Texan Chuck Dandridge became the first adult in the U.S. to receive a newly modified stem cell transplant that uses genetically engineered blood cells from a family member, announced researchers at UT Southwestern Medical Center’s Harold C. Simmons Comprehensive Cancer Center where the procedure was performed.
Babies born with heart defects live longer than ever thanks to advances in the diagnosis and treatment of congenital heart disease. Yet, despite substantial progress, many continue to face bleak odds, lifelong medication, multiple surgeries and progressive heart failure, often requiring a transplant.
Cancer stem cells are like zombies — even after a tumor is destroyed, they can keep coming back. These cells have an unlimited capacity to regenerate themselves, making more cancer stem cells and more tumors. Researchers at University of California San Diego School of Medicine have now unraveled how pre-leukemic white blood cell precursors become leukemia stem cells.
As the promise of using regenerative stem cell therapies draws closer, a consortium of biomedical scientists reports about 30 percent of induced pluripotent stem cells they analyzed from 10 research institutions were genetically unstable and not safe for clinical use. In a study published June 9 by the journal Stem Cell Reports, the multi-institutional research team reports on the comprehensive characterization of a large set of induced pluripotent stem cells (iPSCs).
People disabled by a stroke demonstrated substantial recovery long after the event when modified adult stem cells were injected into their brains.
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UCSF researchers that it is possible to generate healthy new liver cells in the livers of living mice by converting the very cells that drive liver disease, thereby reducing liver damage and improving liver function at the same time.
Intestinal stem cells are located in “pockets” in the intestine to avoid contact with a metabolite abundantly produced by normal gut microbes. That metabolite – butyrate – suppresses stem cell proliferation, potentially interfering with the gut’s ability to repair itself after disease or injury.
Case Western Reserve University will open a new center designed to develop evaluation technology and set standards for testing and improving engineered cartilage that could one day replace a variety of prosthetic devices. Biology Professor Arnold Caplan and colleagues have received a 5-year, $6.7 million grant from the National Institute of Biomedical Imaging and Bioengineering to open and direct the Center for Multimodal Evaluation of Engineered Cartilage.
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A growing body of research is revealing associations between birth defects and a father’s age, alcohol use and environmental factors, say researchers at Georgetown University Medical Center. They say these defects result from epigenetic alterations that can potentially affect multiple generations.
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Researchers at University of California San Diego School of Medicine, with colleagues in Brazil and Senegal, have described the first “direct experimental proof” that the Brazilian strain of Zika virus can actually cause severe birth defects. The findings are published in the May 11 online issue of Nature.
The Gordie Howe Initiative has been formed to fund a clinical trial to help validate the safety and efficacy of the use of stem cells in the treatment of TBI.
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Signaling a potential new approach to treating diabetes, researchers at Washington University School of Medicine in St. Louis and Harvard University have produced insulin-secreting cells from stem cells derived from patients with type 1 diabetes. The new discovery suggests a personalized treatment approach to diabetes may be on the horizon — one that relies on the patients’ own stem cells to manufacture new cells that make insulin.
Researchers have safely transplanted stem cells derived from a patient’s skin to the back of the eye in an effort to restore vision. The research is being presented at the 2016 Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) this week in Seattle, Wash.
This research investigates the role of intraventricular transplantation using bone marrow mesenchymal stem cell in stroke patients.
Researchers at Boston Children's Hospital have reprogrammed mature blood cells from mice into blood-forming hematopoietic stem cells (HSCs), using a cocktail of eight genetic switches called transcription factors. The reprogrammed cells, which the researchers have dubbed induced HSCs (iHSCs), have the functional hallmarks of HSCs, are able to self-renew like HSCs, and can give rise to all of the cellular components of the blood like HSCs.
Organization recognized for innovative research, care
A pair of molecular signals controls skin and hair color in mice and humans — and could be targeted by new drugs to treat skin pigment disorders like vitiligo, according to a report by scientists at NYU Langone Medical Center.
A University of Wisconsin-Madison neuroscientist has inserted a genetic switch into nerve cells so a patient can alter their activity by taking designer drugs that would not affect any other cell. The cells in question are neurons and make the neurotransmitter dopamine, whose deficiency is the culprit in the widespread movement disorder Parkinson's disease.
This ARVO Meeting showcases cutting-edge eye and vision science and an early glimpse into the latest advances in potential treatments for eye disease and blindness — often years ahead of their introduction to the clinic.
Pinellas County a Model for Mosquito-Borne Disease Surveillance, Scientists Unravel the Genetic Evolution of Zika Virus, Worm Infection Counters Inflammatory Bowel Disease and more in the Infectious Diseases News Source
Discovery provides a serious advantage in determining how to maximize blood stem cells in therapeutics and could help ease current stem cell shortages.
It has been disorienting to the scientific and medical community as to why different subtle changes in a protein-coding gene causes many different genetic disorders in different patients -- including premature aging, nerve problems, heart problems and muscle problems. no other gene works like this. According to a new study, co-authored by Binghamton University faculty Eric Hoffman, it has to do with cell “commitment.”
Drug-carrying “nanoghosts” that battle melanoma and new treatments for malignant mesothelioma will be the focus of the first joint research projects led by NYU Langone Medical Center and the Technion-Israel Institute of Technology under a groundbreaking research initiative.
Dr. Kevin Francis’ research appears in Nature Medicine
A noted designer of artistic ties has turned scientific images into a striking design that can be worn by men and women - and the proceeds will aid bipolar disorder research.
An experimental antibody treatment decreased by half the number of cancer stem cells that drive the growth of tumors in nearly all patients with multiple myeloma, a cancer of the bone marrow and bone tissue, according to results of a preliminary clinical trial led by Johns Hopkins Kimmel Cancer Center scientists.
While stem cells have shown promise for treating brain regions damaged by cancer radiation treatments, University of California, Irvine researchers have found that microscopic vesicles isolated from these cells provide similar benefits without some of the risks associated with stem cells.
An investigational stem cell therapy derived from patients’ own blood marrow significantly improved outcomes in patients with severe heart failure, according to a study from the Cedars-Sinai Heart Institute.
End-stage heart failure patients treated with stem cells harvested from their own bone marrow experienced 37 percent fewer cardiac events - including deaths and heart failure hospital admissions - than a placebo-controlled group, according to a new study. Results from ixCELL-DCM, the largest cell therapy clinical trial for treating heart failure to date, will be presented at the 2016 American College of Cardiology annual meeting and published online in The Lancet on April 4.
Linda Carli's "Stereotypes About Gender and Science: Women ≠ Science” shows that despite significant progress made, women are still thought to lack the qualities needed to be successful scientists, and the findings suggest this may contribute to discrimination and prejudice against women in those fields.
Writing in Nature Medicine, researchers at University of California, San Diego School of Medicine and Veterans Affairs San Diego Healthcare System, with colleagues in Japan and Wisconsin, report that they have successfully directed stem cell-derived neurons to regenerate lost tissue in damaged corticospinal tracts of rats, resulting in functional benefit.
Working with human breast cancer cells and mice, scientists say new experiments explain how certain cancer stem cells thrive in low oxygen conditions. Proliferation of such cells, which tend to resist chemotherapy and help tumors spread, are considered a major roadblock to successful cancer treatment.
Dr. Pradeep "Max" Dass, director of the NAU Center of Science Teaching and Learning at NAU, is helping guide STEM teaching methods on the other side of the globe in a small school in India. The CSTL continues its mission to lead the way in global STEM education.
Neuroscientists document some of the first steps in the process by which a stem cell transforms into different cell types.
Dr. Mansoor Husain named first executive director of Ted Rogers Centre for Heart Research
The Princeton Plasma Physics Laboratory hosted a Young Women's Conference in Science, Technology, Engineering and Mathematics for 575 girls. The conference is aimed at sparking young women's interest in STEM and encouraging them to consider STEM careers. Women still lag behind men in STEM careers, especially in certain fields such as computer science, physics, and engineering.
Emma and Molly White and Ru-Shyan and Ru-Huey Yen, a pair of twin sisters and close friends who met in high school 16 years ago, went on to careers in STEM
An overwhelming number of researchers still struggle within the black hole of the effectiveness and safety of stem cell therapy for neurological diseases. While the complexity of understanding how neurons grow, connect and function has long been studied, it remains a mystery, one that Forrest Goodfellow is helping to unravel.
The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine approved yesterday a $6.3 million grant to a research team from the University of California, San Diego School of Medicine and University of California, Davis to pursue a novel human embryonic stem cell-based therapy to rescue and restore neurons devastated by amyotrophic lateral sclerosis or ALS.
Imagine telling a patient suffering from age-related (type-II) osteoporosis that a single injection of stem cells could restore their normal bone structure. This week, with a publication in STEM CELLS Translational Medicine, a group of researchers from the University of Toronto and The Ottawa Hospital suggest that this scenario may not be too far away.
If you want to harness the full power of stem cells, all you might need is an eraser – in the form of a drug that can erase the tiny labels that tell cells where to start reading their DNA. In a surprising new finding, scientists have shown that mouse stem cells treated with the drug reverted to an ‘embryonic’ state.
In one of the first studies to "read" the genetic activity inside individual brain cells, University of Wisconsin-Madison neuroscientist Xinyu Zhao has identified the genetic machinery that causes maturation in a young nerve cell.
Stem cells may have the potential to protect the optic nerve from further damage and slow the progression of vision loss due to glaucoma. Stem cells may also have the potential to replace ocular tissues that have degenerated in eyes with glaucoma.
Scientists at Virginia Commonwealth University have developed computer models that can simulate the recovery of the immune system in patients undergoing stem cell transplants.
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