Increasing the amount of protein in the diet may reduce the liver’s fat content and lower the risk of diabetes in people with nonalcoholic fatty liver disease (NAFLD). The study is published ahead of print in the American Journal of Physiology—Endocrinology and Metabolism.
Married people who fight nastily are more likely to suffer from leaky guts – a problem that unleashes bacteria into the blood and can drive up disease-causing inflammation, new research suggests.
By genetically manipulating and removing the most common mutant form of the p53 gene that promotes colorectal cancer in humans, an international team of scientists demonstrated that this therapy reduces tumor growth and tissue invasion.
When it comes to shedding pounds, it pays to think big, according to new research by The University of Texas Health Science Center at Houston (UTHealth).
Seattle Cancer Care Alliance (SCCA) / University of Washington Medical Center (UWMC) is ranked among the best in the nation for adult cancer care by U.S. News & World Report for 2018-2019.
Although immunotherapy is seen as a very promising treatment for cancer, currently only 20 to 30 percent of patients respond positively. Being able to identify the people most likely to benefit from the costly therapy is a Holy Grail for oncologists.
Mice deficient in innate lymphoid cells are vulnerable to lethal infection by the bacterial pathogen Yersinia enterocolitica (YE), which causes some forms of food poisoning. Moreover, activation by a cytokine called LIGHT, which is a member of the tumor necrosis factor (TNF) superfamily, is necessary for ILCs to mount an anti-bacterial response.
Blue-light cystoscopy has previously been available at some institutions, including UT Southwestern, for use in the operating room, but it wasn’t available in a flexible scope until now.
روتشستر، مينيسوتا. – أشارت دراسة أولية نُشرت في عدد أغسطس الصادر من Mayo Clinic Proceedings أن بكتيريا الأمعاء قد تكون مسؤولة لدى بعض الأشخاص عن عدم قدرتهم على إنقاص الوزن، على الرغم من التزامهم باتباع نظام غذائي صارم وتمارين رياضية منتظمة Mayo Clinic Proceedings.
Cleveland Clinic researchers have designed a potential new class of drugs that may reduce cardiovascular risk by targeting a specific microbial pathway in the gut. The research, published in the September issue of Nature Medicine, was led by Stanley Hazen, M.D., Ph.D.
A new clinical trial shows that consuming crickets can help support the growth of beneficial gut bacteria and that eating crickets is not only safe at high doses but may also reduce inflammation in the body.
A high-fat diet may promote the growth of pancreatic cancer independent of obesity because of the interaction between dietary fat and cholecystokinin (CCK), a digestive hormone. In addition, blocking CCK may help prevent the spread of pancreatic tumors to other areas of the body (metastases).
Endocrinologists at Beth Israel Deaconess Medical Center (BIDMC) have shown for the first time that brown fat can exert control over skeletal muscle function.
Para algumas pessoas, as bactérias intestinais podem ser responsáveis pela incapacidade de perder peso, apesar da prática de dietas e exercícios rigorosos, sugere um estudo preliminar publicado na edição de agosto da Mayo Clinic Proceedings.
After a successful, two-year pilot project that helped patients reverse their metabolic syndrome with lifestyle changes, the William G. McGowan Charitable Fund is expanding the Eat, Love, Move (ELM) program to five cities through a six-year clinical trial, totaling $9 million in grants to Rush University Medical Center.
A preliminary study published in the August issue of Mayo Clinic Proceedings suggests that, for some people, specific activities of gut bacteria may be responsible for their inability to lose weight, despite adherence to strict diet and exercise regimens.
Increasing healthy brown fat might help weight management and reduce symptoms of diabetes. Columbia Engineers have developed a simple, innovative method to directly convert white fat to brown fat outside the body and then reimplant it in a patient. The technique uses fat-grafting procedures commonly performed by plastic surgeons, in which fat is harvested from under the skin and then retransplanted into the same patient for cosmetic or reconstructive purposes.
In a study published in the August issue of Diseases of the Colon & Rectum, investigators from the University of Alabama at Birmingham sought to answer this question. While it has been long recognized that heavy patients are at higher risk of complications after surgery, Dr. Wahl and his colleagues wanted to find out whether there was a difference whether a patient was merely pudgy or downright obese.
What do patients really want? These are Important questions that doctors at the University of Vermont have tried to answer. In the August issue of Diseases of the Colon & Rectum, Dr. Wrenn and his colleagues surveyed 167 patients who had undergone a colorectal resection between 2009 and 2015.
Mice fed a fattening diet develop new liver circadian rhythms that impact the way fat is accumulated and simultaneously burned. The team found that as liver fat production increases, surprisingly, so does the body’s ability to burn fat. These opposing physiological processes reach their peak activity each day around 5 p.m., illustrating an unexpected connection between overeating, circadian rhythms, and fat accumulation in the liver.
A clinical trial is currently underway to evaluate the predictive values of the STELLUX® Chemiluminescence Calprotectin ELISA for the diagnosis of inflammatory bowel diseases (IBDs), specifically Crohn's disease (CD) and ulcerative colitis (UC). The clinical trial will evaluate the use of the assay to aid in the differentiation of IBD from irritable bowel syndrome (IBS) when used in conjunction with other diagnostic testing.
Researchers with UNC Lineberger’s Carolina Cancer Screening Initiative, in collaboration with the Mecklenburg County Health Department in Charlotte, examined the impact of mailing tests to more than 2,100 people insured by Medicaid who were not up-to-date with colorectal cancer screening.
ALPCO, a leading producer of research and clinical immunoassays, announced it will feature its therapeutic drug monitoring (TDM) ELISA portfolio at the AACC’s 70th Clinical Lab Expo July 31-August 2 in Chicago.
Kombucha (pronounced kom-BOO-cha) can help restore the body’s natural microbiome and improve overall health, but it’s important to make informed choices about kombucha sources and consumption.
Ludwig Cancer Research and the Cancer Research Institute (CRI) announce the initiation of a clinical trial to evaluate the combination of ONCOS-102, an experimental anti-tumor virotherapy, with the checkpoint blockade antibody IMFINZI® (durvalumab) for advanced ovarian and colorectal cancers.
A clinical trial to evaluate the combination of ONCOS-102, an experimental anti-tumor virotherapy, with the checkpoint blockade antibody IMFINZI® (durvalumab) for advanced ovarian and colorectal cancers has been initiated.
• The ultimate goal of basic biomedical research is to better the lives of patients through prevention, control or cure of disease.
• Crossing that gap between the lab and bedside is difficult to achieve.
• One great need for better treatment is diabetes, a disorder that afflicts one of every 10 U.S. adults and doubles the risk of early death.
NIBIB-funded researchers at the Massachusetts Institute of Technology have created an ingestible sensor to non-invasively monitor indicators of disease in the stomach and intestines.
Nonalcoholic fatty liver disease, or NAFLD, which affects roughly 100 million Americans, costs the United States healthcare system $32 billion annually, according to a first-of-its-kind study by Intermountain Healthcare researchers on the economic impact of the disease.
The American College of Gastroenterology is pleased to announce that its Monograph on Management of Irritable Bowel Syndrome (IBS) was published this week in The American Journal of Gastroenterology, the College’s flagship journal.
Access the Monograph: https://rdcu.be/19yQ
To make sure that good ideas to enhance healthcare are not lost due to a lack of resources, a growing number of centers at Penn Medicine organize forums to pitch ideas to improve medical devices and technology, hold annual competitions to fund studies to improve patient care while keeping costs down, and sponsor seed grants for programs focused on patients who need individualized tailoring of their treatment. This last category is where precision medicine comes in, which is designed to enhance care for particular groups of patients, based on their genetic background, patient history, and unique diagnosis.
A research team led by Iowa State's Balaji Narasimhan and affiliated with the Nanovcaccine Institute based at Iowa State is studying nanovaccines for treating pancreatic cancer. The study is supported by a $2.67 million grant from the National Cancer Institute of the National Institutes of Health.
Georgetown-led investigators have found that a fairly simple test significantly improves the identification of bladder tumors that will likely become invasive.
In preclinical experiments, Laurie Harrington and colleagues have discovered a subset of immune cells that create and sustain chronic inflammatory bowel disease. These cells could become potential therapeutic targets to ameliorate or cure Crohn’s disease and ulcerative colitis.
Researchers at Washington University School of Medicine in St. Louis have found that immune cells called macrophages can trigger smooth muscle contractions in the intestinal tract, independent of nerve cells.
For the 12th year in a row, NewYork-Presbyterian Hospital ranks in more pediatric specialties than any other New York metro area hospital in U.S. News & World Report’s “Best Children’s Hospitals.” The 2018-19 rankings are published online today.
Using a new tool they call FluVision, University of Wisconsin-Madison researchers are able to witness influenza infection in a living animal in action. It helps them better understand what happens when a virus infects the lungs and the body responds.
Cedars-Sinai has launched an initiative to accelerate the development of novel drugs, devices and therapies aimed at improving treatments for patients with gastrointestinal and metabolic diseases. Physician-scientists and others in the Medically Associated Science and Technology (MAST) Program are focusing their research expertise on disorders of the microbiome. This naturally occurring ecosystem of single-cell organisms—including bacteria, fungi, viruses and archaea—lives within the human gut.
A new study provides a platform for predicting how microbial gut communities work and represents a first step toward understanding how to manipulate the properties of the gut ecosystem. This could allow scientists to, for example, design a probiotic that persists in the gut or tailor a diet to positively influence human health.
En los pacientes diagnosticados con cáncer de páncreas, la glucosa sanguínea puede estar elevada hasta tres años antes del diagnóstico de cáncer, muestran los resultados de un estudio realizado por investigadores de Mayo Clinic y publicado en la revista Gastroenterology.
Pacientes diagnosticados com câncer pancreático podem desenvolver níveis elevados de glicose até três anos antes do diagnóstico do câncer, segundo os resultados de um estudo realizado por pesquisadores da Mayo Clinic e publicado no periódico Gastroenterology.
روتشستر، مينيسوتا. - يمكن أن يُعاني المرضى الذين تم تشخيص إصابتهم بسرطان البنكرياس من ارتفاع مستويات السكر في الدم حتى ثلاث سنوات قبل تشخيص السرطان، وذلك وفقًا لنتائج دراسة أجراها الباحثون في Mayo Clinic وقاموا بنشرها في مجلة Gastroenterology.
West Virginia University researchers are working to improve screening rates for the state, which has one of the highest incidences of colorectal cancer and one of the lowest screening rates in the nation.