With the support of a $2.8 million NIH grant, scientists at The Scripps Research Institute will explore mutations in the nuclear lamina—the outer edge of the cell nucleus— which have been linked to many diseases, from muscular dystrophies and heart disorders to type 2 diabetes and premature aging.
Many human gene variants have evolved specifically to protect older adults against neurodegenerative and cardiovascular diseases, thus preserving their contributions to society, report University of California, San Diego School of Medicine researchers in the November 30 issue of Proceedings of the National Academy of Sciences.
How to age but keep your health? Can science reverse aging? Those are just two of the questions Oscar-winning director Ron Howard will investigate when he hosts the documentary series Breakthrough on the National Geographic channel on Sunday November 29. The segment focuses on Mayo Clinic’s Kogod Center on Aging and features gerontology researcher James Kirkland, M.D., Ph.D.
In a new study that could have implications for future drug discovery efforts for a number of neurodegenerative diseases, scientists from the Florida campus of The Scripps Research Institute (TSRI) have found that the interaction between a pair of brain proteins has a substantial and previously unrecognized effect on memory formation.
UC San Diego paper finds young adults are more envious than older adults. They are more envious over looks and for a wider range of other reasons, too. It also appears that both men and women are more likely to envy someone who is of their own gender and approximately their own age
Older people with an age-related loss of muscle mass and strength may be at greater risk of falling and bone fractures, according to new research led by the University of Southampton.
Chronic inflammation, closely associated with frailty and age-related diseases, is a hallmark of aging. Mayo Clinic researchers have discovered that inhibiting key enzyme pathways reduces inflammation in human cells in culture dishes and decreases inflammation and frailty in aged mice.
Latest research from ACSM
Two experts in elder abuse coin the term and explain the concept in an opinion article published in the Oct. 13 issue of the Annals of Internal Medicine. They also call for research to identify and help older adults at risk from age-associated financial vulnerability, or AAFV for short.
It's hard to be unhappy around young children, who lift your spirits while keeping you on the go. This infusion of energy is good both for attitude and physical health, says a Saint Louis University assistant professor of geriatric medicine.
Traditional societies may see the aging process in a more positive light than modern societies, according to a Cornell researcher in a recent study published in the Journals of Gerontology: Psychological Science.
Health care providers must have detailed discussions with their older adult patients to better determine their true life expectancy, as older adults do not accurately predict their own prognosis, a key factor in making decisions about future health interventions, according to researchers at UC San Francisco and San Francisco Veterans Affairs Medical Center.
Nearly four in ten older adults say that managing their health care needs is difficult for them or their families, that medical appointments or tests get delayed or don’t get done, or that all of the requirements of their health care are too much to handle, new Johns Hopkins Bloomberg School of Public Health research suggests.
As we age, our biological clocks wind down – but why? A Weizmann Institute team studying circadian clocks has found a clue: a link between the clocks and a group of metabolites called polyamines. When added to the drinking water of older mice, polyamines reversed some signs of aging; naturally found in many foods, it’s possible they could do the same for us.
The new technique allows scientists to study diseases like Alzheimer’s and Parkinson’s using cells from human patients
A study of up to 433,390 UK adults, led by The University of Manchester, has linked being under and overweight at birth with poorer hearing, vision and cognition in middle age.
Heart valve replacements made from tissue (bioprosthetic valves) have long been thought to be spared the complication of blood clot formation. Researchers have now found that about 15 percent of all bioprosthetic aortic heart valve patients develop blood clots on the leaflets affecting valve opening, regardless of whether the patient received the new valve via open-heart surgery or a minimally-invasive catheter procedure, a new study from the Cedars-Sinai Heart Institute shows.
Like scratchy-sounding old radio dials that interfere with reception, circuits in the brain that grow noisier over time may be responsible for ways in which we slow mentally as we grow old, according to the results of new studies from UC San Francisco on young and older adults.
University of Florida Health researchers have uncovered more evidence of a link between the brain’s stress response and a protein related to Alzheimer’s disease.
A recently identified molecule produced by skeletal muscle in response to exercise, has been shown to increase bone mass, according to a collaborative study between researchers at the Mount Sinai Bone Program, Icahn School of Medicine at Mount Sinai, the Department of Experimental and Clinical Medicine at University of Ancona in Italy, and the Department of Basic Medical Science, Neuroscience and Sense Organs at the University of Bari in Italy, and published online today in the Proceedings of the National Academy of Sciences (PNAS).
Researchers have found molecular evidence of how a biochemical process controls the lengths of protective chromosome tips, a potentially significant step in ultimately understanding cancer growth and aging.
In a consensus paper, a global panel of leading aging experts suggests physicians routinely screen everyone older than 70 annually for cognitive problems.
The aging of the population, shifting diagnostic criteria, and new health care policy initiatives are some of the factors driving changes in mental health treatment for older Americans, according to the September special issue of the Harvard Review of Psychiatry. The journal is published by Wolters Kluwer.
With the world’s elderly population expected to double by 2050, understanding how aging affects the body is an important focus for researchers globally. Cardiovascular disease, the No. 1 cause of death worldwide, often is associated with aging arteries that restrict blood flow. Now, University of Missouri researchers have identified an age-related cause of arterial dysfunction, a finding that could lead to future treatments for some forms of vascular disease.
University of Iowa scientists have identified the first known cause of age-related muscle weakness and atrophy (the transcription factor ATF4), as well as two natural compounds (ursolic acid, from apple peel, and tomatidine, from green tomatoes) that blunt ATF4 activity in old skeletal muscle, leading to increased strength and muscle mass.
Sarcopenia is a natural part of aging, but it’s also a growing public health concern for older adults. That’s why an Iowa State University researcher is testing a combination of supplements and resistance training to slow or reverse the progression of sarcopenia.
Building on scientific evidence implicating disturbed calcium regulation in brain aging accumulated during the past 30 years, a research team in the University of Kentucky Department of Pharmacology and Nutritional Sciences has found a connection between unhealthy brain aging and a protein responsible for regulating calcium at the molecular level, FKBP1b.
The incidence of bicycle accidents has increased significantly in the U.S. in recent years, with many serious injuries occurring among riders older than 45, according to a new study led by UC San Francisco.
The scientific team of a new biotech company Gero in collaboration with one of the leading academics in the field of aging, Prof. Robert J. Shmookler Reis, has recently brought new insights into biology of aging and age-related diseases, primarily, around the stability and stress resistance of certain gene regulatory networks.
For some, TOR may bring to mind a Celtic mountain or perhaps an Internet privacy group. In the world of molecular biology it’s a cellular pathway that’s found in everything from yeast to mammals.
Nutritional supplements can help those who are malnourished or frail to function better and live longer, a Saint Louis University research review finds.l
A study including researchers from the U.S. Department of Energy’s Argonne National Laboratory and the University of Chicago found evidence that gut microbes affect circadian rhythms and metabolism in mice.
Hysterectomy may be a marker of early cardiovascular risk and disease, especially in women under 35, according to Mayo Clinic experts.
At the University of Kentucky’s Sanders-Brown Center on Aging, researchers are looking for biomarkers that might serve as an early warning system for AD. The process is not without complications, but these scientists possess a collective “Rosie the Riveter” spirit.
Research published in the journal Cell Reports challenges the most popular theory about why our bodies deteriorate in old age. Scientists know that as we grow older our cells accumulate particles, called free radicals. It has long been thought that free radicals wreak havoc by damaging proteins and impairing their function – but the new research shows that proteins can survive unscathed.
After decades of overtreatment for low-risk prostate cancer and inadequate management of its more aggressive forms, patients are now more likely to receive medical care matched to level of risk, according to a study by researchers at UC San Francisco.
Although the causes of many age-related diseases remain unknown, oxidative stress is thought to be the main culprit. Oxidative stress has been linked to cardiovascular and neurodegenerative diseases including diabetes, hypertension and age-related cancers. However, researchers at the University of Missouri recently found that aging actually offered significant protection against oxidative stress. These findings suggest that aging may trigger an adaptive response to counteract the effects of oxidative stress on blood vessels.
Only one in three older Americans have their diabetes under control as measured by guidelines set by the American Diabetes Association, new Johns Hopkins Bloomberg School of Public Health research suggests.
...as a cost effective prevention of more serious cardiovascular-related health issues
University of Missouri researchers have found that certain types of weight-lifting and jumping exercises, when completed for at least six months, improve bone density in active, healthy, middle-aged men with low bone mass. These exercises may help prevent osteoporosis by facilitating bone growth, according to the study published in Bone.
Outcomes following the arthroscopic repair of rotator cuff tears in older athletes appears to be successful a majority of the time, according to research presented today at the American Orthopaedic Society for Sports Medicine’s (AOSSM) Annual Meeting in Orlando, Florida.
Other topics include autism research, biofuel sources, nutrition supplements, and more...
In just two years, people with type 2 diabetes experienced negative changes in their ability to regulate blood flow in the brain, which was associated with lower scores on tests of cognition skills and their ability to perform their daily activities, according to a new study published in the July 8, 2015, online issue of Neurology®, the medical journal of the American Academy of Neurology.
The benefits of exercise are well known, but physical fitness becomes increasingly difficult as people age or develop ailments, creating a downward spiral into poor health. Now researchers at Duke Medicine report there may be a way to improve exercise tolerance and, by extension, its positive effects.
Other topics include repairing injured nerves, busted heart attack treatment, decorative brain molecules, and more...
As advances in medicine allow individuals to live longer, people are facing unique age-related health challenges. As they age, organs such as the kidneys become more susceptible to injury, and their ability to self-repair is decreased. Researchers from the University of Missouri have found a cellular signal that causes kidney cells to die, making the kidneys prone to injury. This finding could lead to improved kidney function in the elderly.
An estimated 65 percent of ischemic stroke survivors experience cognitive impairment and decline. However, little is known about the varying roles of cognitive risk and protective factors before, during and after stroke.
Omega-3 fish oil is a popular supplement because of its perceived cardiovascular benefits, but the scientific evidence has been conflicting. New research in Physiological Reports supports the claims for seniors, finding that healthy seniors who took omega-3 supplements every day had better cardiovascular health after 12 weeks of use.
Studying brain scans and cerebrospinal fluid of healthy adults, scientists have shown that changes in key biomarkers of Alzheimer's disease during midlife may help identify those who will develop dementia years later, according to new research.
New research suggests that a molecule commonly found “decorating” brain cells in higher animals, including humans, may affect brain structure. The study showed that small changes made in how sialic acid attaches to cell surfaces can cause damaged brain structure, poor motor skills, hyperactivity and learning difficulties in mice.
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