It may start with a simple word you can’t pronounce. Your tongue and lips stumble, and gibberish comes out. Misspeaking might draw a chuckle from family and friends. But, then, it keeps happening. Progressively, more and more speech is lost. Some patients eventually become mute from primary progressive apraxia of speech, a disorder related to degenerative neurologic disease.
American Association for the Advancement of Science 2016 Annual Meeting
Scientists from the Florida campus of The Scripps Research Institute have won nearly $1.7 million from the National Institutes of Health’s National Institute of Neurological Disorders and Stroke to investigate the mechanisms that contribute to Huntington’s disease.
University students and residents of senior housing come together in an award-winning project that encourages storytelling collaborations.
Inhibiting the Rho kinases ROCK1 and ROCK2 with fasudil, a drug approved in China and Japan, stimulates tau autophagy in cell culture and flies.
New research from the University of Guelph on the brain and memory could help in developing therapies for people with schizophrenia and Alzheimer’s disease.
Study to investigate the relationship between dementia, atherosclerosis, and other cardiovascular risk factors measured by state-of-the-art imaging technique
Study of plaque production holds promise of helping improve treatment.
A new study suggests that people with brain injuries following head trauma may have buildup of the plaques related to Alzheimer’s disease in their brains. The research is published in the February 3, 2016, online issue of Neurology®, the medical journal of the American Academy of Neurology.
A study lead by researchers from Rush University Medical Center has provided the first report on the relationship of brain concentrations of mercury to brain neuropathology and diseases associated with dementia. Study results were published in the Feb. 2 issue of the Journal of the American Medical Association.
New research published Feb. 2 in the Journal of the American Medical Association found that older adults with a major risk gene for Alzheimer’s disease known as APOEɛ4 who ate at least one seafood serving per week showed fewer signs of Alzheimer’s-related brain changes. In contrast, this association was not found in the brains of volunteers who ate fish weekly but did not carry the risk gene.
Buck Institute/UCLA study finds that apolipoprotein E enters the nucleus and binds to promoter region of 1700 genes.
Older people with higher amounts of a key protein in their brains also had slower decline in their memory and thinking abilities than people with lower amounts of protein from the gene called brain-derived neurotrophic factor, or BDNF, according to a study published in the January 27, 2016, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Alzheimer’s disease is a degenerative brain disease that leads to cognitive decline, dementia and ultimately death, mostly in the elderly. It’s already a huge health burden, and it’s getting worse as the population ages. Alzheimer’s and Dementia, the journal of the Alzheimer’s Association, estimates that by 2050, one in 85 people around the globe—more than 100 million total—will be afflicted.
Researchers have begun to explore in earnest the concept of "mixed vascular dementia," but until recently there was no reliable animal model. When Donna Wilcock of the UK Sanders-Brown Center on Aging discovered that a special diet deficient in B vitamins induced cognitive impairment in mice, she gave science the animal model it needed, plus the potential for a modifiable biomarker for vascular cognitive impairment.
The University of California San Diego’s incoming Alzheimer’s research czar talked with Alzforum about where he wants to take the embattled Alzheimer’s Disease Cooperative Study and neurodegeneration research in the region.
Correctly diagnosing Alzheimer’s disease remains a challenge for medical professionals. Now, a new study published in the current issue of the Journal of Alzheimer’s Disease reveals a new clue to possible misdiagnosis.
A Mayo Clinic study of people who received anesthesia for surgery after age 40 found no association between the anesthesia and development of mild cognitive impairment later in life.
Alzheimer’s disease relentlessly targets large-scale brain networks that support the formation of new memories. However, it remains a mystery as to why the disease selectively targets memory-related brain networks and how this relates to misfolded proteins seen by pathologists at autopsy.
While no cure is in sight, ALS experts see reason to feel hopeful about research progress and possible new treatments.
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