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Smallpox, Once Thought an Ancient Disease, May Have Emerged in More Recent Times, Raising Questions About Its Role in History

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New genetic research from an international team including McMaster University, University of Helsinki, Vilnius University and the University of Sydney, suggests that smallpox, a pathogen that caused millions of deaths worldwide, may not be an ancient disease but a much more modern killer that went on to become the first human disease eradicated by vaccination.

Medicine

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AML, Cancer Vaccine, Beth Israel Deaconess, Beth Israel Deaconess Medical Center, David Avigan, Jacalyn Rosenblatt, Acute Myeloid Leukemia (AML)

Personalized Cancer Vaccine is Associated With Promising Outcomes for Patients with Acute Myeloid Leukemia

A personalized cancer vaccine markedly improved outcomes for patients suffering from acute myeloid leukemia (AML), a potentially lethal blood cancer, in a clinical trial led by investigators at Beth Israel Deaconess Medical Center (BIDMC). The product of a long-term collaboration among investigators at the Cancer Center at BIDMC and Dana-Farber Cancer Institute, the vaccine stimulated powerful immune responses against AML cells and resulted in protection from relapse in a majority of patients, the team of researchers reported today in Science Translational Medicine.

Medicine

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MERS, Middle East Respiratory Syndrome, Rabies, Virus, Vaccine, genes, Camel, bats, DNA, Protein

Researchers Combine MERS and Rabies Viruses to Create Innovative 2-for-1 Vaccine

In a new study, researchers have modified a rabies virus, so that it has a protein from the MERS virus; this altered virus works as a 2-for-1 vaccine that protects mice against both Middle East Respiratory Syndrome (MERS) and rabies.

Medicine

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Influenza, flu, Vaccine, Pharmaceticals, genes

New, More Effective Strategy for Producing Flu Vaccines

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A team of researchers led by Yoshihiro Kawaoka, professor of pathobiological sciences at the University of Wisconsin–Madison School of Veterinary Medicine, has developed technology that could improve the production of vaccines that protect people from influenza B.

Medicine

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flu, Vaccines, Influenza

New Survey Shows Only Half of People Plan to Get Flu Shots This Year

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Americans are split on getting an annual flu shot, with four out of 10 having done so in the past year and around half saying they had already received or were planning to get the vaccine this year, according to new national survey data analyzed by University of Georgia researchers.

Medicine

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Lisa Maragakis, Aaron Milstone, flu, Infectious Diseases, Vaccine, Virus

’Tis the Season to Protect Yourself Against the Flu

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Flu cases are being reported in Maryland and across the country, and experts at the Johns Hopkins University School of Medicine expect to see numbers continue to rise. To prevent the flu, Johns Hopkins experts say everyone 6 months and older should get vaccinated against the influenza virus every year.

Science

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Immunotherapy, Cancer, neoantigen, Personalized Cancer Treatment, Cancer Vaccines

Parker Institute for Cancer Immunotherapy and Cancer Research Institute Launch Collaboration on Cancer Neoantigens

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New collaboration between two nonprofits focused on cancer immunotherapy aims to identify new DNA-based targets for personalized cancer treatments

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TSRI Scientists Develop Vaccine Against Fatal Prescription Opioid Overdose

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Scientists at The Scripps Research Institute (TSRI) have developed a vaccine that blocks the pain-numbing effects of the opioid drugs oxycodone (oxy) and hydrocodone (hydro) in animal models.

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A New Mouse Model to Aid Zika Virus Research, DNA-Based Zika Vaccine Showed Protection From Infection, Research Team Makes Strides in Fight Against Zika, and More in the Zika Virus News Source

Get the latest on Zika in the Zika Virus News Source

Science

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therapeutics for companion animals

The Wistar Institute and Man’s Best Friend Therapeutics Announce Partnership to Advance Canine Melanoma Cancer Vaccine

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The Wistar Institute and Man’s Best Friend Therapeutics are pleased to announce a new collaboration that leverages Wistar’s groundbreaking vaccine research and development with MBFT’s expertise in developing animal health products.

Medicine

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Fellow, Global Health, Pharmaceutical Science, Medicine, Dosage, Painkiller, painkiller addiction, Vaccine, Pancreatic Cancer, Assay

AAPS Announces Nine Fellowships, One of the Highest Organizational Honors

The American Association of Pharmaceutical Scientists (AAPS) is pleased to announce the elevation of nine recipients to Fellow, one of the highest honors given to members of the association. Each year, AAPS elevates a few members to Fellow in recognition of their professional excellence in fields relevant to AAPS’s mission: to advance the capacity of pharmaceutical scientists to develop products and therapies that improve global health.

Medicine

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Vaccine, Typhoid, typhoid fever, Gates Foundation, Developing World, Poverty, Urban

International Consortium Receives $36.9 Million Grant to Fight Typhoid

Typhoid fever remains a serious global problem: it kills almost a quarter of a million people annually. To help promote typhoid vaccines, the Bill & Melinda Gates Foundation has given a $36.9 million grant to the University of Maryland School of Medicine Center for Vaccine Development (CVD). The project is a partnership with the Oxford Vaccine Group and PATH.

Medicine

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HIV, Human Immunodeficiency Virus, AIDS, infected cells, Vaccine, Immune System, DNA, simian immunodeficiency virus, SIV, Antiretroviral Therapy

New Therapeutic Vaccine Approach Holds Promise for HIV Remission

A study led by researchers at Beth Israel Deaconess Medical Center (BIDMC), in collaboration with scientists at Walter Reed Army Institute of Research (WRAIR), Janssen Vaccines & Prevention B.V., one of the Janssen Pharmaceutical Companies of Johnson & Johnson and Gilead Sciences, Inc., has demonstrated that combining an experimental vaccine with an innate immune stimulant may help lead to viral remission in people living with HIV. In animal trials, the combination decreased levels of viral DNA in peripheral blood and lymph nodes, and improved viral suppression and delayed viral rebound following discontinuation of anti-retroviral therapy (ART). The research team’s findings appeared online today in the journal Nature.

Medicine

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zika, Zika vaccine, zika virus, Zika Virus prevention, infectious and emerging disease, Global Health

DNA-Based Zika Vaccine Showed Protection From Infection, Brain Damage and Death

In this preclinical study, 100 percent of the animal models were protected from Zika after vaccination followed by a challenge with the Zika virus. In addition, they were protected from degeneration in the cerebral cortex and hippocampal areas of the brain, while the other cohort showed degeneration of the brain after Zika infection.

Medicine

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UTI, Urinary Tract Infection (UTI), E. Coli, Siderophore, Small Molecule, Vaccine

Could an Iron-Grabbing Molecule Help Prevent UTIs? New U-M Vaccine Shows Promise in Mice

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For the first time, scientists have prevented urinary tract infections in mice by vaccinating them with tiny molecules that UTI bacteria usually use to grab iron from their host and fuel the growth of bacteria in the bladder.

Medicine

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Mmr Vaccine, rubella virus, Pediatrics, primary immunodeficiency diseases, rubella vaccine, Children's Hospital Of Philadelphia, cutaneous granuloma

Rubella Virus Persists After Vaccination in Some Patients with Immunodeficiency Disorders

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Some patients with rare primary immunodeficiency disorders may be at risk for infection by rubella virus, and possibly serious skin inflammation, after receiving the rubella vaccine, usually administered as part of the measles-mumps-rubella (MMR) vaccine. Although the vaccine for rubella (German measles) has an established record of safety and effectiveness in the general population, patients with severe deficiencies in their immune defenses may be susceptible to side effects from the vaccine.

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54-Year-Old ‘Nonbeliever’ Gets His Flu Shot After Close Call with H1N1

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Unique technology saves life of healthy 54-year-old who nearly dies after contracting aggressive, H1N1, flu strain. A former non-believer, he now promotes regular flu shots as prevention

Medicine

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Immunotherapy, Tests, Immunology, Cancer Vaccine, Allergy, Organ Transplantation

New Approach Tests the Strength of Immunity

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A new method to determine how effectively immune cells kill their targets could help personalize immune therapies.

Medicine

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Asthma, hygiene hypothesis, B Cell, Allergy, Cockroach allergen, House Dust Mites, Aspergillus Fumigatus

Vaccination of Newborn Mice with Bacteria Suppresses Asthma as Adults

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Asthma caused by adult exposure to cockroach detritus is blocked in mice that were vaccinated as newborns with a particular bacteria, Enterobacter that expresses alpha-1,3-glucan molecules on its surface.

Medicine

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Economy, flu, Influenza, Vaccines

Get Your Flu Shot, Or We All Pay the Price!

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Despite the proven efficacy and minimal risks associated with vaccines, many American adults continue to forgo getting vaccinations, usually due to doubt of effectiveness, concerns of the safety of the vaccines, or just a lack of consistent follow-up on their personal health care needs. The result is costly health and economic losses, both to themselves and to the general public.







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