Feature Channels: Blood

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Pesquisadores da Mayo Clinic apresentam suas descobertas na Reunião Anual da Sociedade Americana de Hematologia de 7 a 10 de dezembro em Orlando.

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Mayo Clinic研究人员于12月7号至10号在奥兰多举行的美国血液学会年度会议上公布了研究成果。

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Forscher von Mayo Clinic haben auf der Jahrestagung der American Society of Hematology vom 7. bis 10. Dezember 2019 in Orlando ihre Studienergebnisse präsentiert.

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Saint Louis University’s Enrico Di Cera, M.D., has been named a Fellow of the American Association for the Advancement of Science (AAAS) for his distinguished contributions to science.

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Researchers at the Icahn School of Medicine at Mount Sinai have discovered a way to move precision immunotherapy forward by using genomics to inform immunotherapy for multiple myeloma, a blood cancer, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research, in December.

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While the donation and transfusion of blood are very common, and relatively simple as far as medical procedures go, the path from donor to recipient is more complex than most people may realize.

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Researchers at Children’s Medical Center Research Institute at UT Southwestern (CRI) have uncovered why certain melanoma cells are more likely to spread through the body.

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NCCN publishes new NCCN Guidelines for treating children, adolescents and young adults with pediatric aggressive mature B-cell lymphomas (common and curable forms of non-Hodgkin lymphoma), including Burkitt lymphoma and diffuse large B-cell lymphoma.

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Researchers reporting in ACS Nano have devised a blood test that quickly and sensitively diagnoses the disease at early stages.

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Patients with acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML) who are treated with anthracyclines are at a heightened risk of heart failure—most often within one year of exposure to the chemotherapy treatment.

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Weight may affect doctors’ ability to correctly interpret routine blood tests in children, according to new research published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.

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An experimental, off-the-shelf immunotherapy that combines a targeted antibody and chemotherapy can lead to potentially durable responses in multiple myeloma patients whose disease has relapsed or is resistant to other standard therapies

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Toxic environmental agents, to which anyone is involuntarily exposed, represent non-negligible risk for human health and, therefore, environmental contamination has become a theme of primary importance worldwide.

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Mayo Clinic的一项早期研究显示，源自患者自身脂肪的干细胞可进一步改善（而不仅是稳定）脊髓损伤患者的运动和感觉功能。

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Findings from the ABC-PICU study on critically ill children may alter policies at hospitals where fresh red cells are preferentially used.

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In a clinical trial led by Yale Cancer Center (YCC) and Smilow Cancer Hospital, researchers aim to exploit DNA mutations in the treatment of two blood and bone marrow cancers, a different tacit than the more traditional approach of blunting or switching off genetic mutations linked to cancer

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Results from a study conducted by St. Jude Children’s Research Hospital and the Munich Leukemia Laboratory were presented today as a late-breaking abstract at the American Society of Hematology annual meeting. The study integrates genomic and transcriptomic sequencing to provide the most detailed classification of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) to date.

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Mayo Clinic researchers will present findings at the American Society of Hematology Annual Meeting Dec. 7–10 in Orlando. New Mayo Clinic studies to be presented include: DNA analysis identifies elevated risk factor for myeloma in individuals of African ancestry Study identifies more precise assessment measures for patients newly diagnosed with chronic lymphocytic leukemia Researchers develop method to assess cancer-fighting cell therapy's effectiveness

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Deep DNA sequencing analysis conducted by Rutgers Cancer Institute of New Jersey investigators examining genomic differences within tumors for prediction of disease relapse in certain hematologic malignancies has identified small mutations. These may help further guide treatment decision making for patients.

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New findings by Yale Cancer Center (YCC) and Smilow Cancer Hospital researchers show that as the use of the drug ibrutinib climbs in patients with chronic lymphocytic leukemia (CLL), so do the rates of patients who stop taking the drug.

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A one-year follow-up study revealed a majority of patients with mantle cell lymphoma resistant to prior therapies may benefit from treatment with CD19-targeting chimeric antigen receptor (CAR) .

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A new study by Yale Cancer Center (YCC) and Smilow Cancer Hospital researchers suggests that the drug venetoclax aids therapy for relapsed/refractory myelodysplastic syndromes, especially when paired with azacytidine.

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A Phase II study pairing azacitidine with enasidenib boosts complete remission in patients with AML with IDH2 mutations.

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Results of studies on a novel agent to treat multiple myeloma and a combination therapy aimed at slowing the progression of a precursor myeloma condition are among reports being presented by Dana-Farber Cancer Institute investigators at the ASH Annual Meeting.

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For older patients with acute myeloid leukemia (AML), the prospects for success of a stem cell transplant can often be predicted based on the particular set of genetic mutations within the tumor cells, investigators at Dana-Farber Cancer Institute and other research centers will report today at the ASH Annual Meeting.

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Identifying the type of pain an adult with sickle cell disease (SCD) experiences may be useful in improving treatment, according to a new study by researchers at Yale Cancer Center (YCC) and Smilow Cancer Hospital.

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Researchers from St. Jude Children’s Research Hospital will present their work at the 61st annual meeting of the American Society of Hematology.

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A Rutgers Cancer Institute of New Jersey investigator and other collaborators examined prenatal screening practices for blood disorders between different types of care providers and found different variations in prenatal guidance.

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On Dec. 10, Johns Hopkins scientist Gregg Semenza, M.D., Ph.D., along with William Kaelin Jr., M.D., and Peter Ratcliffe, M.D., will accept the 2019 Nobel Prize in Physiology or Medicine in Stockholm, Sweden, for the groundbreaking discovery of the gene that controls how cells respond to low oxygen levels.

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News release about a new collaborative study led by Cleveland Clinic and University Hospitals finding that commonly used clinical indicators of immune status and inflammation can predict mortality in the general population.

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A study led by Hamilton researchers has found a new way to interpret blood test results in patients who are investigated for blood clots in their lungs, a condition known as pulmonary embolism. This new approach applies to D-dimer blood tests, which are used by physicians to rule out the presence of a blood clot.

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UCLA scientists have discovered a link between a protein and the ability of human blood stem cells to self-renew. In a study published today in the journal Nature, the team reports that activating the protein causes blood stem cells to self-renew at least twelvefold in laboratory conditions

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Soft tissue sarcoma cells stop a key metabolic process which allows them to multiply and spread, and so restarting that process could leave these cancers vulnerable to a variety of treatments

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Dana-Farber Cancer Institute researchers will present more than 40 research studies at the 61st American Society of Hematology (ASH) Annual Meeting on December 7-10 in Orlando, Fla.

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Inspired by their use in mechanical systems, Massachusetts Institute of Technology researchers are testing a magnetically-actuated fluidic valve to use in trauma patients suffering from hemorrhage.

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University of South Australia biomedical engineer Dr Marnie Winter has been awarded US$100,000 from the world’s largest private foundation to help better understand and tackle a condition which kills 76,000 women and 500,000 babies each year.

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Researchers reporting in ACS’ Environmental Science & Technology have linked high levels of DDT in Indian immigrants in the U.S. with risk factors for diabetes.

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DHS S&T and FEMA awarded $2.3 million over a three year period to USU NCDMPH to develop lifesaving trauma training for high-school-age students last year.

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Multiple myeloma is a type of blood cancer in which malignant plasma cells accumulate in the bone marrow, and recent studies have shown that some can leave the marrow and enter the blood stream. Until now, it has been difficult to detect these cells, known as clonal circulating plasma cells, in the blood.

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Blood clots have long been implicated in heart attacks and strokes. While the role of one key protein, called von Willebrand factor, has been established, a reliable model for predicting how it collects in blood vessels remains elusive. Researchers review recent work on understanding the behavior of vWF in APL Bioengineering, painting a portrait of vWF, and by highlighting advances in the field, the authors put forth promising avenues for therapies in controlling these proteins.

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A new study by researchers at the University of Montreal shows close to 172,000 Canadians injected drugs in 2016, up from 130,000 just five years earlier, but support varies.

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After decades of little or no progress, biomedical researchers are finally making some headway at detecting and treating sepsis, a deadly medical complication that sends a surge of pathogenic infection through the body and remains a major public health problem. They report data in Science Translational Medicine.

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Israeli and American scientists have discovered that administering probiotics in hospital intensive care units may lead to blood infections, and in some cases the adverse effects could outweigh the potential benefits.

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Recent study found that an effective blood cancer treatment was associated with weight gain, obesity, and increased systolic blood pressure

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A Rutgers Cancer Institute of New Jersey researcher has received a $600,000 Translational Award from the V Foundation for Cancer Research to study treatment impact on chronic lymphocytic leukemia.

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• Peritoneal dialysis performed with an automated wearable artificial kidney was safe and effective for removing toxins from the blood of patients with kidney failure. • Results from the study will be presented at ASN Kidney Week 2019 November 5–November 10 at the Walter E. Washington Convention Center in Washington, DC.

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Below are summaries of recent Fred Hutch research findings with links for additional background and media contacts.