New AI model identifies possible therapies from existing medicines for thousands of diseases, including rare ones with no current treatments. The AI tool generates new insights on its own, applies them to conditions it was not trained for, and offers explanations for its predictions.
A new paper in Nature Machine Intelligence notes that journal articles reporting how well machine learning models solve certain kinds of equations are often overly optimistic. The researchers suggest two rules for reporting results and systemic changes to encourage clarity and accuracy in reporting.
Giving women at risk of premature birth a simple magnesium sulphate infusion (or ‘drip’) can prevent their babies from developing cerebral palsy, a recent Cochrane review has confirmed. The drug itself costs approximately £5 (~$6.50) per dose in England, and requires hospital admission with experienced staff to administer the drug safely to the mother. A new editorial calls for this intervention to be implemented more widely and equitably, as it is still not consistently available worldwide.
جاكسونفيل، فلوريدا - لا تمثل آلام وتشنجات الساق مشكلات عظمية دائمًا، فربما تكون علامات لمرض الشرايين المحيطية أو (مرض الشرايين الطرفية) وهو مشكلة خطيرة في تدفق الدم ذات تبِعات متعلقة بالقلب. وعبر هذا البيان شرحت الطبيبة يونج إربن،أحد جراحي الأوعية الدموية في مايو كلينيك في جاكسونفيل، بولاية فلوريدا كيفية علاج النوع الأكثر انتشارًا ألا وهو مرض الشرايين المحيطية الذي يؤثر في الساقين والقدمين. وتتضمن الخيارات تقنية جراحية قديمة يجري تطويرها وتحسينها من قِبَل جراحي مايو كلينيك وذلك من أجل إعطاء أمل للمرضى في المرحلة المتقدمة من مرض الشرايين المحيطية.
Predatory snails drill holes in the shells of their prey. Using these boreholes, a research team led by palaeontologist Martin Zuschin from the University of Vienna was able to create a time series of predator-prey relationships in the northern Adriatic over the past millennia. This showed that human influences led to a collapse in predator-prey relationships from the 1950s onwards. The study was recently published in the journal Proceedings of the Royal Society B.
This study presents a highly efficient thermal simulation method using a non-gray phonon Boltzmann transport equation. By integrating first-principles phonon properties and advanced computational techniques, the method avoids empirical parameters and achieves remarkable efficiency, solving large-scale 3D problems in under two hours on a personal computer. It enables predictive design of nanostructures with specific thermal conductivity and accurately resolves temperature profiles at the transistor level, aiding in understanding self-heating effects in electronics.
Independent of the temperature and humidity carried by the airflow, portable respiratory sensors are capable of continuously detecting respiratory intensity and frequency. Respiratory monitoring assesses physiological status and potential disease, preventing the escalation of adverse health conditions through early detection of recurrent wheezing, sleep apnoea and diabetes-induced kussmaul breathing.
UCLA's Dr. Roger Lo was awarded a $2 million grant from the National Institutes of Health to investigate innovative strategies to prevent drug resistance in melanoma treatment and improve the effectiveness of MAPK inhibitors, a common treatment for patients with melanomas that carry the BRAFV600 mutation.
Ruby Sharrard and Olivia Allen, two aerospace engineering seniors from The University of Alabama in Huntsville (UAH), a part of The University of Alabama System, were selected to present their propulsion research at the University Consortium for Applied Hypersonics (UCAH) fall forum in Alexandria, Va.
A research team at the Department of Energy’s Oak Ridge National Laboratory created a novel advanced microscopy tool to “write” with atoms, placing those atoms exactly where they are needed to give a material new properties.
Children born to mothers with obesity both before and during pregnancy have an increased risk of neuropsychiatric and behavioural conditions, including autism spectrum disorder (ASD), and attention deficit hyperactivity disorder (ADHD), according to new research from the University of South Australia.
GLP1RA agonists have been increasing in popularity for treating obesity and type 2 diabetes. With this novel treatment proving to be very effective, researchers are curious to know more about what other potential treatments it could also hold.
Using genomics and early treatment response to guide risk-stratification and low-intensity therapy use for ETV6::RUNX1 and high-hyperdiploid B-cell acute lymphoblastic leukemia benefits patients.
In a world where global life expectancy is forecasted to increase from 73.6 years in 2022 to 78.1 years by 2050, the focus is shifting from merely extending lifespan to enhancing healthspan – the number of years lived in good health. At the forefront of this paradigm shift is Hevolution Foundation, a non-profit organization based out of Riyadh, Saudi Arabia - with an unprecedented commitment of up to $1 billion annually to revolutionize the field of aging research.
Longevity research is focussed on extending our time in good health, with the goal of increasing healthspan—the years spent in optimal well-being—rather than simply adding more years to life.
In a review of previous studies, a Johns Hopkins Children’s Center team concludes that some video games created as mental health interventions can be helpful – if modest – tools in improving the mental well-being of children and teens with anxiety, depression and attention-deficit/hyperactivity disorder (ADHD).
Prof. Vincent Guilamo-Ramos, PhD RN Executive Director of the Institute for Policy Solutions (IPS) at Johns Hopkins School of Nursing, joined a diverse group of leaders at the White House today to shine the spotlight on the largely invisible HIV crisis in the Latino community.
The University of California, Irvine has been ranked ninth among the nation’s public universities – and 33rd overall – on U.S. News & World Report’s 2024-25 list of “Best Colleges,” released today. This is the 10th consecutive year in which UC Irvine has placed in the top 10.
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