Feature Channels: Drug Resistance

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Significant time is needed to determine the drug susceptibility profile of a bacterial infection.

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Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have shown that they can circumvent a key mechanism in castration-resistant prostate cancer (CRPC) and possibly make immunotherapies more effective. By infusing nitric oxide (NO) into animal models, the team shrank tumors and paved the way for potential combination therapies. The study was published in Nature Cell Death & Disease.

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Research led by doctors and scientists at UCLA Jonsson Comprehensive Cancer Center and the UCLA Jane & Terry Semel Institute for Neuroscience & Human Behavior has identified a gene that may provide a therapeutic target for the deadly, treatment-resistant brain cancer glioblastoma multiforme (GBM).

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Victor Nizet, MD, Distinguished Professor of Pediatrics at UC San Diego School of Medicine and Pharmacy at Skaggs School of Pharmacy and Pharmaceutical Sciences at UC San Diego, has been elected to the National Academy of Medicine.

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Under a four-year $2 million contract awarded by the Centers for Disease Control and Prevention, scientists from RUSH and the Discovery Partners Institute will test wastewater from long-term care facilities to identify antibiotic-resistant organisms.

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Researchers at Huntsman Cancer Institute have solved a long-standing mystery about how a cancer-promoting protein causes drug-resistent tumors to grow. They hope the discovery leads to more effective cancer drugs. Ben Myers, PhD, explains how this new science is closing the gap in understanding brain and skin tumors and how to combat them.

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UC San Diego scientists are leading a national early-stage clinical trial to assess the safety and efficacy of using bacteriophages to treat drug-resistant bacterial infections in cystic fibrosis patients.

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In a new study published in Molecular Cancer Research, Mayo Clinic researchers identified critical genomic changes in response to abiraterone acetate/prednisone, a standard treatment option for men with progressive, incurable and castration-resistant prostate cancer.

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Researchers have uncovered a novel pathway that explains how cancer cells become resistant to chemotherapies, which in turn offers a potential solution for preventing chemo-resistance.

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A potential new treatment combining natural manuka honey with a widely used drug has been developed by scientists at Aston University to treat a potentially lethal lung infection and greatly reduce side effects of one of the current drugs used for its treatment.

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Whitney and Bullen, together with colleagues at Imperial College London and the University of Manitoba, have studied this toxin for nearly three years to understand exactly how it functions at a molecular level. The breakthrough, to be published in Molecular Cell, was achieved by Bullen following rigorous experimentation on common targets of toxins, such as protein and DNA molecules, before eventually testing the toxin against RNA. This discovery breaks well-established precedents set by protein-targeting toxins secreted by other bacteria, such as those that cause cholera and diphtheria.

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University researchers have found a naturally occurring compound, known as hydroquinine, has bacterial killing activity against several microorganisms.

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An experimental combination of two drugs halts the progression of small cell lung cancer, the deadliest form of lung cancer, according to a study in mice from researchers at Washington University School of Medicine in St. Louis, Grenoble Alpes University in Grenoble, France, and The University of Texas MD Anderson Cancer Center in Houston.

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The latest research on plants brought to you by Newswise.

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For her most recent project, “Mechanical Mechanisms of Biofilm Survival on Implant Surfaces,” Dr. Martha Grady, an associate professor in the Department of Mechanical and Aerospace Engineering at the University of Kentucky, is the recipient of the National Science Foundation's (NSF) prestigious Faculty Early Career Development (CAREER) Award.