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A reporter's PressPass is required to access this story until the embargo expires on 21-Apr-2015 11:00 AM EDT

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Text Message Alerts Keep More Kentucky Children in Up-to-Date with Vaccinations

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Medical residents are testing the effectiveness of a text message alert system to improve patient compliance with the recommended vaccination schedule.

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Children with Neurological Disorders Need Flu Vaccine but Don’t Always Get It

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Children with neurologic or neurodevelopmental disorders (NNDDs) are at increased risk of complications from influenza. Although the Advisory Committee on Immunization Practices has recognized NNDDs as high-risk conditions for influenza complications since 2005, little is known about influenza vaccination practices in this population.

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How Science and Storytelling Influence the Debate Over Vaccines

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If there is a silver lining to the measles outbreaks, it’s that the risk of getting sick might lessen opposition to vaccines. Moving that pendulum will depend in part on how the public responds to news reports and personal stories about the illness.

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Personalized Melanoma Vaccines Marshal Powerful Immune Response

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Personalized melanoma vaccines can be used to marshal a powerful immune response against unique mutations in patients' tumors, according to early data in a first-in-people clinical trial at Washington University School of Medicine in St. Louis. The research is reported April 2 in Science Express.

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Oral Hepatitis B Vaccine Could Become a Reality

In a new study, researchers report progress toward perfecting a radical new method of producing vaccines using genetically modified corn. The approach could lead to an oral hepatitis B vaccine that requires no refrigeration and costs less than $1 per dose to manufacture.

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Ebola Whole Virus Vaccine Shown Effective, Safe in Primates

An Ebola whole virus vaccine, constructed using a novel experimental platform, has been shown to effectively protect monkeys exposed to the often fatal virus. The vaccine, described today (March 26, 2015) in the journal Science, was developed by a group led by Yoshihiro Kawaoka, a University of Wisconsin-Madison expert on avian influenza, Ebola and other viruses of medical importance.

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Enhanced Flu Protection: Four Beats Three

Findings by a Saint Louis University researcher parallel earlier results: Adding a strain of influenza B could improve effectiveness of an influenza vaccine.

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Finding Strengths — and Weaknesses — in Hepatitis C’s Armor

Using a specially selected library of different hepatitis C viruses, a team of researchers led by Johns Hopkins scientists has identified tiny differences in the pathogens’ outer shell proteins that underpin their resistance to antibodies. The findings, reported in the January 2015 issue of the Journal of Clinical Investigation, suggest a reason why some patients’ immune systems can’t fend off hepatitis C infections, and they reveal distinct challenges for those trying to craft a successful vaccine to prevent them.

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Radical Vaccine Design Effective Against Herpes Viruses

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The new vaccine was found to be effective against the two most common forms of herpes that cause cold sores (HSV-1) and genital ulcers (HSV-2). Both are known to infect the body’s nerve cells, where the virus can lay dormant for years before symptoms reappear. The new vaccine is the first to prevent this type of latent infection.