Every biologist knows that small structures can sometimes have a big impact: Millions of signaling molecules, hormones, and other biomolecules are bustling around in our cells and tissues, playing a leading role in many of the key processes occurring in our bodies.
Iowa State University researchers may have solved a long-standing challenge associated with accelerated development of pure genetic lines.
A team at UNC Charlotte and Tuple, a Charlotte-based genomics consulting firm, has used artificial intelligence to rapidly assess the public health implications of the newly emergent SARS-CoV-2 XBB.1.5 variant. Results from simulations run by the team indicate the antibodies currently in our arsenal are effective to neutralize SARS-CoV-2 XBB.1.5.
In 2017, Vanderbilt University Medical Center was selected to be one of four U.S. medical centers in a Strategically Focused Research Network (SFRN) on Obesity funded by a four-year, $15 million award from the American Heart Association to study obesity and train future obesity-focused investigators.
Betalains are a class of plant pigments that are responsible for the characteristic red-violet (betacyanin) or yellow (betaxanthin) color of certain fruits and vegetables.
In a new study published February 16, 2023, in Nature Genetics, researchers from the University of Chicago characterized the impact of a genetic variant associated with higher cholesterol and triglyceride blood levels in women, suggesting that similar genes might lead to different patterns of fat distribution and obesity-related disease risk for women.
A team of researchers has developed a new method to screen FDA-approved drugs to determine if they could be repurposed or improved to help patients with a rare, debilitating disease of the nervous system.
The SLAS Discovery Editor's Top 10 annually showcases ten individual articles that stand out as the most innovative scientific achievements published in SLAS Discovery in the past 12 months.
Canadian researchers show that in Fragile X syndrome, the most common cause of autism, sensory signals from the outside world are underrepresented by cortical pyramidal neurons in the brain. This phenomenon could provide important clues to the underlying cause of the syndrome's symptoms.
T-cells that are part of our immune system are central in the protection against infections and cancer. With the help of TCRs, the cells recognize foreign invaders and tumor cells.
Evolutionary geneticists and forensic experts who have spent years analyzing the remains of Chilean poet and Nobel laureate Pablo Neruda have added important new information to the case regarding a possible covert assassination.
Researchers discover a mechanism used by neurons to repair damage that occurs during neuronal activity
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Researchers reporting in ACS Infectious Diseases have developed a procedure that could help researchers catch up to microbes which can rapidly mutate and evade detection and treatment. Their “AutoPLP” technique designs nucleic acid probes to detect new variants quickly, accurately and easily.
Rice University scientists have enlisted widely used cancer therapy systems to control gene expression in mammalian cells, a feat of synthetic biology that could change how diseases are treated.
عادة ما يُستبعد الرياضيون المصابون بأمراض القلب الوراثية من المشاركة في الرياضات التنافسية بسبب الخطر المُتوقع للإصابة بتوقف القلب المفاجئ. في حين أن تخوف الأطباء قد يكون مبررًا، لكن هل هذه بالضرورة أفضل طريقة للتعامل مع الأمر؟
Los investigadores de Mayo Clinic hicieron una revisión de los atletas que se trataron en Mayo durante un período de 20 años, y los hallazgos publicados en Mayo Clinic Proceedings sugieren que después de que la afección del paciente se haya evaluado y tratado de manera adecuada, es factible que los atletas puedan volver a sus actividades de forma segura.
Atletas com doença cardíaca genética frequentemente são considerados inaptos a participar de esportes competitivos devido ao risco de parada cardíaca súbita. Embora a intenção dos médicos seja compreensível, será que essa é necessariamente a melhor abordagem?
UT Southwestern Medical Center researchers have mapped gene control elements in specialized cardiac cells responsible for coordinating heartbeats. The findings of the genome exploration study, published in The Journal of Clinical Investigation, provide insight into how heartbeats are regulated and could impact diagnosis and risk prediction for a variety of common arrhythmias.
A new study could help explain how the sense of smell is impacted in individuals with autism.
Computer software developed at Washington University School of Medicine in St. Louis can predict what happens to complex gene networks when individual genes are missing or dialed up more than usual. Mapping the roles of single genes in these networks is key to understanding healthy development and finding ways to regrow damaged cells and tissues. Likewise, understanding genetic errors could provide insight into birth defects, miscarriage or even cancer.
Analysis reveals similar changes in the brain’s functioning in both humans and mouse models
Most methods of editing bacterial genomes use plasmids to transfer DNA between bacterial cells, but this approach isn’t always efficient in mixed microbial communities. This research instead developed a new phage-based DNA delivery tool that leverages these viruses’ ability to inject DNA into host bacteria. The researchers also used this tool to edit individual genes inside a target host organism within a living microbial community.
When it comes to DNA, one pesky mosquito turns out to be a rebel among species.
Monkeyflowers glow in a rich assortment of colors, from yellow to pink to deep red-orange.
Viruses use the molecular repertoire of the host cell to replicate. Researchers from the Cluster of Excellence ImmunoSensation2 at the University of Bonn, together with Japanese researchers, want to exploit this for the treatment of influenza.
University of Virginia School of Medicine researchers have discovered a key trigger for non-alcoholic fatty liver disease, a mysterious condition that causes fat to build up in the liver for no clear reason.
It is now widely understood that cancer is a disease of acquired defects in genes and gene function. An article published Feb. 10 in Science, and authored by Andrew Feinberg, M.D., of the Johns Hopkins Kimmel Cancer Center and the Institute for Basic Biomedical Sciences (IBBS) and Andre Levchenko, Sc.D., M.S., of the Yale School of Engineering and Applied Science, addresses new quantitative approaches to better define and measure these defects in gene function, known as epigenetics, and their interplay with the genetic landscape of cancer.
A new Cedars-Sinai study in collaboration with the University of California, Irvine (UCI) and the Answer ALS consortium has examined the expression of thousands of genes in stem cell generated motor neurons that are known to die in patients with amyotrophic lateral sclerosis, a fatal neurological disorder known as ALS or Lou Gehrig's disease.
MicroRNA (miRNA) molecules in pancreatic islets have been thought to play important roles in type 2 diabetes, but until now scientists have not confidently identified which miRNAs are associated with the disease in humans.
Difference in body size (or sexual dimorphism) between males and females is common across the animal kingdom.
Most proteins localize to distinct protein-rich droplets in cells, also known as “cellular condensates”.
A model organism used in laboratories for the past 100 years has evolved so extensively that it may no longer be fit for purpose.
Changes in river systems, overfishing and the appearance of new, invasive species can lead to a drastic decline in the number of native fish inhabiting aquatic ecosystems.
Researchers of the Department of Ethology, Eötvös Loránd University (ELTE) have been investigating dogs' reactions to wolf howls.
According to an international group of researchers including a team from the University of Liverpool, patients experience 30% fewer side effects when medication doses are tailored to their DNA.
Researchers at Tel Aviv University identified a new genetic risk factor for the complex eye disease AMD (Age-related Macular Degeneration), a leading cause for loss of eyesight at an advanced age.
Wistar scientists have identified a gene signature that accurately predicts the functioning of P53 variants, important information to assessing cancer risk and optimizing choices for cancer therapeutics.
Scientists investigating the causes of lymphoedema have made a major discovery, revealing that lymphatic vessels can produce red and white blood cells.
Snakes and mice don’t look alike. But much of what we know about skin coloration and patterning in vertebrates generally, including in snakes, is based on lab mice.
Researchers at the University of Sussex are using Artificial Intelligence (AI) technology to analyse different types of cancer cells to understand different gene dependencies, and to identify genes that are critical to a cell’s survival.
The human body runs on a finely tuned clock synchronized to the 24-hour cycle of Earth’s rotation, known as the circadian clock, which controls various physiological processes such as the sleep-wake cycle, hormone production, and metabolism.
When it comes to courtship, it is important to ensure that one is interacting with a member of the same species.
Human actions are changing the environment at an unprecedented rate. Plant and animal populations must try to keep up with these human-accelerated changes, often by trying to rapidly evolve tolerance to changing conditions.
UT Southwestern Medical Center researchers have discovered a method cells use to turn genes on and off that involves portions of proteins whose function has long been a mystery. The findings, reported in Cell, could lead to new ways of controlling gene regulation and may one day lead to new treatments for a broad array of diseases.
iPSC lines have become essential for determining the underlying genetic drivers of human disease.
Amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig’s disease and Stephen Hawking’s disease, is a neurodegenerative disease that results in the gradual loss of control over the muscles in the body.
University of Virginia researchers and their collaborators have identified genes that play key roles in the development of coronary artery disease, the No. 1 cause of death worldwide.
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