Stem cell transplantation has been applied to treat spinal cord injury (SCI) in clinical trials for many years. However, the clinical efficacies of stem cell transplantation in SCI have been quite diverse. The purpose of our study was to systematically …
Cedars-Sinai scientists have revealed the origins of a common ovarian cancer by modeling fallopian tube tissues, allowing them to characterize how a genetic mutation puts women at high risk for this cancer. The created tissues, known as organoids, hold potential for predicting which individuals will develop ovarian cancer years or even decades in advance, allowing for early detection and prevention strategies.
A new study by researchers at Washington University School of Medicine in St. Louis and St. Jude Children’s Research Hospital helps explain why mRNA vaccines have been so successful at preventing severe disease.
Researchers identify mechanism that explains how tissues form complex shapes that enable organ function
The finding that some genes are active from the get-go challenges the textbook view that genes don't become active in human embryos until they are made up of four-to-eight cells, two or three days after fertilisation.
Investigators at Cedars-Sinai have identified growth hormone in the colon that increases as the colon ages—a discovery that can help guide the development of a new anti-aging therapy.
It is now widely known that COVID-19 is associated with the transient or long-term loss of olfaction (the sense of smell) but the mechanisms remain obscure.
Ever since the first barcode appeared on a pack of chewing gum in 1974, the now-ubiquitous system has enabled manufacturers, retailers and consumers to quickly and effectively identify, characterize, locate and track products and materials. In a paper first posted online Nov. 26, 2021, in the journal Cell, researchers at Johns Hopkins Medicine and The Johns Hopkins University demonstrate how they can do the same thing at the molecular level, studying the ways cancer cells “talk” with one another.
Funded by a Specialized Program of Research Excellence (SPORE) award from the National Cancer Institute (NCI), the Kidney Cancer Program (KCP) at UT Southwestern’s Harold C. Simmons Comprehensive Cancer Center reports the largest and most diverse catalog of kidney cancer tumor models to date.
In a collaborative study, Cleveland Clinic researchers sought to understand how COVID-19 infection affects pregnant mothers and their children. They published the results of their clinical study in Cell Reports Medicine.
The Canadian Distributed Infrastructure for Genomics (CanDIG) is a collaboration of computer scientists, AI specialists, clinicians, and geneticists working together to enable studies needed to address the health challenges faced by Canadians.
Now, in a study published in the journal Cell Reports Medicine, UCLA researchers report a critical step forward in the development of an “off-the-shelf” cancer immunotherapy using human stem cell-derived invariant natural killer T cells, rare but powerful immune cells that could potentially be produced in large quantities, stored for extended periods and safely used to treat a wide range of patients with various cancers.
Young adults who are diagnosed with skin, colon, and other cancer types may require different treatments than older patients receive. That is the primary conclusion of a Mount Sinai study which systematically compared the genomes of 14 different types of cancers that affected both younger and older adults.
UC San Diego researchers have produced a single-cell chromatin atlas for the human genome. Delineating chromatin regions in cells of different human tissue types would be a major step toward understanding the role of gene regulatory elements (non-coding DNA) in human health or disease.
Researchers reveal a previously unrealized complexity in cancer development, one that raises concerns and caution about targeting an enzyme popular in oncological treatments.
A new discovery of a physiological mechanism of psychosomatic illnesses could open a new therapeutic avenue for treating chronic inflammatory conditions such as Crohn's disease, psoriasis, and other autoimmune conditions, by attenuating their memory trace in the brain.
More than four times as many businesses and clinics than were identified in 2016 are selling stem cell products not approved by the U.S. Food and Drug Administration and lack convincing evidence of safety and efficacy, according to a five-year study conducted by University of California, Irvine Program in Public Health professor of health, society and behavior Leigh Turner. The analysis appears online in the journal Cell Stem Cell.
Collaborating with professor Tim Gilberger of the University of Hamburg in Germany, the researcher teams performed a screen of soil bacteria extracts for antimalarials and identified an extremely potent inhibitor of malaria development.
Scientists can now pinpoint and track proteins that are in a desired shape in real time inside living cells. The scientists demonstrated the technique in, essentially, movies that track the active version of an important signaling protein – a molecule, in this case, important for cell growth.
Processing of sensory impressions and information depends very much on how the synapses in our brain work. A team around chemist Robert Ahrends from the University of Vienna and neuroscientist Michael R. Kreutz from Leibniz Institute for Neurobiology in Magdeburg now showed how lipid and protein regulation impact brain’s processing of a beautiful and stimulating environment. The lipids located in the membranes of the synapses are central to signal transmission, the researchers report in “Cell Reports”.
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