Giving the combination of immune checkpoint inhibitors relatlimab and nivolumab to patients with stage III melanoma before surgery was safe and completely cleared all viable tumor in 57% of patients in a Phase II study, researchers from The University of Texas MD Anderson Cancer Center reported in Nature.
An international study led by a Rutgers scientist comparing new and older treatments against complicated urinary tract infections has found a new drug combination to be more effective, especially against stubborn, drug-resistant infections.
尊敬的妙佑医疗国际：我的偏头痛断断续续发作已有五年了，为此我饱受折磨。最近，我发现自己平时服用的口服药物似乎也没那么有效了。我知道市面上有一些更新型的药物，但一位朋友建议我试一试Botox注射。她很认真地告诉我，正是这种药物使她的慢性头痛得到了控制。我想请问一下，Botox注射的安全性怎么样？是如何起作用的？这种药物的治疗方案是什么？需要结合使用其他头痛药物吗？答：Botox又名A型肉毒杆菌毒素，其于2010年经美国食品药品管理局批准用于治疗慢性偏头痛。这种药物并不能根治此病。使用Botox注射治疗头痛的患者通常需要每三个月接受一次注射。
عزيزتي مايو كلينك: أعاني من الشقيقة (الصداع النصفي) بشكل متقطع لمدة خمس سنوات تقريبًا. في الآونة الأخيرة، يبدو أن العلاج الفموي الذي أستخدمه أقل فعالية. بالرغم من أنني أعلم بوجود أدوية جديدة، فقد اقترحت عليَّ إحدى صديقاتي أن أجرب حُقن البوتوكس. حيث تُقسم أنه سيطر على الصداع المزمن لديها. ما مدى أمان هذه الحقن وكيف يعمل البوتوكس؟ ما هو جدول العلاج، وهل سأحتاج أيضًا إلى تناول أدوية أخرى للصداع؟ الإجابة: تمت الموافقة على توكسين أونابوتولينوم أ، أو البوتوكس، من قبل إدارة الغذاء والدواء الأمريكية في عام 2010 لعلاج الشقيقة (الصداع النصفي) المزمنة. ولكنه ليسَ علاجًا نهائيًا. عادةً ما يتلقى الأشخاص الذين يتلقون حقن البوتوكس للصداع العلاج كل ثلاثة أشهر تقريبًا.
ESTIMADA MAYO CLINIC: venho sofrendo com enxaquecas intermitentes há mais ou menos cinco anos. Recentemente, a terapia oral que venho usando parece não estar mais fazendo efeito. Apesar de saber que novos medicamentos estão disponíveis, uma amiga sugeriu que eu experimentasse injeções de Botox. Ela jura que as injeções deixaram seus níveis de dores de cabeça sob controle. Essas injeções são seguras e como o Botox funciona? Qual é o cronograma de tratamento e eu também precisaria tomar outros medicamentos para dor de cabeça? RESPOSTA: a toxina Onabotulínica A, ou Botox, foi aprovada pela Food and Drug Administration (Administração de Alimentos e Medicamentos dos Estados Unidos) em 2010 para tratar enxaquecas. Não se trata de uma cura. As pessoas que recebem injeções de Botox para dores de cabeça geralmente recebem o tratamento mais ou menos a cada três meses.
ESTIMADA MAYO CLINIC: He sufrido migraña de forma intermitente durante aproximadamente cinco años. En el último tiempo, la terapia oral que he recibido pareciera ser menos eficaz. Si bien sé que existen medicamentos más nuevos, una amiga me sugirió que pruebe las inyecciones de bótox. Mi amiga jura que el bótox controló sus dolores de cabeza crónicos. ¿Cuán seguras son estas inyecciones? ¿Cómo funciona el bótox? ¿Cuál es el plan de tratamiento? ¿También tendría que tomar otro medicamento para el dolor de cabeza? RESPUESTA: La onabotulinumtoxina A, o el bótox, fue aprobada por la Administración de Alimentos y Medicamentos en el 2010 para el tratamiento de los dolores de cabeza por migraña crónicos. No es una cura. Las personas que reciben inyecciones de bótox para los dolores de cabeza suelen recibir el tratamiento aproximadamente cada tres meses.
Here are some of the latest articles that have been added to the Drugs and drug abuse channel.
Scientists can detect the virus that causes COVID-19 by using a bubble that spills its contents like a piñata when encountering the virus.
COUR Pharmaceuticals, a clinical-stage biotechnology company developing novel immune-modifying nanoparticles designed to reprogram the immune system for the treatment of autoimmune disorders (COUR NanoParticles or CNPs), today announced that the U.S. Food and Drug Administration has cleared an Investigational New Drug (IND) application to initiate a Phase 1b/2a proof-of-concept study of COUR's investigational therapy, CNP-106.
Numerous studies have shown that drugs called immune checkpoint inhibitors can boost the immune system’s response against various cancers.
The cognitive decline and memory loss observed in Alzheimer’s disease (AD) is attributed to the accumulation of β-amyloid protein (Aβ), which impairs neural function in the brain.
A three-week course of radiation therapy is as safe and effective as four to six weeks of treatment for patients with early-stage breast cancer who have a higher risk of having their tumors recur, results of a randomized phase III clinical trial show. Delivering fewer, but higher, doses of radiation following lumpectomy, while concurrently delivering a radiation boost to the surgical site, led to similar outcomes as a longer course of treatment.
A Cornell University researcher is using optical microscopy and other tools to map the brain’s neural response to psychedelics, an approach that could eventually lead to the development of fast-acting antidepressants and treatments for substance-use disorders and cluster headaches.
The American Society of Anesthesiologists (ASA) today presented Kristin Schreiber, M.D., Ph.D., with its 2022 James E. Cottrell Presidential Scholar Award in recognition of her exemplary translational research on post-surgical pain.
The American Society of Anesthesiologists (ASA) today presented Vivianne Tawfik, M.D., Ph.D., with its 2022 James E. Cottrell Presidential Scholar Award in recognition of her extraordinary contributions to the fundamental understanding of pain mechanisms to treat patients with chronic and post-surgical pain.
Adding radiation therapy to systemic therapy for patients with advanced liver cancer can extend overall survival and delay tumor progression without compromising patients’ quality of life, a randomized phase III clinical trial shows.
Many children live in homes with unused prescription drugs and expired medications, a new national poll suggests.
Engineered particles of purified sand could be the next anti-obesity therapy as new research from the University of South Australia shows that porous silica can prevent fats and carbohydrates from being adsorbed in the body.
Wearing special green eyeglasses for several hours a day reduces pain-related anxiety and may help decrease the need for opioids to manage severe pain in fibromyalgia patients and possibly others who experience chronic pain, according to a study being presented at the ANESTHESIOLOGY® 2022 annual meeting.
Treating high-risk, asymptomatic bone metastases with radiation may reduce painful complications and hospitalizations and possibly extend overall survival in people whose cancer has spread to multiple sites, a phase II clinical trial suggests. Results of the multicenter, randomized trial (NCT03523351) will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting.
FLASH radiation treatment – which delivers therapeutic doses of radiation in a fraction of a second – may hold promise as a potential treatment for tough-to-kill tumors, a first-in-human study in a small number of people with bone cancer suggests.
A new randomized study confirms that men with high-risk prostate cancer can be treated with five versus eight weeks of radiation therapy.
Commonly used cholesterol-lowering statins may reduce the risk of death and severity of COVID-19 disease, suggests a study of more than 38,000 patients being presented at the ANESTHESIOLOGY® 2022 annual meeting.
One is an illegal drug found in marijuana while the other is marketed as a safe herbal alternative.
Significant time is needed to determine the drug susceptibility profile of a bacterial infection.
Pfizer didn’t claim to have tested its COVID-19 vaccine’s ability to prevent transmission, and this information was clearly available in press releases published by the European Medicines Agency as well as the published study containing results from Pfizer’s clinical trials.
In 2023, the Gallogly College of Engineering at the University of Oklahoma will open an interdisciplinary workforce education and research center to serve the growing biopharmaceutical industry in Oklahoma.
The Cordyceps mushroom is best known for its gruesome eating habits: famously, its spores infect insects and kill them, growing into fully-fledged fruiting bodies that sprout from the insects’ flesh.
Two drugs -- one brand new -- reverse pancreatic cell changes that presage one of the hardest cancers to treat. Tested in cells, the drugs would be a promising early cancer treatment if they work in clinical trials.
The National Institutes of Health (NIH) has awarded a $1.1 million grant to the University of Maryland Schools of Pharmacy (UMSOP) and Medicine (UMSOM) to create a training program to enhance diversity in the biomedical workforce. The five-year Initiative for Maximizing Student Development (IMSD) program strives to increase the number of students from underrepresented groups in the doctoral programs in the UMSOP’s Department of Pharmaceutical Sciences (PSC) and UMSOM’s Graduate Program In Life Sciences (GPILS).
A Ludwig Cancer Research study has developed a strategy to noninvasively track immune cells known as macrophages within brain and breast tumors in living mice.
Investigators from the departments of Neurology, Neurosurgery, Psychiatry, Medicine, and Biomedical Sciences at Cedars-Sinai have shown that an immune-suppressing drug similar to one used to treat severe COVID-19 reversed symptoms of delirium in mice whose lungs were injured during mechanical breathing assistance.
UC San Diego Health is now offering a new treatment for patients with low-grade upper tract urothelial cancer that could safely avoid removal of the entire kidney, which may prevent the need for dialysis or kidney transplant in the future.
A study led by the Duke Clinical Research Institute (DCRI) in partnership with Vanderbilt University found no symptomatic or clinical benefit to taking the antidepressant fluvoxamine 50 mg twice daily for 10 days for the treatment of mild-to-moderate COVID-19 symptoms.
The new study showed apixaban is superior to rivaroxaban against stroke or systemic embolism in patients with atrial fibrillation and valvular heart disease
Eesearchers from Trinity College Dublin have developed a new, machine learning-based technique to accurately classify the state of macrophages, which are key immune cells.
A study led by an Oregon State University pharmaceutical sciences researcher has produced a proof of principle for a new “universal” means of treating COVID-19.
Victor Nizet, MD, Distinguished Professor of Pediatrics at UC San Diego School of Medicine and Pharmacy at Skaggs School of Pharmacy and Pharmaceutical Sciences at UC San Diego, has been elected to the National Academy of Medicine.
A systematic review of 42 academic research articles has found that the risk-benefit balance of using opioids to treat musculoskeletal pain in the emergency department (ED) setting remains unclear. The review is published in Annals of Internal Medicine.
A large population-based study of patients with atrial fibrillation (AF) and valvular heart disease (VHD) found that use of apixaban was associated with a lower rate of ischemic stroke or systemic embolism and a lower rate of intracranial or gastrointestinal (GI) bleeding compared with rivaroxaban. The authors say clinicians should consider these findings when selecting anticoagulants in this patient population. The study is published in Annals of Internal Medicine.
Psychedelic compounds found in ‘magic mushrooms’ are increasingly being recognised for their potential to treat health conditions such as depression, anxiety, compulsive disorders and addiction.
A highly innovative method using the latest technology has generated a comprehensive list of SARS-CoV-2 viral and human proteins that interact with each other, with one such interaction showing the virus directly influencing proteins that regulate the human immune system.
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The October issue of SLAS Discovery is now available open access on ScienceDirect.
Patients who have surgery to repair bone fractures typically receive a type of injectable blood thinner, low-molecular-weight heparin, to prevent life-threatening blood clots, but a new clinical trial found that over-the-counter aspirin is just as effective.
Global health has paid a deadly price for not using simple, low-cost blood pressure lowering drugs, statins and aspirin widely in the form of a single pill, also known as the polypill, say two leading cardiologists in a commentary published in The Lancet.
Michigan Medicine research suggests that administration of antibiotics with activity against anaerobic bacteria has a profound effect on the gut microbiome and, ultimately, an adverse impact on critically ill patients.
Heart disease patients with symptomatic COVID-19 are often treated with nirmatrelvir-ritonavir (Paxlovid) to prevent progression to severe disease; however, it can interact with some previously prescribed medications.
Eclipse, a venture capital firm investing in the digital transformation of the world's physical industries, and Mayo Clinic today announced the creation and seed funding of Nucleus RadioPharma, a new company built to ensure cancer patients can access potentially lifesaving radiopharmaceuticals by developing technologies to modernize the clinical development, manufacturing and supply chain of these promising new therapies.
In the article published in the prestigious scientific journal Science, a group of international researchers, including Gorka Orive, Doctor of Pharmacy and researcher in the UPV/EHU’s NanoBioCel group, and Unax Lertxundi of the Bioaraba Institute for Health Research, have issued a warning about the increase in pharmaceutical contamination.
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