Feature Channels: Genetics

• share
• favorite_border

• share
• favorite_border

• share
• favorite_border

IIT Kanpur has licensed a pioneering technology to Reliance Life Sciences Pvt. Ltd. that has the potential to revolutionize the field of gene therapy, especially for many genetic eye diseases, making it the first time that a gene therapy related technology has been developed and transferred from an academic institution to a company in India.

• share
• favorite_border

Researchers at the University at Albany’s RNA Institute have demonstrated a new approach to DNA nanostructure assembly that does not require magnesium. The method improves the biostability of the structures, making them more useful and reliable in a range of applications.

• share
• favorite_border

• share
• favorite_border

Fundamental research offers opportunities for new varieties of pigmented rice and a resource to address malnutrition.

• share
• favorite_border

Artificial intelligence has entered our daily lives. First, it was ChatGPT. Now, it’s AI-generated pizza and beer commercials. While we can’t trust AI to be perfect, it turns out that sometimes we can’t trust ourselves with AI either.

• share
• favorite_border

An observational cohort study out of Roswell Park Comprehensive Cancer Center demonstrates that race and ethnicity affect a woman’s 21-gene recurrence score, a tool used to determine risk of recurrence and distant metastasis in patients with early-stage, hormone-receptor-positive breast cancer. Based on the expression of 21 cancer-related genes detected in pre-treatment tumor specimens, recurrence score is used routinely in clinical care to identify patients who might benefit from chemotherapy as part of their treatment plan. Scores range from 0-100, with a score of 26 or higher indicating greater risk of recurrence and poorer overall survival.

• share
• favorite_border

This study used two DNA methylation-based estimators, known as epigenetic clocks, to examine aging at the cellular level and estimate the difference between chronological age and biological age. Findings showed that neighbourhood deprivation and depressive symptoms were positively associated with acceleration of the epigenetic age estimated using the DNAm GrimAge clock.

• share
• favorite_border

An international team of marine biologists has discovered the remnants of ancient RNA viruses embedded in the DNA of symbiotic organisms living inside reef-building corals.

• share
• favorite_border

• share
• favorite_border

The accuracy of prostate-specific antigen (PSA) screening for prostate cancer can be improved by accounting for genetic factors that cause changes in PSA levels that are not associated with cancer, according to a multi-center study led by UC San Francisco and Stanford University, publishing June 1 in Nature Medicine.

• share
• favorite_border

Researchers recently discovered that extremely thorough “deep sequencing” of the genome in tissue samples and cell-free DNA of patients with potentially life-threatening vascular anomalies captured several genetic variants related to disease that were not captured with conventional genetic sequencing methods. More than 60% of patients saw an improvement in their condition after being placed on targeted therapies related to these newly found genetic variants.

• share
• favorite_border

A new study led by scientists at Uppsala University and INRAE/Université Paris-Saclay has discovered that the pro-viral host protein ZC3H11A plays a critical role in maintaining embryo viability during early development.

• share
• favorite_border

A new study finds a chemical formed when we digest a widely used sweetener is “genotoxic,” meaning it breaks up DNA. The finding raises questions about how the sweetener may contribute to health problems.

• share
• favorite_border

The Endocrine Society has selected five recipients for its Early Investigator Awards.

• share
• favorite_border

Researchers at Indiana University School of Medicine have discovered alternative gene splicing, which occurs during gene expression, can impact a person's risk of alcohol use disorder (AUD). They recently published their findings in Molecular Psychiatry.

• share
• favorite_border

Study suggests person-to-person transmission may not be the dominant mode of infection for an aggressive lung pathogen. Findings shed light on the behavior and mutation tendencies of a little-known microbe. The results should ease fears that the lung bacterium poses a grave threat for spread between individuals with compromised lung function who are waiting for lung transplants.

• share
• favorite_border

The early stages of embryonic development contain many of life’s mysteries. Unlocking these mysteries can help us better understand early development and birth defects, and help develop new regenerative medicine treatments.

• share
• favorite_border

A new method than enables researchers to dial up or tone down the amount of a certain metastatic protein inhibitor (BACH1) within a cell could provide a new path in cancer research that reassesses the effectiveness of protein inhibitors to treat disease.

• share
• favorite_border

The discovery suggests that one possible approach to treat glioblastoma would be a therapy that targets the metabolic process in patients who have that genetic alteration.

• share
• favorite_border

A study published by MBARI researchers and their collaborators today in Nature provides new insights about one of the earliest points in animal evolution that happened more than 700 million years ago.

• share
• favorite_border

People with a genetic predisposition for Alzheimer’s disease may have an increased risk of epilepsy and people with a certain type of epilepsy may have an increased risk of developing Alzheimer’s disease, according to a study published in the May 24, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology.

• share
• favorite_border

Scientists at St. Jude Children’s Research Hospital studied how the epigenetic landscape influences the binding of pioneer transcription factors, affecting access to DNA.

• share
• favorite_border

Read about how Scientists at St. Jude determined how the SWI/SNF chromatin remodeling complex helps cancer cells remember how to be cancerous after division.

• share
• favorite_border

University of Delaware researchers in the lab of Aditya Kunjapur, assistant professor in the College of Engineering’s Department of Chemical and Biomolecular Engineering, have engineered bacteria to synthesize an amino acid that contains a rare functional group that others have shown to have implications in the regulation of our immune system. The researchers also taught a single bacterial strain to create the amino acid and place it at specific sites within target proteins.

• share
• favorite_border

• share
• favorite_border

From advancing artificial intelligence to strengthening our national security, the 2023 Hertz Fellows will address the most pressing challenges facing our nation.

• share
• favorite_border

Cold Spring Harbor Laboratory (CSHL) researchers have flipped the script on autism spectrum disorder (ASD) genetics.

• share
• favorite_border

UT Southwestern Medical Center researchers have identified hundreds of genomic variants associated with autism spectrum disorder (ASD) in East African families who have a markedly higher prevalence of the neurodevelopmental condition than other populations worldwide. The study, published in Cell Genomics, is the first to investigate the genetics of ASD in an African population, an important step toward decreasing racial and ethnic health disparities for this condition, the authors said.

• share
• favorite_border

UC San Diego scientists develop an interactive software that enables scientists to better investigate the DNA damage response.

• share
• favorite_border

Neurons in a key area of the brain have different functions based on their exact genetic identity, and understanding this diversity could lead to better understanding of the brain’s computational flexibility and memory capacity, potentially informing disease treatment options, Cornell researchers report in a new study.

• share
• favorite_border

In a new study published in eLife, lead author Carolyn Elya, postdoctoral researcher in the Department of Organismic and Evolutionary Biology at Harvard, reveals the molecular and cellular underpinnings behind the parasitic fungus, Entomophthora muscae’s (E. muscae), ability to manipulate the behavior of fruit flies.