CBD may help avert lung destruction in COVID-19
Medical College of Georgia at Augusta UniversityCannabidiol, or CBD, may help reduce the cytokine storm and excessive lung inflammation that is killing many patients with COVID-19, researchers say.
Cannabidiol, or CBD, may help reduce the cytokine storm and excessive lung inflammation that is killing many patients with COVID-19, researchers say.
Researchers at the University of Kentucky’s Sanders-Brown Center on Aging (SBCoA) recently screened the first participant in the world for what is known as the AHEAD 3-45 study. This work is looking at a study medication, BAN2401, to determine if it can help prevent worsening memory and thinking among individuals who might be at risk for future decline. They are hoping this study finds that BAN2401 does just that and will ultimately help prevent Alzheimer’s disease.
Memorial Sloan Kettering Cancer Center (MSK) announces its most recent awards and appointments for the institution’s physicians, scientists, nurses, and staff.
A prominent Australian pharmacologist has called for a new approach to treating COVID-19 as hopes fade of finding an effective vaccine or antiviral before the end of the year.
The American Society of Anesthesiologists firmly opposes the use of ketamine or any other sedative/hypnotic agent to chemically incapacitate someone for a law enforcement purpose and not for a legitimate medical reason. Ketamine is a potent analgesic, sedative and general anesthetic agent which can elevate blood pressure and heart rate, and can lead to confusion, agitation, delirium, and hallucinations. These effects can end in death when administered in a non-health care setting without appropriately trained medical personnel and necessary equipment.
Researchers at the Icahn School of Medicine report that roflumilast cream (ARQ-151), which contains a highly potent, selective phosphodiesterase-4 (PDE4) inhibitor demonstrated significant improvements in patients with psoriasis signs and symptoms in as early as two weeks. The phase 2b trial results showed that when patients with plaque psoriasis applied topical roflumilast once-daily they reported clear skin as well as improvement in itch and burden of disease. The results of the paper were published online today in The New England Journal of Medicine.
Researchers have developed a new drug that prevents blood clots without causing an increased risk of bleeding, a common side effect of all antiplatelet medications currently available. A new study published in the journal Science Translational Medicine describes the drug and its delivery mechanisms and shows that the drug is also an effective treatment for heart attack in animal models.
Researchers at the University of East Anglia and University of Manchester have made an important breakthrough that could lead to 'kinder' treatments for children with bone cancer, and save lives.
A common drug, already approved by the Food and Drug Administration (FDA), may also be a powerful tool in fighting COVID-19, according to research published this week in Antiviral Research.
Harvard Medical School has named Robert Gentleman as founding executive director of the newly established Center for Computational Biomedicine. Gentleman, an accomplished statistician and computational scientist with extensive experience in academia and industry, most recently served as vice president of computational biology at the genetic testing company 23andMe.
Announcement of national and international nominations being sought for the 2021 Harrington Prize for Innovation in Medicine, which honors a physician-scientist who has moved science forward with achievements notable for innovation, creativity and the potential for clinical application.
Most patients hospitalized with COVID-19 (coronavirus) pneumonia experienced improvement after receiving a Food and Drug Administration-approved drug normally given for rheumatoid arthritis, according to an observational study at Cedars-Sinai. Outcomes for patients who received the drug, tocilizumab, included reduced inflammation, oxygen requirements, blood pressure support and risk of death, compared with published reports of illness and death associated with severely ill COVID-19 patients.
Diseases of the Colon and Rectum Journal August 2020 Video Abstracts and Editor Picks
UC Davis researchers have found that combining a Western-style high-fat diet with antibiotic use significantly increases the risk of developing pre- inflammatory bowel disease. This combination shuts down the mitochondria in cells of the colon lining, leading to gut inflammation. Mesalazine can help restart the mitochondria and treat pre-IBD condition.
Physicians are studying whether vadadustat, an investigational therapy, could protect the lungs of COVID-19 patients by triggering the body’s protective response to low oxygen levels in a randomized Phase II clinical trial at UTHealth.
The CDI will work with Merck to identify candidate treatments for the still-spreading pandemic.
The University of Texas MD Anderson Cancer Center and Sanofi today announced a five-year strategic collaboration to accelerate the development of investigational treatments, including targeted and immune therapies, for patients with cancer.
Moffitt Cancer Center researchers want to learn more about how PI3K inhibitor therapy works with the body’s immune system to determine if there are ways to predict or mitigate associated adverse effects. Their findings were published in the July 14 issue of Blood Advances, a journal of the American Society of Hematology.
Keck Medicine of USC physicians are enrolling patients as part of an international clinical trial to evaluate the safety and efficacy of an antiviral drug, DAS181, as a possible treatment for hospitalized patients with severe COVID-19.
The mechanisms of action of acalabrutinib led to the hypothesis it might be effective in reducing the massive inflammatory response seen severe forms of COVID19. Indeed, it did provide clinical benefit in a small group of patients by reducing their inflammatory parameters and improving their oxygenation.
The individual mix of microorganisms in the human gastrointestinal tract provides vital clues as to how any future incidence of type 2 diabetes can be predicted, prevented and treated.
A drug used to treat systemic lupus erythematosus (SLE) significantly reduces the incidence of a rare and sometimes fatal heart condition in newborn babies, a new study from NYU Grossman School of Medicine researchers shows.
Only 1.9% of uninfected household contacts who took a single dose of baloxavir marboxil came down with the flu.
An interventional therapy aimed at improving survival chances and reducing the need for critical care treatment due to COVID-19 is being investigated by physicians at The University of Texas Health Science Center at Houston (UTHealth). The clinical trial is underway at Memorial Hermann and Harris Health System’s Lyndon B. Johnson Hospital.
A study from Hospital for Special Surgery (HSS) finds that topical steroids administered during anterior cervical discectomy and fusion (ACDF) surgery help reduce swallowing difficulties following the procedure. This study is available online as part of the AAOS 2020 Virtual Education Experience. The results were also published in The Spine Journal in September 2019.
Critically ill COVID-19 patients who received a single dose of a drug that calms an overreacting immune system were 45% less likely to die overall, and more likely to be out of the hospital or off a ventilator one month after treatment, compared with those who didn’t receive the drug, according to a new observational study.
A Keck Medicine of USC study reveals that kappa opioids, a significantly less addictive opioid, may preserve cartilage in joints and ease pain
One of the fastest-growing pharmaceuticals companies in the country, headquartered in Lexington County, today announced several major expansion and investment projects.
Scientists at USC Dornsife College of Letters, Arts and Sciences may have found the beginnings of a path toward increasing human lifespan.
Fueling transformative research through collaboration, the San Antonio Partnership for Precision Therapeutics (SAPPT) announces the funding of three more collaborative COVID-19 research efforts in San Antonio. SAPPT has awarded more than $600,000 to fund these projects, following the funding of a SARS CoV-2 vaccine project announced in April of this year.
A clinical trial conducted at Washington University School of Medicine in St. Louis and other sites has found evidence that the experimental drug tofersen lowers levels of a disease-causing protein in people with an inherited form of amyotrophic lateral sclerosis, or ALS, caused by mutations in the gene SOD1.
The study will aim to understand whether systemic medications and biologics, such as dupilumab—a monoclonal antibody that binds to an inflammatory molecule, IL-4 receptor alfa, and inhibits the inflammatory response that leads to rashes and itching from atopic dermatitis/eczema—may have a positive or negative impact on COVID-19 responses in patients who have the disease.
As Americans have the highest opioid use rates, leading to abuse, the orthopaedic community has committed itself to studying prescription methods and patient populations to help mitigate potential addiction. A new scientific review article titled, “Ninety-day Postoperative Narcotic Use After Hospitalization for Orthopaedic Trauma,” published in the July issue of the Journal of the American Academy of Orthopaedic Surgeons (JAAOS), found a correlation between patient-reported pain at discharge from inpatient surgery and the number of opioids prescribed during the 90-day postoperative period.
Researchers fear that widespread use of antibiotics during the coronavirus pandemic will add fuel to the fire, making more common infections that were once treatable possibly life threatening.
Every human being has the right to health and new initiatives should be put in place to encourage pharmaceutical companies to ensure that everyone has access to essential medicine, according to a new book from Nicole Hassoun, professor of philosophy at Binghamton University, State University of New York.
Simpler phenolic compounds, known as hydroxybenzoic acids, that result when the gut bacteria break down aspirin and flavonoids from fruits and vegetables may contribute to colorectal cancer prevention.
Only 10.1% of Los Angeles County pharmacies provided this service and 77.4% imposed age-restrictions at 18 years or older, including in neighborhoods with the highest rates of unintended pregnancies and teen births.
Findings from an online survey of more than 53,000 American adults suggest that using heartburn medications known as proton pump inhibitors (PPIs) once or twice daily significantly increases the odds of a positive test for COVID-19 compared to those who do not take PPIs. This research appeared online July 7, 2020 in pre-print format in The American Journal of Gastroenterology.
Researchers at the Seaver Autism Center for Research and Treatment at Mount Sinai have started recruiting participants for a new clinical trial to evaluate the safety, tolerability, and efficacy of a low dose of ketamine in children diagnosed with ADNP syndrome (also known as Helsmoortel-VanDerAa syndrome), a rare neurodevelopmental disorder caused by mutations in the activity dependent neuroprotective protein (ADNP) gene.
Amid news that the United States has bought up virtually the entire global supply of remdesivir, a new Boston University School of Public Health (BUSPH) study outlines how the drug could save lives in countries with less hospital capacity, such as South Africa, where COVID-19 is beginning to overwhelm intensive care units (ICUs).
A team of UD engineers has uncovered the role of surface diffusion in protein transport, which could aid biopharmaceutical processing. This work will lead to the creation of new ways to reduce waste during the expensive drug manufacturing process, enabling more efficient ways of designing and developing manufacturing techniques.
Milestone for therapeutic development of peptides against gastrointestinal disordersThe fascinating family of trefoil factor peptides brings hope to both research and industry to improve the treatment of chronic disorders such as Crohn’s disease. For the first time, a team led by ERC awardee Markus Muttenthaler from the Faculty of Chemistry of the University of Vienna succeeded in the synthesis and folding of the peptide TFF1, a key player in mucosal protection and repair.
What The Study Did: How the prescription of hydroxychloroquine and chloroquine to outpatients has changed in the United States during the COVID-19 pandemic is examined in this study.
Health care providers may unintentionally expose patients to endocrine- disrupting chemicals (EDCs) by prescribing certain medications and using medical supplies, according to a perspective published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
A new study reveals that the common asthma drug salbutamol may offer potential as a treatment for Alzheimer's disease.
Many studies published by major spinal surgery journals do not include full disclosure of researchers’ financial conflicts of interest (COIs), reports a study in Spine. The journal is published in the Lippincott portfolio by Wolters Kluwer.
Mice that received an injection of a new experimental drug, TAT-DP-2, after a stroke had smaller areas of damage, and their long-term neurological function was better than that of untreated animals.
Choice and control are important factors for ensuring a positive childbirth experience, yet until recently, little was known about the impact of alternative administrations of fentanyl – one of the pain relief drugs used during labour– on both mother and baby.