The U.S. Food and Drug Administration recently approved two new wound management products that include patented hydrogels invented by University of Delaware researchers. The unique UD hydrogel materials self-assemble to form a 3D matrix compatible with living cells.
Current methods to model or correct mutations in live cells are inefficient, especially when multiplexing — installing multiple point mutations simultaneously across the genome. Researchers from the UC San Diego have developed new, efficient genome editing tools called multiplexed orthogonal base editors (MOBEs) to install multiple point mutations at once.
This study investigates the genetic regulation of volatile production in melons, identifying over 1000 quantitative trait loci (QTLs) affecting aroma and ripening. Key findings highlight specific chromosomes that influence ester and aldehyde levels, contributing to unique aromas in climacteric and non-climacteric melons, aiding breeding programs aimed at enhancing fruit quality.
A research team has developed a novel conceptual framework for designing plastic-greenhouse soil profiles that cater to the needs of smallholder farmers.
A research team has reviewed the role of MicroRNA156 (miR156) in horticultural plants, uncovering its significant influence on a variety of biological processes such as vegetative growth, floral induction, and stress response.
A research team has meticulously analyzed the transcriptional response of Impatiens walleriana to Plasmopara obducens infection, revealing between 3,000 and 4,500 differentially expressed transcripts at various stages of the disease.
A study has tapped into the peach genome, creating large-scale gene coexpression networks (GCNs) that predict gene functions and streamline the peach breeding process. This innovative approach addresses the complex task of identifying genes linked to desirable breeding traits in peaches.
A study introduces an automated machine learning (Auto-ML) model that predicts the freezing tolerance of grapevines in real-time, a critical advancement for sustainable grape production in cooler climates. This model leverages hourly temperature data and varietal specifics to forecast cold hardiness, a significant step towards precision viticulture.
Recent research has unveiled the genetic foundations of resistance in strawberries to Macrophomina, a formidable soilborne disease. Employing cutting-edge breeding strategies and genomic analysis, scientists have pinpointed crucial genetic loci responsible for resistance, heralding a new era of more robust strawberry varieties.
A recent study has unlocked the genetic secrets behind the sweetness of strawberries, a key factor in consumer preference. The research identifies key genetic markers that influence both the sugar content and yield of strawberries, offering a significant step forward in the breeding of sweeter, more productive varieties.
New genomic insights from researchers unveil critical genes influencing apple fruit size and shape. Through a comprehensive genome-wide association study, the study identifies several genetic markers linked to these traits, offering potential for enhanced breeding strategies.
A new study has uncovered a genetic treasure trove within the melon genome that could revolutionize the plant's defense against pests and diseases. Researchers have identified a cluster of genes that bestow resistance to both powdery mildew and aphids, two of the most devastating threats to melon crops worldwide.
Biotechnological innovation meets horticulture as researchers unveil a cutting-edge genome editing protocol for grapes. This novel technique, integrating protoplast culture with CRISPR-Cas9, facilitates the regeneration of non-chimeric, transgene-free plants across a spectrum of grape varieties.
A study by researchers at Washington University School of Medicine in St. Louis has found that repeat vaccination with updated versions of the COVID-19 vaccine promotes the development of antibodies that neutralize a wide range of variants of the virus that causes COVID-19, as well as related coronaviruses.
Researchers have developed a groundbreaking point-of-care detection method for Vibrio parahaemolyticus, a bacterium responsible for a significant number of foodborne illnesses. The new platform, leveraging recombinant polymerase amplification (RPA) and the CRISPR/Cas12a system combined with an immunochromatographic test strip (ICS), offers a low-cost, simple, and visually intuitive solution for the rapid detection of this pathogen in seafood.
From lemur poop to good old human poop, our waste has a story to tell. The U.S. Department of Energy’s (DOE) Argonne National Laboratory’s Environmental Sample Preparation and Sequencing Facility (ESPSF) has the tools and technology to get to the bottom of genetic mysteries from the natural world. Facility Manager Sarah Owens can help shed light on the quirkier side of genetics.
Disc-related back pain may one day meet its therapeutic match: gene therapy delivered by naturally derived nanocarriers that, a new study shows, repairs damaged discs in the spine and lowers pain symptoms in mice.
F. William Studier, a senior biophysicist emeritus at the U.S. Department of Energy's 'Brookhaven National Laboratory, has won the 2024 Richard N. Merkin Prize in Biomedical Technology for his development in the 1980s of an efficient, scalable method of producing RNA and proteins in the laboratory.
Hae Choon Chang, President of the World Institute of Kimchi (WiKim) announced on April 22 that the institute has developed a 'bio-refactoring-based upcycling technology' that can convert cabbage byproducts discarded as waste during the food manufacturing process into biodegradable plastics.
A new study led by the University of Portsmouth in England has developed an innovative method to customise and strengthen DNA origami structures, which could lead to advances in medicine, biotechnology, and beyond.
The Korea Institute of Science and Technology (KIST) announced that Dr. Sang Soo, Han and Dr. Donghun, Kim of the Computational Science Research Center and Professor Kwan-Young Lee of the Department of Chemical Engineering and Biotechnology at Korea University (President Kim Dong-won) have developed a bespoke synthesis platform of nanomaterials using AI and robotics, called Smart Lab.
In the field of biomedical research and genomics, the advancement of bioinformatics technologies and tools is opening new frontiers in the understanding of diseases and their diagnosis and treatment.
Researchers report in ACS Central Science that they have 3D printed a bioink containing plant cells that were then genetically modified, producing programmable materials. Applications could someday include biomanufacturing and sustainable construction.
Miriam Merad, MD, PhD, a world-renowned immunologist, has been appointed Dean for Translational Research and Therapeutic Innovation of the Icahn School of Medicine at Mount Sinai. The appointment reaffirms Icahn Mount Sinai’s commitment to pioneering medical progress and catalyzing the rapid advancement of research innovation. Dr. Merad, the Mount Sinai Professor in Cancer Immunology, will also continue to serve as the founding Chair of the Department of Immunology and Immunotherapy, Director of the Marc and Jennifer Lipschultz Precision Immunology Institute, and Director of the Human Immune Monitoring Center. As Dean, Dr. Merad aims to elevate early clinical trials at Icahn Mount Sinai, streamline the clinical trial process, cultivate a culture of mechanistic clinical trials throughout the campus, and forge stronger partnerships with the pharmaceutical and biotech sectors.
The repair of bone tissue damage is a complex process that is well-orchestrated in time and space, a focus and difficulty in orthopedic treatment. In recent years, the success of mesenchymal stem cells (MSCs)-mediated bone repair in clinica
Coronavirus disease 2019 (COVID-19) is an acute respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 infection typically presents with fever and respiratory symptoms, which can progress to
Wound repair is a complex challenge for both clinical practitioners and researchers. Conventional approaches for wound repair have several limitations. Stem cell-based therapy has emerged as a novel strategy to address this issue, exhibitin
BACKGROUNDMesenchymal stem cells (MSCs) have been extensively studied for therapeutic potential, due to their regenerative and immunomodulatory properties. Serial passage and stress factors may affect the biological characteristics of MSCs,
BACKGROUNDLeukemia stem cells (LSCs) are found to be one of the main factors contributing to poor therapeutic effects in acute myeloid leukemia (AML), as they are protected by the bone marrow microenvironment (BMM) against conventional ther
BACKGROUNDStem cells are undifferentiated cells that possess the potential for self-renewal with the capacity to differentiate into multiple lineages. In humans, their limited numbers pose a challenge in fulfilling the necessary demands for
Hypoxia can get more ability to inhibit inflammation. But how it impact on survival time of mesenchymal stem cells (MSCs) is confusing and how preconditioned MSCs inhibiting inflammation are partially known. Those issues decided the value o
BACKGROUNDOsteoporosis (OP) has become a major public health problem worldwide. Most OP treatments are based on the inhibition of bone resorption, and it is necessary to identify additional treatments aimed at enhancing osteogenesis. In the
Knee osteoarthritis is a degenerative condition with a significant disease burden and no disease-modifying therapy. Definitive treatment ultimately requires joint replacement. Therapies capable of regenerating cartilage could significantly
Scientists from the University of California San Diego discovered a novel signaling pathway in liver cells, leading to a treatment for fibrosis.
A newly developed nanomaterial that mimics the behavior of proteins could be an effective tool for treating Alzheimer’s and other neurodegenerative diseases. The nanomaterial alters the interaction between two key proteins in brain cells — with a potentially powerful therapeutic effect.
A research team has provided an overview for understanding the genetic basis of ornamental and cold resistance traits in Mei (Prunus mume), a tree valued both for its ornamental and cultural significance in China.
Factor Bioscience Inc., a Cambridge-based biotechnology company focused on developing mRNA and cell-engineering technologies, announced its participation in the American Society of Gene & Cell Therapy (ASGCT) 27th Annual Meeting to be held in Baltimore, MD from May 7-11, 2024.
University of Maryland School of Medicine (UMSOM) Dean Mark T. Gladwin, MD, announced today that Martine Rothblatt PhD, JD, MBA, Chairperson and CEO of United Therapeutics, and inventor of SiriusXM Satellite Radio, will deliver the keynote address for this year’s graduating medical student class. The UMSOM MD graduation ceremony will take place at the Hippodrome Theatre on Thursday, May 16, 2024.
BACKGROUNDThe bone remodeling during orthodontic treatment for malocclusion often requires a long duration of around two to three years, which also may lead to some complications such as alveolar bone resorption or tooth root resorption. Lo
Cumulative evidence suggests that O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) plays an important regulatory role in pathophysiological processes. Although the regulatory mechanisms of O-GlcNAcylation in tumors have been graduall
BACKGROUNDMesenchymal stem cells (MSCs) modulated by various exogenous signals have been applied extensively in regenerative medicine research. Notably, nanosecond pulsed electric fields (nsPEFs), characterized by short duration and high st
BACKGROUNDStem cell transplantation is a promising therapeutic option for curing perianal fistula in Crohn’s disease (CD). Anti-tumor necrotic factor (TNF) therapy combined with drainage procedure is effective as well. However, previous s
Mesenchymal stromal cells (MSCs) hold great promise for tissue regeneration in debilitating disorders. Despite reported improvements, the short-term outcomes of MSC transplantation, which is possibly linked to poor cell survival, demand ext
BACKGROUNDThe self-assembly of solid organs from stem cells has the potential to greatly expand the applicability of regenerative medicine. Stem cells can self-organise into microsized organ units, partially modelling tissue function and re
Mesenchymal stem cells (MSCs) are stem/progenitor cells capable of self-renewal and differentiation into osteoblasts, chondrocytes and adipocytes. The transformation of multipotent MSCs to adipocytes mainly involves two subsequent steps fro
High glucose (HG) culture conditions in vitro and persistent exposure to hyperglycemia in diabetes patients are detrimental to stem cells, analogous to any other cell type in our body. It interferes with diverse signaling pathways, i.e. mam
Psilera, a leading biotechnology company developing groundbreaking therapies for hard-to-treat neurological disorders, is pleased to announce the appointment of Magali Haas, M.D., Ph.D., to its esteemed Board of Directors.
Human artificial chromosomes (HACs) capable of working within human cells could power advanced gene therapies, including those addressing some cancers, along with many laboratory applications, though serious technical obstacles have hindered their development.
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