Feature Channels: Pharmaceuticals

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CLEVELAND: Cleveland Clinic has named D. Geoffrey Vince, Ph.D., as Executive Director of Cleveland Clinic Innovations. In this newly formed role, Dr. Vince will align Cleveland Clinic’s technology development strategies with scientific and research priorities - including unprecedented growth in data and computing sciences - to accelerate the discoveries of new treatments and drugs. He will build strategic partnerships and alliances in these areas to drive revenue growth through commercialization of intellectual property.

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CLEVELAND: According to new findings published in Science Translational Medicine, Cleveland Clinic researchers have identified a promising drug target for treating and preventing aggressive, drug-resistant prostate cancer. The team, led by Nima Sharifi, M.D., of Cleveland Clinic’s Lerner Research Institute, demonstrated that inhibiting the protein H6PD led to significantly reduced tumor sizes and improved survival among mouse models with drug-resistant prostate cancer. The H6PD levels also were elevated in biopsied patient tumors, suggesting the protein might be targeted in patients for treatment.

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Interviews with primary care providers showed support for removal of the FDA’s mifepristone Risk Evaluation and Mitigation Strategy, which prevents pharmacists from dispensing the drugs needed for medication abortions.

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In an interview in the French documentary "Hold-Up," Luc Montagnier, a French virologist and recipient of the 2008 Nobel Prize in Medicine for his discovery of the human immunodeficiency virus (HIV), claimed that Covid-19 vaccines are creating new variants in various parts of the world. He believes that the ongoing vaccinations across the world is an ”enormous mistake.” ”The history books will show that because it is the vaccination that is creating the variants.” Multiple French social media posts that have been shared by thousands have also claimed that COVID-19 vaccines are causing variants of the virus to emerge. We find these claims to be false. There is no evidence the vaccines are creating more variants.

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Neelima Navuluri, MD, of Duke University has been awarded the ATS/Mallinckrodt Research Grant on COVID-19 in Underrepresented Minorities.

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A company founded by Rutgers School of Dental Medicine researcher Scott Kachlany received U.S. Food and Drug Administration (FDA) approval to treat cancer patients with a therapy based on Kachlany’s discovery that a protein produced by an oral bacterium can kill leukemia and lymphoma cells.

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A new Nature Communications study shows that eukaryotic ribosomes can be modified to respond to antibiotics in the same way that prokaryotic ribosomes do.

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Research on a potential therapy for amyotrophic lateral sclerosis (ALS) that’s taking place in a University at Albany chemistry lab is showing promising results.

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Several Phase II clinical trials conducted by researchers from The University of Texas MD Anderson Cancer Center show promising results for patients with melanoma, breast cancer, HER2-positive tumors and ovarian cancer. The results of these studies, which will be presented at the virtual 2021 American Society of Clinical Oncology (ASCO) Annual Meeting, highlight new advances in drug therapy research to improve patient outcomes.

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Irvine, Calif., May 21, 2021 – A record of medicine utilization patterns assembled by an interdisciplinary team of researchers at the University of California, Irvine and the UC San Diego School of Medicine reveals the thought, care and scientific rigor clinicians at UC Health medical centers applied in their treatment of patients with COVID-19 in 2020.

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An oral medication called upadacitinib yielded rapid and significant improvements in patients with moderate to severe atopic dermatitis (AD), also known as eczema, in phase 3 clinical trials, Mount Sinai researchers reported today in The Lancet online.

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A study of more than 3 million insured U.S. adult patients under 65 found that nearly 3% take immunosuppressive drugs that may elevate risk for severe COVID-19 symptoms and hospitalization if they became infected. There is growing evidence that immunosuppressive drugs may also reduce the COVID vaccine's efficacy.

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DALLAS – May 20, 2021 – An experimental drug that has shown promise in protecting healthy tissue from collateral damage caused by radiation therapy for cancer also appears to enhance radiation’s capacity to kill tumors, a new study led by UT Southwestern scientists shows. The findings, published online in Science Translational Medicine, could provide a much-needed boost to the radiation treatments used against a variety of tumor types.

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A combination of two drugs that target different proteins on immune system T cells kept advanced melanoma in check significantly longer than one of the drugs alone in a phase 3 clinical trial involving 714 patients. Dana-Farber Cancer Institute investigators co-led the study.

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Dana-Farber Cancer Institute researchers are presenting dozens of research studies at the 2021 Annual Meeting of the American Society of Clinical Oncology (ASCO). The studies will be presented during the virtual program on June 4-8, 2021. ASCO is the world’s largest clinical cancer research meeting, attracting more than 30,000 oncology professionals from around the world.

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The latest findings show that with clever science, a single fingerprint left at a crime scene could be used to determine whether someone has touched or ingested class A drugs.

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Findings are from a systematic review and meta-analysis. Data from 20 randomized controlled trials, which included a total of almost 12,000 patients, were analyzed in the study, providing strong and clear evidence in support of triple-drug therapy.

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Scientists have successfully treated flies displaying behavioural problems linked to newly discovered schizophrenia-associated genes in humans, using common anti-psychotics.

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People with bipolar disorder may not take their medication because of side effects, fear of addiction and a preference for alternative treatment - according to research from Norfolk and Suffolk NHS Foundation Trust (NSFT) and the University of East Anglia (UEA).

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Results from the NAVIGATOR study of tezepelumab showed that the new biologic therapy significantly reduced exacerbations requiring hospital stays and emergency department (ED) visits for adults and adolescents with severe, uncontrolled asthma, according to research presented at the ATS 2021 International Conference. NAVIGATOR (NCT03347279) is a recently completed randomized, placebo-controlled double-blind multicenter phase 3 clinical trial.

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A team of researchers including Ira S. Cohen, MD, PhD, of the Renaissance School of Medicine at Stony Brook University, has identified a compound that prevents the lengthening of the heart’s electrical event which can cause a lengthening of the EKG’s Q-T interval and a sometimes deadly arrhythmia.

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A team led by researchers including Jianmin Cui, professor of biomedical engineering, discovered a compound that prevents and even reverses the underlying physiological change that can lead some drugs to cause heart problems.

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UC San Diego researchers report that medications commonly prescribed to reduce the severity of physical and mental health symptoms associated with schizophrenia may have a cumulative effect of worsening cognitive function in patients.

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Insulin plays a critical role in the maturation, after injury, of immature olfactory sensory neurons. Applying insulin into the nasal passage could be developed as a therapy for injury caused by a host of issues.

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Cardiologists at Beth Israel Deaconess Medical Center (BIDMC), designed the Safety Assessment of Femoropopliteal Endovascular Treatment With Paclitaxel-coated Devices (SAFE-PAD) study to provide the information necessary to make scientifically-sound regulatory decisions about the safety of these devices.

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New research from the Intermountain Healthcare Heart Institute in Salt Lake City finds that higher EPA blood levels alone lowered the risk of major cardiac events and death in patients, while DHA blunted the cardiovascular benefits of EPA. Higher DHA levels at any level of EPA worsened health outcomes, study finds.

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Treating bacterial meningitis early with dexamethasone, a corticosteroid hormone that is effective at reducing inflammation, along with antibiotics, leads to full recovery in the shortest time, according to a recently published case report by researchers from Hackensack Meridian Jersey Shore University Medical Center and the Cleveland Clinic.

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Evidence from a secondary analysis of Cleveland Clinic’s STRENGTH trial shows that high levels of eicosapentaenoic acid (EPA), an omega-3 fatty acid, offered no benefit to patients at high risk for cardiovascular events.

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In a new study, clinician-researchers at Beth Israel Deaconess Medical Center (BIDMC) analyzed naloxone prescription trends during the COVID-19 pandemic in the United States and compared them to trends in opioid prescriptions and to overall prescriptions.

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In a study of hundreds of patients undergoing total knee or hip replacement, researchers identified a gene called ABCB1 that may predict long-term pain and opioid use.

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FLCCC Alliance calls for whistleblower to step forward from within WHO, the FDA, the NIH, Merck, or Unitaid to counter this misrepresentation

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In a study carried out in mice at the University of Chicago, researchers found that lasofoxifene outperformed fulvestrant, the current gold-standard drug, in reducing or preventing primary tumor growth.

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Researchers have developed a statistical model to predict the use of long-term opioids after total joint replacement.

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The American Society of Anesthesiologists (ASA) is pleased that Pacira Biosciences appeared before a federal magistrate judge on May 7, 2021, and withdrew its motion for a preliminary injunction to force Anesthesiology to retract two papers and an editorial concerning EXPAREL, published in the February 2021 issue.

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COVID-19 has had a significant impact since the pandemic was declared by WHO in 2020, with over 3 million deaths and counting, Researchers and medical teams have been hard at work at developing strategies to control the spread of the infection, caused by SARS-COV-2 virus and treat affected patients.

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There is no long-term benefit to surgically placing tubes in a young child’s ears to reduce recurrent ear infections, compared with giving oral antibiotics, a randomized trial determined.

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A new study led by the Centre for Nutraceuticals in the University of Westminster shows that pink drinks can help to make you run faster and further compared to clear drinks.

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DALLAS – May 12, 2021 – Scientists with UT Southwestern’s Peter O’Donnell Jr. Brain Institute have identified the molecular mechanism that can cause weight gain for those using a common antipsychotic medication. The findings, published in the Journal of Experimental Medicine, suggest new ways to counteract the weight gain, including a drug recently approved to treat genetic obesity, according to the study, which involved collaborations with scientists at UT Dallas and the Korea Advanced Institute of Science and Technology.

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New research from the University of Georgia suggests a component of bacteria’s cell walls may hold the key to crushing the antibiotic-resistant microbes.

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If left untreated, gout can cause severe disability. But unlike rheumatoid arthritis, there are only a handful of ways to treat it. Researchers say a combination of two existing drugs disrupts antibody production and doubles treatment efficacy.

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Using a mouse model, researchers discover pivotal role of cholesterol in chronic pain often caused by chemotherapy, and propose novel therapy.

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A new approach to tackling viruses by targeting the 'control centre' in viral RNA could lead to broad spectrum anti-viral drugs and provide a first line of defence against future pandemics, according to new research at the University of Birmingham.

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AstaReal, pioneer and global leader in the production of natural astaxanthin, has always strived for excellence and advancement of natural astaxanthin research and product development.

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Programs that provide ongoing support to patients with painful conditions and complex medication regimens may also help them avoid using potentially risky opioid pain medications, or reduce the amount they use, a new study finds.

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New research led by a team at Massachusetts General Hospital (MGH) points to a promising strategy to boost tumors' intake of cancer drugs, thereby increasing the effectiveness of chemotherapy treatments. The group's findings are published in Nature Nanotechnology.

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RNA-based drugs may change the standard of care for many diseases, making personalized medicine a reality. So far these cost-effective, easy-to-manufacture drugs haven’t been very useful in treating brain tumors and other brain disease. But a team of researchers at Georgia Tech and Emory University has shown that a combination of ultrasound and RNA-loaded nanoparticles can temporarily open the protective blood-brain barrier, allowing the delivery of potent medicine to brain tumors.

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After the Most Comprehensive Review to Date, a Panel of Leading Medical Experts Conclude that Ivermectin Should be Systematically and Globally Adopted for the Prevention and Treatment of COVID-19

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