Latest News from: Sbarro Health Research Organization (SHRO)

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Released: 23-Jul-2020 8:05 AM EDT
Key Immune System Genes Identified to Explain High COVID Deaths and Spread in Northern Italy Versus Fewer Cases and Deaths in the South
Sbarro Health Research Organization (SHRO)

Not long after the Coronavirus disease (Covid-19) outbreak in China, Italy was hard-hit by the infection and rapidly became one of the countries with the highest mortality rate.

Released: 20-Jul-2020 11:25 AM EDT
Despite Promising Lab Results, Most Precision Medicine Therapies for Mesothelioma Fail in the Clinical Setting
Sbarro Health Research Organization (SHRO)

Malignant mesothelioma (MM) is a lethal cancer mainly caused by exposure to asbestos, for which, unfortunately, no current treatment has proven effective, despite the identification of several promising therapeutic targets over the years.

Released: 23-Jun-2020 10:55 AM EDT
Monoclonal Antibody Restores T-Cell Ability to Kill Cancer
Sbarro Health Research Organization (SHRO)

A new class of anticancer agents can restore the ability of cytotoxic T lymphocytes (CTLs) to infiltrate the tumor and kill target cells in patients with metastatic non-small cell lung cancer (mNSCLC).

Released: 8-Jun-2020 2:05 PM EDT
Targeting Receptor EphA2 Reduces Bladder Cancer Tumor Growth and Increases Chemotherapy Effectiveness
Sbarro Health Research Organization (SHRO)

An international team of investigators has recently discovered that the receptor tyrosine-kinase EphA2 activated by the growth factor progranulin is a tumorigenic driver of bladder cancer progression.

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Released: 29-May-2020 2:40 PM EDT
Genetics May Explain High COVID-19 Mortality in Italy, Inform Global Pandemic Response
Sbarro Health Research Organization (SHRO)

Researchers predict the Human Leukocyte Antigen (HLA) gene has a key role in shaping immune response to COVID.

Newswise: Researchers Silence PRMT5 Gene to Slow Mesothelioma Using Precision Medicine
Released: 1-May-2020 11:50 AM EDT
Researchers Silence PRMT5 Gene to Slow Mesothelioma Using Precision Medicine
Sbarro Health Research Organization (SHRO)

Silencing of the protein coding gene PRMT5 has possible therapeutic potential for treating Mesothelioma (MM), according to a recent in vitro study published in the Journal of Cellular and Molecular Medicine.

Released: 12-Mar-2020 10:15 AM EDT
Considerations about current evolution of SARS-nCOV-2 epidemic in Italy
Sbarro Health Research Organization (SHRO)

In Italy, a COVID-19 epidemic is raging. This analysis, which might be useful also to forecast the next epidemic trends in the U.S., is briefly recapitulated in the following document.

Released: 9-Mar-2020 8:55 AM EDT
Understanding COVID-19 Origins First Step to Treating Cases, Stopping Spread
Sbarro Health Research Organization (SHRO)

“The new virus originating from Wuhan is the third coronavirus that has made the ‘jump’ from animals to humans,” explains Enrico Bucci, Ph.D., professor and research scientist at the Sbarro Health Research Organization (SHRO), at Temple University in Philadelphia.

Released: 6-Mar-2020 8:20 AM EST
Coronavirus: concern and precaution ok, but panic and hysteria unjustified, says expert
Sbarro Health Research Organization (SHRO)

COVID-19 is similar in symptoms to the seasonal flu, but to recognize it there is a different procedure and we have to act accordingly

Released: 7-Feb-2020 8:45 AM EST
Link Found Between Bladder Cancer and Collagen Receptor, Revealing Possible Treatment Target
Sbarro Health Research Organization (SHRO)

A team of investigators has recently discovered that the collagen receptor DDR1 functionally interacts with the insulin-like growth factor system in regulating bladder cancer.

Released: 31-Jan-2020 9:00 AM EST
Lower Survival in Patients with High BMI and HER2+ Metastatic Breast Cancer Treated with Pertuzumab and Trastuzumab
Sbarro Health Research Organization (SHRO)

An international team of researchers found that high BMI correlates to lower survival in patients with HER2+ metastatic breast cancer, even among patients showing initial positive response to new anti-HER2 agents pertuzumab and trastuzumab.

Newswise: Virtual Reality and Breast Cancer, First Italian-American Study Shows Promising Results
16-Jan-2020 3:05 PM EST
Virtual Reality and Breast Cancer, First Italian-American Study Shows Promising Results
Sbarro Health Research Organization (SHRO)

Virtual Reality during chemotherapy shown to improve breast cancer patients’ quality of life during the most stressful treatments, according to a recent study.

Released: 7-Jan-2020 12:50 PM EST
Natural Extract to Counter Nephrotoxicity Induced by Mycotoxin OTA
Sbarro Health Research Organization (SHRO)

Today a team of researchers from the Department of Veterinary Medicine and Animal Production of the Federico II University of Naples, in collaboration with the Sbarro Health Research Organization (SHRO), at Temple University in Philadelphia, and the Department of Biotechnology at the University of Siena, Itay, has discovered the effectiveness of a new extract, of natural origin, able to prevent nephrotoxicity induced by the mycotoxin Ochratoxin A (OTA), and has published this research in the international Journal of Cellular Physiology.

Released: 30-Dec-2019 4:35 PM EST
Turmeric and the Anti-Cancer Properties of Curcumin Discussed in Research Review
Sbarro Health Research Organization (SHRO)

The review has collected studies concerning the anticancer potential of curcumin against the most widespread cancers and also describing the molecular mechanisms of action.

Released: 24-Dec-2019 10:20 AM EST
Researchers Probe Emerging Mesothelioma Treatment Targeting PP2A and CDK
Sbarro Health Research Organization (SHRO)

A collaborative study of researchers from Thomas Jefferson University, Sbarro Institute for Cancer Research and Molecular Medicine of Temple University, University of Siena, and from the Spanish Center for the Applied Medical Research (CIMA) of the University of Navarra have discovered a novel targetable axis in mesothelioma patients.

5-Dec-2019 10:55 AM EST
Land of Fires: Evaluation of heavy metal blood-levels in populations exposed to toxic waste in southern Italy
Sbarro Health Research Organization (SHRO)

Toxic environmental agents, to which anyone is involuntarily exposed, represent non-negligible risk for human health and, therefore, environmental contamination has become a theme of primary importance worldwide.

Newswise: SHRO Founder Presented with Career Award and Appointed Chair of Italian Cancer Association FONICAP
Released: 21-Oct-2019 10:00 AM EDT
SHRO Founder Presented with Career Award and Appointed Chair of Italian Cancer Association FONICAP
Sbarro Health Research Organization (SHRO)

Sbarro Health Research Organization founder and Director, Antonio Giordano, M.D., Ph.D., has been recognized with a career award "for the great contributions he has made and which he will continue to make to science, medicine and research.

Newswise:Video Embedded treatment-for-incurable-breast-cancer-melanoma-improved-by-adding-local-anesthetics
VIDEO
Released: 2-Oct-2019 2:05 PM EDT
Treatment for Incurable Breast Cancer, Melanoma Improved by Adding Local Anesthetics
Sbarro Health Research Organization (SHRO)

Results suggest that the combined treatment can lower the effective chemotherapy dosage, reduce side effects, improve tumor cell apoptosis, and reduce tumor cell migration.

Newswise: Untreatable Olive Tree Disease Can Be Contained, But Must Be Better Monitored, says SHRO Researcher
Released: 12-Aug-2019 10:45 AM EDT
Untreatable Olive Tree Disease Can Be Contained, But Must Be Better Monitored, says SHRO Researcher
Sbarro Health Research Organization (SHRO)

Xylella fastidiosa, subsp. pauca is a bacterial pathogen currently devastating the olive orchards in Southern Italy (Apulia). Due to the epidemic, local production of olive oil has dropped by 90%, olive mills are shut down, the regional economy is suffering, and an invaluable cultural asset is compromised.

Released: 14-Jun-2019 11:05 AM EDT
New Natural Therapeutic Agent to Fight Diabetic Nephropathy
Sbarro Health Research Organization (SHRO)

The extract successfully restored the blood glucose levels, body weight, and normalized oxidative stress on renal function in a test group of Zucker diabetic fatty rats.

Newswise:Video Embedded exploiting-rb1-predictive-value-for-cancer-therapy-in-the-clinical-setting-lost-in-translation
VIDEO
Released: 11-Jun-2019 4:10 PM EDT
Exploiting RB1 Predictive Value for Cancer Therapy in the Clinical Setting: Lost in Translation
Sbarro Health Research Organization (SHRO)

RB1 status has emerged not only as a key factor in cancer development and progression, but also as a crucial determinant of cell fate in response to various anticancer treatments

Released: 4-Jun-2019 9:55 AM EDT
Cervical Cancer During Pregnancy, Though Serious, is Highly Treatable According to New Research Review
Sbarro Health Research Organization (SHRO)

“Individualized therapies are strongly recommended and the treatment decision should be made collaboratively with a multidisciplinary team consisting of obstetricians, gynecologists, oncologists, pediatricians, and psychologists,” says researcher.

Newswise:Video Embedded brain-cancer-drug-reactivates-body-s-natural-defenses
VIDEO
Released: 20-May-2019 4:05 AM EDT
Brain Cancer Drug Reactivates Body's Natural Defenses
Sbarro Health Research Organization (SHRO)

Drug reactivates p53 tumor suppressor protein and increases chemotherapy effectiveness in potential glioblastoma breakthrough.

Newswise: Enzyme Inhibition May Lead to New Melanoma Therapy, Say Researchers at Fox Chase with Support from Sbarro Institute
Released: 10-Apr-2019 12:05 PM EDT
Enzyme Inhibition May Lead to New Melanoma Therapy, Say Researchers at Fox Chase with Support from Sbarro Institute
Sbarro Health Research Organization (SHRO)

Inhibition of the cellular enzyme thymine DNA glycosylase (TDG) may be an effective treatment for melanoma, according to research published in the journal Oncogene in January. The paper, “Thymine DNA glycosylase as a novel target for melanoma,” describes how inhibition of TDG, known for its role in cell repair and proliferation, may be used to trigger cell death of cancerous melanoma cells and halt tumor growth.

Newswise: Decoy Damaged DNA Discovers New Gene Repair Protein
Released: 14-Mar-2019 9:00 AM EDT
Decoy Damaged DNA Discovers New Gene Repair Protein
Sbarro Health Research Organization (SHRO)

A synthetic DNA structure was used as bait to capture nuclear proteins, revealing previously unknown role of HNRNPD in the cellular response to DNA damage.

Released: 4-Feb-2019 11:45 AM EST
Potential to Better Treat Mesothelioma Revealed by Precision Medicine Research
Sbarro Health Research Organization (SHRO)

Researchers have successfully identified two genetic markers for potentially effective treatment of Mesothelioma, an orphan disease most commonly associated with asbestos exposure, and for which few treatments exist.

Released: 11-Dec-2018 7:55 AM EST
Metastatic Breast Cancer Survival Improves with New CDK-Inhibitor Plus Endocrine Therapy
Sbarro Health Research Organization (SHRO)

A study finds that palbociclib, in combination with endocrine therapy, improves progression free survival

Newswise: SHRO Partners with Film Festival to Recognize Importance of Virtual Reality in Medicine and Celebrate Italian-Origin Filmmakers
Released: 10-Dec-2018 2:05 PM EST
SHRO Partners with Film Festival to Recognize Importance of Virtual Reality in Medicine and Celebrate Italian-Origin Filmmakers
Sbarro Health Research Organization (SHRO)

This week, SHRO partners with the Italian Movie Award International Film Festival to support Italian-American work in cinema, particularly in recognition for accomplishments with the use of Virtual Reality (VR) in applications in medicine

Newswise: Italian-American Foundation Honors Antonio Giordano, MD, PhD Founder & President of Sbarro Health Research Organization
Released: 12-Nov-2018 9:00 AM EST
Italian-American Foundation Honors Antonio Giordano, MD, PhD Founder & President of Sbarro Health Research Organization
Sbarro Health Research Organization (SHRO)

Italian-American Foundation, Filitalia, honors Antonio Giordano, MD, PhD, Founder & President of Sbarro Health Research Organization at Temple University with the Humanitarian award at the foundation’s 31st Anniversary Gala.

Newswise: Dompé at the medical conference “The Impact of Environment and Healthy Lifestyles in Human Health” - October 13th, Washington, D.C
Released: 13-Oct-2018 2:00 PM EDT
Dompé at the medical conference “The Impact of Environment and Healthy Lifestyles in Human Health” - October 13th, Washington, D.C
Sbarro Health Research Organization (SHRO)

Sbarro Health Research Organization, on the occasion of the medical conference “The impact of environment and healthy lifestyles in human health,” honoured Nathalie Dompé, CEO Dompé Holdings, with a special Award for Societal Impact in Business & Biotechnology, for her work and effort in promoting social responsibility.

Newswise: Medical Conference: The Impact of Environment and Healthy Lifestyles in Human Health
Released: 3-Oct-2018 9:00 AM EDT
Medical Conference: The Impact of Environment and Healthy Lifestyles in Human Health
Sbarro Health Research Organization (SHRO)

The medical conference is organized by the Sbarro Health Research Organization (SHRO), in collaboration with Temple University’s College of Science and Technology, the National Italian American Foundation (NIAF), and the Giovan Giacomo Giordano Foundation

Newswise: Healthier Planet, Healthier People, and More Innovative Medical Science with Italian-American Researchers at Annual NIAF Convention
Released: 2-Oct-2018 9:00 AM EDT
Healthier Planet, Healthier People, and More Innovative Medical Science with Italian-American Researchers at Annual NIAF Convention
Sbarro Health Research Organization (SHRO)

Foundation Awards Presented for Ethics and Creativity in Medical Research, and Societal Impact in Business & Biotechnology

Released: 24-Aug-2018 1:45 PM EDT
New MicroRNA Target May Inhibit Mesothelioma and Unveils Method to Identify Potential Treatments
Sbarro Health Research Organization (SHRO)

Inhibition of miR-24-3p reduced growth of cancer cells and was found to regulate proteins as a potential treatment target for Mesothelioma (MPM). The new potential target, and the method researchers have used to identify it, is an important step in addressing this challenging disease.

Released: 12-Jun-2018 2:05 PM EDT
Olive Oil Production Threatened by New Deadly Plant Pathogen Recently Introduced to Europe
Sbarro Health Research Organization (SHRO)

One of the iconic ingredients of the Mediterranean diet, which often has been associated with beneficial effects in the prevention of cancer as well as several other disorders, is extra-virgin olive oil. For thousands of years, olive trees were planted on Mediterranean coasts, initially by ancient Greek colonists, followed by several other civilizations and cultures, one generation after the other.

Released: 29-May-2018 3:30 PM EDT
In Debate of Scheduled Versus Spontaneous Exercise, Which Motivates You More?
Sbarro Health Research Organization (SHRO)

Older adults seem to be more motivated by scheduled workouts, including the role of a fitness coach or a significant person involved in their exercise goals, when compared to those getting exercise only through spontaneous physical activity.

Newswise: Molecular Inhibitors Can Boost Natural Tumor Suppression to Fight Lung Cancer and Mesothelioma
Released: 2-Apr-2018 9:00 AM EDT
Molecular Inhibitors Can Boost Natural Tumor Suppression to Fight Lung Cancer and Mesothelioma
Sbarro Health Research Organization (SHRO)

Inhibition of the oncogenic kinase AKT, a key protein governing the cell cycle, was found to arrest cancer cell proliferation and triggered their programmed death by apoptosis. The study, published today in Oncogene, represents significant progress in the clinical translation of previous basic scientific discoveries.

Newswise: Virtual Reality: An Escape From Painful and Stressful Medical Treatments
Released: 9-Mar-2018 8:55 AM EST
Virtual Reality: An Escape From Painful and Stressful Medical Treatments
Sbarro Health Research Organization (SHRO)

VR has shown promise in several clinical trials assessing its possible utility as a distraction tool to alleviate pain and distress during medical procedures.

Newswise: Repurposed Parasite Drug New Weapon Against Mesothelioma
Released: 6-Mar-2018 8:55 AM EST
Repurposed Parasite Drug New Weapon Against Mesothelioma
Sbarro Health Research Organization (SHRO)

Anthelmintic drug already approved to treat infections of pinworm parasite was shown to effectively impair both mesothelioma cell growth and migration.

Newswise: Diverse Role of CDK9 Gene in Cell Regulation Continues to Reveal Cancer Treatment Targets 25 Years After Discovery
Released: 1-Mar-2018 9:00 AM EST
Diverse Role of CDK9 Gene in Cell Regulation Continues to Reveal Cancer Treatment Targets 25 Years After Discovery
Sbarro Health Research Organization (SHRO)

A gene discovered by Temple University researchers has proved to be an important target for cancer therapy, with the discovery of its roles in controlling cell proliferation, differentiation, apoptosis, and DNA repair.

Newswise: Fluctuations of Sex Steroid Hormone Could be Culprit in Age-Related Macular Degeneration
Released: 17-Jan-2018 4:05 PM EST
Fluctuations of Sex Steroid Hormone Could be Culprit in Age-Related Macular Degeneration
Sbarro Health Research Organization (SHRO)

Gender-based differences may influence several ocular conditions, suggesting that fluctuations in sex steroid homeostasis may have direct effects on eye physiology and the pathogenesis of conditions like Age-Related Macular Degeneration (AMD).

Newswise: Detecting Pompe Disease with More Accuracy Key to Urgent Intervention
Released: 2-Jan-2018 9:00 AM EST
Detecting Pompe Disease with More Accuracy Key to Urgent Intervention
Sbarro Health Research Organization (SHRO)

Researchers identified a new, more sensitive screening test to recognize Pompe disease, a metabolic disorder affecting cellular processing of glycogen in numerous tissues of the body.

Released: 21-Dec-2017 2:30 PM EST
Xylella: A Conscience, Not a Science Problem
Sbarro Health Research Organization (SHRO)

The Sbarro Health Research Organization congratulates the Italian researchers who were able to prove a direct causal link between the infection by Xylella fastidiosa and the death of olive trees in southern Italy.

Newswise: From Medical Discovery to Food and Fine Arts, Italian-American Contributions Celebrated at Annual Foundation Conference
Released: 4-Dec-2017 8:55 AM EST
From Medical Discovery to Food and Fine Arts, Italian-American Contributions Celebrated at Annual Foundation Conference
Sbarro Health Research Organization (SHRO)

At this year’s 42nd annual NIAF Gala Weekend at the Washington Marriott Wardman Park Hotel in D.C., all aspects of Italian heritage were celebrated, including food, the fine arts, and scientific discovery. The weekend’s events included the medical conference, “Mediterranean Diet, Human Health and Longevity,” sharing the latest in research into a vital part of Italian culture –– diet and food. Conference presentations explored how the recipes of Italian grandmothers are among the healthiest in the world and can even help fight disease, such as cancer.


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