A research team led by a University of Massachusetts Amherst scientist has made a significant genetic discovery that sheds light on the use of the drug caspofungin to treat a deadly fungal infection, Aspergillus fumigatus, which kills some 100,000 severely immunocompromised people each year.
مقاطعة يو كلير، ويسكنسن — تلعب الجينات دورًا في جميع مجالات الصحة تقريبًا. يشبه الجين دليل التعليمات الذي يخبر الجسم كيف يؤدي وظائفه ويتطور ويبقى بصحة جيدة. لدى الناس حوالي 20,000 جين في أجسامهم. وقد يساعد اختبار الجينات في تحديد إذا ما كان الشخص عُرضة بشكل متزايد لحالات معينة موجودة في أسرهم. برينا ميتشل، المستشارة الجينية في نظام مايو كلينك الصحي في يو كلير، تجيب عن الأسئلة الشائعة حول اختبار الجينات.
s genes desempenham um papel em quase todas as áreas da saúde. Um gene é como um manual de instruções que diz ao corpo como funcionar, se desenvolver e permanecer saudável. As pessoas têm cerca de 20.000 genes em seus corpos. Os exames genéticos podem ajudar a indicar se uma pessoa tem risco elevado de desenvolver determinadas doenças presentes na família. Breanna Mitchell, conselheira genética do Sistema de Saúde da Mayo Clinic em Eau Claire, responde algumas das questões mais comuns sobre exames genéticos.
Los genes desempeñan alguna función en casi todas las áreas de la salud. Un gen es como un manual de instrucciones que indica al cuerpo cómo funcionar, desarrollarse y mantenerse sano. La gente tiene alrededor de 20 000 genes en el cuerpo. Las pruebas genéticas indican si una persona corre más riesgo de desarrollar ciertas afecciones que se encuentran presentes en su familia. Breanna Mitchell, consejera genética del Sistema de Salud de Mayo Clinic en Eau Claire, responde varias preguntas frecuentes sobre las pruebas genéticas.
Moffitt Cancer Center has named Joseph L. Kissil, Ph.D., chair of its Molecular Oncology Department.
Russian scientists acquired stable and bright fluorescent protein moxSAASoti, which can change color and intensity of its fluorescence. To achieve this aim, the scientists made point changes in the sequence of the coding gene.
Blocking the overexpression of specific repeat RNA sequences could prove promising for the treatment of premature aging syndromes.
An Undiagnosed Diseases Network (UDN) study led by Dr. Hugo Bellen, investigator at the Jan and Dan Duncan Neurological Research Institute (NRI) at Texas Children’s Hospital and distinguished service professor at the Baylor College of Medicine, has found a spontaneous mutation in MTSS2 gene to be the underlying cause of a new syndromic intellectual disability.
A new study from the Garvan Institute of Medical Research shows how rises in core body temperature may trigger the inflammatory flares in people with a rare genetic autoinflammatory disease.
UC San Diego study finds enhanced PKCγ activity drives spinocerebellar ataxia type 14; suggests inhibiting the enzyme may have therapeutic potential
The latest dinosaur discoveries in the Dinosaurs channel on Newswise.
The American Physiological Society (APS) congratulates geneticist Svante Pääbo, PhD, recipient of the 2022 Nobel Prize in Physiology or Medicine.
Clemson geneticists Trudy Mackay and Robert Anholt will work to discover why some people become addicted to drugs while others don't.
The USDA National Institute of Food and Agriculture is awarding more than $1.8 million to the Agricultural Genome to Phenome Initiative led by Iowa State University, which aims to foster research collaborations to improve the long-term efficiency and resilience of U.S. agriculture.
“I'm a professional pin-in-a-haystack seeker,” geneticist Thijn Brummelkamp responds when asked why he excels at tracking down proteins and genes that other people did not find, despite the fact that some have managed to remain elusive for as long as forty years.
New study identifies how oxidative breaks form and are repaired in what scientists thought to be ‘junk’ DNA
Research from the Reik lab at the Babraham Institute has advanced our understanding of the role of DNA methylation during the earlier stages of development.
The Basser Center for BRCA at the Abramson Cancer Center of the University of Pennsylvania has awarded Mayo Clinic's Fergus Couch, Ph.D., with the 10th annual Basser Global Prize. This highly distinguished award recognizes a leading scientist who has advanced research related to BRCA1 and BRCA2 genes. People with mutations in these genes are at an increased risk of breast, ovarian, pancreatic and prostate cancers.
An international team has reconstructed the genome organization of the earliest common ancestor of all mammals.
Researchers from Barts Cancer Institute (BCI) at Queen Mary University of London, the Italian Institute for Genomic Medicine, and the University of Milan have identified a novel role for a cancer-causing gene in controlling an important genetic process that underpins genetic variation in prostate cancer.
University of Virginia School of Medicine researchers and their collaborators have solved a decades-old mystery about how E. coli and other bacteria are able to move.
Value & Outcomes Spotlight, the health economics and outcomes research (HEOR) news magazine of ISPOR—The Professional Society for Health Economics and Outcomes Research, announced the publication of a supplement, “A Plan of Action: Accelerating Patient Access to Next-Generation Sequencing in Oncology.”
New research has revealed Duchenne muscular dystrophy (DMD) begins much earlier in cells destined to become muscle fibres, known as myoblasts.
UC San Diego researchers have for the first time discovered a pattern of DNA mutations that links bladder cancer to tobacco smoking. The work could help researchers identify what environmental factors, such as exposure to tobacco smoke and UV radiation, cause cancer in certain patients. It could also lead to more customized treatments for a patient’s specific cancer.
Retinoblastoma is a cancer of the eye that occurs in infants and toddlers and can lead to loss of vision, loss of one or both eyes, and even death. Unlike most tumors, these cannot be biopsied because of the risk of spreading cancer to the rest of the body. In 2017, Jesse Berry, MD, surgeon and ocular oncologist at Children’s Hospital Los Angeles, discovered that fluid removed from the eye during treatment of retinoblastoma contained tumor DNA and functioned as a liquid biopsy—providing information about the tumor and opening the door to earlier diagnosis and treatment.
In a new paper, University of California, Irvine researchers explain how precision genome editing agents have enabled precise gene correction and disease rescue in inherited retinal diseases (IRDs). The study, titled, “Precision genome editing in the eye,” was published this week in the Proceedings of the National Academy of Sciences.
St. Jude scientists have created a tool that can find safe places to put corrected genes into the genome, called safe harbor sites, using genomic and epigenetic information from specific tissue, such as blood cells.
Almost three hundred years after the Romans left, scholars like Bede wrote about the Angles and the Saxons and their migrations to the British Isles.
Scientists have engineered mosquitoes that slow the growth of malaria-causing parasites in their gut, preventing transmission of the disease to humans.
A genetic predisposition for smoking increases a person’s risk of worse recovery from an ischemic stroke, according to a study published in the September 21, 2022, online issue of Neurology®, the medical journal of the American Academy of Neurology. An ischemic stroke is caused by a blockage of blood flow to the brain and is the most common type of stroke.
A team led by researchers from Nagoya University in Japan has discovered new pathways that cells use to repair themselves following exposure to ultraviolet (UV) light, and a new agent involved in these pathways known as RFWD3.
It may be the most baffling quirk of COVID: What manifests as minor, flu-like symptoms in some individuals spirals into severe disease, disability, and even death in others.
Moffitt Cancer Center has conducted the first prospective study to investigate genomic biomarkers associated with aggressive disease in African American men with prostate cancer. The study results were published in the Journal of the National Cancer Institute.
Ordering and managing genomic testing in electronic health records significantly cut the time Penn Medicine clinicians spent doing it
The genetic fingerprint of the sea anemone Nematostella vectensis shows that the members of this evolutionarily very old animal phylum use the same gene cascades for the differentiation of neuronal cell types as more complex organisms. These genes are also responsible for the balance of all cells in the organism throughout the anemone’s life. The results were published by a team of developmental biologists led by Ulrich Technau of the University of Vienna in "Cell Reports".
RNA is an important transmitter of information in our cells and serves as a blueprint for the production of proteins.
Researchers from the Institute of Biotechnology, University of Helsinki, pioneers in identifying the first patient mutations on the NFkB1-gene, cooperated with international clinicians to identify and characterise a plethora of unreported NFKB1 variants on patients with immune system related illnesses.
LMU molecular biologist Gunnar Schotta has investigated which mechanisms prevent endogenous retroviruses from becoming overly active.
The first large-scale genomic study of musicality — published on the cover of today’s Nature Human Behaviour — identified 69 genetic variants associated with beat synchronization, meaning the ability to move in synchrony with the beat of music.
Children with certain immunodeficiency diseases carry mutations in genes that regulate the body’s immune system against viral infections and they have a higher mortality rate due to COVID-19.
The University of Pennsylvania’s Basser Center for BRCA at the Abramson Cancer Center today announced a $55 million gift from Penn alumni Mindy and Jon Gray to establish the Basser Cancer Interception Institute, creating a new weapon to target hereditary cancers at their earliest stages.
Dr. Daniel Geschwind was awarded the National Academy of Medicine’s top annual prize in mental health in recognition of his pioneering research and leadership in autism genetics.
Researchers from Cleveland Clinic’s Florida Research and Innovation Center (FRIC) found that disruption of a cellular structure, known as the actin cytoskeleton, is a “priming signal” for the body to respond to a virus. These findings, published in Cell this week, potentially lay the groundwork for development of new anti-viral vaccines and treatments.
“Dr. Welford works closely with both basic science and clinical investigators to understand the biology of cancer and develop new therapies that will lead to better clinical outcomes. His excellence in translational research is founded on strong basic science discoveries,” Dr. El-Rifai said.
Upper tract urothelial carcinoma (UTUC) is a rare malignancy accounting for 5-10% of all urothelial cancers. When considering metastatic upper tract urothelial carcinoma (mUTUC) existing data is still limited.
Rutgers Cancer Institute expert shares evidence-based cancer information with this population and steps that can be taken now to prevent and reduce risk of disease.
A new, large study led by researchers at the American Cancer Society and The University of Texas MD Anderson Cancer Center shows rising costs of cancer treatments led to increases in total costs of care, and when compounded with greater cost sharing, increased out-of-pocket costs for privately insured, patients under 65 years old.
If evolutionary biologist Terence D. Capellini were to rank the body parts that make us quintessentially human, the pelvis would place close to the top.
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