Vitamin D Deficiency Linked to Lung Transplant Rejection

Newswise — Vitamin D deficiency is associated with a significant increase in lung transplant rejection, according to research conducted at Loyola University Health System (LUHS). These data were presented Monday at The American Society for Bone and Mineral Research 2010 annual meeting in Toronto, Ontario.

“Vitamin D deficiency is prevalent among lung transplant recipients,” said Pauline Camacho, MD, study investigator and director of the Loyola University Osteoporosis and Metabolic Bone Disease Center. “This study shed greater light on the serious impact that this deficiency has on lung transplant patients.”

Patients who undergo lung transplants are at risk for rejecting the organ, and 77 percent of these patients are vitamin D deficient. Researchers believe that vitamin D helps the immune system tolerate the organ. Thus optimal levels of this supplement are critical for positive outcomes.

This study evaluated 122 patients who underwent a lung transplant at Loyola between January 2005 and June 2008. Sixty-four patients were male and 58 were female with an average age of 49.2 years. Vitamin D levels were checked following the transplants. Of the 122 patients, 50 percent were vitamin D deficient, 18 percent were not deficient and 32 percent were unknown. Vitamin D deficiency was associated with a significant increase in rejection for 51.7 percent of patients during the first year following transplant. Vitamin D deficiency also showed a trend toward increased airway inflammation in 16.7 percent of patients.

The health benefits of vitamin D are widespread and range from warding off cancer, osteoporosis, heart disease, diabetes and depression. Researchers speculate that vitamin D also may improve the health of lung transplant patients. Further studies will evaluate the effect of vitamin D therapy on short- and long-term lung transplant rejection rates, lung function and long-term survival.

Thomas Cascino, third-year medical student at Loyola University Chicago Stritch School of Medicine (Stritch); Charles Alex, MD, FCCP, program director for lung transplant at LUHS; and Ramon Durazo, PhD, assistant professor of preventive medicine and epidemiology at Stritch, also were study investigators.

For more information, visit www.loyolahealth.org

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Based in the western suburbs of Chicago, Loyola University Health System is a quaternary care system with a 61-acre main medical center campus, the 36-acre Gottlieb Memorial Hospital campus and 25 primary and specialty care facilities in Cook, Will and DuPage counties. The medical center campus is conveniently located in Maywood, 13 miles west of the Chicago Loop and 8 miles east of Oak Brook, Ill. The heart of the medical center campus, Loyola University Hospital, is a 570-licensed bed facility. It houses a Level 1 Trauma Center, a Burn Center and the Ronald McDonald® Children’s Hospital of Loyola University Medical Center. Also on campus are the Cardinal Bernardin Cancer Center, Loyola Outpatient Center, Center for Heart & Vascular Medicine and Loyola Oral Health Center as well as the LUC Stritch School of Medicine, the LUC Marcella Niehoff School of Nursing and the Loyola Center for Health & Fitness. Loyola's Gottlieb campus in Melrose Park includes the 250-bed community hospital, the Gottlieb Health & Fitness Center and the Marjorie G. Weinberg Cancer Care Center.