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Released: 27-Mar-2022 12:00 PM EDT
A cancer stem cell population underlies a multi-lineage phenotype and drug resistance in prostate cancer
Preprints

Michael L. Beshiri, Brian J. Capaldo, Ross Lake, Anson T. Ku, Danielle Burner, Caitlin M. Tice, Crystal Tran, Julianna Kostas, Aian Neil Alilin, Juanjuan Yin, Supreet Agarwal, Samantha A. Morris, Fatima H. Karzai, Tamara L. Lotan, William L. Dahut, Adam G. Sowalsky, Kathleen Kelly

Released: 27-Mar-2022 12:00 PM EDT
Phase Separation of a Nodulin Sec14-like protein Maintains Auxin Efflux Carrier Polarity at Arabidopsis Plasma Membranes
Preprints

Chen Liu, Andriani Mentzelopoulou, Alexandra Deli, Fotini Papagavriil, Prashanth Ramachandran, Artemis Perraki, Lucas Claus, Sebastian Barg, Peter Doermann, Yvon Jaillais, Philipp Johnen, Eugenia Russinova, Electra Gizeli, Gabriel Schaaf, Panagiotis Nikolaou Moschou

Released: 27-Mar-2022 12:00 PM EDT
A spatial genome aligner for multiplexed DNA-FISH
Preprints

Bojing Blair Jia, Adam P Jussila, J Colin Kern, Quan Zhu, Bing Ren

Released: 27-Mar-2022 12:00 PM EDT
LAMC2 marks a tumor-initiating cell population with an aggressive signature in pancreatic cancer
Preprints

Donatella Delle Cave, Silvia Buonaiuto, Maria Mangini, Bruno Sainz, Annalisa Di Domenico, Tea Teresa Iavazzo, Gennaro Andolfi, Carme Cortina Duran, Marta Sevillano, Christopher Heeschen, Vincenza Colonna, Marco Corona, Antonio Cucciardi, Martina Di Guida, Eduard Batlle, AnnaChiara De Luca, Enza Lonardo

Released: 27-Mar-2022 12:00 PM EDT
Variation in TAF1 expression in female carrier induced pluripotent stem cells and human brain ontogeny has implications for adult neostriatum vulnerability in X-linked Dystonia Parkinsonism
Preprints

Laura D'Ignazio, Ricardo S. Jacomini, Bareera Qamar, Kynon J.M. Benjamin, Ria Arora, Tomoyo Sawada, Taylor A. Evans, Kenneth E. Diffenderfer, Aimee R. Pankonin, William T. Hendriks, Thomas M Hyde, Joel E Kleinman, Daniel R Weinberger, D. Cristopher Bragg, Apua C.M. Paquola, Jennifer A. Erwin

Released: 27-Mar-2022 12:00 PM EDT
Development of a Novel Microfluidic Co-culture model to study Organoid Vascularization
Preprints

M. Guy Roukens, Lydia S. Schulla, E. Diana Alupoaie, Leanne De Silva, Debby Gawlitta, Sabine Middendorp, Paul J. Coffer

Released: 27-Mar-2022 12:00 PM EDT
Targeting tumor stemness switch phenotype by activating pathogen induced stem cell niche defense
Preprints

Bikul Das, Seema Bhuyan, Bidisha Pal, Lekhika Pathak, Partha Jyoti Saikia, Shirsajit Mitra, Sukanya Gayan, Reza Bayat Mokhtari, Hong Li, Chilakamarti V Ramana, Debabrat Baishya

Released: 26-Mar-2022 12:00 PM EDT
Differentiation of airway cholinergic neurons from human pluripotent stem cells for airway neurobiology studies
Preprints

Pien Goldsteen, Angelica Sabogal Guaqueta, Sophie Bos, Loes Kistemaker, Luke Van der Koog, Manon Eggens, Andrew J Halayko, Amalia Dolga, Reinoud Gosens

Released: 26-Mar-2022 12:00 PM EDT
Optimization of adipose tissue-derived mesenchymal stromal cells transplantation for bone marrow repopulation following irradiation
World Journal of Stem Cells

BACKGROUNDBone marrow (BM) suppression is one of the most common side effects of radiotherapy and the primary cause of death following exposure to irradiation. Despite concerted efforts, there is no definitive treatment method available. Recent

Released: 26-Mar-2022 12:00 PM EDT
In vitro induced pluripotency from urine-derived cells in porcine
World Journal of Stem Cells

BACKGROUNDThe generation of induced pluripotent stem cells (iPSC) has been a game-changer in translational and regenerative medicine; however, their large-scale applicability is still hampered by the scarcity of accessible, safe, and reproducib

Newswise: New pathway for DNA transfer discovered in tumor microenvironment
Released: 25-Mar-2022 4:25 PM EDT
New pathway for DNA transfer discovered in tumor microenvironment
University of Notre Dame

University of Notre Dame researchers have discovered another way tumor cells transfer genetic material to other cells in their microenvironment, causing cancer to spread.

Released: 25-Mar-2022 2:45 PM EDT
Value Cocreation in Health Care: Systematic Review
Journal of Medical Internet Research

Background: Value cocreation in health care (VCCH), mainly based on service-dominant logic, emphasizes that participants, including both patients and physicians, can effectively enroll in the health care value creation process. Effec...

Newswise: Rapid glacial advance reconstructed during the time of Norse occupation in Greenland
Released: 25-Mar-2022 2:35 PM EDT
Rapid glacial advance reconstructed during the time of Norse occupation in Greenland
Geological Society of America (GSA)

The Greenland Ice Sheet is the second largest ice body in the world, and it has the potential to contribute significantly to global sea-level rise in a warming global climate.

Released: 25-Mar-2022 2:25 PM EDT
Rescued Victorian rainfall data smashes former records
University of Reading

Record-breaking Victorian weather has been revealed after millions of archived rainfall records dating back nearly 200 years were rescued by thousands of volunteers during the first Covid-19 lockdown.

Newswise: Attention to objects in peripheral vision is not driven by tiny eye movements
Released: 25-Mar-2022 2:00 PM EDT
Attention to objects in peripheral vision is not driven by tiny eye movements
NIH, National Eye Institute (NEI)

New research by National Eye Institute (NEI) investigators shows that while microsaccades seem to boost or diminish the strength of brain signals underlying attention, the eye movements are not drivers of those brain signals.

Released: 25-Mar-2022 1:40 PM EDT
Medicaid health plan community health workers have positive impact on care
Michigan Medicine - University of Michigan

Community health workers employed by Medicaid health plans can help low-income people who face barriers to care rely less on the emergency room, and more on outpatient care, a new study finds.

Newswise: Cryo-EM reveals how ‘911’ molecule helps fix damaged DNA
Released: 25-Mar-2022 1:15 PM EDT
Cryo-EM reveals how ‘911’ molecule helps fix damaged DNA
Van Andel Institute

GRAND RAPIDS, Mich. (March 21, 2022) — When something goes wrong during DNA replication, cells call their own version of 911 to pause the process and fix the problem — a failsafe that is critical to maintaining health and staving off disease.

Newswise: Birds are laying their eggs earlier, and climate change is to blame
Released: 25-Mar-2022 1:05 PM EDT
Birds are laying their eggs earlier, and climate change is to blame
Field Museum

Spring is in the air. Birds are singing and beginning to build their nests.

Released: 25-Mar-2022 12:55 PM EDT
True and false claims: online behaviors behind COVID-19 vaccine uptake
Health Data Science

Vaccine uptake constitutes a key barometer as governments lead the communities out of the COVID-19 pandemic. Facts and fake news have apparently influenced vaccination willingness. But how valid is this proposition?

Released: 25-Mar-2022 12:45 PM EDT
Puff Bars, Tobacco Policy Evasion, and Nicotine Dependence: Content Analysis of Tweets
Journal of Medical Internet Research

Background: Puff Bars are e-cigarettes that continued marketing flavored products by exploiting the US Food and Drug Administration exemption for disposable devices. Objective: This study aimed to examine discussions...

Released: 25-Mar-2022 12:35 PM EDT
Light Therapy Improves Breast Cancer Survivors’ Sleep
Michigan State University

Cancer alters the circadian rhythm functions, which results in fatigue and disrupted sleep/wake patterns. ​​​​​​​​​​​​​​Dr. Horng-Shiuann Wu studies how using extremely bright light to “reset” a female breast cancer patient’s internal clock can help them sleep better.​​​​​​​

Released: 25-Mar-2022 12:30 PM EDT
Quantum physics sets a speed limit to electronics
Vienna University of Technology

How fast can electronics be? When computer chips work with ever shorter signals and time intervals, at some point they come up against physical limits.

Newswise: The hardy wild grass that could save our bread
Released: 25-Mar-2022 12:05 PM EDT
The hardy wild grass that could save our bread
John Innes Centre

An obscure species of wild grass contains “blockbuster” disease resistance that can be cross bred into wheat to give immunity against one of the deadliest crop pathogens.

Released: 25-Mar-2022 12:00 PM EDT
Efficacy and Pharmacokinetic of Human iPSC-derived Cardiomyocytes for Treating Heart Failure in Non-Human Primates
Preprints

Ningxia Liang, Qian Wang, He Zhang, Zhaomin Li, Taotao Chen, FaXiang Xu, Zhixin Guo, Guokai Chen, Huang-Tian Yang, Dongjin Wang, Guangji Wang, Jiaxian Wang

Released: 25-Mar-2022 12:00 PM EDT
A cell cycle-linked mechanism for the glutamine driven establishment of stem cell fate
Preprints

Michael J Xiao, Chia-Hua Wu, Graham Meek, Brian Kelly, Lyndsay E.A Young, Sara Martire, Dara Buendia Castillo, Purbita Saha, Altair L Dube, Matthew Gentry, Laura A Banaszynski, Ramon C Sun, Chintan Kikani

Released: 25-Mar-2022 12:00 PM EDT
Catalytic-independent function of PARP-1 is essential in regulating human islet-cell differentiation from stem cells
Preprints

Nidheesh Dadheech, Abhay Srivast, Rashmi G. Shah, Girish M. Shah, Sarita Gupta

Released: 25-Mar-2022 12:00 PM EDT
Ficoll density gradient sedimentation isolation of pelage hair follicle mesenchymal stem cells from adult mouse back skin: A novel methods for hair follicle mesenchymal stem cells isolation.
Preprints

Yuyang Gan, Hailin Wang, Lijuan Du, Zhexiang Fan, Pingping Sun, Kaitao Li, Qian Qu, Jin Wang, Ruosi Chen, Zhiqi Hu, Yong Miao

Released: 25-Mar-2022 11:40 AM EDT
Legal language affects how police officers are judged
Cornell University

Research by social psychology doctoral student Mikaela Spruill and her adviser, Neil Lewis Jr., assistant professor of communication, revealed that referring to police using the legal phrase “objectively reasonable” puts the officer in a more favorable light, regardless of race.

Released: 25-Mar-2022 11:40 AM EDT
Study Examines Racial Disparities Among Women with Syphilis
University at Albany, State University of New York

As syphilis cases continue to rise across the United States, a new analysis from researchers at the Coalition for Applied Modeling for Prevention (CAMP) offers further insight into racial and ethnic disparities in syphilis rates among heterosexually active women, featuring a new approach to analyzing disease impact.

Newswise: Like father like child – male parents lead young birds on first migration
Released: 25-Mar-2022 11:35 AM EDT
Like father like child – male parents lead young birds on first migration
University of Helsinki

GPS tracking of Caspian terns showed that male parents carry the main responsibility for leading young during their first migration from the Baltic Sea to Africa.

Released: 25-Mar-2022 11:30 AM EDT
Family-based treatment of children with severe obesity shows promising results according to new study
University of Bergen

The FABO study showed that delivered at an obesity outpatient clinic, family-based behavioral treatment improved weight-related outcomes significantly more than treatment as usual among children aged 6-18 years with severe obesity.

Released: 25-Mar-2022 11:15 AM EDT
Vagus Nerve Stimulation Lowers Costs of Care for Children with Uncontrolled Epilepsy
Ann and Robert H. Lurie Children's Hospital of Chicago

A new study from Ann & Robert H. Lurie Children’s Hospital of Chicago published in the journal Epilepsia examined a population of pediatric patients with drug-resistant epilepsy. For these patients, the study found that the patients who received vagus nerve stimulation (VNS), when used with anti-seizure medications (ASM), had lower hospital costs compared to the use of ASM alone. The study found that the patients treated with ASM plus VNS had savings of over $3,000 of epilepsy-related annual costs per year, compared to treatment with ASM only.

Newswise: Unstable Molecule Clicks with Synthetic Strategy
Released: 25-Mar-2022 11:00 AM EDT
Unstable Molecule Clicks with Synthetic Strategy
University of California San Diego

Capitalizing on the diagonal relationship between phosphorus and carbon, researchers at the University of California San Diego report binding diphosphorus to a single metal ion center through coordination chemistry, something that had historically remained elusive.

Newswise: Half of all women experience false positive mammograms after 10 years of annual screening
25-Mar-2022 11:00 AM EDT
Half of all women experience false positive mammograms after 10 years of annual screening
UC Davis Health (Defunct)

Half of all women experience a false positive mammogram after 10 years of annual breast cancer screening with 3D mammography, a UC Davis-led study estimates. This risk was lower for women who had mammograms every other year. 3D screening showed slightly lower false positive results than standard mammography.

Released: 25-Mar-2022 10:05 AM EDT
New Study Estimates Annual Cost of Incarcerating Adults Convicted of Child Sex Crimes Topped $5.4 Billion in 2021
Johns Hopkins Bloomberg School of Public Health

Paper notes that the U.S. federal government budgeted $1.5 million in 2021 for child sexual abuse prevention research.

Newswise: COVID-19 infection linked to higher risk of neuropathy
Released: 25-Mar-2022 8:30 AM EDT
COVID-19 infection linked to higher risk of neuropathy
Washington University in St. Louis

Researchers at Washington University School of Medicine have found that many people who tested positive for the coronavirus in the early months of the pandemic also experienced peripheral neuropathy — pain, tingling and numbness in the hands and feet — during and following their bouts with COVID-19.

Released: 25-Mar-2022 8:05 AM EDT
UCI researchers first to sample permafrost CO2 emissions during fall and winter
University of California, Irvine

The Arctic is warming along with the rest of the planet, and as this is happening, its permafrost – perennially frozen arctic soil that holds a lot of trapped organic matter from dead plants – is thawing. As the permafrost thaws, the organic matter it holds is thawing, too, and this is opening the door for microorganisms to decompose that matter and, in the process, release climate-warming greenhouse gases like carbon dioxide and methane into the atmosphere.

Newswise: Probing the Inner Workings of High-Fidelity Quantum Processors
Released: 25-Mar-2022 7:05 AM EDT
Probing the Inner Workings of High-Fidelity Quantum Processors
Department of Energy, Office of Science

Tiny silicon quantum processors have finally surpassed 99 percent fidelity, an important milestone toward future quantum computers. Three research groups demonstrated 99 percent fidelity for “if-then” logic gates between two silicon qubits. The researchers used a technique called gate set tomography to achieve this in two of the three experiments, an important methodological step.

Released: 25-Mar-2022 7:00 AM EDT
Anti-inflammatory effects of mesenchymal stem cell-conditioned media inhibited macrophages activation in vitro
Scientific Reports

… In this study, we hypothesized that several paracrine cytokines exist in stem cell culture media that may facilitate the immunomodulation of macrophages. The IL4 treatment of stem cells could lead to a greater production of those compounds which …

Newswise: Breakthrough application of moisture-trapping film from NUS to reduce heat stress in personal protective suits
Released: 25-Mar-2022 6:05 AM EDT
Breakthrough application of moisture-trapping film from NUS to reduce heat stress in personal protective suits
National University of Singapore (NUS)

A team of researchers from the National University of Singapore has developed a novel super-hygroscopic material that enhances sweat evaporation within a personal protective suit, to create a cooling effect for better thermal comfort for users such as healthcare workers and other frontline officers. With this innovation, users will feel 40% cooler and their risk of getting heat stroke is lowered significantly.

Released: 25-Mar-2022 3:00 AM EDT
Role of Telemedicine in Inflammatory Bowel Disease: Systematic Review and Meta-analysis of Randomized Controlled Trials
Journal of Medical Internet Research

Background: Telemedicine plays an important role in the management of inflammatory bowel disease (IBD), particularly during a pandemic such as COVID-19. However, the effectiveness and efficiency of telemedicine in managing IBD are un...

Released: 25-Mar-2022 2:45 AM EDT
The Evaluation of a Social Media Campaign to Increase COVID-19 Testing in Migrant Groups: Cluster Randomized Trial
Journal of Medical Internet Research

Background: A low test positivity rate is key to keeping the COVID-19 pandemic under control. Throughout the pandemic, several migrant groups in Norway have seen higher rates of confirmed COVID-19 and related hospitalizations, while ...

Released: 25-Mar-2022 2:30 AM EDT
Internet-Delivered Cognitive Behavioral Therapy for Generalized Anxiety Disorder in Nationwide Routine Care: Effectiveness Study
Journal of Medical Internet Research

Background: Therapist-supported, internet-delivered cognitive behavioral therapy (iCBT) is efficacious for generalized anxiety disorder (GAD), but few studies are yet to report its effectiveness in routine care. Objective:

Released: 25-Mar-2022 2:15 AM EDT
The Effectiveness of Physical Activity-Promoting Web- and Mobile-Based Distance Weight Loss Interventions on Body Composition in Rehabilitation Settings: Systematic Review, Meta-analysis, and Meta-Regression Analysis
Journal of Medical Internet Research

Background: Overweight and obesity are major problems worldwide, and they lead to an increased risk for several diseases. The use of technology in the treatment of obesity is promising, but in the existing literature, there is consid...

Newswise: Scientists Identify Overgrowth of Key Brain Structure in Babies Who Later Develop Autism
24-Mar-2022 2:40 PM EDT
Scientists Identify Overgrowth of Key Brain Structure in Babies Who Later Develop Autism
University of North Carolina School of Medicine

Scientists have known the amygdala is abnormally large in school-age children with autism, but now, for the first time, researchers from the Infant Brain Imaging Study (IBIS) Network, used magnetic resonance imaging (MRI) to demonstrate that the amygdala grows too rapidly in infancy.

Released: 25-Mar-2022 12:00 AM EDT
Adult neural stem cells and schizophrenia
World Journal of Stem Cells

Schizophrenia (SCZ) is a devastating and complicated mental disorder accompanied by variable positive and negative symptoms and cognitive deficits. Although many genetic risk factors have been identified, SCZ is also considered as a neurodevelo

Released: 25-Mar-2022 12:00 AM EDT
Mesenchymal stem/stromal cells as adjuvant therapy in COVID-19-associated acute lung injury and cytokine storm: Importance of cell identification
World Journal of Stem Cells

Theoretically, mesenchymal stem cells (MSCs) are very promising as adjuvant therapy to alleviate coronavirus disease 2019 (COVID-19)-associated acute lung injury and cytokine storm. Several published studies, which used MSCs to alleviate COVID-



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