Researchers at the Georgia Institute of Technology have created a new type of origami that can morph from one pattern into a different one, or even a hybrid of two patterns, instantly altering many of its structural characteristics.
Using CRISPR gene editing, a research team has thwarted a lethal lung disease, in an animal model, in which a harmful mutation causes death within hours after birth. This proof-of-concept study showed that in utero editing could be a promising new approach for treating lung diseases before birth.
Researchers used CRISPR gene editing to thwart a lethal lung disease in an animal model in which a harmful mutation causes death within hours after birth. This proof-of-concept study showed that in utero editing could be a promising new approach for treating lung diseases before birth.
Artificial intelligence approach predicts the 3D structure of proteins based on its amino acid sequence
Scientists from Sanford Burnham Prebys have uncovered a molecular signaling pathway involving Stat3 and Fam3a proteins that regulates how muscle stem cells decide whether to self-renew or differentiate—an insight that could lead to muscle-boosting therapeutics for muscular dystrophies or age-related muscle decline. The study was published in Nature Communications.
Two proteins that bind to stress hormones work together to maintain a healthy heart in mice, according to scientists at the National Institutes of Health and their collaborators. These proteins, stress hormone receptors known as the glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), act in concert to help support heart health.
Researchers at the McKelvey School of Engineering have received funding to to engineer microbes that create an underwater adhesive based on, but stickier than, the natural adhesive made by mussels.
A novel type of body awareness training helps women recover from drug addiction, according to new research from the University of Washington. People in the study made marked improvement, and many improvements lasted for a year.
In a new article in JNCI reporting the first known prognostic marker for triple-negative breast cancer, researchers provide evidence that a widely used breast cancer drug, tamoxifen, may be effective against this notoriously aggressive disease subtype.
First major multisite randomized controlled trial of a workplace wellness program shows mixed results at 18 months Program led employees to increase exercise and improve weight-management habits, but it had no effect on health outcomes Program did not improve worker absenteeism, tenure or job performance Program did not reduce employees’ use of health care services or health care spending in the short term
Using liquid in a solid-state NMR experiment, UC San Diego researchers show which parts of a protein are involved in the formation of the jelly-like state and that other nuclear components can modulate the jelly state, providing a way to regulate how and where it forms.
Hematology researchers have further refined how a treatment currently used urgently to control bleeding in hemophilia patients holds promise for prevention as well. A study in animals may lead to a new therapy for patients who now develop antibodies to the standard maintenance treatment.
New algorithm successfully identifies patients with a tumor-fueling DNA repair defect found in multiple cancers and treatable with a common cancer drug.
Largest study to date uncovers the reality of young doctors’ lives in the hospital.
Reactive neurostimulation reduces seizure frequency by remodeling the brain, and early electrical signatures of this process could be used to accelerate and personalize treatment.
A gene that dictates which of three sexes a papaya tree will become could spur a leap in the ultra-nutritious crop’s production.
Working with human colon cancer cells and mice, researchers led by experts at the Johns Hopkins Kimmel Cancer Center say they have successfully blocked the activity of portions of a protein known as UHRF1 and restored the function of hundreds of cancer-fighting genes that became “misregulated” by the disease.
For decades, hospitals have worked to get staff to wash their hands and prevent the spread of germs. But a new study suggests they may want to expand those efforts to their patients, too. Fourteen percent of 399 hospital patients had “superbug” antibiotic-resistant bacteria on their hands or nostrils early in their hospital stay, and nearly a third of tests for such bacteria on objects that patients commonly touch came back positive.
University of California San Diego Department of Philosophy professor Manuel Vargas and Santiago Amaya of the Universidad de los Andes in Bogotá, Colombia have been awarded a $1.2 million grant from the John Templeton Foundation to advance understanding of agency, free will and responsibility — three interrelated concepts at the core of everyday life.
Gold atoms ski along boron nitride nanotubes and stabilize in metallic monolayers. The resulting gold quantum dots could be a promising material for future electronics and quantum computing.
A million Americans with injury or age-related disabilities need someone to help them eat. Now engineers have taught a robot to pick up food with a fork and gingerly deliver it to a person’s mouth.
Johns Hopkins Kimmel Cancer Center researchers say a new study of clusters of mouse cells known as “organoids” has significantly strengthened evidence that epigenetic changes, common to aging, play a essential role in colon cancer initiation. The findings show that epigenetic changes are the spark that pushes colon-cancer driving gene mutations into action, the researchers say.
In a recent University of California, Irvine-led study published in Nucleic Acids Research, a team of scientists described a catalog of 4489 putative mitochondrial DNA (mtDNA) deletions, including their frequency and relative read rate. This catalog comprises the first comprehensive database of mitochondrial deletions derived from human brain.
Nurse practitioners and nursing students can use local, real-time maps of opioid overdoses to inform their clinical work with adolescents in community health settings, finds new research from NYU Rory Meyers College of Nursing.
For decades, articles in research journals and the popular press alike have reported that being a family caregiver takes a toll on a person’s health, boosting levels of inflammation and weakening the function of the immune system. Now, after analyzing 30 papers on the levels of immune and inflammatory molecules in caregivers, Johns Hopkins researchers say the link has been overstated and the association is extremely small. Caregiver stress explains less than 1 percent of the variability in immune and inflammation biomarkers, they report. Their new meta-analysis was published March 10 in The Gerontologist.
Researchers have used a molecular “can opener” and advanced imaging to expose parts of the HIV envelope and reveal in detail a previously unknown virus shape with unique vulnerabilities that can be targeted by antibodies. This could open new directions for vaccine development.
In studies with lab-grown human cells and in mice, Johns Hopkins Medicine researchers have found that an experimental drug may be twice as good at fighting vision loss as previously thought.
Electricity harvested from the sun or wind can be used interchangeably with power from coal or petroleum sources. Or sustainably produced electricity can be turned into something physical and useful. Researchers in Arts & Sciences at Washington University in St. Louis have figured out how to feed electricity to microbes to grow truly green, biodegradable plastic, as reported in the Journal of Industrial Microbiology and Biotechnology.
Single-cell sequencing reveals 25 subpopulations of myeloid immune cells in lung cancer tumors. Many subpopulations are similar across humans and mice, supporting the use of mouse models in immunotherapy research. Findings set stage to assess myeloid cells as targets for new or improved immunotherapies.
Researchers have identified for the first time an imbalance in a key neural pathway that explains how some people reactivate negative emotional memories. The finding could help scientists unlock new ways to treat psychiatric disorders such as post-traumatic stress disorder.
Results of a small clinical trial suggest that supplementing chemotherapy with high doses of vitamin D may benefit patients with metastatic colorectal cancer by delaying progression of the disease, say scientists from Dana-Farber Cancer Institute.
New research from Washington University in St. Louis suggests that many "redundant" enzymes are actually specialists that ensure maximal growth across different environments. Further, these enzymes were found to increase E. coli’s resistance to antibiotics at low pH conditions, such as those found in the GI tract or urinary tract — raising concerns that current antibiotic susceptibility tests are inadequate.
New research points to a potential way to prevent acute liver damage, or even treat it -- as well as a possible way to better monitor the health of patients who have suffered from it. It's based on the discovery that a protein involved in one of the liver’s most basic functions also sounds the alarm when liver cells get hurt.
The molecular "scissors" known as CRISPR-Cas9 has transformed genetic research in recent years. Now, an international team has unveiled a new CRISPR-based tool that acts more like a shredder, able to wipe out long stretches of DNA in human cells with programmable targeting. It's based on Type I CRISPR-Cas3, which has been shown to work in human cells for the first time.
BIDMC's Cancer Center researchers identified a new pathway that offers promising targets for preventing lung tumor relapse.
The widely used CyberInfrastructure for Phylogenetic REsearch (CIPRES) science gateway, based at the San Diego Supercomputer Center (SDSC), has been awarded a one-year Internet2 grant funded by the NSF to give users AWS cloud access.
Using information from two national surveys, researchers from Johns Hopkins Medicine and the Guttmacher Institute have found that in some metropolitan areas, more than a quarter of young, African American men reported having sexual intercourse before age 13, and for about 45 percent of them, the sex was either unwanted or experienced with “mixed feelings.”
Engineers developed 3D printed metamaterials with unique optical properties going beyond what is possible using conventional materials. The fabrication methods developed by the researchers demonstrate the potential, both present and future, of 3D printing to expand the range of optical devices used in instrumentation and telecommunications.
Children with acute respiratory infections were prescribed antibiotics more often during direct-to-consumer telemedicine visits than during in-person primary care appointments or urgent care visits, according to UPMC Children’s Hospital of Pittsburgh research reported today in Pediatrics.
Marie Kondo herself couldn’t do it any better. Now researchers at Washington University in St. Louis have uncovered a previously unknown structural feature of living cells that is critical to tidying up.
High-resolution images capture previously unseen features of PDE6. Included among them were some very promising regions that resemble fish-hooks. These regions are responsible for controlling PDE activity. By targeting the fish-hook-like region with a new class of PDE inhibitors, drug development companies may be able to eliminate unwanted side effects of certain PDE targeting drugs.
Researchers from Washington University in St. Louis and the Donald Danforth Plant Science Center used a new imaging technique to reveal a takeover strategy that has worked for weedy rice over and over again: roots that minimize below-ground contact with other plants.
Scientists at Harvard Medical School and the Dana-Farber Cancer Institute have developed a method that exploits the multitargeted nature of a chemical inhibitor to pinpoint vulnerabilities within cancer cells.
These strange bacteria conduct electricity through a structure never before seen in nature -- a structure scientists can co-opt to miniaturize electronics, create powerful-yet-tiny batteries, build pacemakers without wires and develop a host of other medical advances.
Insulin triggers genome-wide changes in gene expression via an unexpected mechanism. The insulin receptor is transported from the cell surface to the cell nucleus, where it helps initiate the expression of thousands of genes. Targeted genes are involved in insulin-related functions and disease but surprisingly not carbohydrate metabolism. Findings outline a set of potential therapeutic targets for insulin-related diseases and establish a wide range of future avenues for the study of insulin signaling.
A study of pregnant women with systemic lupus erythematosus has identified early changes in the RNA molecules present in the blood that could be used to determine the likelihood of them developing preeclampsia. The study, which will be published April 8 in the Journal of Experimental Medicine, may also help researchers develop treatments to prevent other pregnancy complications associated with lupus, including miscarriage and premature birth.
The Institute for Genome Sciences (IGS) at the University of Maryland School of Medicine (UMSOM) was awarded $17.5 million from the National Institute of Allergy and Infectious Diseases (NIAID) to fund the IGS Genome Center for Infectious Diseases (GCID) for another five years.
Scientists have developed a novel fabrication method to create dyed threads that change color when they detect a variety of gases. Woven into clothing, smart, gas-detecting threads could provide a reusable, washable, and affordable safety asset in medical, workplace, military and rescue environments. The study describes the fabrication method and its ability to extend to a wide range of dyes and detection of complex gas mixtures.
In the years following bariatric surgery, a person’s overall eating behaviors and the amount of time spent watching television, playing video games and using a computer are a better indication of long-term weight loss success than specific weight control practices like counting calories.
More than 125 million people worldwide wear contact lenses, and while many are exposed to relatively common bacteria through their contact lenses, not all contract an eye infection. Researchers at the Case Western Reserve School of Medicine and University Hospitals (UH) Cleveland Medical Center will study whether a contact-wearer’s genetics may play a role in who does or doesn’t contract infection—especially Microbial keratitis (MK), a bacteria-caused infection of the cornea, which, if left untreated, can cause blindness.
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