Researchers at The Saban Research Institute of Children’s Hospital Los Angeles now reveal an unexpected role for ghrelin in early brain development and show its long-term impact on appetite regulation. Their study will be published online January 20 by The Journal of Clinical Investigation.
Researchers at the University of California, San Diego School of Medicine, with collaborators in Korea and Scotland, have identified a novel signaling pathway critical to the immune response of cells associated with the initiation of allergic asthma. The discovery, they say, could point the way to new therapies that suppress the inflammatory allergic response, offering potential relief to millions of Americans with the chronic lung condition and potentially other allergic diseases.
In the midst of the California rainy season, scientists are embarking on a field campaign designed to improve the understanding of the natural and human-caused phenomena that determine when and how the state gets its precipitation. They will do so by studying atmospheric rivers, meteorological events that include the famous rainmaker known as the Pineapple Express.
SLAC staff physicist Peter Rowson has been elected a fellow of the American Physical Society, the largest physics association in the world. APS confers this distinction on a small percentage of the society’s membership; it is especially significant because it is a peer-nominated honor.
Researchers at UC San Diego School of Medicine previously reported that a drug used for almost a century to treat trypanosomiasis, or sleeping sickness, reversed environmental autism-like symptoms in mice. Now, a new study published in this week’s online issue of Molecular Autism, suggests that a genetic form of autism-like symptoms in mice are also corrected with the drug, even when treatment was started in young adult mice.
In a new study researchers at the UCLA Jonsson Comprehensive Cancer Center have uncovered how melanoma becomes resistant to a promising new drug combo therapy utilizing BRAF+MEK inhibitors in patients after an initial period of tumor shrinkage.
Nobel laureate Martin Chalfie, PhD, will be the keynote speaker at Cedars-Sinai’s Nanomedicine for Imaging and Treatment Conference, where two dozen experts from around the world will discuss emerging trends in the study and treatment of diseases at the molecular and atomic levels.
Pilots receive extensive training on effectively handling emergency situations that may arise in the cockpit. However, during several recent airline incidents, the pilots neglected to apply the skills they learned in training, resulting in fatal crashes. Were these accidents rare exceptions?
The bacteria Vibrio vulnificus, found in warm saltwater, can cause people to get sick, or die, after they eat raw tainted shellfish or when an open wound comes in contact with seawater. A new UCLA study finds out not only why this potentially deadly bacteria is so dangerous in iron overload disease but also discovers that it can be cured.
The aim of the 50 Breakthroughs study is to give philanthropies, aid agencies, businesses, and technologists a blueprint for where to invest their resources to achieve the highest impact.
Scientists from the Florida campus of The Scripps Research Institute have identified a novel synthetic compound that sharply inhibits the activity of a protein that plays an important role in in the progression of breast and pancreatic cancers.
UC San Diego School of Medicine was today named one of the nation’s top residency training programs in 10 specialties by Doximity.
UCLA transplantation researchers have developed a novel method that more accurately calculates the risk of disease recurrence in liver cancer patients who have undergone a liver transplant, providing a new tool to help physicians make treatment and surveillance decisions.
In a groundbreaking new study, UCLA researchers have discovered that children of melanoma survivors are not adhering optimally to sun protection recommendations. This is concerning as sunburns are a major risk factor for melanoma, and children of survivors are at increased risk for developing the disease as adults.
A team from The Scripps Research Institute has designed a more effective nicotine vaccine and proven that the structures of molecules used in vaccines is critical.
Pieter Dorrestein, PhD, has been selected to receive the 2015 John Jacob Abel Award in Pharmacology by the American Society for Pharmacology and Experimental Therapeutics (ASPET). Dorrestein is a professor of pharmacology, chemistry and biochemistry in the Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California, San Diego.
A team led by scientists at The Scripps Research Institute has identified an enzyme that produces a class of inflammatory lipid molecules in the brain. Abnormally high levels of these molecules appear to cause a rare inherited neurodegenerative disorder.
Researchers at Lawrence Berkeley National Laboratory and the University of California, Berkeley, have developed a new precision approach for synthesizing graphene nanoribbons from pre-designed molecular building blocks. Using this process the researchers have built nanoribbons that have enhanced properties—such as position-dependent, tunable bandgaps—that are potentially very useful for next-generation electronic circuitry.
Plans for the construction of the world’s largest digital camera at the Department of Energy's SLAC National Accelerator Laboratory have reached a major milestone. The 3,200-megapixel centerpiece of the Large Synoptic Survey Telescope (LSST), which will provide unprecedented details of the universe and help address some of its biggest mysteries, has received key “Critical Decision 2” approval from the DOE.
Why do some people develop post-traumatic stress disorder (PTSD) while others who suffered the same ordeal do not? A new UCLA discovery may shed light on the answer.
The American Diabetes Association (ADA) has awarded La Jolla Institute (LJI) researcher Stephanie Stanford, Ph.D., a $1.6 million grant to investigate the genetic and environmental factors that trigger the onset of type 1 diabetes.
Berkeley Lab’s quantum dots have not only found their way into tablets, computer screens, and TVs, they are also used in biological and medical imaging tools, and now Paul Alivisatos’ lab is exploring them for solar cell as well as brain imaging applications.
A new study by researchers at Children’s Hospital Los Angeles has shown that tissue-engineered small intestine grown from human cells replicates key aspects of a functioning human intestine.
A team led by structural biologists at The Scripps Research Institute has taken a big step toward understanding the intricate molecular mechanism of a metabolic enzyme— nicotinamide nucleotide transhydrogenase—produced in most forms of life on Earth.
The community of microbes that inhabits the body, known as the microbiome, has a powerful influence on the brain and may offer a pathway to new therapies for psychiatric and neurological disorders, according to researchers.
Axel Rosengart, MD, PhD, a prominent neurologist and clinical researcher whose work fostered the creation of medical devices to treat brain-injured patients, has joined Cedars-Sinai in two key neurology posts.
In 2014, prostate cancer was the leading cause of newly diagnosed cancers in men and the second leading cause of cancer death in men. A team of scientists and physicians from the University of California, San Diego School of Medicine, with counterparts at University of California, Los Angeles, describe a novel imaging technique that measurably improves upon current prostate imaging and may have significant implications for how patients with prostate cancer are ultimately treated.
Several new technologies being used in the Cedars-Sinai Neonatal Intensive Care Unit, part of the Maxine Dunitz Children’s Health Center, are helping our smallest babies with more rapid and healthier weight gain. Doctors have begun routinely using a device known as the Pea Pod to measure the body composition of the infants.
UCLA researchers have for the first time developed a method that defines many stages of reprogramming skin or blood cells into pluripotent stem cells. Study analyzed the reprogramming process at the single-cell level on a daily basis. Results determined that stages of cell change were the same across different reprogramming systems and cell types analyzed.
Salk scientists made a more effective diet pill
Outbreaks of infectious diseases, such as Ebola in West Africa, offer insight for how healthcare professionals can respond more effectively to current and future challenges, according to editors of the American Journal of Critical Care (AJCC ).
Following is a tip sheet of story ideas from Cedars-Sinai Medical Center. To arrange interviews, please contact the individual listed.Tip sheet topics include organ transplantation, ALS research, sudden cardiac arrest research and more.
When it comes to skin infections, a healthy and robust immune response may depend greatly upon what lies beneath. In a new paper published in the January 2, 2015 issue of Science, researchers at the University of California, San Diego School of Medicine report the surprising discovery that fat cells below the skin help protect us from bacteria.
While people who eat a lot of red meat are known to be at higher risk for certain cancers, other carnivores are not, prompting researchers at the University of California, San Diego School of Medicine to investigate the possible tumor-forming role of a sugar called Neu5Gc, which is naturally found in most mammals but not in humans.
A new study from scientists at The Scripps Research Institute suggests therapies that change gene expression in parents could help their children. Research showed offspring of mice treated with a drug also had delayed onset and reduced symptoms of Huntington’s disease.
A free app for Android and Apple devices called The Particle Adventure makes checking out the world of quarks, dark matter, and particle accelerators as easy as tapping touchscreen icons.
A door has been opened to low-power off/on switches in micro-electro-mechanical systems (MEMS) and nanoelectronic devices, as well as ultrasensitive bio-sensors, with the first observation of piezoelectricity in a free standing two-dimensional semiconductor by a team of researchers with Berkeley Lab.
Scientists at The Scripps Research Institute have found that resveratrol, the red-wine ingredient once touted as an elixir of youth, powerfully activates an evolutionarily ancient stress response in human cells. The finding should dispel much of and controversy about how resveratrol really works.
A new Kid Captain program will recognize pediatric patients from Mattel Children's Hospital UCLA who face life-threatening illnesses with courage, strength and determination.
During a live Google Hangout, three astrophysicists separated science from science fiction in the blockbuster film Interstellar, revealing a story steeped in real scientific knowledge but not afraid to delve into the unknown.
About 15 percent of women in the United States suffer from anxiety disorders and depression during their pregnancies, and many are prescribed antidepressants. However little is known about how early exposure to these medications might affect their offspring as they mature into adults.
Scientists have found the first direct evidence that a mysterious phase of matter known as the "pseudogap" competes with high-temperature superconductivity, robbing it of electrons that otherwise might pair up to carry current through a material with 100 percent efficiency.
Study concludes that Chez Panisse restaurant's open innovation strategies made owner Alice Waters a cultural entrepreneur and created an “ever-growing global ecosystem” in the world of slow, sustainable food.
Collaborating scientists from The Scripps Research Institute and the University of California San Diego have developed a powerful new system for studying how proteins and other biological molecules form and lose their natural folded structures.
Berkeley Lab researchers used an electric field to reverse the magnetization direction in a multiferroic spintronic device at room temperature, a demonstration that points a new way towards spintronics and smaller, faster and cheaper methods of storing and processing data.
Chemists at The Scripps Research Institute have invented a powerful and extraordinarily robust method for joining complex organic molecules that can be used to make pharmaceuticals, fabrics, dyes, plastics and other materials previously inaccessible to chemists.
Children's Hospital Los Angeles infectious diseases specialist Pia Pannaraj, MD, discusses the importance of getting an annual flu vaccine and why opting out should not be an option.
Social media such as Twitter and Facebook, combined with behavioral psychology, could be a valuable tool in the fight against AIDS by prompting high-risk individuals to be tested.
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