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Diversion of an HIV Vaccine Immune Response by Antibodies Reactive with Gut Microbiome

A recent HIV vaccine trial testing the HIV envelope as an immunogen was unsuccessful for protection against HIV infection. A new study has found that this vaccine selectively recruited antibodies reactive with both the HIV envelope and common intestinal microbes — a phenomenon previously reported by the same investigators to occur in the setting of acute HIV infection.

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Doctors at Cincinnati Children’s Remind Parents about the Importance of Vaccination

Doctors at Cincinnati Children’s Hospital Medical Center want to remind parents about the importance of immunizing their children when preparing to send their children back to school.

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Lingering Lymphocytes Lash Out Against Leishmania

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Immune cells that hang around after parasitic skin infection help ward off secondary attack. These skin squatters may prove to be the key to successful anti-parasite vaccines.

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TSRI Researcher Wins $4.5 Million in Grants to Support Development of AIDS Vaccine

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The Scripps Research Institute has been awarded two grants from the Bill & Melinda Gates Foundation totaling more than $4.5 million to fund new tools to collect and process high-resolution images of HIV proteins interacting with antibodies with goal to develop a vaccine against HIV/AIDS.

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Aggressive Vaccination Prevented Amish Measles Contagion From Spreading Broadly

Under-vaccinated communities face heightened risk of measles outbreaks that can spread nationally within a year unless squelched quickly, but a vigorous vaccination response during a 2014 outbreak in North American Amish communities in Ohio prevented widespread transmission, according to a recent study published in the online version of Risk Analysis, a publication of the Society for Risk Analysis.

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Adjuvants Improve Immune Response to H7N9 Flu Vaccine

In a phase 2 trial that included nearly 1,000 adults, the AS03 and MF59 adjuvants (a component that improves immune response of inactivated influenza vaccines) increased the immune responses to two doses of an inactivated H7N9 influenza vaccine, with AS03-adjuvanted formulations inducing the highest amount of antibody response, according to a study in the July 21 issue of JAMA.

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UofL Physicians Conducting Vaccine Trial for Children with Relapsed Tumors at Kosair Children’s Hospital

Children with cancer and their parents are finding hope in a Phase I research study led by Kenneth G. Lucas, M.D., at the University of Louisville, who is making progress in developing a vaccine that one day could possibly prevent recurrence of some childhood cancers.

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Few States Require HPV Vaccine

An examination of state vaccination requirements for adolescents finds that the human papillomavirus (HPV) vaccine is currently required in only two states, many fewer than another vaccine associated with sexual transmission (hepatitis B) and another primarily recommended for adolescents (meningococcal conjugate), according to a study in the July 14 issue of JAMA.

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Vanderbilt Researchers Develop Antibodies to Fight Chikungunya Virus

Vanderbilt University Medical Center’s James Crowe, M.D., Ann Scott Carell Professor and director of the Vanderbilt Vaccine Center, and his team are reporting the first large panel of antibody treatments against the chikungunya virus in the current issue of Cell Host and Microbe.

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Hispanic Health Disparities, Statins and Aggression in Men, Supercharged Stem Cells, and More Top Stories 6 July 2015

Other topics include memories and protein, physics and gas mileage, agriculture and food safety, vaccine for Dengue, retinoblastoma proteins in cancer progression, and more.