Researchers at University of California San Diego School of Medicine report that they have successfully created spinal cord neural stem cells (NSCs) from human pluripotent stem cells (hPSCs) that differentiate into a diverse population of cells capable of dispersing throughout the spinal cord and can be maintained for long periods of time.
Researchers have identified a gene that when inhibited or reduced, in turn, reduced or prevented human non-small cell lung cancer tumors from growing.
Researchers at UC Davis, Genentech and Foundation Medicine are the first to show that a blood-based test to assess tumor mutational burden (TMB) accurately identifies non-small cell lung cancer (NSCLC) patients who could benefit from immunotherapies called checkpoint inhibitors. The blood test offers a much less invasive and more repeatable alternative to tissue testing. The study was published online today in Nature Medicine.
Cleveland Clinic researchers have designed a potential new class of drugs that may reduce cardiovascular risk by targeting a specific microbial pathway in the gut. The research, published in the September issue of Nature Medicine, was led by Stanley Hazen, M.D., Ph.D.
New research has discovered a previously unknown mechanism for controlling cellular decisions, one which combines an on-and-off switch in a single protein, either promoting or preventing the transition to flowering in plants.
A uniquely designed experimental vaccine against Zika virus has proven powerful in mice, new research has found.
Almost one year after the U.S. Food and Drug Administration (FDA) approval of chimeric antigen receptor (CAR) T-cell therapy for children with acute lymphoblastic leukemia (ALL), researchers at The University of Texas MD Anderson Cancer Center and the Pediatric Acute Lung Injury and Sepsis Investigators Network (PALISI) today published treatment guidelines for managing the treatment in the online issue of Nature Reviews Clinical Oncology.
By looking into the brains of locusts, researchers in the School of Engineering & Applied Science at Washington University in St. Louis have determined how one smell can affect another, and how a locust can recognize a smell even though its brain activity looks different depending on the context.
The study, which has yielded a provisional patent, establishes a method for wicking chemically compatible vegetable oils into the surfaces of common extruded plastics.
Drawing on genomic data from more than one million individuals, researchers from the University of Michigan have led a large collaborative effort to discover as-yet unknown genetic risk factors for atrial fibrillation.
A new study using machine learning has identified brain-based dimensions of mental health disorders, an advance towards much-needed biomarkers to more accurately diagnose and treat patients.
A mouse mother's prior dengue immunity would protects her unborn pups from devastating brain defects such as microencephaly associated with ZIKV. These findings could guide development of more effective flavivirus vaccines and hint at what types of immune responses are maximally protective against fetal brain damage after Zika invasion.
Studying lab animals and humans, researchers at Joslin Diabetes Center discovered that a protein called JNK helps to drive response to exercise. If JNK is activated during exercise, the researchers say, that stimulates skeletal muscle growth. If it’s not activated, muscles improve their adaptation for endurance and aerobic capacity.
A group of researchers, including scientists at the Department of Energy’s SLAC National Accelerator Laboratory and Fermi National Accelerator Laboratory, summarize current applications and future prospects of machine learning in particle physics in a paper published today in Nature.
Hollow molecular structures known as COFs suffer from an inherent problem: It’s difficult to keep a network of COFs connected in harsh chemical environments. Now, a team at the Berkeley Lab has used a chemical process discovered decades ago to make the linkages between COFs much more sturdy, and to give the COFs new characteristics that could expand their applications.
The vast reservoir of carbon stored beneath our feet is entering Earth’s atmosphere at an increasing rate, according to a new study in the journal Nature. Blame microbes: When they chew on decaying leaves and dead plants, they convert a storehouse of carbon into carbon dioxide that enters the atmosphere.
Researchers have discovered a new, rare type of cell in the human airway. These cells appear to be the primary source of activity of the gene which causes cystic fibrosis.
Scientists at the Innovative Genomics Institute have concocted a transformative new way to harness the power of evolution. Today in Nature, researchers at UC Berkeley describe yet another creative application for CRISPR: a platform to spur evolution of specific genes inside cells. Their inventive new system, “EvolvR,” lets scientists shake up the DNA letters in their gene of choice until they find the variation that’s just right. The technology opens up countless possibilities, like engineering yeast that efficiently turn waste into biofuels, or developing new human therapeutics.
In a recently published study in the journal Nature Microbiology, researchers at Los Alamos National Laboratory show that computer simulations can accurately predict the transmission of HIV across populations, which could aid in preventing the disease.
ORNL story tips: Residents’ shared desire for water security benefits neighborhoods; 3D printed molds for concrete facades promise lower cost, production time; ORNL engineered the edges of structures in 2D crystals; chasing runaway electrons in fusion plasmas; new tools to understand U.S. waterways and identify potential hydropower sites; better materials for 3D-printed permanent magnets could last longer, perform better.
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