The gene identified and characterized in this study will enhance the understanding of how woody perennial plants begin their growth cycle, enabling development of new approaches to population management.
MINNEAPOLIS – New research shows that a genetic risk score may detect those at higher risk for Alzheimer’s disease long before symptoms appear—even possibly in healthy young adults, according to a study published in the July 6, 2016, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Precise predictions of whether a tumor is likely to spread would help clinicians and patients choose the best course of treatment. But such forecasts are not yet possible. New research reveals that profiling primary tumor samples using genomic technologies can improve the accuracy of breast cancer survival predictions compared to clinical information alone. The study was published in the journal GENETICS, a publication of the Genetics Society of America.
In a study of nearly 3,000 people, Einstein researchers have found that those who live 95 years or more are able to stave off age-related disease, with serious sickness compressed into only a few years late in life.
Researchers have identified genetic mutations affecting the immune system which may lead to the development of more than one bowel tumour at the same time. Understanding how these cancers develop could improve targeting of therapies, according to the study published in Nature Communications.
A research group led by Project Professor Morioka Ichiro (Kobe University Graduate School of Medicine, Department of Pediatrics) and Assistant Professor Iwatani Sota (Kobe University Hospital, Center for Perinatal Care) in collaboration with Doctor Miyawaki Atsushi (team leader at the Brain Science Institute, RIKEN) have clinically proven that a fluorescent protein sourced from Japanese eel muscles can be used to accurately detect unconjugated bilirubin in newborns. This detection method is ideal for newborn patients who can only give limited blood samples, and could revolutionize ways of monitoring jaundice in newborn infants. The findings were published on June 21, 2016 in the online edition of Scientific Reports.
QUT evolutionary biologist Dr Matthew Phillips used molecular dating from DNA sequences to challenge the dominant scientific theory that placental mammals diversified 20 million years before dinosaurs became extinct.
A receptor, first known for its role in mediating the harmful effects of the environmental pollutant dioxin in our body, is now understood to play other important roles in modulating the innate immune response.
Mice are one of the most commonly used laboratory organisms, widely used to study everything from autism to infectious diseases. Yet genomic studies in mice have lagged behind those in humans. In a study, researchers at University of California San Diego School of Medicine used 1,200 outbred mice, which are more similar to a natural population, to test a new cost-effective technique to search for specific genes linked with 66 different physical and behavioral traits.
Using a novel, newly developed mouse model that mimics the development of Alzheimer’s disease in humans, Johns Hopkins researchers say they have been able to determine that a one-two punch of major biological “insults” must occur in the brain to cause the dementia that is the hallmark of the disease
Researchers at Umeå University in Sweden are first to discover that bacteria can multiply disease-inducing genes which are needed to rapidly cause infection. The results were published in Science on June 30, 2016.
TORONTO, June 30, 2016 - Fruit flies may seem simple, but these common visitors to the fruit bowl can drastically alter their gene expression and metabolism to respond to temperature changes in their environment, an international team of researchers have shown.
Using a database of human tumor genomic data, researchers at the University of California San Diego, School of Medicine and Moores Cancer Center discovered that mutation hotspots known as kataegis are a positive marker in breast cancer — patients with kataegis have less invasive tumors and better prognoses. The study, published June 30 in Cell Reports, also suggests kataegis status could help doctors determine treatment options that might work best for patients with the mutation pattern.
The Perelman School of Medicine at the University of Pennsylvania has launched a program, called AAV 3.0™, to create new viral vectors to find quicker and better treatments for an array of diseases. James M. Wilson, MD, PhD, a professor of Medicine and director of the Orphan Disease Center, will lead an interdisciplinary team of over 30 scientists.
Extending what they learned from flies to a mouse model, researchers discover a possible first therapy for an uncommon childhood disease.
Biologists from Queen Mary University of London (QMUL) have discovered that the evolutionary history of a hormone responsible for sexual maturity in humans is written in the genes of the humble starfish.
Using so-called next-generation genome sequencing, researchers at Johns Hopkins have identified 84 potential inherited gene mutations that may contribute to the most severe forms of bipolar disorder. About 5.6 million Americans are estimated to have bipolar disorder.
A team of scientists has uncovered the global, evolving, and historic make-up of Plasmodium vivax, one of the five species of malaria that infect humans. The research, which links the spread of the parasite back to colonial seafaring, among other phenomena, underscores the challenges health experts face in controlling the parasite.
A University of Adelaide analysis of genetic mutations which cause early-onset Alzheimer’s disease suggests a new focus for research into the causes of the disease.
International researchers centered at Nagoya University use a highly sensitive technique to identify significantly more DNA sequence repeats in patients with schizophrenia than in control individuals, and outline a possible link between genome instability and disease.
Cold Spring Harbor, NY -- The genome of the corn plant - or maize, as it's called almost everywhere except the US - "is a lot more exciting" than scientists have previously believed. So says the lead scientist in a new effort to analyze and annotate the depth of the plant's genetic resources.
Obese male mice and normal weight female mice produce female pups that are overweight at birth through childhood, and have delayed development of their breast tissue as well as increased rates of breast cancer. The findings come from one of the first animal studies to examine the impact of paternal obesity on future generations’ cancer risk.
Experts from WCS (Wildlife Conservation Society) and the National University of Singapore (NUS) have made a surprising discovery that could subvert the significance of traditional criteria used for species classification.
A study by UNC Lineberger Comprehensive Cancer Center researchers has revealed the genetic mechanism for how acute myeloid leukemia cells with a specific DNA mutation stay as undifferentiated cells.
The neurodegeneration that occurs in Parkinson's disease is a result of stress on the endoplasmic reticulum in the cell rather than failure of the mitochondria as previously thought, according to a study in fruit flies. It was found that the death of neurons associated with the disease was prevented when chemicals that block the effects of endoplasmic reticulum stress were used.
Traumatic experiences in childhood increase the risk of developing behavioral and psychiatric disorders later in life. It is also known that the consequences of a trauma can likewise be observed in the children of people affected even if those children have themselves not experienced any trauma. However, childhood trauma in some conditions can also help individuals deal better with difficult situations later in life. This ability, too, is passed onto following generations. These findings have recently been uncovered by Isabelle Mansuy, Professor of Neuroepigenetics at the University of Zurich and ETH Zurich, during investigations carried out in mice.
Indiana University researchers have that found a suite of genes in both fruit flies and humans -- including one dubbed "smoke alarm" -- plays a role in nerve sensitivity. The study, published June 23 in Cell Reports, could help lead to new drug targets in pain management.
Using an innovative approach to identify a cancer’s genetic vulnerabilities by more swiftly analyzing human tumors transplanted into mice, researchers have identified a new potential target for pancreatic cancer treatment, published online in Cell Reports.
The multifunctional “scaffold” protein Alix is essential for maintaining the integrity of the cell cytoskeleton and the blood-cerebral spinal fluid barrier in the choroid plexus of the mouse brain; animals lacking Alix develop hydrocephalus.
Go here for the latest research, experts and features on Zika in the Zika Virus News Source
Case Western Reserve University School of Medicine is one of six recipients of a five-year, $10.8 million award from the National Institute on Aging, part of the National Institutes of Health, to establish the Coordinating Center for Genetics and Genomics of Alzheimer’s disease.
By studying the fruit fly, Kansas State University researchers have found a connection between a gene called clueless and genes that cause Parkinson's disease.
In a proof-of-principle study, a team of physicians and bioinformatics experts at Johns Hopkins reports they were able to diagnose or rule out suspected brain infections using so called next-generation genetic sequencing of brain tissue samples.
For women in rural communities, traveling to meet in person with cancer genetic counselors can be time-consuming and expensive. Now, a new study shows that getting cancer genetic counseling over the phone can be just as good as getting the same counseling in person. The work, led by Anita Kinney, PhD, RN, at The University of New Mexico Comprehensive Cancer Center, was published in the Journal of Clinical Oncology.
Rice University scientists have synthesized a novel anti-cancer agent, Thailanstatin A, which was originally isolated from a bacterial species collected in Thailand.
"Clock genes" turn on and off, or "Express", in rhythmic patterns throughout the body to regulate physiological conditions and behaviour. When and how these genes express, especially in tissues outside the brain, is still poorly understood. Until now, scientists have lacked sufficient means to simultaneously monitor gene rhythms in specific tissues in freely moving subjects.
The results of the largest genetic study on migraine thus far were published online in the journal Nature Genetics today, June 20. The study was based on DNA samples of 375,000 European, American and Australian participants. Almost 60,000 of them suffer from migraine
Mount Sinai CEO Kenneth L. Davis, MD and Other Leaders to be Featured Speakers, June 23 to July 2, 2016 Complementary Heart Health and Skin Cancer Screenings at the Mount Sinai Health Concourse
Click here to go directly to the Diabetes News Source on Newswise
Natural selection favors people who help close kin at their own expense: It can increase the odds the family’s genes are passed to future generations. But why assist distant relatives? Mathematical simulations by a University of Utah anthropologist suggest “socially enforced nepotism” encourages helping far-flung kin.
Mechanism of genome replication arrest provides pioneering insight about cell life span and aging
The Global Alliance for Genomics and Health (GA4GH) has called for a federated data ecosystem for sharing genomic and clinical data in an article published June 10 in Science.
How much impact do genes have on behavioral changes? Dr. Luciano Matzkin of the University of Alabama in Huntsville (UAH) want to better understand the genetic underpinnings of ecologically relevant behaviors.
Research will advance the development of salt-tolerant turf varieties.
Salk team first to discover protein that controls the strength of body’s circadian rhythms
Students at the University of Leicester have been using simple calculations to explain the feasibility of the powers behind of some of the most prominent comic book superheroes known around the world.
Joel McGlothlin’s team found that the ancestors of garter snakes gained toxin-resistant nerves almost 40 million years ago.
Incorrectly folded proteins can cause a variety of diseases. Danish researchers have found a solution for preventing this misfolding.
Publication in Genes & Development: researchers at the Université libre de Bruxelles, ULB develop new techniques to assess the fate of stem cells in vivo.
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