Multiple Sclerosis Appears to Originate in Different Part of Brain than Long Believed
Rutgers UniversityThere is important new physical evidence that most research on the origins of multiple sclerosis has focused on the wrong part of the brain. Until now, most investigation has focused on the brain's white matter, where degradation of myelin that coats nerves occurs. But advanced analysis of cerebrospinal fluid via proteomics and high-resolution mass spectrometry, unattainable until recently, reveals proteins linked to gray matter in patients with newly discovered cases of MS ... pointing to gray matter as a critical initial target as MS develops.