IDRs comprise a large percentage of the human proteome and are particularly important for nuclear proteins that govern our genomic architecture and gene expression.
As one of just six sites in the country chosen for a new consortium of the National Institutes of Health (NIH), UTHealth Houston School of Public Health in Brownsville will use multi-omics in combination with environmental, epidemiologic, and clinical data, along with social determinants of health, to study non-alcoholic and non-viral liver disease in Hispanics/Latinos.
Researchers at Dana-Farber Brigham Cancer Center have found that a shorter course of radiation therapy after mastectomy and breast reconstruction surgery provides the same protection against breast cancer recurrence and equivalent physical side-effects but substantially reduces life disruption and financial burden for patients.
The reasons why people attempt suicide are complex and include external triggers like trauma and stress, as well as inherited genetic factors. A new study has identified 12 DNA variants, or variations in the human genetic code, that are associated with risk of attempting suicide.
Researchers at Stanford University School of Medicine, Yale University School of Medicine, and the Hospital for Special Surgery Research Institute have uncovered new details about how the immune system prevents the production of antibodies that can recognize and damage the body’s own, healthy tissues. The study, to be published September 29 in the Journal of Experimental Medicine (JEM), also reveals how this process is impaired in autoimmune disorders such as systemic sclerosis and systemic lupus erythematosus and suggests potential new strategies to treat these diseases.
CLEVELAND: A team from Cleveland Clinic has developed a new model for prioritizing patients waiting for a lung transplant, aimed at improving outcomes and reducing deaths among those in need of donor lungs. The new method offers an improved strategy for organ allocation by taking into account how the time a patient has spent on the waiting list could impact the severity of their disease and the urgency of their need for a transplant.
The results of a study looking at this new method were published today in The American Journal of Respiratory and Critical Care Medicine.
Researchers at Washington University in St. Louis have developed a technique called sonobiopsy that uses ultrasound and microbubbles to disrupt the blood-brain barrier temporarily and allow RNA, DNA and proteins from the brain to spill out into the blood, where they can be detected and analyzed.
In a groundbreaking study, a team of Georgia Tech researchers has unveiled a remarkable discovery: the identification of novel bacterial proteins that play a vital role in the formation and stability of methane clathrates, which trap gigatons of greenhouse gas beneath the seafloor. These newfound proteins not only suppress methane clathrate growth as effectively as toxic chemicals used in drilling but also prove to be eco-friendly and scalable. This innovative breakthrough not only promises to enhance environmental safety in natural gas transportation but also sheds light on the potential for similar biomolecules to support life beyond Earth.
Researchers at the Icahn School of Medicine at Mount Sinai have been awarded a $10.2 million grant from the National Heart, Lung and Blood Institute of the National Institutes of Health to investigate risk factors for malignant arrhythmias in mitral valve prolapse.
Penn State College of Medicine researchers said they conducted a “first-of-its-kind study,” revealing how various demographic factors intersect to affect a person’s risk of having suicidal thoughts and behaviors.
The normal brain protein tau sometimes gets knotted up into tangles and turns toxic, injuring brain tissue and causing tauopathies, a group of brain diseases characterized by problems with learning, memory and movement.
UC San Diego engineers have devised a new solution to control a major agricultural menace, root-damaging nematodes. Using plant viruses, the researchers created nanoparticles that can deliver pesticide molecules to previously inaccessible depths in the soil.
Continuous wrist temperature monitoring can uncover insights into the potential for future disease risk for ailments like Type 2 diabetes, hypertension, liver disease, kidney failure, and more.
Rutgers researchers have developed a way of detecting the early onset of deadly infectious diseases using a test so ultrasensitive that it could someday revolutionize medical approaches to epidemics.
SMU chemistry professor John Buynak and his team have received a $3.5 million, 5-year grant from the National Institutes of Health to design and synthesize new antibiotics to fight some of the deadliest and most clinically challenging infections of the 21st century – drug resistant strains of bacteria that cause tuberculosis and leprosy.
Researchers discover how molecules in ancient glass rearrange and recombine with minerals over centuries to form a patina of photonic crystals – ordered arrangements of atoms that filter and reflect light in very specific ways - an analog of materials used in communications, lasers and solar cells
A multidisciplinary research group specializing in pediatrics, genetics, and psychophysics, co-led by the Monell Chemical Senses Center, has identified wide variation in the sensory perception of a pediatric formulation of ibuprofen — some that were tied to genetic ancestry, and some that were not.
The risk of incarceration for Black men in the United States was cut nearly in half between 1999 and 2019, according to a new study that assesses the impact of falling rates of imprisonment in each of the 50 states.
Researchers at The University of Texas MD Anderson Cancer Center have discovered that certain nano-based cancer therapies may be less effective in younger patients, highlighting the need for further investigation into the impact of aging on the body’s ability to respond to treatment.
Moffitt Cancer Center has been awarded a four-year, $3 million grant from the Department of Defense’s Congressionally Directed Medical Research Programs to develop new treatments for rare melanomas, including uveal melanoma. The grant will fund two projects aimed at advancing targeted alpha-particle therapies.
High rates of firearm injury among urban Black men in the U.S. can lead to long physical and psychological recovery times, worsened by limited access to mental health services.
Earthquake rupture forecast studies provide information about the probabilities of when earthquakes will occur, where they’ll take place and how strong they'll be, but the computational tools and data aren't available to a wide scientific community. That's about to change.
People who bought firearms during the height of the COVID-19 pandemic have much higher rates of recent suicidal thoughts, self-harm behaviors, and intimate partner violence, a new study suggests, compared with other firearm owners and people who do not own firearms.
University of Illinois researchers received NSF funding to acquire a fully automated polymer analysis instrument to be housed at the Beckman Institute.
Lab-based studies reveal how carbon atoms diffuse on the surface of interstellar ice grains to form complex organic compounds, crucial to reveal the chemical complexity in the universe.
From 2013 to 2019 the share of U.S. health care visits delivered by non-physicians such as nurse practitioners or physician assistants increased from 14 to 26 percent.
Scientists at Johns Hopkins All Children’s Hospital are shedding new light on the causes of Type 2 diabetes and offering a potential strategy for developing new therapies, or perhaps, even prevent Type 2 diabetes from developing.
An abstract unveiling a new mouse model for brain arteriovenous malformations (AVMs) developed by UTHealth Houston researchers has been selected for a poster presentation at the second annual National Institutes of Health (NIH) Investigator Meeting for Interoception Research in November.
A University of Arkansas at Little Rock professor and students are part of a university startup that has received a $2.2 million grant to develop an advanced artificial-intelligence automation and rapid-recovery hardware to protect industrial control systems from cybersecurity attacks.
Joel M. Smith, an assistant professor of Chemistry and Biochemistry, received the Maximizing Investigators’ Research Award, or MIRA, from the National Institute of General Medical Sciences to study the potential that synthesizing small, complex molecules could have on the biomedical and pharmaceutical industries.
Researchers at the Icahn School of Medicine at Mount Sinai have identified the structure of a special transporter found in red blood cells and how it interacts with drugs.
Crustaceans, insects and mushrooms are rich sources of the dietary fiber chitin, which activates the immune system and benefits metabolism, according to a new study, in mice, led by researchers at Washington University School of Medicine in St. Louis.
SMU biology professor Zhihao Wu has received a $1.8 million, 5-year Maximizing Investigators' Research Award (MIRA) from the National Institutes of Health to determine if different quality control pathways in our bodies might be working together to repair damaged components in cells.
Beckman researchers and collaborators received $30 million from the U.S. National Science Foundation to establish the NSF Science and Technology Center for Quantitative Cell Biology.
Global, population-weighted PM2.5 exposure -- related to both pollution levels and population size -- increased from 1998 to a peak in 2011, then decreased steadily from 2011 to 2019, largely driven by exposure reduction in China and slower growth in other regions, new research shows.
Dr. Weiping Zhang, professor in the Department of Pathobiology, was recently awarded a five-year, $5.6 million R01 grant from the National Institutes of Health (NIH) to optimize a promising vaccine against enterotoxigenic Escherichia coli (ETEC).
Scientists at Wake Forest University School of Medicine are reporting results from a Phase I trial in an area of promising research for Alzheimer's disease—cellular senescence.
A Florida State University researcher has received a five-year, $1.86 million grant from the National Institutes of Health to study how a little-understood part of the brain affects our sense of smell.
The University of Miami School of Nursing and Health Studies (SONHS) has been awarded an unprecedented $23.57 million grant from the National Institutes of Health (NIH) to join the Environmental influences on Child Health Outcomes (ECHO) Program.
A "living material," made of a natural polymer combined with genetically engineered bacteria, could offer a sustainable and eco-friendly solution to clean pollutants from water. UC San Diego researchers developed their living material using a seaweed-based polymer and bacteria that have been programmed to produce an enzyme that transforms various organic pollutants into harmless compounds. In tests, their material decontaminated water solutions tainted with a pollutant from textile manufacturing: indigo carmine, a blue dye that is used to color denim.
University of Illinois researchers and a Swiss pharmaceutical company have developed a machine learning model that eliminates the need for extensive experimentation to determine the best conditions for an important carbon-nitrogen bond forming reaction known as the Buchwald-Hartwig reaction.
La Jolla Institute for Immunology (LJI) scientists have published a pair of studies that show how we might harness CD4+ T cells while boosting the cancer-fighting power of CD8+ "killer" T cells.
A research team at the University of Illinois Urbana-Champaign suggests gut microbe communities may be responsible for variation in extracting benefits of broccoli and other brassica vegetables. With a new grant from the USDA’s National Institute of Food and Agriculture, the team plans to identify which microbes maximize the benefits of these vegetables.
Rutgers-led research found that marine heat waves – prolonged periods of unusually warm ocean temperatures – haven’t had a lasting effect on the fish communities that feed most of the world. The finding is in stark contrast to the devastating effects seen on other marine ecosystems cataloged by scientists after similar periods of warming, including widespread coral bleaching and harmful algal blooms.
The rapid sea level rise and resulting retreat of coastal habitat seen at the end of the last Ice Age could repeat itself if global average temperatures rise beyond certain levels, according to an analysis by an international team of scientists from more than a dozen institutions, including Rutgers.