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A new study from Memorial Sloan Kettering Cancer Center (MSK) provides important insights into cancer metastasis.
The first generation of COVID-19 vaccines have been highly effective, but also have limitations. Now Wistar scientists have developed a more targeted vaccine that, in animal studies, shows stronger, broader, and more durable protection in a single, low dose.
… We performed scATAC-seq on human fetal retina and human embryonic stem cell (hESC)-derived retinal organoids (Table S1), including 7 fetal retinas (2 that were cultured for 4 days in vitro [DIV]) and 5 organoid samples containing approximately …
Neuroscientists at the David Geffen School of Medicine at UCLA in collaboration with scientists at UC Berkeley have discovered that visual stimulation not only guides the way brain cells connect, but actually influences the types of cells that form in the first place – something that was thought to be genetically programmed.
… , stem cell marker expression, cell invasion, and sphere formation. Furthermore, in vivo knockdown completely inhibited tumor growth in mouse xenograft model. We propose that cytoplasmic SOX9-mediated cell death suppression would contribute to …
… Adipose-derived stem cell (ADSC) or crushed adipose tissue injection into the joint cavity reportedly improve knee function and symptoms, including pain. Stem cell spheroids may be promising treatment options due to their anti-inflammatory …
Host microbiota crosstalk is essential for the production and functional modulation of blood-cell lineages. Whether, and if so how, the microbiota influences hematopoietic stem cells (HSCs) is unclear. Here, we show that the microbiota regulates HSC self-renewal …
… RICH1 inhibits stem cell-like properties in breast cancer and maintains the normal epithelial architecture of … 3: RICH1 inhibits stem cell-like properties in breast cancer and maintains the normal epithelial architecture … RICH1 inhibits stem cell-like …
A significant portion of people who contract the SARS-CoV-2 virus – some estimates suggest more than 40 percent – suffer chronic effects known as Post Acute Sequelae of COVID-19 (PASC), commonly referred to as long COVID. PASC symptoms include fatigue, brain fog, the loss of taste and smell, shortness of breath, and more.
 CREDIT Chalif et al - Cell.jpg.png&width=400&height=400)
For more than a century, scientists have known that while the commands that initiate movement come from the brain, the neurons that control locomotion once movement is underway reside within the spinal cord.
Studies since the start of the pandemic have noted that pigs exposed to the coronavirus don’t show clinical signs of disease nor do they transmit the virus to other animals. Iowa State University scientists have uncovered important clues that shed light on why pigs don’t get sick, and the discovery could lead to better treatments for COVID-19 in humans.
An investigational cancer drug that starves tumors of their energy supply also shows evidence of improving whole body metabolism, leading to improved weight control, according to a new study in mice from researchers at Washington University School of Medicine in St. Louis.
Researchers discover how a gene mutation in gliomas leads to cell cycle dysregulation and heightened sensitivity to a class of inhibitors.
The giant panda feeds exclusively on fibrous bamboo, yet they still manage to stay chubby and healthy.
A research team led by Prof. Stephan Ludwig, a virologist at the Institute of Virology at the University of Münster, has found a new dual attack mode of action while working on the development of a drug candidate against SARS-CoV-2 infections.
It is well established that exercise improves health, and recent research has shown that exercise benefits the body in different ways, depending on the time of day.
… -stem-cell-derived RPE cells injected subretinally were able to preserve vision in a rat model of RPE cell dysfunction (Davis et al., 2017). These studies further highlight the utility and clinical applications of stem-cell-… The developmental stage …
In mammals, white adipose tissues are largely divided into visceral epididymal adipose tissue (EAT) and subcutaneous inguinal adipose tissue (IAT) with distinct metabolic properties. Although emerging evidence suggests that subpopulations of …
… This review article mainly discusses the advances in application of stem cell and progenitor transplantation for retinitis pigmentosa. Stem cell sources such as mesenchymal stem cells, embryonic stem cells, induced pluripotent stem cells …
… , but the molecular mechanisms that coordinately control basal cell fate and stem cell quiescence are elusive. Here, we report an epithelium-… stem cell function to Zeb1-deficient basal cells. Thus, Zeb1 is a transcriptional regulator that maintains …
Metabolic differences could explain why some metastatic breast cancer cells rapidly generate tumors after migrating from primary tumors to the brain, while others linger for months or years before forming these secondary tumors, UT Southwestern scientists report in a new study. The findings, published in Cell Metabolism, highlight metabolic vulnerabilities in malignant cells that could eventually lead to new cancer therapies.
Harnessing the power of genomics to find risk factors for major diseases or search for relatives relies on the costly and time-consuming ability to analyze huge numbers of genomes. A team co-led by a Johns Hopkins University computer scientist has leveled the playing field by creating a cloud-based platform that grants genomics researchers easy access to one of the world’s largest genomics databases.
Research led by scientists at the Jonsson Comprehensive Cancer Center (JCCC) at UCLA provides new insights into molecular “crosstalk” in pancreas cancer cells, identifying vulnerabilities that could provide a target for therapeutic drugs already being studied in several cancers.
Intestinal stem cells continuously self-renew and differentiate into a variety of specialized epithelial cells that maintain gut health. New research in this issue of Cell Stem Cell (Baghdadi et al., 2022) shows that enteric glial cells regulate the intestinal …
Neurodegenerative diseases are characterized by progressive cell loss leading to disruption of the structure and function of the central nervous system. Amyotrophic lateral sclerosis (ALS) was among the first of these disorders modeled in patient …
Results of a new study by researchers at Case Western Reserve University represent a step toward improving our understanding of Crohn’s disease and the factors that cause its intestinal inflammation.
An additional “booster” dose of Moderna or Pfizer mRNA-based vaccine is needed to provide immunity against the Omicron variant of SARS-CoV-2, the virus that causes COVID-19, according to a study by researchers at the Ragon Institute of MGH, MIT and Harvard.
Gee Euhn Choi, Chang Woo Chae, Mo Ran Park, Jee Hyeon Yoon, Young Hyun Jung, Hyun Jik Lee, Ho Jae Han
Yi Wang, Qinchao Wu, Yang Zheng, Chao Wang, Xu Ding, Heming Wu, Yunong Wu, Wei Zhang, Xiaomeng Song
Researchers have discovered that bacterial communities are far more advanced than previously believed. Scientists found that biofilm cells are organized in elaborate patterns, a feature previously only associated with higher-level organisms such as plants and animals.
The lab of Youyang Zhao, PhD, from Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago developed a unique nanoparticle to deliver genome editing technology, including CRISPR/Cas9, to endothelial cells, which are cells that line blood vessel walls. This is the first time that vascular endothelial cells could be reached for genome editing, since the usual way to deliver CRISPR/Cas9 – through a virus – does not work for this cell type.
Katarína Kacvinská, Martina Trávničková, Lucy Vojtová, Petr Poláček, Jana Dorazilová, Martin Kohoutek, Júlia Pajorová, Mária Tirpáková, Lucie Bačáková
Hematopoietic stem cell transplantation (HSCT) from haploidentical donors is a viable option for patients lacking HLA-matched donors. Here we report the results of a prospective multicenter phase I/II trial of transplantation of TCRαβ and CD19 …
Stem cell transplantation has been applied to treat spinal cord injury (SCI) in clinical trials for many years. However, the clinical efficacies of stem cell transplantation in SCI have been quite diverse. The purpose of our study was to systematically …
Cedars-Sinai scientists have revealed the origins of a common ovarian cancer by modeling fallopian tube tissues, allowing them to characterize how a genetic mutation puts women at high risk for this cancer. The created tissues, known as organoids, hold potential for predicting which individuals will develop ovarian cancer years or even decades in advance, allowing for early detection and prevention strategies.
A new study by researchers at Washington University School of Medicine in St. Louis and St. Jude Children’s Research Hospital helps explain why mRNA vaccines have been so successful at preventing severe disease.
Researchers identify mechanism that explains how tissues form complex shapes that enable organ function
The finding that some genes are active from the get-go challenges the textbook view that genes don't become active in human embryos until they are made up of four-to-eight cells, two or three days after fertilisation.
Investigators at Cedars-Sinai have identified growth hormone in the colon that increases as the colon ages—a discovery that can help guide the development of a new anti-aging therapy.
It is now widely known that COVID-19 is associated with the transient or long-term loss of olfaction (the sense of smell) but the mechanisms remain obscure.
Ever since the first barcode appeared on a pack of chewing gum in 1974, the now-ubiquitous system has enabled manufacturers, retailers and consumers to quickly and effectively identify, characterize, locate and track products and materials. In a paper first posted online Nov. 26, 2021, in the journal Cell, researchers at Johns Hopkins Medicine and The Johns Hopkins University demonstrate how they can do the same thing at the molecular level, studying the ways cancer cells “talk” with one another.
Funded by a Specialized Program of Research Excellence (SPORE) award from the National Cancer Institute (NCI), the Kidney Cancer Program (KCP) at UT Southwestern’s Harold C. Simmons Comprehensive Cancer Center reports the largest and most diverse catalog of kidney cancer tumor models to date.
In a collaborative study, Cleveland Clinic researchers sought to understand how COVID-19 infection affects pregnant mothers and their children. They published the results of their clinical study in Cell Reports Medicine.
The Canadian Distributed Infrastructure for Genomics (CanDIG) is a collaboration of computer scientists, AI specialists, clinicians, and geneticists working together to enable studies needed to address the health challenges faced by Canadians.
Now, in a study published in the journal Cell Reports Medicine, UCLA researchers report a critical step forward in the development of an “off-the-shelf” cancer immunotherapy using human stem cell-derived invariant natural killer T cells, rare but powerful immune cells that could potentially be produced in large quantities, stored for extended periods and safely used to treat a wide range of patients with various cancers.
Young adults who are diagnosed with skin, colon, and other cancer types may require different treatments than older patients receive. That is the primary conclusion of a Mount Sinai study which systematically compared the genomes of 14 different types of cancers that affected both younger and older adults.
UC San Diego researchers have produced a single-cell chromatin atlas for the human genome. Delineating chromatin regions in cells of different human tissue types would be a major step toward understanding the role of gene regulatory elements (non-coding DNA) in human health or disease.
Researchers reveal a previously unrealized complexity in cancer development, one that raises concerns and caution about targeting an enzyme popular in oncological treatments.
A new discovery of a physiological mechanism of psychosomatic illnesses could open a new therapeutic avenue for treating chronic inflammatory conditions such as Crohn's disease, psoriasis, and other autoimmune conditions, by attenuating their memory trace in the brain.
More than four times as many businesses and clinics than were identified in 2016 are selling stem cell products not approved by the U.S. Food and Drug Administration and lack convincing evidence of safety and efficacy, according to a five-year study conducted by University of California, Irvine Program in Public Health professor of health, society and behavior Leigh Turner. The analysis appears online in the journal Cell Stem Cell.
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