Location: California

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X-ray devices have long been used to see the inner structure of things, from bone breaks in the human body to the contents of luggage at airport security checkpoints. But to see life's chemistry and exotic materials at the scale of individual atoms, you need a far more powerful X-ray device. Enter the Linac Coherent Light Source (LCLS) X-ray laser at the Department of Energy's SLAC National Accelerator Laboratory.

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The governing board of the California Institute for Regenerative Medicine (CIRM) has awarded two University of California, San Diego researchers almost $3 million in combined funding to pursue new technologies intended to accelerate advances moving stem cell therapies out of the lab and into the clinic.

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Officials of the University of California, San Diego and Perdana University in Malaysia have announced a plan to collaborate on further development of the Perdana University Graduate School of Medicine (PUGSOM). UC San Diego was chosen from among the top schools of medicine in the United States to lead this initiative.

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A new study from scientists at The Scripps Research Institute (TSRI) helps explain how booster shots prompt immune “memory” to improve, an important step toward the development of more effective, longer-lasting vaccines.

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Two scientists from the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have received a California Institute of Regenerative Medicine (CIRM) Tools and Technology Award that will forward revolutionary stem cell medicine. The UCLA researchers were among only 20 scientists nationwide to receive the Tools and Technologies Award, the most of any institution represented.

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Extracorporeal life support is a promising treatment for pediatric patients in cardiac arrest who are unresponsive to traditional CPR. A Critical Care Nurse article examines ECPR and addresses ethical principles related to its use and the continued advancement of end-of-life care.

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Encouraging adversaries to have more interpersonal contact to find common ground may work on occasion, but not necessarily in the U.S. Senate, according to new research.

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A pioneering surgery may help people suffering from a frustrating breathing condition in which the damaged phrenic nerve prevents the diaphragm from getting the message to breathe.

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February is American Heart Month. UCLA cardiologists from the UCLA Barbra Streisand Women’s Heart Health Program offer heart healthy tips.

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A team at The Scripps Research Institute (TSRI) has won a $1,784,000 grant from the California Institute for Regenerative Medicine (CIRM) to support the development of a new method for detecting DNA damage in stem cells to ensure that only the highest quality cells are used in transplantation or therapy.

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Researchers from the University of California, San Diego School of Medicine and University of California, San Francisco, with support from a diverse team of collaborators, have launched an ambitious new project – dubbed the Cancer Cell Map Initiative or CCMI – to determine how all of the components of a cancer cell interact.

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Salk scientists discover how a "mini-brain" in the spinal cord aids in balance

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The American Association of Critical-Care Nurses will bestow the 2015 Circle of Excellence Award on 25 nurses nationwide at its National Teaching Institute & Critical Care Exposition, San Diego, May 18-21.

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UC San Diego researchers say they can predict the spread of flu a week into the future with as much accuracy as Google Flu Trends can display levels of infection right now.

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Theodore Friedmann, MD, professor in the Department of Pediatrics at University of California, San Diego School of Medicine was named today one of three recipients of the 2015 Japan Prize, a prestigious international award honoring laureates whose “original and outstanding achievements in science and technology have advanced the frontiers of knowledge and served the cause of peace and prosperity for mankind.”

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Ten months after California legislators enacted a controversial law mandating that radiologists notify women if they have dense breast tissue, UC Davis researchers have found that half of primary care physicians are still unfamiliar with the law and many don’t feel comfortable answering breast density-related questions from patients. The findings, to be published in the March print edition of Journal of the American College of Radiology, suggest that if the law is going to have any significant impact on patient care, primary care providers need more education about breast density and secondary imaging options.

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Richard Kim, MD, a cardiac surgeon at Children’s Hospital Los Angeles, recently used a 3D printed heart as a model to plan a life-saving procedure for his young patient, Esther Perez.

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Researchers working in part at the Department of Energy’s SLAC National Accelerator Laboratory have discovered that a key protein for cell health, which has recently been linked to diabetes, cancer and other diseases, can multitask by having two identical protein parts divide labor.

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Jerome Cohen, a New York University professor and senior American expert on Chinese and East Asian Law, will be the first speaker for UC Irvine’s 2015 Long Institute Distinguished Lecture Series slated for February 23, 2015 from 2:00 to 4:30 p.m. in the Executive Commons at UC Irvine’s Paul Merage School of Business. Cohen will present, “Xi Jinping’s Rule of Law at Home and In the World,” along with his own thoughts on the development of law in China, discussing both the domestic and international implications.

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Researchers in the Cedars-Sinai Board of Governors Regenerative Medicine Institute have devised a novel way to generate transplantable corneal stem cells that may eventually benefit patients suffering from life-altering forms of blindness.

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Tony Heinz, a scientist known for exploring the properties of nanoscale materials and developing important new tools for that exploration, has joined the Department of Energy’s SLAC National Accelerator Laboratory as a professor of photon science and Stanford University as a professor of applied physics. He will also lead the SLAC Chemical Sciences Division.

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People who carry a variant of a gene that is associated with longevity also have larger volumes in a front part of the brain involved in planning and decision-making, according to researchers at UC San Francisco.

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In a new study from Sanford-Burnham Medical Research Institute, researchers have used human pluripotent stem cells to generate new hair. The study represents the first step toward the development of a cell-based treatment for people with hair loss. In the United States alone, more than 40 million men and 21 million women are affected by hair loss. The research was published online in PLOS One yesterday.

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In a pair of related studies, scientists from the Florida campus of The Scripps Research Institute have shown their drug candidates can target biological pathways involved in the destruction of brain cells in Parkinson's disease.

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Fresh from giving the January Rossi Prize Lecture, the astrophysicists who discovered two enormous radiation bubbles in the center of our galaxy discuss what they may tell us about the Milky Way and how they could help in the search for dark matter.

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Researchers at Children's Hospital Los Angeles demonstrated the efficacy and safety of a new fusion protein in mouse models of aggressive human leukemia using leukemia cells taken directly from patients with ALL.

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To better understand PLA2 enzymes and help drive therapeutic drug development, researchers at University of California, San Diego School of Medicine developed 3D computer models that show exactly how two PLA2 enzymes extract their substrates from cellular membranes. The new tool is described in a paper published online the week of Jan. 26 by the Proceedings of the National Academy of Sciences.

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Deepa Bhojwani, MD, joins Children’s Hospital Los Angeles (CHLA) as director of the Leukemia/Lymphoma program within the Children’s Center for Cancer and Blood Diseases on February 15, 2015.

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January tip sheet of patient features and human interest story ideas from Cedars-Sinai. All of these patients have been -- or are being -- treated for brain-related disorders -- malignant and benign brain tumors, arteriovenous malformations, and essential tremor, etc. From a former professional singer to a young mother of three, to a retired church pastor, all have compelling stories to tell and are available for interviews along with their physicians. A detailed backgrounder is available for each individual highlighted.

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UC Irvine’s Paul Merage School of Business Full-Time MBA program has climbed two spots among public school in the U.S. to rank seventh in the 2015 Financial Times Top Full-Time Global MBA Programs rankings report released today. The Merage School ranked 21st in the U.S. overall, up from 25th in 2014, and tied for 43rd in the world, up from 48th in 2014.

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A new study finds that the factors influencing children’s readiness for kindergarten include not only whether they attend preschool, but also their families’ behaviors, attitudes and values — and that parents’ expectations go a long way toward predicting children’s success throughout their schooling.

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On Jan. 23-25, more than 15 stroke survivors and their caregivers will go on a mini-vacation in La Jolla, CA, as part of a therapeutic retreat for those whose lives have been affected – sometimes turned upside down – by stroke. The 50s-themed stroke camp is being co-hosted by UC San Diego Health System, which has one of the nation’s first certified Comprehensive Stroke Centers.

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Researchers at the Department of Energy’s SLAC National Accelerator Laboratory are trying to find out why uranium persists in groundwater at former uranium ore processing sites despite remediation of contaminated surface materials two decades ago. They think buried organic material may be at fault, storing toxic uranium at levels that continue to pose risks to human health and the environment, and hope their study will pave the way for better long-term site management and protection of the public and environment.

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Researchers have shown that neonatal mouse hearts have varying regenerative capacities depending upon the severity of injury. Approaches to extend this regenerative capacity in a mammalian model, from the neonatal period to the juvenile or adult period, could help identify new treatment options for humans.

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UCLA researchers have treated mice that mimic human autism with a neuropeptide called oxytocin, and have found that it restores normal social behavior. In addition, the findings suggest that giving oxytocin as early as possible in the animal’s life leads to more lasting effects in adults and adolescents.

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Researchers at University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences and the Bridge Institute at the University of Southern California report the first crystal structure of the cellular receptor CXCR4 bound to an immune signaling protein called a chemokine. The structure answers longstanding questions about a molecular interaction that plays an important role in human development, immune responses, cancer metastasis and HIV infections.

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In an historic first for Rady Children’s Hospital-San Diego, a team of surgeons successfully implanted a heart in 11-year-old Eric Montaño from San Diego.

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A new model of the impact of California’s existing and proposed policies on its greenhouse gas (GHG) reduction goals suggests that the state is on track to meet 2020 goals, and could achieve greater emission reductions by 2030, but the state will need to do more to reach its 2050 climate goals.

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Upending decades-old dogma, a team of scientists at the University of California, San Diego School of Medicine say enzymes long categorized as promoting cancer are, in fact, tumor suppressors and that current clinical efforts to develop inhibitor-based drugs should instead focus on restoring the enzymes’ activities.

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Center for Advancement of Science in Space (CASIS) awarded grant funding to UCLA for stem cell researchers to send rodents into space to test new therapy for prevention of bone loss. Research has enormous translational potential for astronauts in space flight and patients on Earth with osteoporosis or other bone loss problems from disease, illness or trauma.

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Researchers have proposed a system for off-label drug prescriptions combining reporting, testing and enforcement regulations, and allowing interim periods of off-label use. This would give patients more treatment options while providing regulators with evidence of the drugs’ safety and efficacy.

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University of California, San Diego Professor Frank Würthwein, an expert in high-energy particle physics and advanced computation, has joined the university’s San Diego Supercomputer Center (SDSC) to help implement a high-capacity data cyberinfrastructure across all UC campuses.

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University of California, San Diego Professor Frank Würthwein, an expert in high-energy particle physics and advanced computation, has joined the university’s San Diego Supercomputer Center (SDSC) to help implement a high-capacity data cyberinfrastructure across all UC campuses.

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Linda and Nick Holland, marine biologists based at Scripps Institution of Oceanography at UC San Diego since 1987 and 1966, respectively, have been selected to receive one of the world’s most prestigious awards in the field of evolutionary biology.

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Scientists from the Florida campus of The Scripps Research Institute have produced an approach that completely protects animal models against a type of genetic disruption that causes intellectual disability, including serious memory impairments and altered anxiety levels.