An experimental drug to fight aggressive brain cancer has proved so successful in the first trial on humans that University of South Australia scientists will fast-track the second stage. The development provides a glimmer of hope for glioblastoma patients, who face a survival time of only 12 to 18 months after diagnosis.
For the first time, researchers have shown that a class of anti-fibrotic drugs slows the progression of interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA).
UC San Diego engineers have developed microscopic robots, called microrobots, that can swim around in the lungs, deliver medication and be used to clear up life-threatening cases of bacterial pneumonia. In mice, the microrobots safely eliminated pneumonia-causing bacteria in the lungs and resulted in 100% survival. By contrast, untreated mice all died within three days after infection.
How do the hundreds of individual pieces that make up viruses assemble into shapes capable of spreading disease from cell to cell?
An international phase 3 clinical trial for a rare, inherited form of ALS led by Washington University School of Medicine in St. Louis, showed that an investigational drug, known as tofersen, reduced molecular signs of the fatal disease, but at six months did not improve motor control and muscle strength. However, the trial, which was sponsored by the pharmaceutical company Biogen, found evidence that longer-term use of the drug may help stabilize muscle strength and control.
Melatonin use among children and teenagers is on the rise. Today, the American Academy of Sleep Medicine released a health advisory encouraging parents to talk to a health care professional before giving melatonin or any supplement to children.
During the pandemic, physicians used infusions of monoclonal antibodies to help patients fight off COVID-19 infections. Now, in response to the U.S. opioid crisis, researchers at UC Davis are trying to create monoclonal antibodies that can help fight chronic pain.
New discoveries in anesthesiology and pain management are being made every day, and ANESTHESIOLOGY® 2022 (Oct. 21-25) is the best place to be in-the-know about these important findings.
Apremilast (brand name Otezla) has helped psoriasis patients achieve clearer skin and ease the symptoms of their psoriatic arthritis. Now, new data from researchers at the Perelman School of Medicine at the University of Pennsylvania shows it could also help people with psoriasis shed unhealthy body fat and therefore improve cardiovascular health, a well-known vulnerability for those with psoriasis.
Adolescent and young adult women who were diagnosed with cancer and received chemotherapy treatment prior to pregnancy did not have a higher risk of stillbirth, according to research led by Caitlin C. Murphy, PhD, MPH, with UTHealth Houston.
Researchers in China have discovered that inhibiting a protein called the GABAA receptor can protect intestinal stem cells from the toxic effects of chemotherapy and radiotherapy. The study, published September 20 in the Journal of Experimental Medicine (JEM), suggests that the FDA-approved anti-sedative flumazenil, which targets GABAA receptors, could alleviate some of the common gastrointestinal side effects, such as diarrhea and vomiting, induced by many cancer treatments.
Early intervention with rituximab, a drug used in the treatment of rheumatoid arthritis (RA), can reduce the risk of deterioration in myasthenia gravis, an autoimmune disease that causes loss of muscle control.
Thank the rare crested ibis for a clue that could someday help our bodies make better drugs.
When patients who are on a commonly prescribed blood thinner stop taking aspirin, their risk of bleeding complications drops significantly (more than 30%), a new study finds. Researchers say aspirin should only be taken under the direction of a physician to review if the expected benefit outweighs the risk.
Acinetobacter baumannii is a bacterial pathogen responsible for serious hospital-related infections that is becoming increasingly resistant against antibiotics.
A new study from the University of Michigan Rogel Cancer Center suggests androgen receptor inhibitors can fundamentally rewire and reshape how prostate tumors function, and in certain cases even make them more aggressive. These findings will be published in Nature Communications on Sept. 15.
New research from Wake Forest University School of Medicine shows that taking a daily supplement may improve cognition in older adults. In the study, researchers estimated that three years of multivitamin supplementation roughly translated to a 60% slowing of cognitive decline (about 1.8 years).
The ability of microfungi to destruct organic compounds can be the object of envy for any processing plant. However, they sometimes destroy things that people prefer to keep safe – for example, paints of the masterpieces. The good news is that some of their biochemical reactions can be used in pharmacy.
Can you teach an old drug new tricks? Although drug treatments for the core symptoms of autism spectrum disorder (ASD) are not currently available, could an existing drug provide a new treatment, even if it previously had no association with ASD?
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