Focus: Hidden - Philly Metro

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The Mahoney Institute for Neurosciences (MINS) at the University of Pennsylvania announced that Michael R. Bruchas, PhD, the Henry E. Mallinckrodt Professor in the departments of Anesthesiology and Neuroscience at Washington University School of Medicine, St. Louis, is the recipient of the inaugural Rising Star Award in neuroscience research.

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Infants who consumed soy-based formula as newborns had differences in some reproductive-system cells and tissues, compared to those who used cow-milk formula or were breastfed, according to a new study. The differences were subtle and not a cause for alarm, but reflect a need to further investigate the long-term effects of exposure to estrogen-like compounds found in soy-based formulas.

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Today, in a late-breaking featured clinical research session at the American College of Cardiology Scientific Sessions 2018, researchers from Penn Medicine present first-of-its-kind data on the impact of real-time CYP2C19 genotype results when prescribing antiplatelet drugs in the clinic.

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High-altitude areas—particularly the US intermountain states—have increased rates of suicide and depression, suggests a review of research evidence in the Harvard Review of Psychiatry. The journal is published by Wolters Kluwer.

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Researchers found that the fruit fly blood brain barrier has a molecular clock that makes it more penetrable during certain hours of the day. Giving mutant flies a drug for treating seizures at night was more effective.

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Many women suffer from acid reflux in early pregnancy, but it can often be confused with other early pregnancy symptoms or go undiagnosed.

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The PM-DNP curriculum is designed to prepare professionals to become leaders in practice innovation by providing education in the translation of evidenced-based practice, project management, and leadership development.

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Children with mitochondrial diseases who suffered acute metabolic strokes benefited from rapid intravenous treatment with the amino acid arginine, experiencing no side effects from the treatment. In half of the stroke episodes, patients showed clinical improvements in symptoms such as seizures and partial paralysis.

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VR has shown promise in several clinical trials assessing its possible utility as a distraction tool to alleviate pain and distress during medical procedures.

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VR has shown promise in several clinical trials assessing its possible utility as a distraction tool to alleviate pain and distress during medical procedures.

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According to a new study by The Wistar Institute, EZH2 inhibitors that are currently in clinical development for hematological malignancies and solid tumors may be effectively targeted to epithelial ovarian cancers overexpressing the CARM1 protein.

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Shinjae Chung, PhD, an assistant professor of Neuroscience, and Iain Mathieson, PhD, an assistant professor of Genetics, both from the Perelman School of Medicine at the University of Pennsylvania, have been awarded highly competitive 2018 Sloan Research Fellowships.

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More than 100 students who have participated in the Fly in 4 program have graduated early.

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Cognitive therapies should be considered when addressing the harmful psychological consequences of trauma in victims of human trafficking, according to a review and recommendations in the Journal of Psychiatric Practice. The journal is published by Wolters Kluwer.

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Two-thirds of theater technicians and actors have experienced head impacts related to working in theater environments, according to a survey study in the March Journal of Occupational and Environmental Medicine.

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Aseem R. Shukla, MD, a pediatric urologist at Children’s Hospital of Philadelphia, along with several of his colleagues from around the world, have created an innovative program to help address urological needs in India. The team is specifically addressing bladder exstrophy, a complex, rare disorder that occurs during fetal development when the bladder does not form completely and drains onto the surface of the abdomen.

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Medicare’s experimental mandatory bundled payment model for knee and hip replacements is more likely to yield cost savings when the surgeries are performed in larger hospitals that do more of these procedures, according to a study from the Perelman School of Medicine at the University of Pennsylvania. Non-profit and major teaching hospital status also appear to be associated with cost savings, the Penn Medicine analysis found.

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A new study conducted by researchers at The Wistar Institute revealed how a key protein residing in the endoplasmic reticulum (ER) helps cells respond to stress. This process is especially important for B cells to respond to severe stress conditions and their ability to produce antibodies. The research was published online in the Journal of Cell Biology.

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Anthelmintic drug already approved to treat infections of pinworm parasite was shown to effectively impair both mesothelioma cell growth and migration.

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Increasing the body’s ability to produce lipids in the lungs after damage prevents the progression of pulmonary fibrosis in preliminary studies.

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Researchers profiled the epigenomic landscape of Alzheimer’s brains, specifically in one of the regions affected early in AD, the lateral temporal lobe. They compared these to both younger and elderly cognitively normal control subjects. The team described the genome-wide enrichment of a chemical modification of histone proteins that regulates the compaction of chromosomes in the nucleus. Changes along the genome in disease versus normal aging brains may signify places for future drug development.

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23rd NCCN Annual Conference: Improving the Quality, Effectiveness, and Efficiency of Cancer Care will take place March 22 – 24, 2018, in Orlando, Florida, and address value-based healthcare models, payer perspectives, new NCCN Guidelines, and other updates in cancer care.

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The Castleman Disease Research Program is collaborating with Pulse Infoframe Inc., a medical informatics company, to power its global ACCELERATE Natural History Registry platform, which is designed to help improve understanding of the rare disease, facilitate research and clinical studies, and identify effective therapies.

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Patients who sustain severe head injuries tend to have better outcomes if they are taken to a designated trauma center, but 44 percent of them are first taken to hospitals without these specialized care capabilities, according to new research from the Perelman School of Medicine at the University of Pennsylvania.

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A gene discovered by Temple University researchers has proved to be an important target for cancer therapy, with the discovery of its roles in controlling cell proliferation, differentiation, apoptosis, and DNA repair.

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Children and adolescents undergoing surgery can be swept up in the ongoing opioid epidemic, according to a review and update in the Journal of Pediatric Orthopaedics, official journal of the Pediatric Orthopaedic Society of North America (POSNA). The journal is published by Wolters Kluwer.

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In addition to restoring the pre-pregnancy shape of the abdomen, abdominoplasty ('tummy tuck') surgery with muscle repair can improve back pain and urinary incontinence after childbearing, reports a study in the March issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

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In patients undergoing reconstructive surgery of the face, treatment with botulinum toxin A (BTX-A, or 'Botox') can improve the final appearance of surgical scars, reports a clinical trial in the March issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).

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Hip replacement surgery not only improves quality of life but is also associated with increased life expectancy, compared to people of similar age and sex, reports a study in Clinical Orthopaedics and Related Research® (CORR®), a publication of The Association of Bone and Joint Surgeons®. The journal is published by Wolters Kluwer.

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Hilary Van Horn, whose stepdad is suffering from Lewy body dementia, challenges everyone to make an "Earth Angel" in an awareness and fundraising campaign for the Penn Memory Center.

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Newly identified stem cells in the lung that multiply rapidly after a pulmonary injury may offer an opportunity for innovative future treatments that harness the body’s ability to regenerate. Scientists describe cells that could become a new tool to treat lung diseases across the lifespan, from premature infants to the elderly.

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Researchers have identified a lung stem cell that repairs the organ’s gas exchange compartment. They isolated and characterized these progenitor cells from mouse and human lungs and demonstrated they are essential to repairing lung tissue damaged by severe influenza and other respiratory ailments.

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Blood plasma samples from a mouse that received the Angptl3 CRISPR treatment (right) and a mouse that was untreated (left). The cloudiness of the sample on the left is from the high content of cholesterol and triglycerides.

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New NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Cancer in People Living With HIV seek to reduce unnecessary, deadly cancer care gaps.

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The world of DTC DNA test kits, namely for cardiovascular disease

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Commonly used ICU risk scores can be "repurposed" as continuous markers of severity of illness in critically ill patients—providing ongoing updates on changes in the patient's condition and risk of death, according to a study in the March issue of Critical Care Medicine, official journal of the Society of Critical Care Medicine (SCCM). The journal is published by Wolters Kluwer.

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The National Comprehensive Cancer Network® (NCCN®) Oncology Research Program (ORP) announces the selection and implementation of the iEnvision medical affairs platform developed by Envision Technology Solutions.

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At most US maternity units, women in labor are put on nil per os (NPO) status—they're not allowed to eat or drink anything, except ice chips. But new nursing research questions that policy, showing no increase in risks for women who are allowed to eat and drink during labor. The study appears in the March issue of the American Journal of Nursing, published by Wolters Kluwer.

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The gift will support The Albert M. Greenfield Special Collections Research Center Reading Room in Temple’s new library, slated to open in 2019.

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The gift will support The Albert M. Greenfield Special Collections Research Center Reading Room in Temple’s new library, slated to open in 2019.

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Researchers studying a rare genetic disorder that causes severe, progressive neurological problems in childhood have discovered insights into biological mechanisms that drive the disease, along with early clues that an amino acid supplement might offer a targeted therapy.

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Recent studies suggest that ketamine, a widely used anesthetic agent, could offer a wholly new approach to treating severe depression—producing an antidepressant response in hours rather than weeks. Two reviews of recent evidence on ketamine and related drugs for treating depression appear in the Harvard Review of Psychiatry, published by Wolters Kluwer.

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Joining prestigious research universities such as Brown, Cornell, Harvard and NYU, Temple recently ranked among the institutions that produced the most participants in the Fulbright U.S. Student Program.

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February 27 is Anosmia Awareness Day. Many people don’t appreciate what it means to be unable to smell. As someone with congenital anosmia, I know first-hand what it feels like to go through each day without the sense of smell.

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Researchers describe the role of a transcription factor called TCF-1 in targeting the condensed chromatin and regulating the availability of genome sequences in T-cell development. The new connection between TCF-1 and chromatin will aid in developing new therapies using epigenetic drugs to alter T-cell fate in cancer, autoimmune disorders, and infectious diseases.

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Researchers engineered mice in which the damage caused by a mutant human TDP-43 protein could be reversed by one type of brain immune cell. TDP-43 is a protein that misfolds and accumulates in the motor areas of the brains of ALS patients. They found that microglia, the first and primary immune response cells in the brain and spinal cord, are essential for dealing with TDP-43-associated neuron death.