Older Americans receive prescriptions for mental health drugs at more than twice the rate that younger adults do, but they’re much less likely to be getting their mental health care from a psychiatrist, a new study shows. Some seniors could be at risk of problems caused interactions between drugs.
The proposed studies are designed to test whether nonviral gene delivery into the oral cancer could be used to treat cancer pain effectively and safely.
Periodic telephone counseling can be a highly effective, low-cost tool for lowering blood-sugar levels in minority, urban adults with uncontrolled diabetes. The findings are the result of a clinical trial led by researchers at Albert Einstein College of Medicine and their collaborators at the New York City Department of Health and Mental Hygiene (Health Department). The study published online today in the American Journal of Preventive Medicine.
Article in journal Bioinformatics from University of Colorado Cancer Center describes a new tool that improves the ability to match drugs to disease: the Kinase Addiction Ranker (KAR) predicts what genetics are truly driving the cancer in any population of cells and chooses the best “kinase inhibitor” to silence these dangerous genetic causes of disease.
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded $1.4 million from the National Institute of Mental Health of the National Institutes of Health (NIH) to explore the development of drug candidates for a wide range of conditions, including circadian rhythm disorders.
Facial motion capture – the same technology used to develop realistic computer graphics in video games and movies – has been used to identify differences between children with childhood apraxia of speech and those with other types of speech disorders, finds a new study by NYU’s Steinhardt School of Culture, Education, and Human Development.
Researchers at Children’s Hospital Los Angeles and The Saban Research Institute of CHLA created a dynamic functional mouse model for lung injury repair, a tool that will help scientists explain the origins of lung disease and provide a system by which new therapies can be identified and tested.
Published today in Cancer Discovery, results of LOXO-101 against TRK fusion cancer confirm that stage IV patient's tumors had substantially regressed. With four months of treatment, additional CT scans demonstrated almost complete disappearance of the largest tumors.
Researchers at the National Institutes of Health have discovered a protein that plays a vital role in healthy egg-sperm union in mice. The protein RGS2 can delay an egg’s development into an embryo in order to allow time for sperm to arrive and merge with the egg in a healthy fertilization process. The embryo cannot survive without the male chromosomes.
With the decline of the development of new antibiotics due to the complexity and expense of discovering them, there has been a rapid growth of antibiotic resistant pathogens that is one of the leading causes of death. With the help of a nearly $4.9 million, 5-year grant from the National Institute for Allergy and Infectious Diseases of the National Institutes of Health, Wayne State University School of Medicine researchers are leading a landmark multi-center, international study that will provide essential information to clinicians for use of polymoxin B in critically ill patients where no other treatments will work.
Scientists uncover a port of liver entry for malaria parasites, and if these results hold up in humans, drugs that target this entry protein might help prevent the spread of disease.
Immune cells that hang around after parasitic skin infection help ward off secondary attack. These skin squatters may prove to be the key to successful anti-parasite vaccines.
Researchers at the University of Georgia College of Veterinary Medicine will lead a collaborative four-year study aimed at understanding the neurological mechanisms responsible for changes in taste following Roux-en-Y gastric bypass surgery and also diet-induced obesity.
Scientists from the Florida campus of The Scripps Research Institute have been awarded nearly $1.5 million from the National Institute of General Medical Sciences to explore the therapeutic potential of a class of proteins that play essential roles in the regulation and maintenance of human health.
Coating the inside of glass microtubes with a polymer hydrogel material dramatically alters the way capillary forces draw water into the tiny structures, researchers have found. The discovery could provide a new way to control microfluidic systems, including popular lab-on-a-chip devices.
Looking at measurements of the vertebrae – the series of small bones that make up the spinal column – in newborn children, investigators at Children’s Hospital Los Angeles found that differences between the sexes are present at birth.
New research indicates that adults born very premature are more likely to be socially withdrawn and display signs of autism.
A Vanderbilt research team has successfully created a mechanical wrist less than 1/16th of an inch thick -- small enough to use in needlescopic surgery, the least invasive form of minimally invasive surgery.
A new study from researchers at Beth Israel Deaconess Medical Center (BIDMC) compared open surgical repair of abdominal aortic aneurysm with a catheter-based procedure and found that the less invasive endovascular aortic repair has clear benefits for most patients, providing both a safer operation and a quicker recovery.
The brain’s effect on other parts of the body has been well established. Now, a group that includes two University of Florida Health researchers has found that it’s a two-way street: Body fat can send a signal that affects the way the brain deals with stress and metabolism.
In their bid to find the best combination of therapies to treat anaplastic thyroid cancer (ATC), researchers on Mayo Clinic’s Florida campus demonstrated that all histone deacetylase (HDAC) inhibitors are not created equal.
The algorithm ENVE could be the Google for genetic aberrations — and it comes from Case Western Reserve. The findings about the algorithm that distinguishes “noise” from real evidence, as well as some genetic characteristics of colon cancer in African Americans, appears this week in Genome Medicine.
Like a collection of ragtag villagers fighting off an invading army, the mix of bacteria that live in our guts may band together to keep dangerous infections from taking hold, new research suggests. But some “villages” may succeed better than others at holding off the invasion, because of key differences in the kinds of bacteria that make up their feisty population.
Despite heightened awareness of surveillance tactics and privacy breaches, existing computer security tools aren't meeting the needs of journalists working with sensitive material, a new UW study finds.
In a survey of a diverse group of almost 250 young, low-income, inner-city pregnant and postpartum women, Johns Hopkins researchers have learned that more than 90 percent use smartphones or regular cellphones to give and get information.
A paper published today in the Proceedings of the National Academy of Sciences argues against the commonly held "accumulation of mutations" model of oncogenesis in favor of a model that depends on evolutionary pressures acting on populations of cells.
Although the causes of many age-related diseases remain unknown, oxidative stress is thought to be the main culprit. Oxidative stress has been linked to cardiovascular and neurodegenerative diseases including diabetes, hypertension and age-related cancers. However, researchers at the University of Missouri recently found that aging actually offered significant protection against oxidative stress. These findings suggest that aging may trigger an adaptive response to counteract the effects of oxidative stress on blood vessels.
Only one in three older Americans have their diabetes under control as measured by guidelines set by the American Diabetes Association, new Johns Hopkins Bloomberg School of Public Health research suggests.
Johanna Olson, MD, and her colleagues at Children’s Hospital Los Angeles, provide care for the largest number of transyouth in the U.S. and have enrolled 101 patients in a study to determine the safety and efficacy of treatment that helps patients bring their bodies into closer alignment with their gender of identity.
Individuals with new-onset type 1 diabetes who took two courses of alefacept (Amevive®, Astellas Pharma Inc.) soon after diagnosis show preserved beta cell function after two years compared to those who received a placebo.
A new drug acts as a roadblock for malaria, curing mice of established infection, according to researchers. Treatment was not associated with obvious side effects, suggesting that the drug may also be safe and effective in humans.
Using existing drugs, such as lithium, to restore basic biological processes in human cells and animal models, researchers may have broken a long-standing logjam in devising effective treatments for human mitochondrial diseases.
Anyone who’s ever noticed a water puddle drying in the sun has seen an environment that may have driven the type of chemical reactions that scientists believe were critical to the formation of life on the early Earth.
A research team out of Michigan Tech has found a way to solve one of the biggest challenges of making metamaterials. Their optical work is a big step towards creating a "perfect lens".
A research team funded by the National Institutes of Health has generated a novel system for growing cardiac tissue from undifferentiated stem cells on a culture plate. This heart on a chip is a miniature physiologic system that could be used to model early heart development and screen drugs prescribed during pregnancy. Researchers from the University of California (UC) Berkeley; the Gladstone Institutes, in San Francisco; and UC San Francisco, reported their work in the July 14, 2015, online issue of Nature Communications.
Scientists at The Scripps Research Institute Florida campus have been awarded a pair of grants totaling nearly $2.8 million to develop a new therapeutic agent to reduce latent levels of HIV that hide from the immune system in infected individuals.
A new study suggests people who speak two languages have more gray matter in the executive control region of the brain.
Hospitalizations for heart conditions, neurological illness, and other conditions were higher among people who live near unconventional gas and oil drilling (hydraulic fracturing), according to new research.
Since 2007, clinical trials using gene therapy have resulted in often-dramatic sight restoration for dozens of children and adults who were otherwise doomed to blindness. Now, researchers have found evidence that this sight restoration leads to strengthening of visual pathways in the brain.
Peter Lichtenberg, Ph.D., director of the Institute of Gerontology at Wayne State University, won the Judge Edward Sosnick Courage to Lead Award for his extensive work to create ways of identifying older adults at risk of financial exploitation. The award is presented annually by the Oakland County SAVE (Serving Adults who are Vulnerable and/or Elderly) Task Force.
Dr. Richard Dix, professor in the Department of Biology at Georgia State University, has received a four-year, $1.48 million federal grant to study an eye disease that causes vision loss and blindness in HIV-immunosuppressed patients who do not have access to antiretroviral therapy or don’t respond to the therapy.
Stem cells are key for the continual renewal of tissues in our bodies. As such, manipulating stem cells also holds much promise for biomedicine if their regenerative capacity can be harnessed. Researchers are making headway in this area by studying stem cells in their natural environment in fruitflies.
Children with even mild or passing bouts of depression, anxiety and/or behavioral issues were more inclined to have serious problems that complicated their ability to lead successful lives as adults, according to research from Duke Medicine.
Case Western Reserve is one of three institutions to win federal ‘big data’ grants for developing ways to ensure the integrity and comparability of the reams of U.S. health care information. If successful, the work could lead to insights leading to cures or even disease prevention.
33% of students who used bath salts reported using only once or twice; however, frequent use was also common among users with an alarming 18% of users reporting using 40 or more times in the last year.
In recent years, researchers have hotly pursued immunotherapy, a promising form of treatment that relies on harnessing and training the body’s own immune system to better fight cancer and infection. Now, results of a study led by Johns Hopkins investigators suggests that a device composed of a magnetic column paired with custom-made magnetic nanoparticles may hold a key to bringing immunotherapy into widespread and successful clinical use. A summary of the research, conducted in mouse and human cells, appears online July 14 in the journal ACS Nano.
Breast cancer survivors with a family history of the disease, including those who carry BRCA1 and BRCA2 gene mutations, gained more weight over the course of four years than cancer-free women — especially if they were treated with chemotherapy, according to a prospective study by Johns Hopkins Kimmel Cancer Center researchers.
By using electrode implants to track nerve cells firing in the brains of rats as they plan where to go next, Johns Hopkins scientists say they have learned that the mammalian brain likely reconstructs memories in a way more like jumping across stepping stones than walking across a bridge. The research sheds light on what memories are and how they form, and gives clues about how the system can fail.
Wayne State University received a $1.9 grant from NIH that aims to provide valuable information and potential therapeutic targets for enhancing endothelial progenitor cells (EPCs)-based cell therapy for certain vascular diseases, as well as advance the field of chemokine receptor biology.
From 2004 to 2010 in Texas, mental illness was the most common reason for the hospitalization of children ages 10-14 while pregnancy/birth was the most common reason for the hospitalization of adolescents ages 15-17, according to researchers at The University of Texas Health Science Center at Houston (UTHealth) Medical School.
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