Feature Channels: Kidney Disease

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• Racial disparities in access to kidney transplantation persist in the United States. New research indicates that registering Black patients on the kidney transplant waitlist at a slightly higher level of kidney function compared with white patients might lessen racial inequality in patients’ wait time prior to kidney failure onset, and ultimately improve racial equity in access to kidney transplantation.

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A recommendation for more intensive blood pressure management from an influential global nonprofit that publishes clinical practice guidelines in kidney disease could, if followed, benefit nearly 25 million Americans.

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Around 80% of the UK population is currently infected with human cytomegalovirus (HCMV) and in developing countries this can be as high as 95%.

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• Veterans who receive all of their post–kidney transplant care within the Veterans Health Administration (VA) have a lower risk of death than those who receive care outside the VA through Medicare coverage, according to a recent study.

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The Cardio-Renal Pediatric Dialysis Emergency Machine (CARPEDIEM) is a new system for patients with acute kidney injury or kidney failure requiring dialysis. This ground-breaking technology is intended to provide continuous renal replacement therapy (CRRT) to patients weighing between 5 and 20 pounds.

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Un estudio dirigido por investigadores de Mayo Clinic y publicado en Kidney International Reports (Informes Internacionales sobre el Riñón) descubrió que los inhibidores de los puntos de control inmunitario pueden tener consecuencias negativas en algunos pacientes, incluida una inflamación aguda del riñón conocida como nefritis intersticial.

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Patients with advanced kidney cancer, who received a targeted drug combined with a checkpoint-blocker immunotherapy agent had longer survival than patients treated with the standard targeted drug, said an investigator from Dana-Farber Cancer Institute, reporting results from a phase 3 clinical trial.

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• Despite wide recognition, policy reforms, and extensive research to address barriers in patients’ access to kidney transplantation, investigators found no improvement in rates of wait list placement and transplantation over 2 decades. • Moreover, rates among vulnerable populations are especially low.

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People undergoing long-term dialysis are almost 4 times more likely to die from COVID-19 and should be prioritized for vaccination, found a new Ontario study published in CMAJ (Canadian Medical Association Journal).

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— The American Society of Nephrology (ASN) re- affirms its support for the Organ Procurement Organizations (OPOs) Conditions for Coverage final rule issued on November 20, 2020. The society calls for the Biden-Harris administration to implement this final policy as expediently as possible. By bringing objective and verifiable standards to assess the performance of OPOs, this final rule will increase the number of organs available for transplant and reduce racial inequity in the U.S. transplant system.

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A study by Mayo Clinic researchers published in Kidney International Reports finds that immune checkpoint inhibitors, may have negative consequences in some patients, including acute kidney inflammation, known as interstitial nephritis. Immune checkpoint inhibitors are used to treat cancer by stimulating the immune system to attack cancerous cells.

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Rheoscan (model: Rheoscan-And300, Rheoscan-D300) system is an in vitro diagnostic device that tests the erythrocyte deformability, aggregation, and critical shear stress used as a POC device.

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• Race and social determinants of health were associated with the likelihood of undergoing kidney transplantation among US adults with kidney failure. • Interventions that target social determinants of health may improve access to kidney transplantation.

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New research suggests the toxic effects of nicotine on the kidneys’ filtering function are partly responsible for the progression of diabetes-related kidney disease in people who smoke. The study is published ahead of print in the American Journal of Physiology-Renal Physiology.

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On December 9, 2020, Gianna Graw saved four lives and became the first patient to make a “good samaritan” kidney donation through Hackensack University Medical Center’s partnership with National Kidney Registry (NKR), an organization that facilitates living donor kidney transplants.

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UC San Diego Health’s lung, heart, kidney and liver transplant programs rank at the top nationally in the latest biannual Scientific Registry of Transplant Recipients (SRTR) report. Innovative treatment and multi-disciplinary care contribute to the high rankings for one-year survival outcomes.

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The American Society of Nephrology (ASN) welcomes Susan E. Quaggin, MD, FRCP(C), FASN, as ASN President, effective January 1, 2021. Dr. Quaggin succeeds Anupam Agarwal, MD, FASN.