Feature Channels: Bone Health

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Ultrasound -- sound with frequencies higher than those audible to humans -- is commonly used in diagnostic imaging of the body's soft tissues, including muscles, joints, tendons and internal organs. A technology called high-intensity focused ultrasound (HIFU) is also being explored for therapeutic uses including the removal of uterine fibroids and the destruction of tumors. A suite of noninvasive, adaptive focusing techniques -- that allow ultrasonic beams to be focused through the rib cage and skull -- will be described during Acoustics ’17 Boston.

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Type 2 diabetes (T2D) and osteoporosis often coexist in patients, but managing both conditions can be a challenge. A comprehensive review published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism highlights the most effective treatment options for treating these conditions together.

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A discovery, described in a recent study by researchers at Beaumont Health, revealed ACL tears send a signal to stem cells throughout our body. This could lead to future breakthroughs to enable stem cells to repair injuries and reduce development of conditions like osteoarthritis.

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Nationwide Children’s Hospital and Honda announced today a $1 million gift from the automaker to establish the Honda Center for Gait Analysis and Mobility Enhancement designed to enhance pediatric mobility.

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UAB’s Stefan Kertesz, M.D., provides commentary on a new trial comparing yoga and physical therapy for those who suffer from low back pain.

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There hasn’t been a gold standard for how orthopaedic spine surgeons promote new bone growth in patients, but now Northwestern University scientists have designed a bioactive nanomaterial that is so good at stimulating bone regeneration it could become the method surgeons prefer.

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Scientists on the Florida campus of The Scripps Research Institute (TSRI) have improved a state-of-the-art gene-editing technology to advance the system’s ability to target, cut and paste genes within human and animal cells—and broadening the ways the CRISPR-Cpf1 editing system may be used to study and fight human diseases. 

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In the first such collaboration of its kind, an expert panel of rheumatologists and orthopedic surgeons has developed guidelines for the management of anti-rheumatic medication in patients undergoing hip or knee replacement. The goal was to lower the risk of infection, which is linked to the use of the medications.

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The joint guideline between ACR and AAHKS provides eight recommendations on preoperative management of total hip and knee replacements.

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NASA has selected Alan Hargens, PhD, professor of orthopedic surgery at UC San Diego School of Medicine, to receive a 2017 Distinguished Public Service Medal. This is NASA's highest form of recognition for any non-government employee whose distinguished service, ability or vision has personally contributed to NASA's advancement of U.S. interests. Selection for this award means that Hargens’ achievements and contributions demonstrate a level of excellence that has made such a profound and lasting impact to NASA mission success that other forms of recognition by NASA would be inadequate.

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CoreMechanics defines CoreForm as a wearable exercise product to prevent and stabilize musculoskeletal injury. The expertise needed to refine the device and measure its effectiveness is found within several disciplines at URI.

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Researchers believe this is the first study of its kind to reveal the body’s systemic stem cell response to an ACL injury. Osteoarthritis affects more than 30 million adults in the United States. Many cases occur after trauma to a joint. It’s also a leading cause of disability.

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Hackensack Meridian Health Riverview Medical Center today announced it is the first hospital in New Jersey to earn The Joint Commission’s Gold Seal of Approval® for Advanced Certification for Total Hip and Total Knee Replacement. The advanced certification is for Joint Commission-accredited hospitals, critical access hospitals and ambulatory surgery centers seeking to elevate the quality, consistency and safety of their services and patient care.

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University of Virginia Cancer Center has earned recognition as a national center of excellence for its care of patients with myelodysplastic syndrome (MDS), a cancer of the bone marrow that often leads to leukemia.

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For patients undergoing shoulder joint replacement surgery (arthroplasty), higher body mass index is linked to increased complications—including the need for "revision" surgery, reports a study in the June 7 issue of The Journal of Bone & Joint Surgery. The journal is published in partnership with Wolters Kluwer.

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Calcium carbonate combined with sea urchin proteins form tiny stacks of ‘bricks’ that creates a structure which provides a tough, exoskeleton defense for the sea creature. NYU Dentistry research studying the protein may enable the development of tunable fracture resistant materials that one day will find its use in developing lightweight ‘armor' and ‘sturdier’ dental composites.

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Saint Louis University scientist Daniela Salvemini, Ph.D., reports discovering a key pathway that drives cancer-related bone pain while providing a potential solution with a drug that already is on the market.

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The American College of Rheumatology’s (ACR) updated clinical guideline for the prevention and treatment of Glucocorticoid-Induced Osteoporosis is now available online. The guideline provides recommendations on assessing fracture risk and treatment for adults and special patient populations.

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Sales of the essential oil copaiba [koh-pey-buh] are increasing, at least in part, because more than 54 million Americans suffer from arthritis. The traditional way to treat arthritis is using NSAIDs and COXIBs, which are not without adverse events. For arthritis sufferers, copaiba may turn out to be a silver bullet or, perhaps, snake oil.

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Researchers from Houston Methodist and Italian super sports car maker Automobili Lamborghini are working together on new carbon fiber materials for implantable devices used in therapeutic drug delivery and orthopedics.

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Andrea Dunaif, MD, an internationally renowned diabetes and women’s health expert, has been appointed the new Chief for the Hilda and J. Lester Gabrilove Division of Endocrinology, Diabetes, and Bone Disease for the Mount Sinai Health System.

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Is it just bad luck or do our spinal columns age badly? Why are our spines so vulnerable? Deborah L. Benzil, MD, FACS, FAANS discusses osteoporosis and bone health.

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An international, multidisciplinary research team, including an engineering professor at the University of Arkansas, has discovered a mechanism that controls the formation and function of plate-like nanocrystals that play a critical role in bone composition.

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Scientists at The Scripps Research Institute (TSRI) have given new superpowers to a lifesaving antibiotic called vancomycin, an advance that could eliminate the threat of antibiotic-resistant infections for years to come.

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A growing number of patients who suffer severe ankle arthritis are undergoing ankle replacement surgery, enabling them to walk again without pain. Helping drive the trend are new implants and surgical techniques that are improving outcomes.

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A study from Fred Hutchinson Cancer Research Center that will be presented at the American Society of Clinical Oncology annual meeting on June 5 in Chicago shows that asymptomatic women who have been treated for early-stage breast cancer often undergo advanced imaging and other tests that provide little if any medical benefit, could have harmful effects and may increase their financial burden.

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The American College of Rheumatology (ACR) today expressed opposition to the Trump Administration’s proposed budget cuts to federal programs and institutions that provide critical resources in the fight against rheumatic diseases, including the National Institutes of Health (NIH), the U.S. Food and Drug Administration (FDA), and the Children’s Health Insurance Program (CHIP). The rheumatology provider community praised budget proposals to repeal the Independent Payment Advisory Board (IPAB) and to increase funding for Graduate Medical Education (GME) programs.

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Keck School of Medicine of USC has received a $2.2 million NIH grant to fund research on gene therapy that could help manage challenging bone repairs

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Rubin Institute for Advanced Orthopedics at LifeBridge Health in Baltimore, Maryland is looking for participants for non-surgical treatment trial.

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The health of children’s bones could be determined before they are born, a new University of Southampton study has shown.

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A new device gently suctions, processes and uses a patient’s own fat tissue to provide a potential source of stem cells and growth factors to promote healing.

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The pros and cons of same-day double knee replacement.

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For the first time, UNC School of Medicine researchers show that exercising burns the fat found within bone marrow and offers evidence that this process improves bone quality and the amount of bone in a matter of weeks.

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Six months after knee replacement surgery, pain outcomes were not as good for patients who previously took prescription opioids, according to a study in the May 17 issue of The Journal of Bone & Joint Surgery. The journal is published in partnership with Wolters Kluwer.

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A Cedars-Sinai-led team of investigators has successfully repaired severe limb fractures in laboratory animals with an innovative technique that cues bone to regrow its own tissue. If found to be safe and effective in humans, the pioneering method of combining ultrasound, stem cell and gene therapies could eventually replace grafting as a way to mend severely broken bones.

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A pair of Creighton University undergraduates are collecting data on women in heels with an eye on the health effects of the shoes, especially as it pertains to lower back problems and the potential earlier onset of osteoarthritis in the knee.

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Researchers examined the mechanisms of B cell immune reconstitution in pediatric patients who had undergone bone marrow transplantation and discovered a disruption in the maturation of B cells – critical to the immune system – preventing the production of antibodies that fight infection.

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When a group of six Binghamton University biomedical engineering students launched a collaboration to create a functional biomechanical hand using 3D printing technology one year ago, their thoughts turned to an amputee whom they would often see every day, and to the opportunity to improve her life.

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Maintaining the supply of a molecule that helps to nourish cartilage prevented osteoarthritis in animal models of the disease, according to a report published in Nature Communications online May 11.

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As a kickoff to the 26th American Medical Society for Sports Medicine Annual Meeting, the AMSSM Collaborative Research Network announces $300,000 in funding to support one or more quality, multi-site research proposal(s) to address key priority areas within the field of sports medicine.

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Engineers at the University of California San Diego have developed biomimetic bone tissues that could one day provide new bone marrow for patients needing transplants.

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The American College of Rheumatology today praised Congressional leaders for reaching a spending deal that provides a significant boost in federal funding for medical research.

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Some types of sarcomas elicit a greater immune response than others, which sheds light on how immunotherapy could be used for this connective-tissue cancer, according to a new study in Cancer. Photos, video available: http://www.fredhutch.org/en/news/media-relations/bios-photos/pollack-seth.html

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Pablo G. Castañeda, MD, an internationally renowned expert in pediatric and adolescent hip conditions, has joined Hassenfeld Children’s Hospital of New York at NYU Langone as its new chief of pediatric orthopedic surgery. Prior to joining, he practiced for 10 years in Mexico City.

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Using CRISPR technology, a team of researchers led by Farshid Guilak, PhD, at Washington University School of Medicine in St. Louis, rewired stem cells' genetic circuits to produce an anti-inflammatory arthritis drug when the cells encounter inflammation. The technique eventually could act as a vaccine for arthritis and other chronic conditions.

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A new clinical trial at Baylor Scott & White Research Institute is exploring a novel treatment option for patients with multiple myeloma, a type of cancer formed in bone marrow plasma cells that is considered incurable.

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In a preclinical study in mice and human cells, researchers report that selectively removing old or 'senescent' cells from joints could stop and even reverse the progression of osteoarthritis.

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Bone mineral density, an indicator of bone strength, typically increases with regular exercise, acting as a protective mechanism against bone fractures and osteoporosis. But a new study suggests that the extended, high-intensity training sessions of elite athletes could reverse beneficial bone changes. Researchers from Brock University in Canada will present their findings today at the American Physiological Society (APS) annual meeting at Experimental Biology 2017 in Chicago.

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Winner of the Sanford J. Larson, MD, PhD, Award, Daipayan Guha, MD, presented his research, Optical Topographic Imaging for Intra-Operative Three-Dimensional Navigation in the Cervical Spine: Accuracy Validation and Initial Clinical Feasibility, during the 2017 American Association of Neurological Surgeons (AANS) Annual Scientific Meeting.

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After nearly 40 years of advancing the field of osteopathic medicine and blazing trails for women and minorities, Barbara Ross-Lee, D.O., is retiring as vice president for Health Sciences and Medical Affairs at New York Institute of Technology (NYIT), an institution she served for 16 years in multiple leadership roles. A longtime advocate for advancing medical treatment in underserved communities and an expert in national health care policy, Ross-Lee has inspired thousands of medical students to pursue careers in osteopathic medicine.