Research on fungi underway at the University of Kansas has helped transform tough-to-recycle plastic waste from the Pacific Ocean into key components for making pharmaceuticals.
To tackle the climate crisis, biodiversity loss, and pollution, humanity will need to move to a circular economy, where all resources are recycled.
Human cells are often a mixture of both abnormal and normal DNA – a mosaic, so to speak, and like the art form, this complex montage is difficult to understand. Neuroscience researchers are training computers to unveil new methods for DNA mosaic recognition.
A smart intraocular lens that can be inserted into the eye to diagnose Alzheimer's has been developed for the first time in Korea.
GenVault, one of the nation’s most secure, comprehensive commercial facilities for bioinventory storage and transport, recently received three significant certifications, augmenting its already robust list of certifications, registrations, and compliance.
Lignin, the complex polymer that gives plants their structural integrity, makes them difficult to break down and creates challenges for the creation of biochemicals and bioproducts. Building blocks that are present in small amounts in the lignin of the bioenergy crop poplar are valuable platform chemicals that are easy to “clip-off” during plant deconstruction. Scientists engineered a new type of poplar to have more of a specific building block in its lignin and less lignin overall. This results in wood that is easier to deconstruct and more valuable as a bioproduct raw material.
Arthrex, a global leader in minimally invasive surgical technology, announced today its ACL TightRope implant has received clearance from the U.S. Food and Drug Administration (FDA) for pediatric indications.
A durable copper-based coating developed by Dartmouth College researchers can be precisely integrated into fabric to create responsive and reusable materials such as protective equipment, environmental sensors, and smart filters, according to a recent study.
Despite some hesitation about gene-edited foods, taste trumps everything, according to a Washington State University-led survey of U.S. consumers.
Cheng et al. delineate a comprehensive m6A landscape during acute myeloid leukemia (AML) development and identify PRMT6, regulated by IGF2BP2, acting as a key for leukemia stem cell maintenance by restraining MFSD2A expression and docosahexaenoic ac
Chemical modifications of RNA are regulated by a series of readers, writers, and erasers that dictate gene expression. Two new studies in Cell Stem Cell1,2 identify roles for the N6-methyladenosine (m6A) methyltransferase METTL16 and the m6A reader I
By generating a multiomic cell atlas of embryonic human lungs and establishing a human tip progenitor cell organoid culture system, two recent studies demonstrated the exciting research advances in human lung development.
Serrano et al. used human iPSC-derived cardiomyocytes and deep learning data analysis to establish an in vitro safety margin that predicts clinical proarrhythmic effects of drugs. Their platform shows high accuracy in identifying risky drugs as wel
Organoids provide a platform for recapitulating and exploring development, and synthetic biology offers a toolbox to genetically manipulate cell communication, adhesion, and even cell fate. Using modular synthetic biology tools in organoids will impr
Editors’ note: The Ogawa-Yamanaka Stem Cell Prize recognizes groundbreaking work in translational regenerative medicine using reprogrammed cells. The prize is supported by Gladstone Institutes, in partnership with Cell Press. This article features
While many animals can completely repair injured tissues, the mammalian heart possesses limited regenerative capabilities. Yan and Cigliola et al. show that AAV-mediated, zebrafish-derived tissue regeneration enhancer elements (TREEs) can direct pro
(Cell Stem Cell 26, 657–674; May 7, 2020)
Deng and colleagues identify METTL16, an m6A writer, as a strong dependency in AML. METTL16 exerts its tumor-promoting role by altering the abundance of m6A-regulated proteins, BCAT1 and BCAT2, and rewiring BCAA metabolism in AML.
Building tissues and organs is one of the most complex and important tasks that cells must accomplish during embryogenesis.
Porpiglia and colleagues identify a dysfunctional CD47hi muscle stem cell (MuSC) subset in aged mice, which arises from increased U1 snRNA-driven CD47 alternative polyadenylation. CD47hi MuSCs trigger deleterious thrombospondin-1/CD47 signaling. A th
Sights, smells and sounds of everyday life can supply the triggers that take someone with PTSD right back to the scarring scene they’re trying to forget.
BACKGROUNDIschemic stroke is a condition in which an occluded blood vessel interrupts blood flow to the brain and causes irreversible neuronal cell death. Transplantation of regenerative stem cells has been proposed as a novel therapy to restor
BACKGROUNDSpermatogonial stem cells (SSCs) are the origin of male spermatogenesis, which can reconstruct germ cell lineage in mice. However, the application of SSCs for male fertility restoration is hindered due to the unclear mechanisms of pro
BACKGROUNDThere is still no consensus on which concentration of mesenchymal stem cells (MSCs) to use for promoting fracture healing in a rat model of long bone fracture. AIMTo assess the optimal concentration of MSCs for promoting fracture hea
Intervertebral disc degeneration is the main cause of low back pain. In the past 20 years, the injection of mesenchymal stromal cells (MSCs) into the nucleus pulposus of the degenerative disc has become the main approach for the treatment of lo
Using a specialized MRI sensor, MIT researchers have shown that they can detect light deep within tissues such as the brain.
Carnegie Mellon University’s Yongxin (Leon) Zhao and the Chinese University of Hong Kong’s Shih-Chi Chen have a big idea for manufacturing nanodevices.
Protein detection based on antigen–antibody reaction is vital in early diagnosis of a wide range of diseases. How to effectively detect proteins, however, has frequently bedeviled researchers.
Scientists used patient stem cells and 3D bioprinting to produce eye tissue that will advance understanding of the mechanisms of blinding diseases. The research team from the National Eye Institute (NEI), part of the National Institutes of Health, printed a combination of cells that form the outer blood-retina barrier—eye tissue that supports the retina's light-sensing photoreceptors. The technique provides a theoretically unlimited supply of patient-derived tissue to study degenerative retinal diseases such as age-related macular degeneration (AMD).
In the new study the authors have examined how conditions under which an amino group attaches to the polymer (temperature and the amount of arginine) affect the resulting qualities of the polycaprolactone film
BioVU, Vanderbilt University Medical Center’s biobank, has reached another milestone — deep-freeze storage of more than 300,000 biological samples.
The incredibly fast spread of COVID-19 throughout the world brought to light a very important fact: we need better methods to diagnose infectious diseases quickly and efficiently.
UC San Diego Herbert Wertheim School of Public Health and Human Longevity Science led 70 participants from 14 nations in a discussion on the ways in which a gene drive project registry could both contribute to and detract from the fair development, testing and use of gene-drive modified organisms.
The Wistar Institute Biomedical Technician Training (BTT) Program was awarded Workforce Champion of the Year in the 3rd Annual 2022 BioBuzz Awards. The program is a collaborative that includes The Wistar Institute, West Philadelphia Skills Initiative, Iovance Biotherapeutics, PIDC, and others.
This week, the United Nations is meeting in Montreal for the UN Biodiversity Conference. The conference brings together leaders from around the world to discuss how to prevent loss of biodiversity and how to restore habitats that are already hurting.
“Our new Ion Bronchoscopy system is a robotic-assisted minimally invasive biopsy platform. It features an ultra-thin, ultra-maneuverable catheter that allows navigation far into the lung, reaching smaller airways, said Faiz Y. Bhora, MD, FACS, chair of surgery, and chief of thoracic surgery, central region, Hackensack Meridian Health. “This platform’s unprecedented stability enables the precision needed for biopsy compared to manual techniques and the ability to diagnose lung cancer at the earliest stage when it is most treatable."
A new biobattery being developed at Binghamton University, State University of New York could power ingestible cameras in the small intestine.
Since oral cancer occurs in one of the most accessible sites in the body, it can be easily treated if detected promptly. In Journal of Vacuum Science & Technology B, researchers report a breakthrough hand-held biosensor that enables quick and accurate detection of oral cancer. The group's biosensor consists of a sensor strip, similar to a glucose strip, and a circuit board (a hand-held terminal like a glucometer) for detection.
In early 2020, before COVID-19 vaccines and effective treatments were widely available, universal mask wearing was a central strategy for preventing the transmission of COVID-19. But hospitals and other settings with mask mandates faced a challenge.
Using models, researchers at UC San Diego School of Medicine, with colleagues elsewhere, describe using RNA-targeting CRISPR/Cas13d technology to develop a new therapeutic strategy that specifically eliminates toxic RNA that causes Huntington’s Disease.
Restoring natural vision is far in the future. But Neuralink's technology, which will assist the blind to navigate in their world, is on the verge of attainability.
At the session "Can science become a family value?", representatives of scientific and educational organizations, development institutions and businesses discussed how to make science more popular among society.
Biomedical and genetic engineers at Duke University and the Albert Einstein College of Medicine have designed a small fluorescent protein that emits and absorbs light that penetrates deep into biological tissue.
Researchers are using a natural material derived from seaweed to promote vascular cell growth, prevent blood clots and improve the performance of synthetic vascular grafts used in heart bypass surgery.
Former FDA official Steven R. Bauer, PhD, will be an available resource to the ever-growing biotechnology innovation ecosystem underway in the Innovation Quarter of Winston-Salem, NC.
Engineers developed a battery-free, pill-shaped ingestible biosensing system that gives scientists the ability to monitor gut metabolites in real time, which wasn’t possible before. The work could lead to a new understanding of intestinal metabolite composition, which significantly impacts human health.
Early life experiences can impact the activity of our genes much later on and even affect longevity, finds a new study in fruit flies led by UCL researchers.
Researchers discover that dual knockout of genes in organoids grown from human tissue generates a model of and potential therapeutic target for gastroesophageal junction cancer
Fang and colleagues provide a comprehensive transcriptomic analysis of the cell types occupying the interface between tendon and bone, the enthesis. They establish a framework for understanding enthesis maturation and identify a potent Gli1-lineage p
Repair of the tendon enthesis (e.g., after a rotator cuff tear) is a clinical challenge. To motivate novel cell-based treatment strategies for enthesis repair, Fang et al. define enthesis cell transcriptomes and differentiation trajectories. A uniqu
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