Feature Channels: Genetics

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UC San Diego researchers report that conducting genomic evaluations of advanced malignancies can be effective in guiding first-line-of-treatment, rather than waiting until standard-of-care therapies have failed.

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The NIGMS Human Genetic Cell Repository (HGCR) and NHGRI Sample Repository for Human Genetic Research (SRHGR) now offer high molecular weight (HMW) DNA samples isolated from cell lines in the collections. HMW DNA is useful for long-read next-generation sequencing and studies that investigate large-scale genomic variation such as structural variation.

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Ian Cheeseman, Ph.D., and his collaborators can now sequence the genomes of individual parasites found in the blood of infected patients -- even when the infection burden is very low, which can occur during asymptomatic infections. Gaining this incredibly detailed view is expected to help develop more effective treatments, vaccines or therapies.

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Yale Cancer Center and Smilow Cancer Hospital experts explain why the PALB2 gene can increase your breast cancer risk.

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Researchers at UC San Diego School of Medicine awarded $11.7 million by National Institutes of Health to identify genomic and socioeconomic factors contributing to health and disease in admixed individuals. The new center aims to bring the genomic revolution to all.

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The reconstituted biological clock maintains daily cycles for days on end, allowing researchers to study the interactions of its component parts

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A team of researchers at UT Southwestern Medical Center’s Touchstone Diabetes Center have successfully used CRISPR gene editing to turn fat cells normally used for storage into energy-burning cells.

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SEATTLE — Oct. 5, 2021 — Below are summaries of recent Fred Hutch research findings and other news.

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Neurologists say it's time for a moonshot for their patients with ALS, the neurodegenerative disease that is always deadly, often in just a few years or less.

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Jian Zhou, Ph.D., Assistant Professor in UT Southwestern’s Lyda Hill Department of Bioinformatics, has been awarded $1.5 million from the National Institutes of Health (NIH) to use artificial intelligence to investigate the three-dimensional structure of DNA and its impact on health.

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University of Kentucky College of Medicine researchers were part of a new study that gives insight into how limb development evolved in vertebrates.

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Van Andel Institute’s J. Andrew Pospisilik, Ph.D., and Maine Medical Center Research Institute’s Joseph Nadeau, Ph.D., have earned a five-year, $9.6 million Transformative Research Award from the National Institutes of Health to answer a set of questions that could fundamentally transform our understanding of health and disease: If you were born multiple times under the exact same circumstances, would you turn out to be the same person each time?

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“Throw me the idol; I’ll throw you the whip!” - From Raiders of the Lost Ark

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A new study from Washington University School of Medicine in St. Louis estimates that 78% to 92% of lung cancers in patients who have never smoked can be treated with precision drugs already approved by the Food and Drug Administration to target specific mutations in a patient’s tumor.

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In three Science papers, UC San Diego and UC San Francisco researchers mapped out how hundreds of gene mutations involved in cancer affect the discrete groups of proteins that are the ultimate actors behind the disease. The work points the way to identifying new precision treatments.

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A nationwide team of researchers, led by scientists at University of Utah Health and The Rockefeller University, has determined how a genetic mutation found in mice and monkeys interferes with viruses such as HIV and Ebola. They say the finding could eventually lead to the development of medical interventions in humans.

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International group of researchers identify new childhood genetic condition and a potential cure that can be delivered during pregnancy.