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Gut Bacteria May Contribute to Poor Health in Patients with Kidney Disease

• In patients with chronic kidney disease, those with more advanced disease had higher blood levels of the bacterial metabolite phenylacetylglutamine. • Patients with high phenylacetylglutamine had an elevated risk of developing cardiovascular disease as well as a heightened risk of dying prematurely.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 31-May-2016 11:00 AM EDT

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 2-Jun-2016 12:00 PM EDT

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Early-Life Stress Causes Digestive Problems and Anxiety in Rats

Traumatic events early in life can increase levels of norepinephrine—the primary hormone responsible for preparing the body to react to stressful situations—in the gut, increasing the risk of developing chronic indigestion and anxiety during adulthood, a new study in American Journal of Physiology—Gastrointestinal and Liver Physiology reports.

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How Do You Kill a Malaria Parasite? Clog It with Cholesterol

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Drexel scientists have discovered an unusual mechanism for how two antimalarial drugs kill Plasmodium parasites. Amidst growing concerns about drug resistance, these findings could help to develop more effective drugs against the disease.

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Metagenomics Pathogen Detection Tool Could Change How Infectious Diseases Are Diagnosed

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Scientists at the University of Utah, ARUP Laboratories, and IDbyDNA, Inc., have developed ultra-fast, meta-genomics analysis software called Taxonomer that dramatically improves the accuracy and speed of pathogen detection. In a paper published today in Genome Biology, the collaborators demonstrated the ability of Taxonomer to analyze the sequences of all nucleic acids in a clinical specimen (DNA and RNA) and to detect pathogens, as well as profile the patient’s gene expression, in a matter of minutes.

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Weight Gain in Children Associated with Low Hormone Levels

A Mayo Clinic-led study found that obese teenagers have lower levels of a hormone potentially tied to weight management than teens of normal weights. The study is published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.

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Mayo Clinic to be Home of National Precision Medicine Initiative (PMI) Cohort Program Biobank

Mayo Clinic will be awarded $142 million in funding over five years by the National Institutes of Health (NIH) to serve as the national Precision Medicine Initiative (PMI) Cohort Program biobank. The biobank will hold a research repository of biologic samples, known as biospecimens, for this longitudinal program that aims to enroll 1 million or more U.S. participants to better understand individual differences that contribute to health and disease to advance precision medicine.

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UT Southwestern Researchers Determine 3-D Atomic Structure of Cholesterol Transporter

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Using X-ray crystallography, UT Southwestern Medical Center researchers have determined the 3-D atomic structure of a human sterol transporter that helps maintain cholesterol balance.

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Surrogate Endpoints Poor Proxy for Survival in Cancer Drug Approval Process

ROCHESTER, Minn. — Surrogate endpoints used to support the majority of new cancer drugs approved in the U.S. often lack formal study, according to the authors of a study published in the June issue of Mayo Clinic Proceedings. This analysis questions whether the U.S. Food and Drug Administration (FDA) is adhering to standards that demand that surrogates be “reasonably likely to predict” or “established” to be used to grant approvals.

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University Hospitals Case Medical Center Neurosurgeon Studying if Deep Brain Stimulation Can Help Bipolar Disorder Sufferers

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A neurosurgeon who specializes in deep brain stimulation (DBS) is seeking a target in the brains of bi-polar disorder patients for possible DBS implantation to provide help to them.

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New Resource to Support Canadians Living with the Epidemic of Heart Failure

Online educational tool targets the most rapidly rising cardiovascular disease in Canada

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Researcher Selected as 2016 Texas Inventor of the Year for His Breakthrough Treatments for Breast and Prostate Cancer

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Marc Cox, Ph.D., associate professor in The University of Texas at El Paso’s Department of Biological Sciences, has been selected as the 2016 Texas Inventor of the Year for his treatments for breast and prostate cancer developed at UTEP.

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Loyola First Center in Illinois to Receive Physical Therapy Accreditation in Women's Health

Loyola University Medical Center is the first center in Illinois to be accredited by the American Physical Therapy Association as a post-professional residency program for physical therapists in women’s health. Loyola is one of nine centers nationwide to receive the accreditation.

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The Chances Your Nurse Correctly Monitors for Side Effects of Pain Meds? About One in Four

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A study led by University at Buffalo nursing researcher Carla Jungquist reveals that the vast majority of post-operative patients given opioid medications through intravenous infusions are not monitored often enough to detect respiratory depression, a potentially deadly result of overdose.

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TSRI Researchers Show Experience Plays Powerful Role in Early Stages of Brain Circuit Development

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A study from The Scripps Research Institute suggests external stimulation guides certain neurons’ early development so that inhibitory neurons split into two different types of neurons, each with a different job, adding another level of complexity and regulation to the brain’s circuitry.

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TSRI Scientists Discover Mechanism that Turns Mutant Cells into Aggressive Cancers

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Scientists at The Scripps Research Institute have caught a cancer-causing mutation in the act. A new study shows how a gene mutation found in several human cancers, including leukemia, gliomas and melanoma, promotes the growth of aggressive tumors.

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UT System Institutions Fighting Stroke with New Tools and Technology

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UTHealth’s Mobile Stroke Unit —the nation’s first — is one of many ways the UT System’s 14 health and academic institutions are fighting stroke through research, technology and patient care.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 1-Jun-2016 6:00 AM EDT

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Another Reason to Stay Active as We Age

Researchers found that individuals who maintain an active jogging habit into their senior years are spending nearly the same amount of metabolic energy as a 20-year-old.