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KINGSTON, R.I. – Jan. 31, 2023 – China’s National Bureau of Statistics recently released data showing the country’s first population decline in decades. At the end of 2022, the population of mainland China stood at 1.411 billion people, down 850,000 from the previous year.Around the world, experts called it a tipping point for a nation looking to continue an era of rapid economic expansion and boost its falling birth rate.

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ESTIMADA MAYO CLINIC: Tenho pouco mais de 50 anos e adoro meu estilo de vida ativo. Recentemente, ouvi relatos sobre o aumento de torções e fraturas no tornozelo, particularmente em uma população mais velha, devido em parte à atividade e ao envelhecimento. Em primeiro lugar, como posso evitar essas lesões?

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Tengo poco más de 50 años y disfruto de un estilo de vida activo. Hace poco, me enteré de que hay informes sobre un aumento de esguinces y fracturas de tobillo, particularmente entre la población más adulta, debido a una combinación de dos factores: la actividad y la edad. ¿Cómo puedo evitar estas lesiones en primer lugar?

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Age-based heuristics can lead to large differences in breast cancer treatment based on small differences in chronologic age, according to a new analysis of more than 500,000 patient records. Patients aged 70 were nearly twice as likely to be passed over for standard-of-care radiation as those aged 69. There were no similar gaps between other age pairs. The study is among the first to demonstrate an age cutoff heuristic in oncology.

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The typical person living with arthritis in the UK is 20% less likely to be in work than their equivalent without the condition, new research shows.

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Whether you call them comfort foods, highly processed foods, junk foods, empty calories or just some of Americans’ favorite foods and drinks, about 13% of Americans aged 50 to 80 have an unhealthy relationship with them.

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Below are some of the latest articles that have been added to the Behavioral Science channel on Newswise, a free source for journalists.