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Antibodies Identified That Thwart Zika Virus Infection

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Scientists at Washington University School of Medicine in St. Louis have identified antibodies capable of protecting against Zika virus infection, a significant step toward developing a vaccine, better diagnostic tests and possibly new antibody-based therapies.

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Researchers ‘Solve’ Key Zika Virus Protein Structure

Researchers have revealed the molecular structure of a protein produced by the Zika virus that is thought to be involved in the virus’s reproduction and its interaction with a host’s immune system.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 29-Jul-2016 2:00 PM EDT

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Scientists Use Already-Approved Drugs to Force Cancer Cell Death, How to Decide if Watchful Waiting Is the Right Choice, Some Adolescent Cancer Survivors May Require More Comprehensive Mental Health Screening, and MORE in the Cancer News Source

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Comprehensive HIV Vaccine Project Funded at $23 Million by NIH

To support a coordinated, innovative approach to the development of an AIDS vaccine, Texas Biomedical Research Institute scientists, together with an international coalition of experts, have received a grant for $23 million from the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health. The goal of this program is to establish a vaccine approach that targets a frontline defense at the mucosa, while generating backup immune responses in the blood and tissues.

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Researchers Produce First Widely Protective Vaccine Against Chlamydia

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The first steps towards developing a vaccine against an insidious sexual transmitted infection (STI) have been accomplished by researchers at McMaster University.

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Intranasal Flu Vaccine Produces Long-Lasting Immune Response in Mice

Intranasal flu vaccines may be able to provide long-lasting protection against pandemic flu strains, according to a new study from immunologists at Columbia University Medical Center.

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NIH Funds Yellow Fever Vaccine Research at Saint Louis University

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Saint Louis University scientists are studying an investigational vaccine to protect against Zika's deadly cousin, which also is spread by Aedes mosquitoes.

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Checkpoint in B Cell Development Discovered with Possible Implications on Vaccine Potency

University of Alabama at Birmingham researchers report a new quality-control checkpoint function in developing B cells, cells that produce antibodies to protect the body from pathogens.

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Breakthrough Study of HIV in Macaques Confirms Clinically Viable Vaccine Paving the Way for Future Treatment for Humans

In the study, researchers worked with a species of Old World monkeys, rhesus macaques to reproduce the trial results of RV144, the only HIV vaccine that has been tested and shown to reduce the rate of HIV acquisition in a phase III clinical trial.

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Researchers Begin Promising Malaria Vaccine Trial in Burkina Faso

Malaria is one of the world’s deadliest diseases: it infects hundreds of millions of people every year, and kills about half a million, most of them under five years of age. There is no vaccine. Now, researchers at the University of Maryland School of Medicine are testing a malaria vaccine that has shown success in early tests.

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E. Coli: The Ideal Transport Vehicle for Next-Gen Vaccines?

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Researchers have developed an E. coli-based transport capsule designed to help next-generation vaccines do a more efficient and effective job than today’s immunizations. The research, described in a study published July 1 in the journal Science Advances, highlights the capsule’s success fighting pneumococcal disease, an infection that can result in pneumonia, sepsis, ear infections and meningitis.

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Viral Protein Silences Immune Alarm Signals

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Viruses must avoid a host’s immune system to establish successful infections—and scientists have discovered another tool that viruses use to frustrate host defenses. New research demonstrates a novel mechanism by which viruses shut down alarm signals that trigger immune responses. This finding may open the door to future tools for controlling unwanted inflammation in severe infections, cancers and other settings.

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TSRI Scientists Stabilize HIV Structure, Design Potential AIDS Vaccine Candidates

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Two new studies led by scientists at The Scripps Research Institute advance efforts to produce HIV vaccine candidates, potentially suitable for large-scale production.

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New Research Shows Vaccine Protection Against Zika Virus

The rapid development of a safe and effective vaccine to prevent the Zika virus (ZIKV) is a global priority, as infection in pregnant women has been shown to lead to fetal microcephaly and other major birth defects. The World Health Organization declared the Zika virus epidemic a global public health emergency on February 1, 2016.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 31-Jul-2016 12:00 AM EDT

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Stopping Zika: Saint Louis University to Launch Human Vaccine Trial

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Saint Louis University's vaccine center has been tapped by the National Institutes of Health to conduct a human clinical trial of a vaccine to prevent the Zika virus, which can cause devastating birth defects in babies.

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Novel Study in Nairobi Infants May Accelerate Path to HIV Vaccine

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The first and only study to look at isolate HIV-neutralizing antibodies from infants has found that novel antibodies that could protect against many variants of HIV can be produced relatively quickly after infection compared to adults.

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The Wistar Institute Contributes Technology Critical to the Development of the First Zika Vaccine to Be Tested in Human Clinical Trial

The U.S. Food and Drug Administration has approved initiation of the first phase I human trial for a Zika vaccine, based on new research with key findings generated in the lab of David B. Weiner, Ph.D., executive vice president, director of the Vaccine Center, and the W.W. Smith Endowed Chair in Cancer Research at The Wistar Institute.

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Drones Could Be Cheaper Alternative to Delivering Vaccines in Developing World

Using unmanned drones to deliver vaccines in low- and middle-income countries may save money and improve vaccination rates, new research led by the Johns Hopkins Bloomberg School of Public Health and the Pittsburgh Supercomputing Center suggests.