A species of bacteria that infect corn crops compel their hosts to produce a feast of nutrients that keeps the pathogens alive and thriving long before they start to kill the plant’s cells, new research shows.
The findings suggest these single-celled organisms have programmed or regulated cell-death mechanisms like those that are known to work in animals and other complex organisms.
How do the lungs develop after taking their first breaths outside the womb? What cellular events and changes early in life give rise to lung malfunction and disease? To help answer these questions, scientists have constructed the first single-cell atlas of postnatal lung development in humans and mice. The research could help provide a more detailed understanding—at the level of individual cells—of which genetic and epigenetic factors affect lung health across the human lifespan, starting from birth.
Metabolic syndrome increases a person’s risk for diabetes, heart disease, and stroke, and includes conditions such as obesity, high blood pressure and high blood sugar. In a recent mouse-model study, published in Cell Metabolism, researchers at University Hospitals (UH), Harrington Discovery Institute at UH, and Case Western Reserve University have furthered their progress to develop a drug to treat metabolic syndrome by identifying a receptor that controls appetite and body weight.
New study outlines scalable protocol to enhance development and understanding of human pluripotent stem cells in cardiac muscles
Mutation of a gene called ARID2 plays a role in increasing the chance that melanoma, a deadly skin cancer, will turn dangerously metastatic, Mount Sinai researchers report.
UTSW scientists identify key molecule produced by male parasitic worms that affects sexual maturity in females and leads to schistosomiasis
Scientists have created a battery designed for the electric grid that locks in energy for months without losing much storage capacity. It’s a step toward batteries that can be used for seasonal storage: saving renewable energy in one season, such as the spring, and spending it in another, like autumn.
The poor function of microglia, the brain’s immune cells in individuals exposed to early life adversity (ELA) promotes aberrant responses to stress in adulthood that may be linked to mental illness, according to a new study led by researchers at the University of California, Irvine. During brain development, microglia prune unnecessary synapses resulting in the formation of refined, functional circuits. Disruption of that process leaves too many synapses, changing the behavioral and hormonal responses to further stresses later in life.
UT Southwestern researchers have identified a four-protein complex that appears to play a key role in generating ribosomes – organelles that serve as protein factories for cells – as well as a surprising part in neurodevelopmental disorders. These findings, published in Cell Reports, could lead to new ways to manipulate ribosome production, which could impact a variety of conditions that affect human health.
Researchers have found that dysfunction in an important cell subtype in the brain’s neuronal network contribute to chronic symptoms in the neurodevelopmental disorder Dravet syndrome.
University of Notre Dame researchers have discovered another way tumor cells transfer genetic material to other cells in their microenvironment, causing cancer to spread.
People who consume sugar and other carbohydrates in excess over a long period of time have an increased risk of developing an autoimmune disease.
Ebola virus polymerase hijacks a cellular protein called GSPT1. An experimental drug that targets GSPT1 for degradation can also halt Ebola virus infection in human cells.
An antiviral drug used to treat SARS-CoV-2 remains effective against the newest variants of the evolving virus, according to Rutgers researchers. The study, published in the journal Cell Research, is one of the first to explore the full extent of SARS-CoV-2 mutations.
Mount Sinai scientists have developed a new technology allowing them to link specific genes to complex tumor characteristics at a scale and resolution not previously possible. The results could lead to new approaches for targeting anti-cancer drugs.
A laboratory study at the Miller School of Medicine’s Desai Sethi Urology Institute has uncovered new clues about the cellular processes that can lead to deficiencies of androgens (male hormones) such as testosterone.
New study provides insights into how the microbiome processes seaweed, consumed around the world in various forms, including sushi and as a processed food additive.
When we are stressed or excited, it can be difficult for us to fall asleep—and finding ways to wind down prior to sleep is a habit of many.
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