Will Coffee Let Patients Go Home Faster After Surgery?
Diseases of the Colon and Rectum JournalThe much-talked-about "Coffee Study" is featured in the August 2019 issue of the medical journal Diseases of the Colon and Rectum.
The much-talked-about "Coffee Study" is featured in the August 2019 issue of the medical journal Diseases of the Colon and Rectum.
A study of patients' gut bacteria highlights likely reasons behind the pandemic spread of resistant E. coli strains, and the need to re-think the clinical significance of bacteria in the urine without symptoms, because treatment-resistant strains can be highly pathogenic to the urinary system.
Scientists have known that bacteria in the gut, along with environmental and genetic factors, contribute to the debilitating intestinal ailment of Crohn’s disease (CD). But in 2016, Mahmoud A Ghannoum, PhD, FAAM, FIDSA, professor and director of the Center for Medical Mycology at Case Western Reserve School of Medicine and University Hospitals Cleveland Medical Center, was the first to identify a specific fungus in humans that interacted with bacteria in the development of the disease. Now, to learn precisely how that fungus interacts with bacteria to trigger CD, Ghannoum has received a five-year, $3M grant from the National Institutes of Health. His investigation will involve innovative molecular and cellular technologies, to delete specific genes in the fungus and note the effects on the inflammation that is a marker for CD using powerful microscopic analysis.
Targeting medical treatment to an ailing body part is a practice as old as medicine itself. A Band-Aid is placed on a skinned knee. Drops go into itchy eyes. A broken arm goes into a cast.
A specific class of bacteria from the gut prevents mice from becoming obese, suggesting these same microbes may similarly control weight in people, a new study reports. The beneficial bacteria, called Clostridia, are part of the microbiome — collectively trillions of bacteria and other microorganisms that inhabit the intestine. University of Utah Health investigators led the study which publishes online in the journal Science on July 25.
A Phase II clinical trial led by MD Anderson found that treatment with the FGFR inhibitor erdafitinib was effective in 40% of patients with metastatic bladder cancers marked by FGFR3 mutations. The trial results led to FDA approval of the drug.
A research team led by Tufts University engineers has developed a 3D printed pill that samples bacteria found in the gut -- known as the microbiome -- as it passes through the gastrointestinal tract (GI). The ability to profile bacterial species throughout the GI tract could have important implications for the diagnosis and treatment of many diseases.
Getting up close – and a little dirty – with farm animals just might help us fend off illness, say researchers who’ve further demonstrated the benefits of early exposure to a wide variety of environmental bacteria.
A new spectroscopic technique reveals that glucose use in live cells provides valuable information about the functional status of cells, tissues, and organs. Shifts in a cell’s use of glucose can signal changes in health and progress of disease.
Having healthy gut flora – the trillions of bacteria housed in our intestines – could lower the risk of infection following knee and hip replacement surgeries, while an unhealthy intestinal flora may increase the risk of infection.
Johns Hopkins Kimmel Cancer Center study coauthors Anne Marie Lennon, Simeon Springer, Marco Dal Molin, Christopher Wolfgang and Bert Vogelstein will participate in a press teleconference organized by the American Association for the Advancement of Science at 11 a.m. Tuesday, July 16. To RSVP, send an email to [email protected]. An audio recording and transcript will be available on the MedPak webpage (eurekalert.org/journls/scitransmed/) at the end of the teleconference.
Results suggest some forms of PD are an autoimmune disease triggered years before noticeable symptoms
Scientists created human pancreas on a chip that allowed them to identify the possible cause of a frequent and deadly complication of cystic fibrosis (CF) called CF-Related Diabetes, or CFRD. It may be feasible to also use the small two-chambered device, which features bioengineered human pancreatic organoids to study the causes of non-CF-related conditions such as type 1 and 2 diabetes, according to researchers who report findings in Nature Communications.
A new large-scale genome-wide association study published in Nature Genetics, has identified eight genetic variants significantly associated with anorexia nervosa; and the research shows that the origins of this serious disorder appear to be both metabolic and psychiatric.
A new study finds that trends in colonoscopy rates did not fully align with the increase in colorectal cancer (CRC) in younger adults
Findings published today in the journal Science Translational Medicine suggest that a type of white blood cell called tumor associated macrophages that have been deceived by pancreatic cancer cells into not attacking them can be “reprogrammed” by a specially designed molecule that activates a protein found on their surfaces.
A new type of therapeutic food, specifically designed to repair the gut microbiomes of malnourished children, is superior to standard therapy in an initial clinical trial conducted in Bangladesh.
Nearly ten years ago, a group of Israeli clinical researchers emailed Berkeley Lab geneticist Len Pennacchio to ask for his team’s help in solving the mystery of a rare inherited disease that caused extreme, and sometimes fatal, chronic diarrhea in children.
The males of one species of butterfly are more attracted to females that are active, not necessarily what they look like, according to a recent research conducted at Augustana University.The paper, “Behaviour before beauty: Signal weighting during mate selection in the butterfly Papilio polytes,” found that males of the species noticed the activity levels of potential female mates, not their markings.
The three-drug combination of encorafenib, binimetinib and cetuximab significantly improved overall survival (OS) in patients with BRAF-mutated metastatic colorectal cancer (mCRC), according to results of the BEACON CRC Phase III clinical trial led by researchers at The University of Texas MD Anderson Cancer Center.
Scientists at McMaster University have identified new biomarkers for Irritable Bowel Syndrome (IBS) in urine, which could lead to better treatments and reduce the need for costly and invasive colonoscopy procedures currently used for diagnosis.
A small chemical change – shifting the position of two hydrogen atoms – makes the difference between mice that are healthy and mice with insulin resistance and fatty liver, major risk factors for diabetes and heart disease. Making the change prevented the onset of these symptoms in mice fed a high-fat diet and reversed prediabetes in obese mice. The finding highlights the role of ceramides in metabolic health and pinpoints a “druggable” target that could be used to develop new therapies for metabolic disorders.
Researchers at Washington University School of Medicine in St. Louis and Rush University in Chicago have found a compound that promotes a vigorous immune assault on pancreatic cancer. The findings, in mice, suggest a way to improve immunotherapy for the deadly disease in patients.
Researchers have discovered two distinct subtypes of pancreatic neuroendocrine tumors – known as pNETs – that have dramatically different risks of recurrence following surgical treatment [or surgery]. The finding could yield predictive tests, ease anxiety in patients whose tumors are found to be unlikely to recur, while focusing vigilant follow-up monitoring on patients with pNETs having a higher rate of recurrence.
An adequate consumption of milk and dairy products at different life stages can help prevent various chronic diseases.
成人确诊乳糜泻时常伴有营养缺乏,包括维生素B12和D的缺乏,以及叶酸、铁、锌和铜的缺乏。根据Mayo Clinic研究人员开展的一项研究,此时应补充这些缺乏的营养。
A Rutgers-led study sheds light on one of the most enduring mysteries of science: How did metabolism – the process by which life powers itself, by converting energy from food into movement and growth – begin? To answer that question, the researchers reverse-engineered a primordial protein and inserted it into a living bacterium, where it successfully powered the cell’s metabolism, growth and reproduction, according to the study in Proceedings of the National Academy of Sciences.
Doctors know that screening for colorectal cancer reduces mortality. However, more than one-third of age-eligible Americans go unscreened every year even though colon cancer remains the second leading cause of cancer death in the United States.
Researchers at the Johns Hopkins Kimmel Cancer Center, the Greenberg Bladder Cancer Institute, the Bloomberg~Kimmel Institute for Cancer Immunotherapy, the Brady Urological Institute, and the Center for Computational Genomics at Johns Hopkins have received a $3.2 million grant from the National Institutes of Health to study new treatment options for early-stage bladder cancer.
يكون نقص التغذية عرضًا شائعًا لدى البالغين في وقت تشخيص الداء البطني، ويشمل ذلك نقص الفيتامينين ب-12 ود، وكذلك حمض الفوليك والحديد والزنك والنحاس. وينبغي معالجة هذا النقص في ذلك الوقت، وفقًا لدراسة أعدها باحثون من Mayo Clinic.
A study led by researchers at the Johns Hopkins Bloomberg School of Public Health found that individuals reported more gastrointestinal bloating when they ate a diet high in salt.
In experiments in mice, Johns Hopkins Medicine researchers say they have found additional evidence that Parkinson’s disease originates among cells in the gut and travels up the body’s neurons to the brain. The study, described in the June issue of the journal Neuron, offers a new, more accurate model in which to test treatments that could prevent or halt Parkinson’s disease progression.
New NCCN Guidelines for Patients: Bladder Cancer explains the lengthy surveillance process that follows active treatment for the sixth most-common cancer in the United States.
En el momento de diagnosticar la enfermedad celíaca entre los adultos, es común encontrar deficiencias nutricionales, tales como de vitamina B12, vitamina D, folato, hierro, zinc y cobre.
Metabolomics, the study of small molecules the body produces during metabolism (metabolites) may be a future key to identifying diabetes-related kidney disease. The finding will be presented today at the American Physiological Society (APS)/American Society of Nephrology (ASN) conference, Control of Renal Function in Health and Disease, in Charlottesville, Va.
Micronutrient deficiencies, including vitamins B12 and D, as well as folate, iron, zinc and copper, are common in adults at the time of diagnosis with celiac disease. These deficiencies should be addressed at that time, according to a study by Mayo Clinic researchers.
Researchers at Washington University School of Medicine in St. Louis have figured out how to grow the intestinal parasite Cryptosporidium in the lab, an achievement that will speed efforts to treat or prevent diarrhea caused by the parasite.
Scientists at Cincinnati Children’s Hospital Medical Center have identified an expression pattern of 14 genes at the time of diagnosis that predicts two year, transplant-free survival in children with biliary atresia – the most common diagnosis leading to liver transplants in children. The researchers also found that the antioxidant N-acetyl-cysteine (NAC) reduced liver injury and fibrosis (excess fibrous connective tissue) in mice with biliary atresia and increased survival times.
An increasing number of studies are finding intimate communication between the gut and brain, as well as complex interplay among the gut microbiome, the brain and the rest of the body. But does the gut affect epilepsy? More specifically, can certain populations of bacteria predispose to seizures, and can we harness the power of the microbiome to stop seizures?
Intermountain Healthcare and deCODE genetics have announced a major global collaboration and study focused on discovering new connections between genetics and human disease that will involve the collection of half a million DNA samples.
An unhealthy, inflamed gut causes breast cancer to become much more invasive and spread more quickly to other parts of the body, new research from the University of Virginia Cancer Center suggests.
تُعد الدراسات الجديدة حول الكشف المبكر عن سرطان القولون والمستقيم ونوعية تأثير الحياة للمعالجة بالخلايا من بين العروض التقديمية العديدة التي تقدمها Mayo Clinic في الاجتماع السنوي للجمعية الأمريكية لعلم الأورام السريري في شيكاغو.
A new study has found that not sticking to a regular bedtime and wakeup schedule--and getting different amounts of sleep each night--can put a person at higher risk for obesity
A multicenter team led by investigators at Washington University School of Medicine in St. Louis has taken a big step toward identifying the cysts likely to become cancerous. Testing fluid from cysts for a biomarker — an antibody called mAb Das-1 — the researchers were able to identify pancreatic cysts likely to become cancerous with 95 percent accuracy.
Entre varias presentaciones que Mayo Clinic hace durante la reunión anual de la Sociedad Americana de Oncología Clínica en Chicago, están estudios nuevos sobre la detección temprana del cáncer colorrectal y la repercusión de la terapia celular sobre la calidad de vida.
Treatment with the drug olaparib significantly reduced the risk of disease progression or death from metastatic pancreatic cancer, according to findings from the recently completed, international, phase-III POLO (Pancreas cancer OLaparib Ongoing) trial.
There are no approved treatment options for patients with advanced bladder cancer after standard chemotherapy and immune treatments, but the results of a phase II clinical trial led by Yale Cancer Center and Smilow Cancer Hospital researchers demonstrates an effective treatment for this deadly disease.
New studies on early detection of colorectal cancer and the quality-of-life impact of cell therapy are among several Mayo Clinic presentations at the American Society of Clinical Oncology annual meeting in Chicago.
A study from researchers at Washington University School of Medicine in St. Louis and Veterans Affairs St. Louis Health Care System has linked long-term use of drugs known as proton pump inhibitors (PPIs) to fatal cases of cardiovascular disease, chronic kidney disease and upper gastrointestinal cancer. The researchers found that such risks increase with the duration of PPI use, even when taken at low doses.
Mayo Clinic的研究人员与国际专家一起在2019年消化疾病周会议(Digestive Disease Week 2019)上发布研究结果,该疾病周是世界上最大的胃肠病学和相关领域的医生、研究人员和行业领导者的聚会。