While cancer treatment advances are being made in precision medicine and immunotherapy, a unique combination of traditional therapies can also provide some patients benefit. A Rutgers Cancer Institute of New Jersey expert shares more about an approach combining cytoreductive surgery and hyperthermic chemotherapy for cancers that have spread to the abdominal cavity.
International Genetic Study Identifies Gene Associated with Crohn’s Disease
Paul E. Oberstein, MD, a nationally renowned clinician-scientist, will join NYU Langone Health and its Perlmutter Cancer Center on March 1 as director of Gastrointestinal (GI) Medical Oncology and assistant director of its recently established Pancreatic Cancer Center.
Patients with an inherited form of colon cancer harbor two bacterial species that collaborate to encourage development of the disease, and the same species have been found in people who develop a sporadic form of colon cancer, a study led by a Johns Hopkins Bloomberg~Kimmel Institute for Cancer Immunotherapy research team finds.
Nurhan Torun, MD, an accomplished ophthalmologist internationally recognized for her expertise in ocular motility disorders, has been named Chief of Ophthalmology in the Department of Surgery at Beth Israel Deaconess Medical Center (BIDMC).
Mesenteric ischemia and infarction (MI) are infrequent but often deadly conditions in acute and critically ill patients, with a mortality rate of 50 to 60 percent. By considering the uncommon diagnosis in patient assessment and evaluation, nurses can help identify patients at risk more quickly so appropriate diagnostics and interventions may ensue.
Brant’s hire establishes Rutgers as one of the six IBD Genetics Consortium centers.
In breakthrough colon cancer research, scientists at Christiana Care Health System’s Center for Translational Cancer Research (CTCR) of the Helen F. Graham Cancer Center & Research Institute have discovered that over-expression of HOXA4 and HOXA9 genes in colon cancer stem cells promotes cell replication and contributes to the overpopulation of stem cells that drives colon cancer development. The findings suggest treatment with vitamin A derivatives, called retinoid drugs, could provide a therapeutic strategy for decreasing the expression of these HOX genes and for targeting highly resistant cancer stem cells.
“See every obstacle as an opportunity in life.” That’s just some of the advice packed into a new campaign by Fight Colorectal Cancer featuring Texas Rangers third-base coach Tony Beasley.
Although the incidence of appendicitis in the United States has been in decline for many years, the condition still affects approximately seven percent of Americans annually.
Colorectal and bariatric surgery patients benefited from an enhanced recovery after surgery (ERAS) program, leaving the hospital sooner and requiring fewer opioids to control pain, according to new research presented at the American Society of Anesthesiologists PRACTICE MANAGEMENT 2018 meeting.
Leaders from the community and health system celebrate with ribbon cutting and open house.
UCLA scientists found that boosting mice's cholesterol levels spurred intestinal stem cells to divide more quickly, enabling tumors to form faster. The study identifies a new drug target for colon cancer treatment.
A newly discovered family of viruses appears to play a major role in killing marine bacteria and maintaining the ocean’s ecology. Preliminary evidence suggests that related bacterial viruses also occur in the human gut. The study, by researchers at Albert Einstein College of Medicine and Massachusetts Institute of Technology (MIT), was published online today in the journal Nature.
Women who have polycystic ovary syndrome (PCOS), a common hormone condition that contributes to infertility and metabolic problems, such as diabetes and heart disease, tend to have less diverse gut bacteria than women who do not have the condition, according to researchers at University of California San Diego School of Medicine, in collaboration with colleagues at Poznan University of Medical Sciences in Poland and San Diego State University.
Women who have a common hormone condition that contributes to infertility and metabolic problems tend to have less diverse gut bacteria than women who do not have the condition, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
FIT tests, or fecal immunochemical tests, are noninvasive and simple to collect in the privacy of one's own home, with no dietary or medical restrictions. But just how accurate are these new FIT tests? That’s what faculty at Texas Tech University Health Sciences Center El Paso (TTUHSC El Paso) and a team of scientists from across the U.S. hope to find out in a new study.
A CSU Northridge microbial ecologist and his students are investigating a gut bacteria that may affect weight gain and obesity.
In the February 2018 issue of Diseases of the Colon & Rectum, researchers from Denmark discuss their findings involving women with endometriosis who are not responding to hormonal treatment. If hormonal treatments are unsuccessful, surgery is often recommended. However, there has been controversy as to which type of surgery is best. Endometriosis experts from Denmark share the results of a large study of women who underwent laparoscopic colorectal resection for endometriosis not responding to hormonal treatment.
Researchers at UT Southwestern’s Simmons Cancer Center have shown that RAS molecules act in pairs, known as dimers, to cause cancer, findings that could help guide them to a treatment.
A groundbreaking report, led by Professor Mark Lawler, Chair in Translational Cancer Genomics at Queen’s University Belfast highlights a plan to end bowel cancer, the second most common cause of cancer death in Europe. The report has been published in the January edition of top international journal Gut (http://gut.bmj.com/).
A new study shows how stress accelerates pancreatic cancer development. Beta-blockers, which block stress hormones, may increase survival for patients with the disease.
A Michigan State University researcher is providing new insight into how certain types of stress interact with immune cells and can regulate how these cells respond to allergens, ultimately causing physical symptoms and disease.
The “Putting Patients First” issue of The American Journal of Gastroenterology is an entire issue of the College’s flagship journal dedicated to patient-reported outcomes.
UT Southwestern Medical Center researchers have used precision editing of the bacterial populations in the gut to prevent or reduce the severity of inflammation in a mouse model of colitis.
Mayo Clinic researchers show that hysterectomy with ovarian conservation is associated with a significantly increased risk of several cardiovascular diseases and metabolic conditions. The findings are published in Menopause.
Researchers identified a new, more sensitive screening test to recognize Pompe disease, a metabolic disorder affecting cellular processing of glycogen in numerous tissues of the body.
A new study published in Nature Communications and led by University of Kentucky Markey Cancer Center researcher Qing-Bai She identifies biomarker targets that may make existing drugs more effective in fighting certain cancers.
New recommendations, led by experts at the University of Birmingham, have been published to improve the use of liver blood tests.
New study, published in the American Journal of Surgery, highlights the prevalence of ED cancer diagnoses; calls for new screening methods.
Further enhancing a commitment to cutting-edge clinical research efforts, Rutgers Cancer Institute of New Jersey and RWJBarnabas Health are welcoming Howard S. Hochster, MD, an internationally recognized leader in the development of cancer clinical trials and early phase cancer drugs.
The scientists hope understanding how immune cells adapt as they enter different tissues will spur the design of better, more specific, medicines.
SEATTLE – (Dec. 18, 2017) –Virginia Mason has become the first health system in Washington state to begin a new therapy that targets neuroendocrine tumors, an uncommon cancer that affects the intestines, pancreas, lungs and other parts of the body.
Small bacterial infections that may go unnoticed and which the body easily clears without treatment, such as occurs during mild food poisoning, nevertheless can start a chain of events that leads to chronic inflammation and potentially life-threatening colitis.
Being over ideal body weight has known risks with respect to heart and blood pressure problems, but the list is growing! In the January issue of Diseases of the Colon & Rectum, researchers from Seoul, Korea, studied nearly 3000 patients undergoing routine physicals over a 6-year period. The authors refer to a fatty liver index. fatty liver index > or equal to 30 was associated with an increased risk of having colon polyps (odds ratio 1.26; 95% confidence interval 1.06-1.49). Thirty-six percent of patients with a fatty liver index > or equality to 30 has colon polyps as compared to 27% of patients with a fatty liver index < 30. This high fatty liver index group also had more polyps, and they were more frequently in the upper colon. One more reason to work on losing those extra pounds!
Genentech researchers have identified an enzyme that shifts pancreatic cancer cells to a more aggressive, drug-resistant state by epigenetically modifying the cells’ chromatin. The study, which will be published December 11 in the Journal of Cell Biology, suggests that targeting this enzyme could make pancreatic cancer cells more vulnerable to existing therapies that currently have only limited effect against this deadly form of cancer.
Countries in Africa, Asia, the Middle East and South America have seen a rise in incidence of inflammatory bowel disease as they have become increasingly industrialised and westernised, a new study has found.
DNA sequences between mitochondria within a single cell are vastly different, found researchers. This knowledge will help to better illuminate the underlying mechanisms of many disorders that start with accumulated mutations in individual mitochondria and provide clues about how patients might respond to specific therapies.
Overcoming a major hurdle in microbiome research, scientists have developed a method to elucidate cause-effect relationships between gut bacteria and disease. The approach could help identify disease-modulating microbes and open doors to precision-targeted therapies derived from microbial molecules.
Fight Colorectal Cancer (Fight CRC) and the Cancer Research Institute (CRI) are proud to announce “A Blueprint to Advance Colorectal Cancer Immunotherapies”
Social group membership is the most important factor in structuring gut microbiome composition, even when considering shared diet, environment and kinship, according to research on lemurs at The University of Texas at Austin.
正在成为个体化医疗的重要组成部分。 微生物群落有助于改良诊断，及早发现和治疗疾病，并降低疾病风险。 Mayo Clinic的研究人员在最新一期的医学杂志Mayo Clinic Proceedings上发表了一篇综述来介绍其重要性。
ROCHESTER, Minn. – In the latest issue of Mayo Clinic Proceedings, Mayo Clinic researchers reviewed the importance of the microbiome as a key component of personalized medicine to improve diagnosis, reduce disease risk and optimize early detection and treatment. The microbiome is the combined genetic material of the microorganisms in a particular environment.
New findings uncover the mechanisms by which gut bacteria can trigger inflammation in the brain and contribute to multiple sclerosis
The traits we inherit from our family define and connect us in countless ways. Sometimes these traits are obvious, like curly hair or dimples. But sometimes what we inherit remains hidden, like BRCA gene mutations. With the help of celebrities like actress Cobie Smulders, star of television comedy series How I Met Your Mother and in the Marvel Cinematic Universe, the Basser Center for BRCA launched a video and social media campaign—with the hashtag #invisiblegenes—in the hopes that it will highlight illnesses that can be prevented or treated with early detection.
Elevated pathogen colonization and a lack of bacterial diversity in the mouth were identified in people with precancerous lesions that could precede stomach cancer, finds a new study led by New York University College of Dentistry and New York University School of Medicine.
Exposure to antibiotics in mothers may increase risk for inflammatory bowel diseases in their offspring.
PHILADELPHIA—Anil K. Rustgi, MD, chief of the division of Gastroenterology and T. Grier Miller Professor of Medicine and Genetics, and Hongzhe Li, PhD, a professor of biostatistics in Biostatistics and Epidemiology, both at the Perelman School of Medicine at the University of Pennsylvania, have been named fellows of the American Association for the Advancement of Science, the world’s largest general scientific society and publisher of the journal Science.
Rutgers Cancer Institute of New Jersey, Rutgers Health, and University Hospital have committed to increasing colorectal cancer screening across New Jersey by joining a national effort with the American Cancer Society in the fight against this disease.
An investigator at Children’s Hospital Los Angeles, has been awarded $1.5 million by the National Institute of Diabetes and Digestive and Kidney Diseases of the NIH for the study of tumor necrosis factor (TNF) and its role in inflammatory bowel disease (IBD).
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