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Three independent investigations published online April 21 ahead of print in the peer-reviewed journal Environmental Health Perspectives (EHP) have reached similar conclusions, associating prenatal exposure to organophosphate (OP) pesticides with IQ deficits in school-age children. The fact that three research groups reached such similar conclusions independently adds considerable support to the validity of the findings.

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Researchers from Mount Sinai School of Medicine have for the first time determined that the ketogenic diet, a specialized high-fat, low carbohydrate diet, may reverse impaired kidney function in people with Type 1 and Type 2 diabetes.

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Tufts University researchers observed that a genetic variant on the perilipin 4 (PLIN4) locus was associated with an increased risk of obesity yet, carriers with higher omega-3 fatty acid intakes tended to weigh less than carriers who consumed little or no omega-3 fatty acids. Furthermore, the researchers identified a microRNA (miRNA) which may help elucidate the mechanism behind the gene-diet interaction.

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Melting glaciers and ice caps on Canadian Arctic islands play a much greater role in sea level rise than scientists previously thought, according to a new study led by a University of Michigan researcher.

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The brain’s hypothalamus plays a key role in obesity and one of its major complications – type 2 diabetes. Nerve cells in the hypothalamus detect nutrients and hormones circulating in the blood and then coordinate a complex series of behavioral and physiological responses to maintain a balance between calories eaten and calories burned. Obesity and diabetes can result when this regulatory mechanism goes awry.

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Cancer survival rates could improve soon with whole-genome sequencing, according to two studies published in the April 20, 2011, issue of the Journal of the American Medical Association that describe the first clinical applications of the high-tech process in patients with cancer.

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Two new studies in the Journal of the American Medical Association highlight the power of sequencing cancer patients’ genomes as a diagnostic tool, helping doctors decide the best course of treatment and researchers identify new cancer susceptibility mutations that can be passed from parent to child.

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Researchers at the University of California, San Diego School of Medicine say antibodies to a non-human sugar molecule commonly found in people may be useful as a future biomarker for predicting cancer risk, for diagnosing cancer cases early and, in sufficient concentration, used as a treatment for suppressing tumor growth.

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With ubiquitous social media sites like Facebook and Twitter blurring private and professional lines, there is an increasing need for physicians to create a healthy distance between their work and home online identities, two Beth Israel Deaconess Medical Center physicians assert.

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New research suggests that people who are exposed to low levels of sunlight coupled with a history of having a common virus known as mononucleosis may be at greater odds of developing multiple sclerosis (MS) than those without the virus. The research is published in the April 19, 2011, print issue of Neurology®, the medical journal of the American Academy of Neurology.

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A multi-center study to be published April 26 in the Journal of the American College of Cardiology reports a new biomarker is more effective than current best practice for early detection of adverse outcomes after acute kidney injury (AKI) – fatal for an estimated 50 percent of the critically ill patients who get the condition

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Dana-Farber scientists have developed a laboratory model that mimics the process by which fallopian tube cells may morph into cancer cells that appear to have come from the ovaries, supporting the theory that high-grade serous ovarian cancer may originate from the fallopian tubes.

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A new study of older diabetes patients has found that well-controlled blood sugar levels were associated with a lower risk of major complications but the very lowest blood sugar levels were associated with a small but significant increased risk of death.

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Patients with chronic obstructive pulmonary disease (COPD) who are hospitalized for pneumonia and treated with inhaled corticosteroids (ICS) have decreased mortality when compared to those who are not treated with ICS, according to a retrospective analysis of almost 16,000 COPD patients admitted to VA hospitals.

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Jefferson researchers used gene signatures and energy metabolism to predict clinical outcome, rather than gene mutations.

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1) Most of the mortality from melanoma comes from metastasis; 2) Current monitoring requires costly imaging methods.

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A group of 264 Mexican-American children living in California had higher levels of polybrominated diphenyl ether (PBDE) flame retardants in their blood serum than 283 counterparts living in Mexico, according to research published online April 15 ahead of print in the peer-reviewed journal Environmental Health Perspectives (EHP).

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Taking a statin before having major elective surgery reduces potentially serious kidney complications, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN).

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Kidney transplant recipients who develop antibodies in response to receiving new organs can develop accelerated arteriosclerosis, or narrowing of the arteries that supply blood to the kidney, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). The results indicate that arteriosclerosis resulting from such donor-specific antibodies may play an important role in organ rejection following transplantation.

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(1) U.S. men who have sex with men have escalated risk of HIV-related mortality (2) Access to mental health drugs among vulnerable populations living with HIV is affected by state-level factors (3) Substance-abusing women offenders benefit from community-based aftercare program once leaving prison

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Wind blowing on the ocean is a crucial factor mixing carbon dioxide into the ocean depths. For more than two decades scientists have suspected there’s another source of mixing at ocean fronts. However, there’s never been a way to get enough measurements of such a front to prove this – until now.

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The Johns Hopkins researchers who first showed that the commonly used blood pressure drug losartan may help prevent life-threatening aneurysms of the aorta in patients with Marfan syndrome have now discovered new clues about the precise mechanism behind the drug’s protective effects.

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A study conducted at the University of Rochester’s Baby Lab shows that toddlers actually use their parents’ stumbles and hesitations (technically referred to as disfluencies) to help them learn language more efficiently.

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Researchers at Johns Hopkins have discovered in mice a molecular wrecking ball that powers the demolition phase of a cycle that occurs at synapses — those specialized connections between nerve cells in the brain — and whose activity appears critical for both limiting and enhancing learning and memory. The newly revealed protein, which the researchers named thorase after Thor, the Norse god of thunder, belongs to a large family of enzymes that energize not only neurological construction jobs but also deconstruction projects.

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Using human kidney cells and brain tissue from adult mice, Johns Hopkins scientists have uncovered the sequence of steps that makes normally stable DNA undergo the crucial chemical changes implicated in cancers, psychiatric disorders and neurodegenerative diseases. The process may also be involved in learning and memory, the researchers say.

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A new research study of the effect of a commonly used strategy to reduce the spread of antibiotic-resistant bacteria in hospital intensive care units (ICU) shows that the strategy had no significant effect. That’s the surprising finding of a multisite study led by Mayo Clinic investigators.

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A new drug called perampanel appears to significantly reduce seizures in people with hard-to-control epilepsy, according to results of the first clinical trial to test the higher 12 mg dose of the drug. The late-breaking research will be presented at the 63rd Annual Meeting of the American Academy of Neurology, April 9–16, 2011, in Honolulu.

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Areas of the brain affected by Alzheimer’s disease may start shrinking up to a decade before dementia is diagnosed, according to a new study published in the April 13, 2011, issue of Neurology®, the medical journal of the American Academy of Neurology (AAN).

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Treating high blood pressure, high cholesterol, diabetes and other vascular risk factors may help lower the risk of Alzheimer’s disease in people who already show signs of declining thinking skills or memory problems. The research is published in the April 13, 2011, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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A study on the relationship between multiple sclerosis and chronic cerebral venous insufficiency, a narrowing of the extracranial veins that restricts the normal outflow of blood from the brain, found that CCSVI may be a result of MS, not a cause.

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Researchers at the Johns Hopkins Bloomberg School of Public Health have developed a non-steroid based strategy for improving the lung’s innate immune defense and decreasing inflammation that can be a problem for patients with chronic obstructive pulmonary disease (COPD). In a study, researchers targeted the Nrf2 pathway using sulforaphane, an ingredient that is present in broccoli in a precursor form, to enhance the Nrf2 pathway in the lung that mediates the uptake of bacteria.

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After a century of studying the causes of schizophrenia-the most persistent disabling condition among adults-the cause of the disorder remains unknown. Now induced pluripotent stem cells (iPSCs) generated from schizophrenic patients have brought researchers from the Salk Institute for Biological Studies a step closer to a fundamental understanding of the biological underpinnings of the disease.

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Animal model finds reduced tissue damage after heart attacks following acute, high-fat feeding

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Increase in key hormone adiponectin linked to fat-burning, better insulin sensitivity

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McGill researchers suggest malfunctions in neurons that filter visual information may be responsible for diseases such as ADHD and schizophrenia

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Tragically, infants experience severe or fatal head trauma as a result of intentional abuse. Shaken baby syndrome, now commonly referred to as non-accidental head trauma, is a serious form of abuse inflicted upon a child. While there have been other studies analyzing the relationship between economic hardship and child abuse, including head trauma, this research focuses specifically on severe head trauma trends in infants.

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Of the 4,030 new cases of brain tumors diagnosed in 2010, an estimated 2,880 were in children younger than 15. As many as 15 percent of these pediatric brain tumors occur in the brainstem. Eighty percent of brainstem gliomas (BSG’s) are diffuse intrinsic pontine gliomas (DIPGs), an almost always fatal tumor with no effective treatment. Researchers studied the biology of pediatric brainstem glioma in an effort to advance treatment of this leading cause of brain tumor death in children.

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There has been increased awareness in the last year related to head injuries incurred in the NFL as well as in collegiate and high school football. While there have been many studies related to concussion in football, and more recently, the development of chronic traumatic encephalopathy related to repetitive brain trauma in sports, this is the first in-depth analysis of the biomechanics of subdural hemorrhage formation specific to American football.

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Birds are known more for their senses of vision and hearing than smell, but new research suggests that millions of years ago, the winged critters also boasted a better sense for scents.

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During the symposium, “Pathobiology of Liver Injury and Fibrosis,” Dr. Samuel French Jr. explains the effects of several flavonoids on hepatitis C viral infection.

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New evidence suggests that walking on a treadmill at a comfortable speed and for longer duration is the most effective exercise to improve mobility in people with Parkinson’s disease. That’s according to the first randomized trial comparing three types of exercise training in Parkinson’s disease. The late-breaking research will be presented at the 63rd Annual Meeting of the American Academy of Neurology, April 9–16, 2011, in Honolulu.

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University of Maryland researchers found that Parkinson's patients who did low intensity training on a treadmill for a longer duration improved their walking more than patients who walked at a higher-intensity for a shorter time.

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Women in the treatment group had significantly lower total Postpartum Depression Screening Scale scores, with significantly fewer symptoms common to postpartum depression.

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New research suggests that a high number of Iraqi refugees are affected by brain and nervous system disorders, including those who are victims of torture and the disabled. The late-breaking research will be presented at the 63rd Annual Meeting of the American Academy of Neurology, April 9 – 16, 2011, in Honolulu.

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Study is the first to evaluate the long-term cardioprotective effects of daily consumption of apple in postmenopausal women.

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Research suggests that stress hormones program child's genes

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Brisk walking several times per week bestows benefits in just 3 months

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Results of the first randomized, placebo-controlled long-term clinical trial show the investigational drug safinamide may reduce dyskinesia or involuntary movements in mid-to-late stage Parkinson’s disease. The findings will be presented as late-breaking research at the 63rd Annual Meeting of the American Academy of Neurology, April 9–16, 2011, in Honolulu.

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Low back and leg pain secondary to degeneration of the lumbar spine (spondylolisthesis) is occurring with increasing frequency, concurrent with the rising population of people age 65 and older living in the US. As a result, there has been a marked increase in the rate of spinal fusion operations and corresponding healthcare costs over the past two decades. Researchers at Vanderbilt University Medical Center in Nashville, Tenn. set out to assess the cost-effectiveness of TLIF, a single lumbar fusion surgical technique commonly used to stabilize the vertebrae of the spine and disc between the vertebrae.

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Anterior cervical discectomy and fusion (ACDF) has been the mainstay surgical treatment for cervical disc degeneration for many years. A study performed by researchers at Boulder Neurosurgical Associates and the University of Colorado at Boulder suggests that more optimistic patient expectation and mental health are significant factors that lead to improved clinical outcomes and higher patient satisfaction scores following cervical spine surgery.