As 10,000 baby boomers reach 65 each day, the incidence of cancer is increasing, estimated to increase by 67% between 2010 and 2030, bringing attention to the nation’s response to cancer care. Cancer is diagnosed at a higher rate, accounts for more survivors, and results in more deaths than in younger patients.
As we age, our body rhythms lose time before they finally stop. Breaking the body clock by genetically disrupting a core clock gene, Bmal1, in mice has long been known to accelerate aging , causing arthritis, hair loss, cataracts, and premature death. New research now reveals that the nerve cells of these mice with broken clocks show signs of deterioration before the externally visible signs of aging are apparent, raising the possibility of novel approaches to staving off or delaying neurodegeneration.
Dana Hayden, MD, Loyola colorectal surgeon, points out that 15 million women ages 40 and older (1 in 5) suffer from accidental bowel leakage. “Fecal incontinence is not a part of normal aging. It is a medical condition and there is treatment available,” says Hayden. “People with this condition become inhibited, stop socializing and do not even complete everyday routines such as grocery shopping or going to church because they fear an accident.” Loyola is one of the first medical institutions to offer a new outpatient procedure for fecal incontinence that often results in immediate improvement. In the new procedure, a gel is given through four injections into the wall of the anal canal.
Our epigenome is a set of chemical switches that turn parts of our genome off and on and are impacted by environmental factors including diet, exercise and stress. Research at the Buck Institute reveals that aging also effects the epigenome in human skeletal muscle. The study provides a method to study sarcopenia, the degenerative loss of muscle mass that begins in middle age.
The progressive loss of skeletal muscle during aging, known as sarcopenia, underlies limitations in physical function and mobility, which in turn lead to falls, loss of independence, institutionalization and even death. Mayo Clinic researcher Nathan LeBrasseur, Ph.D., of Mayo Clinic’s Robert and Arlene Kogod Center on Aging and Department of Physical Medicine and Rehabilitation, presented an update on promising strategies and therapies to restore skeletal muscle health in the face of aging and disease during a symposium at the American Congress of Rehabilitation Medicine Annual Conference.
Stanford University researchers say surgical weight loss may turn back the effects of aging at a genetic level, in the first study* of its kind presented here during ObesityWeek 2013.
People in middle age who have a high blood pressure measure called pulse pressure are more likely to have biomarkers of Alzheimer’s disease in their spinal fluid than those with lower pulse pressure, according to research published in the November 13, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology.
The novel compound IRL-1620 may be useful in treating Alzheimer’s disease (AD) as it has been shown to prevent cognitive impairment and oxidative stress in animal models.
Groundbreaking clinical study shows patented magnesium formula prevents synapse loss and reverses memory decline in mice with Alzheimer’s Disease.
UAB experts have advice on how to slow aging, and how this can help with appearance and self-esteem.
On Nov. 6, 12:30-1 pm PST, Nobel Laureate Dr. Eric R. Kandel, and Drs. Elias Pavlopoulos and Scott A. Small, will answer questions about compelling new evidence that age-related memory loss is a syndrome in its own right, apart from Alzheimer’s.
Older individuals hospitalized with a serious condition may face a slimmer risk of surviving if their thyroid hormone levels are low, according to a recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM).
The effects of gravity may explain the apparently paradoxical effects of testosterone in male pattern baldness, or androgenic alopecia (AGA), according to a special topic paper in Plastic and Reconstructive Surgery—Global Open®, the official open-access medical journal of the American Society of Plastic Surgeons (ASPS).
The major genetic risk factor for Alzheimer’s disease, present in about two-thirds of people who develop it, is ApoE4, the cholesterol-carrying protein that about a quarter of us are born with. But one of the unsolved mysteries of AD is how ApoE4 causes this risk. Researchers at the Buck Institute have found a link between ApoE4 and SirT1, an “anti-aging protein” that is targeted by resveratrol, present in red wine.
Can complex thinking stave off the effects of aging? A new study from the University of Texas at Dallas shows that learning new, mentally challenging tasks, such as digital photography, improves memory in seniors, while less demanding tasks, such as socializing or playing simple games, does not.
Researchers at Columbia University Medical Center (CUMC) have devised a hair restoration method that can generate new human hair growth, rather than simply redistribute hair from one part of the scalp to another. The approach could significantly expand the use of hair transplantation to women with hair loss, who tend to have insufficient donor hair, as well as to men in early stages of baldness. The study was published today in the online edition of the Proceedings of the National Academy of Sciences (PNAS).
A UCLA study is the first to identify a biological clock able to gauge the age of most human tissues. Some parts of the anatomy, like a woman’s breasts, age faster than the rest of the body.
Scientists report in Nature they have found a novel and unexpected molecular switch that could become a key to slowing some of the ravages of getting older as it prompts blood stem cells to age.
Even for elderly people with no signs of dementia, those with hardening of the arteries are more likely to also have the beta-amyloid plaques in the brain that are a hallmark of Alzheimer’s disease, according to a study published in the October 16, 2013, online issue of Neurology®, the medical journal of the American Academy of Neurology.
Have you ever wondered why young children can eat bags of Halloween candy and feel fine the next day – compared to adults who experience all sorts of agony following the same junk food binge? Evolution and a gene called Foxo may be to blame.
A new study of women ages 50 and older examines the 12.2 percent who say they are satisfied with their body size to unlock the secrets of body satisfaction. This minority of midlife women who report being satisfied with their body size appears to exert considerable effort to achieve and maintain this satisfaction.
Elderly surgical patients are more likely to suffer from debilitating post-operative delirium if they have diabetes, undergo longer surgery or respond poorly to stress, according to a study presented at the ANESTHESIOLOGY™ 2013 annual meeting.
A Mayo Clinic study looked at one of those -- cataract surgery-- and found that more people are getting the vision-improving procedure, seeking it at younger ages and having both eyes repaired within a few months, rather than only treating one eye.
People are living longer, but not necessarily living healthier, and that is something Iowa State University researchers want to change. They hope to accomplish that goal by using video games to promote fitness and encouraging older adults to get active.
Leaders of the American Federation for Aging Research, a national non-profit organization that has devoted more than $150 million to fund over 3,000 aging researchers during the last 31 years, commented recently on Google’s announcement of the formation of “Calico,” a company focused on aging research.
Half of those in nursing homes fear falling, which can turn into a self-fulfilling prophesy, a Saint Louis University nursing faculty member writes in a review article.
New research from Wake Forest Baptist Medical Center shows that physical activity and weight loss conducted together for older, overweight and obese adults results in improved body composition, translating into lower cardiovascular disease risk (CVD) and improved mobility.
Some overweight older adults don’t need to lose weight to extend their lives, but they could risk an earlier death if they pack on more pounds.
A clinical review from geriatricians at the University of Alabama at Birmingham suggests that mobility limitations are a litmus test for healthy aging and urges primary care physicians to take a more aggressive role in ascertaining the mobility of their older patients.
A small pilot study shows for the first time that changes in diet, exercise, stress management and social support may result in longer telomeres, the parts of chromosomes that affect aging.
Roundup of what's new and what's news at the Center for Innovative Care in Aging at the Johns Hopkins University School of Nursing
Cornell University researchers have developed a reliable method to distinguish memory declines associated with healthy aging from the more-serious memory disorders years before obvious symptoms emerge. The method also allows research to accurately predict who is more likely to develop cognitive impairment without expensive tests or invasive procedures.
-Proteins are the chief actors in cells, carrying out the duties specified by information encoded in our genes. Most proteins live only two days or less, ensuring that those damaged by inevitable chemical modifications are replaced with new functional copies.
Among scientists, the role of proteins called sirtuins in enhancing longevity has been hotly debated, driven by contradictory results from many different scientists. But new research at Washington University School of Medicine in St. Louis may settle the dispute.
When the tiny roundworm C. elegans reaches middle age—at about 2 weeks old—it can't quite move like it did in the bloom of youth. But rather than imposing an exercise regimen to rebuild the worm's body-wall muscles, researchers can bring the wriggle back by stimulating the animal's neurons. And, they say, pharmaceuticals might have a similar effect in mammals.
Cell senescence, an irreversible arrest of proliferation, is thought to be associated with normal aging and is protective against cancer. Penn researchers found that senescent cells undergo changes in their chromatin, similar to changes in cells that are prematurely aging. When the nuclear protein lamin B1 is deleted in senescent cells, large-scale changes in gene expression occurred. This loss of lamin B1 may cause changes in chromatin architecture and add to premature cell aging.
Adults age 45 and older who engaged in moderate physical activity up to two and a half hours a week did not increase their risk of developing knee osteoarthritis over a 6-year follow-up period, a new study finds.
A team of Columbia University Medical Center researchers, led by Nobel laureate Eric R. Kandel, MD, has found that deficiency of a protein called RbAp48 in the hippocampus is a significant contributor to age-related memory loss and that this form of memory loss is reversible. The findings were published today in the online edition of Science Translational Medicine.
Beat the Blues, an inexpensive intervention, shows promise at easing depression among older African Americans in studies by faculty at the Johns Hopkins University School of Nursing.
A researcher at Michigan Technological University is looking into neural connections to high blood pressure and congestive heart failure.
If Popeye were to age naturally like the rest of us, he would need more than just big muscles to stay independent during his senior years. When it comes to muscles and aging, the important thing is quality, not quantity.
Scientists at Sanford-Burnham Medical Research Institute have identified a key factor that regulates the autophagy process, a kind of cleansing mechanism for cells in which waste material and cellular debris is gobbled up to protect cells from damage, and in turn, modulates aging.
Researchers at the University of California, San Diego School of Medicine offer an explanation for why we all don't get Alzheimer's disease (AD) - a trick of nature that in most people maintains critical separation between a protein and an enzyme that, when combined, trigger the progressive cell degeneration and death characteristic of AD.
A study by Valentina Moskvina, Ph.D., of the Cardiff University School of Medicine, Wales, United Kingdom, and colleagues, examined the genetic overlap between Parkinson disease (PD) and Alzheimer disease (AD).
In the past, the only treatment available for varicose veins was a type of surgery called vein stripping, which required general anesthesia and weeks of downtime. Now, dermatologists who have received additional training are using minimally invasive procedures to treat varicose veins, allowing patients to get back to their lives more quickly and resume activities that they may have avoided beforehand.
Johns Hopkins Nursing researchers focus on the discrimination-depression link, herpes tests for teens, the baby-mom bond, violence against women across the globe, and more in the July-August 2013 research news briefs.
In a first-of-its-kind clinical trial, physician-scientists at University Hospitals Case Medical Center found that sleep quality impacts skin function and aging. The study, commissioned by Estée Lauder, demonstrated that poor sleepers had increased signs of skin aging and slower recovery from a variety of environmental stressors, such as disruption of the skin barrier or ultraviolet (UV) radiation. Poor sleepers also had worse assessment of their own skin and facial appearance.
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