Feature Channels: Drug Resistance

• share
• favorite_border

Los investigadores y colaboradores de Mayo Clinic han identificado una proteína expresada en células inmunitarias que podría desempeñar un rol clave en el desarrollo de la esclerosis lateral amiotrófica (ELA), también conocida como enfermedad de Lou Gehrig. El equipo también descubrió que un tratamiento inmunomodulatorio que bloquea la proteína era capaz de restaurar la función motriz en modelos preclínicos. Los hallazgos indican que la proteína, conocida como integrina α5 (pronunciado integrina alfa 5), es un posible blanco terapéutico para la ELA.

• share
• favorite_border

Pesquisadores e colaboradores da Mayo Clinic identificaram uma proteína que é expressa por células imunológicas que pode desempenhar uma função importante no desenvolvimento daesclerose lateral amiotrófica (ELA), também conhecida como doença de Lou Gehrig. A equipe também descobriu que um tratamento imunomodulador que bloqueia a proteína conseguiu restaurar a função motora em modelos pré-clínicos. As descobertas sugerem que a proteína, conhecida como integrina α5 (pronunciada como integrina alfa 5), é um possível alvo terapêutico para ELA.

• share
• favorite_border

With the rise in machine learning applications and artificial intelligence, it's no wonder that more and more scientists and researchers are turning to supercomputers. Supercomputers are commonly used for making predictions with advanced modeling and simulations. This can be applied to climate research, weather forecasting, genomic sequencing, space exploration, aviation engineering and more.

• share
• favorite_border

Damage to the protein production capacity neutralizes the trypanosome parasite, which causes sleeping sickness. Joint research by Prof.

• share
• favorite_border

Researchers from at University of California San Diego, West Health, and the University of Washington have found evidence that the private insurers that sponsor Medicare Part D are artificially inflating the costs of certain generic drugs by overpaying pharmacies.

• share
• favorite_border

A study that assesses the effects of hypochlorous acid (HOCI), commonly known as bleach, as it is generated during the immune response of a cell (phagocytosis) when fighting a common fungal pathogen, Candida albicans, reveals that HOCI is a potent killing agent. The laboratory finding is highlighted in the journal mBio.

• share
• favorite_border

Many of the most potent human oncoproteins belong to a class of proteins called transcription factors, but designing small molecule drugs that target transcription factors is a major challenge.

• share
• favorite_border

The number of patients admitted with opioid use disorder (OUD) and injection-related infections who left the hospital before completing treatment increased significantly between 2016 and 2020 (from 9.3 percent to 17 percent) according to analysis from researchers at the Perelman School of Medicine at the University of Pennsylvania.

• share
• favorite_border

The largest review of papers for brain cancer that has spread from the lungs has found abnormalities in the brain cancer and for which licensed drugs could be clinically trialled to find out if they could treat the disease.

• share
• favorite_border

• share
• favorite_border

A team of Stony Brook University researchers led by Gábor Balázsi, PhD, have been testing drug resistance with mammalian cell lines. Their latest investigation reveals that by taking a part of a DNA amplification from a cell, which causes resistance, and placing it back in, actually stops the drug resistance. Their findings will be published this week in PNAS.

• share
• favorite_border

Researchers tease apart the relationships between bacterial languages

• share
• favorite_border

• share
• favorite_border

The American Society for Pharmacology and Experimental Therapeutics (ASPET) has selected 16 individuals as 2023 ASPET Fellows.

• share
• favorite_border

Stay informed! Keep up with the latest research on the COVID-19 virus in the Coronavirus channel on Newswise.

• share
• favorite_border

Scientists have developed an ingestible device that can safely monitor vital signs like breathing and heart rate from inside humans. The tool, described November 17 in the journal Device, has the potential to provide accessible and convenient care for people at risk of opioid overdose.

• share
• favorite_border

Migraine is more than just a headache. Often the pain is accompanied by nausea, vomiting, light sensitivity, and sound sensitivity. Chronic migraine can be disabling and may prevent many, especially women, from contributing to working life.