Feature Channels: Autoimmune Diseases

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Together with other rare disease organizations, The Myositis Association is encouraging those who live with myositis diseases to Celebrate Your Rare by speaking out about the challenges they face and the need for more research into the causes, treatments, and possible cures for these diseases.

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The conference brings together internationally recognized clinicians, scientists and educators who will share their research and clinical insights into the understanding, diagnosis and management of chronic diseases that are rising at an unprecedented rate throughout the US and internationally.

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A Ludwig Cancer Research study has uncovered a cellular mechanism by which melanomas that fail to respond to checkpoint blockade may be made susceptible to such immunotherapies. Led by Ping-Chih Ho of the Lausanne Branch of the Ludwig Institute for Cancer Research and reported in the current issue of Nature Immunology, the study also identifies an existing diabetes drug that could be used to accomplish that feat.

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A practical resource-based public health approach for the rapid initiation of antiretroviral therapy in HIV-infected individuals living in low- and middle-income countries could save thousands of lives, according to an Essay published January 15 in the open-access journal PLOS Medicine by Mark Tenforde of the University of Washington School of Medicine, and colleagues.

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UCLA researchers led by Dr. Donald Kohn have created a method for modifying blood stem cells to reverse the genetic mutation that causes a life-threatening autoimmune syndrome called IPEX.

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Scientists at Washington University School of Medicine in St. Louis have identified a previously unknown route for cellular fuel delivery, a finding that could shed light on the process of aging and the chronic diseases that often accompany it.

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MSU scientists have discovered SLAMF7, an immune receptor, has the ability to tone down the body’s immune response when activated on certain white blood cells. Yet, for certain HIV patients who experience a myriad of health issues, the researchers found that these patients’ receptors don’t work properly.

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When researchers unlock the mysteries of Castleman disease, they may single out 2018 as one of the years in which they laid the foundation to help them turn the key, and the University of Pennsylvania has been the epicenter.

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Experts and research on important topics in the healthcare system

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The American Neurological Association (ANA), the professional organization representing the nation’s top academic neurologists and neuroscientists, today released a list of the most-accessed articles of 2018 in its Annals of Neurology and Annals of Clinical & Translational Neurology (ACTN).

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Of the 34 million people worldwide with HIV, and the 200 million with schistosomiasis, the majority live in Africa— where millions of people are simultaneously infected with both diseases. Now, researchers reporting in PLOS Neglected Tropical Diseases have shown that schistosomiasis infections are associated with increased HIV onward transmission, HIV acquisition in HIV negative women with urogenital schistosomiasis, and progression to death in HIV positive women.

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The new Sherman Institute will advance basic research on novel therapies for a range of disorders, including autoimmune, neurodegenerative, and infectious diseases, as well as cancer.

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AIDS patients suffer higher rates of cancer because they have fewer T-cells in their bodies to fight disease. But new research examines why HIV-infected patients have higher rates of cancer—among the leading causes of death among that population—than the general population.

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CINCINNATI--A gene mutation that is believed to have safeguarded some people in 14th century Europe from the bubonic plague today may be protecting HIV patients co-infected with hepatitis C from potentially fatal liver scarring, says a University of Cincinnati (UC) College of Medicine physician-scientist.

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Preclinical experiments by University of Alabama at Birmingham researchers suggest the cancer drugs vorinostat, belinostat and panobinostat might be repurposed to treat infections caused by human papillomaviruses, or HPVs.

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Algunos virus son capaces de apoderarse de una enzima que supuestamente previene enfermedades autoinmunitarias con el fin de evitar ser detectados. Este descubrimiento de los investigadores de Mayo Clinic y de sus colaboradores se publica en PLOS Biology.

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ROCHESTER, Minn. — An enzyme intended to prevent autoimmune disease can be hijacked and used by some viruses to avoid immune detection. That discovery from Mayo Clinic researchers and collaborators appears in PLOS Biology. There's also good news. The same team also defined how much viral genetic material is needed to reverse the process and instead activate the immune system against the virus.

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The Myositis Association (TMA), the leading international patient organization dedicated to improving the lives of people affected by myositis, is pleased to announce the appointment of five new members to its Board of Directors.