With antibiotic-resistant bacteria on the rise, scientists have been searching for ways to shut down the Type IV secretion system (T4SS), a protein complex on the outer envelope of bacterial cells that helps them to exchange DNA with neighboring bacteria and resist antibiotics.
Results from relevant studies indicate that gender-affirming hormone therapy may increase blood levels of creatinine (indicating potential kidney dysfunction or simply a change in lean muscle mass) in transgender men but does not significantly impact blood levels of creatinine in transgender women.
UPTON, NY--Scientists studying a COVID-19 coronavirus enzyme at temperatures ranging from frosty to human-body warm discovered subtle structural shifts that offer clues about how the enzyme works. The findings, published in IUCrJ, the journal of the International Union of Crystallography, may inspire the design of new drugs to counteract COVID-19 -- and possibly help head off future coronavirus pandemics.
Researchers at McMaster University have found a class of well-known antiviral drugs could be part of a one-two punch to treat seasonal influenza and prevent a flu pandemic when used in combination with antibody therapies.
Women giving birth during the COVID-19 pandemic have been denied nitrous oxide (laughing gas) for pain relief due to fears of virus transmission from the aerosol-generating procedure.
Mais de um terço das pessoas diagnosticadas com transtorno depressivo maior não têm resposta suficiente a tratamentos antidepressivos específicos. Os pacientes frequentemente precisam tentar opções diferentes até que uma seja eficaz.
Más del 33 por ciento de las personas diagnosticadas con trastorno depresivo mayor no responden lo suficiente a los tratamientos antidepresivos específicos. Con frecuencia, es necesario que el paciente intente con distintas alternativas hasta encontrar una que sea eficaz.
جاكسونفيل، فلوريدا: لا يستجيب أكثر من ثلث الأشخاص الذين تم تشخيصهم بالاضطراب الاكتئابي الرئيسي بشكل كافٍ لمجموعة محددة من العلاجات المضادة للاكتئاب. وغالبًا ما يحتاج المرضى إلى تجربة خيارات مختلفة حتى تُثبت فعالية إحداها.
在被诊断出重度抑郁障碍的人群中有三分之一的人对特定抗抑郁治疗反应不佳。患者通常需要尝试不同的治疗方法，直到找到有效的治疗。
A team of researchers led by the University of California, Irvine has discovered that treatment with an extract from the roots of the Rhodiola rosea plant might be effective for helping manage type 2 diabetes, showing promise as a safe and effective non-pharmaceutical alternative. The study, recently published online in Scientific Reports, found that in a mouse model of human type 2 diabetes, Rhodiola rosea lowered fasting blood sugar levels, improved response to insulin injections, modulated the composition of bacteria in the gastrointestinal tract and decreased several biomarkers of inflammation.
In a lookback study of prescribing patterns among thousands of American ophthalmologists and optometrists, Johns Hopkins Medicine researchers concluded that eye doctors who receive even small financial incentives from pharmaceutical companies, such as free food, sponsored travel to attend meetings or consulting fees, are up to twice as likely to prescribe the companies’ brand name eyedrops for glaucoma instead of cheaper generic versions.
The American College of Rheumatology (ACR) today applauded the passage of key drug pricing reforms in the Inflation Reduction Act that will improve rheumatology patients’ access to needed drug therapies and treatments.
Avails Medical, a pioneer in rapid, automated and fully electrical antibiotic susceptibility testing (eAST™) announced today the commencement of U.S. pivotal clinical trials for its eQUANT system, which will be used to support a submission for FDA clearance.
Mayo Clinic researchers say the monoclonal antibody bebtelovimab, already authorized by the Food and Drug Administration for emergency use on the omicron variant of COVID-19, is a reliable option to treat BA.2 and other COVID-19 subvariants. The findings of their multisite, retrospective study involving 3,607 high-risk patients appear in the Journal of Infectious Diseases.
Houston Methodist researchers present clinical evidence supporting the safety and efficacy of injecting pain medication directly into the tibia during knee replacement surgery for better postoperative pain management. The study revealed patients receiving a mixture of morphine and vancomycin injected into the shin bone have less pain post-surgery than those who received the infusion without morphine during surgery.
Johns Hopkins Medicine researchers say that an experimental dendrimer nanoparticle treatment called OP-101 substantially reduced the risk of death and need for a ventilator in a study of 24 severely ill adults hospitalized with COVID-19.
Lung disease caused by a new drug for cancers—including metastatic or advanced breast cancer—can be effectively treated using approaches that focus on early detection and prompt management, according to a study published in ESMO Open on August 11, 2022.
Gerontology researchers teamed up with hematologic-oncology investigators from Brigham and Women’s Hospital and the Dana-Farber Cancer Institute to look at the association between older patients with blood cancers who were taking multiple medications and their corresponding frailty. They also created a new scale based on a list of Potentially Inappropriate Medications (PIMs) from the NCCN Guidelines® for Older Adult Oncology—called the Geriatric Oncology-Potentially Inappropriate Medications (GO-PIMs) Scale—and found it to be more effective at predicting frailty than conventional methods.
New study suggests that readily available PET scanning could enable a whole-body analysis of the effects of systemic STING-activating therapy in humans, potentially providing a diagnostic tool to guide clinical development of this treatment approach.
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