Trending news releases with the most views in a single day. Topics include: diet supplements and cancer, pancreatic cancer, bird flu, parenting, respiratory health, physics from the DOE office of science, breast cancer awareness, and childhood cancer survivors.
Researchers from The University of Manchester working with drug development company Evgen Pharma, have developed a new combination of drugs which could overcome treatment resistance and relapse in breast cancer.
A new mathematical model that uses drug-target kinetics to predict how drugs work in vivo may provide a foundation to improve drug discovery, which is frequently hampered by the inability to predict effective doses of drugs. The discovery by Peter Tonge, a Professor of Chemistry and Radiology, and Director of Infectious Disease Research at the Institute for Chemical Biology and Drug Discovery (ICB & DD) at Stony Brook University, along with collaborators at Stony Brook University and AstraZeneca, will be published advanced online on April 20 in Nature Chemical Biology.
The PD-1 inhibitor pembrolizumab, a cancer immunotherapy drug, shrank or halted growth of tumors in 76 percent of patients with pleural mesothelioma, a rare and deadly form of cancer that arises in the outer lining of the lungs and internal chest wall, according to a new study from researchers in the Perelman School of Medicine at the University of Pennsylvania. Patients diagnosed with the disease, which is tied to exposure to asbestos, have a median survival rate of about one year.
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Among patients with atrial fibrillation who filled prescriptions for the anticoagulant dabigatran at Veterans Health Administration sites, there was variability in patient medication adherence across sites, with appropriate patient selection and pharmacist-led monitoring associated with greater adherence to the medication, according to a study in the April 14 issue of JAMA.
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A medicinal liquid form of marijuana may show promise as a treatment for children with severe epilepsy that is not responding to other treatments, according to a study released today that will be presented at the American Academy of Neurology’s 67th Annual Meeting in Washington, DC, April 18 to 25, 2015.
Cancerous tumors have the ability to evade targeted therapies by activating alternative pathways. Tumors also contain cancer stem cells, believed responsible for metastasis and drug resistance. Now scientists in the Cancer Research Institute at Beth Israel Deaconess Medical Center have identified a drug target that addresses both of these challenges.
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Researchers studying the commonly used pain reliever acetaminophen found it has a previously unknown side effect: It blunts positive emotions.
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Resistance to therapy is a major problem in the cancer field. Using human cell lines of the HER2-positive breast cancer subtype, researchers detailed the surprising ways in which resistance to the drug lapatinib manifests and how to defeat resistance before it happens.
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New research forthcoming in Management Science determines that the “shelf life” of malaria-fighting drugs plays a significant role in how donors should subsidize the medicine in order to ensure better affordability for patients.
A commonly prescribed antidepressant caused up to a six-fold increase in atherosclerosis plaque in the coronary arteries of non-human primates, according to a study by researchers at Wake Forest Baptist Medical Center. Coronary artery atherosclerosis is the primary cause of heart attacks.
In the largest study to date documenting the significant risks to children’s health associated with prescription antipsychotics, results suggest that initiating antipsychotics may elevate a child’s risk not only for significant weight gain, but also for Type II diabetes by nearly 50 percent.
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Nathan Mitchell, a graduate student at the University of Texas Health Science Center in San Antonio wanted to know why the therapeutic benefit afforded by SSRIs was so limited in children and teenagers. If researchers can uncover the biological mechanisms preventing available treatments from producing antidepressant effects, scientists can then target those mechanisms to develop new antidepressants that will treat childhood and adolescent depression more effectively.
Researchers at the University of Michigan Comprehensive Cancer Center have developed a new drug that shows potential in laboratory studies against a rare type of acute leukemia. And additional studies suggest the same compound could play a role in prostate cancer treatment as well.
These data indicate that TG2 is a possible chemotherapeutic target for Glioblastoma Multiforme (GBM) treatment.
Rhodiola rosea (R. rosea), or roseroot, may be a beneficial treatment option for major depressive disorder (MDD), according to results of a study in the journal Phytomedicine led by Jun J. Mao, MD, MSCE, associate professor of Family Medicine, Community Health and Epidemiology and colleagues at the Perelman School of Medicine of University of Pennsylvania.
Antibiotic resistance is poised to spread globally among bacteria frequently implicated in respiratory and urinary infections in hospital settings, according to new research at Washington University School of Medicine in St. Louis.
Magnetic nanoparticles can open the blood-brain barrier and deliver molecules directly to the brain, say researchers from the University of Montreal, Polytechnique Montréal, and CHU Sainte-Justine. This barrier runs inside almost all vessels in the brain and protects it from elements circulating in the blood that may be toxic to the brain. The research is important as currently 98% of therapeutic molecules are also unable to cross the blood-brain barrier.
A National Alert for Serious Medication Errors has been issued by ASHP and the Institute for Safe Medication Practices (ISMP), warning of potentially dangerous mix-ups between two relatively new presentations of older medications, neostigmine injection and phenylephrine injection.
Cancer patients over the age of 65 often take multiple drugs, which can interfere with cancer treatment. A new study shows that currently used tools to prevent over-medicating senior cancer patients need improvement
The concept was simple: If two compounds individually show promise in preventing colon cancer, it’s worth trying the two together. Metformin and Vitamin D3 proved dramatically better than either option alone. Their findings served as the cover feature for the February Cancer Prevention Research.
Roflumilast, a drug recently approved in the United States to treat severe chronic obstructive pulmonary disease (COPD), increases the production of a protein that causes inflammation, which possibly results in patients developing a tolerance to the drug after repeated use and makes the drug less effective, according to researchers at Georgia State University, Kumamoto University and the University of Rochester Medical Center.
A generic version of insulin, the lifesaving diabetes drug used by 6 million people in the United States, has never been available in this country because drug companies have made incremental improvements that kept insulin under patent from 1923 to 2014. As a result, say two Johns Hopkins internist-researchers, many who need insulin to control diabetes can’t afford it, and some end up hospitalized with life-threatening complications, such as kidney failure and diabetic coma
Drugs aimed at quelling the behavior problems of dementia patients may also hasten their deaths more than previously realized, a new study finds. The research adds more troubling evidence to the case against antipsychotic drugs as a treatment for the delusions, hallucinations and aggression that many people with Alzheimer’s disease experience.
New animal studies at Henry Ford Hospital found that sildenafil, a drug commonly used to treat erectile dysfunction, may be effective in relieving painful and potentially life-threatening nerve damage in men with long-term diabetes.
The cost of treating people infected with the hepatitis C virus (HCV) with newly approved therapies will likely place a tremendous economic burden on the country’s health care system. The prediction comes from a cost-effectiveness analysis led by researchers at The University of Texas MD Anderson Cancer Center.
An FDA-approved drug for high blood pressure, guanabenz, prevents myelin loss and alleviates clinical symptoms of multiple sclerosis (MS) in animal models, according to a new study. The drug appears to enhance an innate cellular mechanism that protects myelin-producing cells.
A reformulation of OxyContin that makes it less likely to be abused than the older formulation has curtailed the drug’s illicit use. But researchers at Washington University School of Medicine in St. Louis have found that a significant percentage still abuse the drug despite package labeling that emphasizes its abuse-deterrent properties.
Chlorine, a disinfectant used in most wastewater treatment plants, may be failing to eliminate pharmaceuticals from wastes. As a result, trace levels get discharged from the treatment plants into waterways. Now, scientists are reporting that chlorine treatment may encourage the formation of new, unknown antibiotics that could enter the environment, potentially contributing to the problem of antibiotic resistance. They will present the research at the 249th National Meeting & Exposition of the American Chemical Society.
Since HIV emerged in the ‘80s, drug “cocktails” transformed the deadly disease into a manageable one. But the virus is adept at developing resistance to drugs, and treatment regimens require tweaking that can be costly. Now scientists at the 249th National Meeting & Exposition of the American Chemical Society are announcing new progress toward affordable drugs that could potentially thwart the virus’s ability to resist them.
Saccharin, the artificial sweetener that is the main ingredient in Sweet ‘N Low®, Sweet Twin® and Necta®, could do far more than just keep our waistlines trim. According to new research, this popular sugar substitute could potentially lead to the development of drugs capable of combating aggressive, difficult-to-treat cancers with fewer side effects.
Laura Kiessling, Ph.D., will present new findings that could exploit differences between human and microbial carbohydrates to fight infections during today’s “The Fred Kavli Innovations in Chemistry Lecture” at the 249th National Meeting & Exposition of the American Chemical Society.
Scientists will report in a presentation today that they have turned to the opossum to develop a promising new and inexpensive antidote for poisonous snake bites. They predict it could save thousands of lives worldwide without the side effects of current treatments. The presentation will take place here at the 249th National Meeting & Exposition of the American Chemical Society, the world’s largest scientific society.
Lots of potentially useful medical information is getting lost. McGill researchers discovered this when they looked into the lack of reporting of information from “stalled drug” trials in cancer, cardiovascular and neurological diseases.
In patients with advanced thyroid cancer, sunitinib, a drug approved for treatment of several other cancers, showed significant cancer-fighting activity t, a new phase 2 clinical trial has found. Results of the single-center study will be presented Sunday at the Endocrine Society’s 97th annual meeting in San Diego.
A new testosterone nasal gel raises men’s low testosterone levels to normal, with few side effects, according to the results of a phase 3 clinical trial to be presented Saturday at the Endocrine Society’s 97th annual meeting in San Diego.
An experimental drug causes loss of weight and fat in mice, a new study has found. The study results will be presented Friday at the Endocrine Society’s 97th annual meeting in San Diego.
Among prescriptions filled for menopausal hormone therapy (HT) in the U.S., almost half now are custom-compounded “bioidentical” hormones, according to analysis of a recent survey of nearly 500 pharmacists. The study results will be presented Friday March 6th at the Endocrine Society’s 97th annual meeting in San Diego.
A new study by researchers at the Intermountain Medical Center Heart Institute has found that screening for and treating depression could help to reduce the risk of heart disease in patients with moderate to severe depression.
New research suggests that widely used statin therapy provides the most benefit to patients with the highest genetic risk of heart attack. Using a relatively straightforward genetic analysis, the researchers assessed heart attack risk independently of traditional risk factors such as age, sex, so-called good and bad cholesterol levels, smoking history, family history and whether the patient has diabetes.
Drug-induced acute liver failure is uncommon, and over-the-counter medications and dietary and herbal supplements -- not prescription drugs -- are its most common causes, according to new research from the Perelman School of Medicine at the University of Pennsylvania. The findings are published in the current issue of Gastroenterology.
It's time to clear up the confusion and debunk the false reports surrounding the potentially serious health risks of Hormone Therapy.
An aggressive campaign to reduce the unnecessary use of antibiotics has helped cut the rate of infection with a dangerous drug-resistant bacteria at The Valley Hospital in Ridgewood, NJ, by nearly 40 percent.
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