Researchers from Sanford Burnham Prebys and the Chinese University of Hong Kong have developed a computational approach to predict whether a person with type 2 diabetes will develop kidney disease. The findings could help doctors prevent or better manage kidney disease in people with type 2 diabetes.
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.
Many people have experienced infections from E. coli, which are primarily seen as inconvenient and unpleasant. For some patients, like those with blood cancer, however, there is a risk that the bacteria will travel into the bloodstream.
Fitterfly’s diabetes digital therapeutics program shows real-world effectiveness in improving glycemic control and weight management among people with type 2 diabetes mellitus
The Kathryn F. Kirk Center for Comprehensive Cancer Care and Women’s Cancers is a major expansion of Huntsman Cancer Institute, designed with the most advanced cancer care expertise and technology.
En Cedars-Sinai, hay otra gran razón para donar sangre: lo que muchos consideran la parte más dolorosa del proceso—la punción en el dedo de una aguja para medir el nivel de hemoglobina—ya tiene otra opción.
AACC has issued expert guidance on clinical testing for procalcitonin, a blood marker that helps detect serious bacterial infections and sepsis. By giving clinicians and laboratory professionals much-needed clarity on how to best use procalcitonin tests, the new guidelines could improve the treatment of critically ill patients and those with certain lower respiratory infections.
In a study of 17 people from five families, Johns Hopkins Medicine researchers say they found that ultra-lengthy DNA endcaps called telomeres fail to provide the longevity presumed for such people. Instead, people with long telomeres tend to develop a range of benign and cancerous tumors, as well as the age-related blood condition clonal hematopoiesis.
Glucocorticoid therapy is widely used during pregnancies at risk of premature delivery to promote fetal lung maturation. While it is an effective treatment, it can also trigger heart and blood vessel problems. New research published in The FASEB Journal uncovers the mechanisms behind the cardiovascular-related effects of the most commonly used glucocorticoids, Dexamethasone (Dex) and Betamethasone (Beta).
A new study from Washington University School of Medicine in St. Louis suggests that some dangerous bloodstream infections in premature infants may be caused by strains of bacteria already lurking in their gut microbiomes.
Left ventricular conduction disease occurs when there is an electrical blockage of the heart’s normal electrical conduction system. Treatment to lessen its effects involves implanting a permanent pacemaker, but there have been no proven preventive strategies for this condition. In a study publishing May 3, 2023 in JAMA Cardiology, first author Emilie Frimodt-Møller, MD, and senior author Gregory Marcus, MD, MAS, found that intensive BP control is associated with lower risk of left ventricular conduction disease, indicating left ventricular conduction disease may be preventable.
In observance of National STOP THE BLEED® Month in May, the American College of Surgeons (ACS) continues to pioneer efforts to educate and empower the public to learn simple bleeding control techniques that can save a life.
When Russia’s War on Ukraine began, individuals around the world mobilized to support the Ukrainian people. Among those offering help is a group from Michigan Medicine’s Max Harry Weil Institute for Critical Care Research and Innovation.
A new approach to the genetic engineering of cells promises significant improvements in speed, efficiency, and reduction in cellular toxicity compared to current methods. The approach could also power the development of advanced cell therapies for cancers and other diseases, according to a study from researchers in the Perelman School of Medicine at the University of Pennsylvania.
Multiple myeloma is a rare blood cancer caused by the uncontrolled multiplication of abnormal plasma cells. These plasma cells are a special type of white blood cells that play an important role in the immune system by producing essential antibodies in the bone marrow and lymph nodes.
A research team from Wake Forest University School of Medicine has developed an open-source, web-based application that allows users to generate customized hypertension statistics using National Health and Nutrition Examination Survey (NHANES) data.
Safer and more effective blood thinners could be on the way following a groundbreaking discovery by researchers at UBC and the University of Michigan, published today in Nature Communications.
New research suggests that even mild cases of COVID-19 can have long-term detrimental effects on cardiovascular health. The study was the first to compare pre and post COVID-infection levels of arterial stiffness; a marker associated with the ageing and function of our arteries.
The FLASH (FlowTriever All-Comer Registry for Patient Safety and Hemodynamics) study results were published recently in EuroIntervention, the journal of the European Association of Percutaneous Coronary Interventions, with interim results published earlier in 2022 in Catheterization & Cardiovascular Interventions.
In Physics of Fluids, researchers model the behavior of blood drops during secondary atomization to examine how the phenomenon affects a crime scene. The team examined different starting droplet sizes, confirming their model with experiments. They found the effect of secondary atomization was significant and predictable: The smaller droplets were easier to sweep up by the firearm’s gases and turn around toward the victim. This discovery could explain how a short-range shooter might stay clean from blood stains.
A federal grant to study treatment resistance in certain lymphoma patients, new research showing rogue Natural Killer cells are present in an aggressive breast cancer and likely promote tumor progression, a National Cancer Institute grant to study the role opioids may play in breast cancer, and leading blood cancer experts worldwide presented research advances at the recent Miami Leukemia Symposium are highlighted in this month’s tip sheet from Sylvester Comprehensive Cancer Center.
Researcher will discuss the study which involved a sleeping aid known as suvorexant that is already approved by the Food and Drug Administration (FDA) for insomnia, hints at the potential of sleep medications to slow or stop the progression of Alzheimer’s disease.
Children with acute lymphoblastic leukemia (ALL) who live in extreme poverty and were undergoing maintenance therapy faced an almost two-fold greater risk of relapse compared with kids who weren’t as poor, according to a study published in today’s issue of Blood.
In the journal Angewandte Chemie, a research team has now introduced a novel insulin formulation that can be switched on by glucose: Lipid nanoparticle carriers release more or less insulin depending on the blood sugar level.
Tisch Cancer Center scientists have developed unique models of the deadliest blood cancer, acute myeloid leukemia (AML), creating a transformative resource to study this cancer and eventually its drug response and drug resistance. The models were described in a late-breaking abstract at the annual meeting of the American Association of Cancer Research and simultaneously published in Blood Cancer Discovery, a journal of the American Association for Cancer Research.
Indiana University Melvin and Bren Simon Comprehensive Cancer Center served as the lead site for a promising first-in-human clinical trial for patients with relapsed multiple myeloma. Patients treated with higher doses of the immunotherapy called REGN5459 resulted in a 90.5 percent overall response rate.
Researchers have made huge strides in ensuring that red blood cell substitutes – or artificial blood – are able to work safely and effectively when transfused into the bloodstream.
Scientists at St. Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard showed how prime editing can correct mutations that cause sickle cell disease in a potentially curative approach.
An international phase 3 clinical trial led by physicians at Washington University School of Medicine in St. Louis has shown that the investigational drug motixafortide — when combined with the standard therapy for mobilizing stem cells — significantly increases the number of stem cells that can be harvested, compared with treatment with the standard agent alone.
Patients with sickle cell disease (SCD) who undergo total knee replacement are at higher risk for complications than non-SCD patients, according to a large-scale, retrospective study by researchers from UT Southwestern Medical Center and the University of Calgary. The study was published in Archives of Orthopaedic and Trauma Surgery.
There is a need for new drugs. For example, many of the antibiotics that we have been using for a long time are becoming less effective. Chemists and pharmaceutical scientists are frantically searching for new active substances, especially those that can penetrate cell membranes, as these are the only ones that patients can take orally in the form of a tablet or syrup.
A large clinical trial of more than 8,700 patients published in the New England Journal of Medicine concluded that the sex of a donor has no effect on the survival of recipients of red blood cell transfusions.
Mayo Clinic has made significant strides biomanufacturing early-stage therapeutics. The focus is on new medicines derived from the human body, called biotherapeutics, which are shaping the future of medicine.
An international coalition of biomedical researchers co-led by Alexander Bick, MD, PhD, at Vanderbilt University Medical Center has determined a new way to measure the growth rate of precancerous clones of blood stem cells that one day could help doctors lower their patients’ risk of blood cancer. The technique, called PACER, led to the identification of a gene that, when activated, drives clonal expansion.
The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. This special edition features presentations by MD Anderson researchers at the American Association for Cancer Research (AACR) Annual Meeting 2023.
St. Jude Children’s Research Hospital scientists developed a combination therapy for a leukemia subtype harboring rearrangements in the KMT2A gene. The approach overcomes the cancer’s drug resistance, without adding toxicity. The study appears in Proceedings of the National Academy of Science.