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Infants Much Less Likely to Get the Flu if Moms Are Vaccinated While Pregnant

A study found that 97 percent of confirmed flu cases among babies 6 months and younger occurred in those whose moms were not vaccinated while they were pregnant.

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LJI Scientists Discover Molecular Mechanism for Generating Specific Antibody Responses to Pathogens

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LA JOLLA, CA—Follicular helper T cells (Tfh cells), a rare type of T cells, are indispensible for the maturation of antibody-producing B cells. They promote the proliferation of B cells that produce highly selective antibodies against invading pathogens while weeding out those that generate potentially harmful ones. In their latest study, researchers at La Jolla Institute for Allergy and Immunology identified a key signal that drives the commitment of immature Tfh cells into fully functional Tfh cells and thus driving the step-by-step process that results in a precisely tailored and effective immune response.

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Upstate Medical University Launches New Program to Address Global Health Issues of Pregnant Women, Young Children

Program's first clinical trial will study whether giving the vaccine to mothers in the last part of pregnancy may keep the newborn safe from the RSV during the most vulnerable first several months.

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Vaccinations Are More Effective When Administered in the Morning

The findings, published in the journal Vaccine, suggest administering vaccinations in the morning, rather than the afternoon, could induce greater, and thus more protective, antibody responses.

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Exposure to Routine Viruses Makes Mice Better Test Subjects

Vaccines and therapeutics developed using mice sometimes don’t work as expected in humans. New research at Washington University School of Medicine in St. Louis points to the near-sterile surroundings of laboratory mice as a key reason. When the researchers infected laboratory mice with the mouse equivalent of microbes that cause common infections in humans, the infections changed the animals’ immune systems so they were more similar to adult humans’.

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Scientists Describe New Model to Enhance Zika Virus Research

Researchers at the University of Wisconsin–Madison School of Veterinary Medicine (SVM) have developed one of the first mouse models for the study of Zika virus. The model will allow researchers to better understand how the virus causes disease and aid in the development of antiviral compounds and vaccines.

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Return of Vaccine-Preventable Diseases Has Implications for Hospital Care

With the re-emergence of measles, mumps, diphtheria, and other vaccine-preventable diseases (VPDs), many healthcare providers are encountering these diseases—and their potentially serious and even fatal outcomes—for the first time. A special article in Anesthesia & Analgesia presents a review and update for hospital-based providers who may encounter VPDs—particularly the operating room and intensive care unit.

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Researchers Uncover Earliest Events Following HIV Infection, Before Virus Is Detectable

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New research in monkeys exposed to SIV, the animal equivalent of HIV, reveals what happens in the very earliest stages of infection, before virus is even detectable in the blood, which is a critical but difficult period to study in humans. The findings, published online today in the journal Cell, have important implications for vaccine development and other strategies to prevent infection.

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Mymetics’ HIV Vaccine Candidate Confirms Promise in Preclinical Study with the Texas Biomed

HIV vaccine candidate has shown to generate more than 80% protection in groups of twelve female monkeys against high dose, repeated AIDS virus exposures during part of a preclinical study.

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San Diego to Be Research Hub for New Human Vaccines Project

The University of California, San Diego, J. Craig Venter Institute, La Jolla Institute for Allergy and Immunology and The Scripps Research Institute have teamed up to create the “Mesa Consortium,” a new scientific hub for the Human Vaccines Project. Under a collaborative agreement, the Mesa Consortium and the Human Vaccine Project aim to transform current understanding of the human immune system and expedite development of vaccines and biologics to prevent and treat many global diseases.

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TSRI Scientists Get First-Ever Glimpse of ‘Teenage’ HIV-Neutralizing Antibody

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Scientists at The Scripps Research Institute (TSRI) and collaborating institutions have described the first-ever immature or “teenage” antibody found in a powerful class of immune molecules effective against HIV.

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Salmonella-Based Oral Vaccine a Promising Therapy for Preventing Type 1 Diabetes

A combined vaccine therapy including live Salmonella is a safe and effective way to prevent diabetes in mice and may point to future human therapies, a new study finds. The results will be on Sunday, April 3, at ENDO 2016, the annual meeting of the Endocrine Society, in Boston.

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Novel Vaccine Strategy Produces Rapid and Long-Term Protection Against Chikungunya Virus

Now, new research from The Wistar Institute has demonstrated how a novel vaccine strategy that boosts the immune system by rapidly producing antibodies against CHIKV, combined with a traditional DNA-based vaccine approach, can provide both short term and long term protection against the virus. Study results are published in the Journal of Infectious Diseases.

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UGA, Sanofi Pasteur Develop New Vaccine for H1N1 Influenza

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Researchers at the University of Georgia and Sanofi Pasteur, the vaccines division of Sanofi, announced today the development of a vaccine that protects against multiple strains of both seasonal and pandemic H1N1 influenza in mouse models. They published their findings in the Journal of Virology.

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UCI Scientists Receive $8 Million to Help Develop Q Fever Vaccine

A University of California, Irvine scientific team led by infectious diseases researchers Philip Felgner and Aaron Esser-Kahn has received $8 million from the U.S. Department of Defense’s Defense Threat Reduction Agency to help develop a new vaccine for Q fever.

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New Findings in Humans Provide Encouraging Foundation for Upcoming AIDS Vaccine Clinical Trial

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Some people infected with HIV naturally produce antibodies that effectively neutralize many strains of the rapidly mutating virus, and scientists are working to develop a vaccine capable of inducing such “broadly neutralizing” antibodies that can prevent HIV infection.

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Last Piece of Dengue Vaccine Puzzle Found Effective in Small Trial

In a small clinical trial led by the Johns Hopkins Bloomberg School of Public Health, researchers say that a promising single-dose dengue vaccine, developed by scientists at the National Institutes of Health, was 100 percent effective in preventing human volunteers from contacting the virus, the most prevalent mosquito-borne virus in the world.

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Tips on Seeking a Thyroid Surgeon, How to Improve Cancer Immunotherapy, Drug Combination Shuts Down Tumor Growth in Aggressive Lung Cancer, and more in the Cancer News Source

Tips on Seeking a Thyroid Surgeon, How to Improve Cancer Immunotherapy, Drug Combination Shuts Down Tumor Growth in Aggressive Lung Cancer, and more in the Newswise Cancer News Source

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Mismatched Expectations Most Common Reason for Patients Not Completing HPV Vaccine Series

Conflicting expectations between parents and medical providers about who is responsible for scheduling follow-up appointments is resulting in a failure of young girls completing the Human Papilloma Virus (HPV) vaccination series, according to a new study led by Boston Medical Center researchers.

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St. Jude Research Will Guide Development of New Anti-Influenza Drugs

St. Jude Children’s Research Hospital scientists have revealed new details about how a promising class of anti-influenza drugs blocks the virus from replicating.