The heart cannot regenerate muscle after a heart attack. Injecting heart muscle cells grown in vitro could help the failing heart, but engraftment rates are low. A new and simple method to improve the quality of the delivered cells has now been tested in mice, and it doubles the engraftment rate.
One out of four sepsis patients who survive their hospital stay have elevated levels of inflammation a year after discharge, and they are at higher risk for major health problems and death.
– Old lungs are not as capable as young lungs of fighting off an infection of the bacteria that causes tuberculosis (TB), placing seniors at a greater risk of developing TB. The microbe that causes this infectious disease, Mycobacterium tuberculosis (Mtb), currently kills more people in the world than any other pathogen. Texas Biomed researchers published an article in the Journal of Infectious Diseases in July 2019. The study details an experiment that took place in vitro (in the lab) and in vivo (in animals) that showed fluid in the lining of the lungs plays a big role in the elderly’s susceptibility to infection with the bacterium Mtb.
New research led by scientists at The Rockefeller University in New York may help explain why Zika virus infection causes birth defects in some children but not others. The study, which will be published August 14 in the Journal of Experimental Medicine, suggests that the risk of developing an abnormally small head (microcephaly) depends on the types of antibody produced by pregnant mothers in response to Zika infection.
Posting on social media, texting, and appearing in photos while high is prevalent among people who use drugs—and many regret these behaviors, according to a study by the Center for Drug Use and HIV/HCV Research (CDUHR) at NYU College of Global Public Health.
The University of Illinois at Chicago’s College of Nursing is partnering with Erie Family Health Centers on a $3.3 million grant for health care improvements in underserved communities.
Four biomedical research projects to improve the health of Virginians will be funded by the integrated Translational Health Research Institute of Virginia (iTHRIV), a Clinical Translational Science Award Hub.
A new analysis of data on more than 900 Baltimore adults by Johns Hopkins Medicine researchers has linked stressful life experiences among middle-aged women but not men to greater memory decline in later life.
Wenquan Zou, MD, PhD, an expert in prion and degenerative neurological diseases, has received a two-year grant for developing diagnostic tools for Alzheimer’s disease, Parkinson’s disease, and other related brain-based degenerative disorders via an innovative skin test that uses ultrasensitive technology. The new test is much less invasive than evaluating brain tissue, which is the only approach for making a definitive diagnosis today.
It nearly baffled researchers to see amino acids that make up life today link up under lab conditions that mimicked those of pre-life Earth. The result was predecessors to today's proteins. The researchers made it hard on the amino acids by adding non-biological competitors, but nature selected the life chemicals.
A blood test to detect the brain changes of early Alzheimer’s disease has moved one step closer to reality. Researchers from Washington University School of Medicine in St. Louis report that they can measure levels of the Alzheimer’s protein amyloid beta in the blood and use such levels to predict whether the protein has accumulated in the brain. The findings represent a key step toward a blood test to diagnose people on track to develop the devastating disease before symptoms arise.
Macrophages are white blood cells that accumulate in tumors, and aid cancer progression. Now scientists have identified a surface protein found only on the macrophages residing in tumors, exposing a target for precise tumor treatments.
More than 1 million sepsis survivors are discharged annually from acute care hospitals in the United States. Although the majority of these patients receive post-acute care (PAC) services, with over a third coming to home health care (HHC), sepsis survivors account for a majority of readmissions nationwide. Effective interventions are needed to decrease these poor outcomes.
Researchers from Roswell Park have developed a new bioinformatics-based approach for monitoring key changes in cancer cells — a data-driven method that might help to enhance and personalize cancer treatment.
A rare, short-lived population of immune cells in the bloodstream may serve as ‘periscopes’ to monitor immune status via lymph nodes deep inside the body.
A study from the University of Pittsburgh Graduate School of Public Health shows that using an estradiol patch was associated with accumulation of fat around the heart and worsening of coronary artery calcification.
Researchers mapped distinct bone marrow niche populations and their differentiation paths for the bone marrow factory that starts from mesenchymal stromal cells and ends with three types of cells — fat cells (adipocytes), bone-making cells (osteoblasts) and cartilage-making cells (chondrocytes).
Conservation tillage does not lower yield in modern cropping systems
More than a tenth of adults age 65 and older currently binge drink, putting them at risk for a range of health problems, according to a study by researchers at NYU School of Medicine and the Center for Drug Use and HIV/HCV Research (CDUHR) at NYU College of Global Public Health.
University of Detroit Mercy (Detroit Mercy) and Wayne State University’s (WSU) ReBUILDetroit program recently received a renewal grant of more than $19 million over five years from the National Institutes of Health (NIH). The ReBUILDetroit program works to encourage undergraduate students from underrepresented or economically disadvantaged backgrounds to pursue careers in biomedical research.
A wireless, wearable monitor built with stretchable electronics could allow comfortable, long-term health monitoring of adults, babies and small children without concern for skin injury or allergic reactions caused by conventional adhesive sensors with conductive gels.
Working with mouse and human tissue, Johns Hopkins Medicine researchers report new evidence that a protein pumped out of some — but not all — populations of “helper” cells in the brain, called astrocytes, plays a specific role in directing the formation of connections among neurons needed for learning and forming new memories.
The National Science Foundation has awarded the San Diego Supercomputer Center (SDSC) at UC San Diego a two-year grant worth almost $400,000 to deploy a new system called CC* Compute: Triton Stratus as an enhancement to the existing Triton Shared Computing Cluster (TSCC) campus High-Performance Computing (HPC) platform.
In their latest study, published in this week’s online issue of Proceedings of the National Academy of Sciences, researchers at La Jolla Institute for Immunology (LJI), reveal how the finely tuned balance between DNA methylation and demethylation prevents genomic instability and cancer.
For respiratory infections in children under 12, physicians are increasingly more likely to recommend antihistamines and less likely to recommend cough and cold medicines, a Rutgers study found. Antihistamines are widely used over-the-counter to treat various allergic conditions. However, these medicines have little known benefit for children with colds, and some older antihistamines cause sedation and occasionally agitation in children.
Researchers from Case Western Reserve University School of Medicine have developed a new combination treatment regimen that enhances the immune system’s ability to kill leukemias that do not respond to standard treatments. The regimen includes a therapeutic antibody designed to draw natural killer immune cells to cancer cells.
A team of engineers at Washington University in St. Louis has found what they believe is a more stable, less toxic semiconductor for solar applications, using a novel double mineral discovered through data analytics and quantum-mechanical calculations.
High blood pressure among children is on the rise and a lack of research about how to treat it has left pediatricians trying to make their best guess. That’s until researchers released results of a pioneering study that used a series of personalized trials to identify a preferred therapy for kids – the first step in tackling the problem.
A study of patients' gut bacteria highlights likely reasons behind the pandemic spread of resistant E. coli strains, and the need to re-think the clinical significance of bacteria in the urine without symptoms, because treatment-resistant strains can be highly pathogenic to the urinary system.
Scientists have known that bacteria in the gut, along with environmental and genetic factors, contribute to the debilitating intestinal ailment of Crohn’s disease (CD). But in 2016, Mahmoud A Ghannoum, PhD, FAAM, FIDSA, professor and director of the Center for Medical Mycology at Case Western Reserve School of Medicine and University Hospitals Cleveland Medical Center, was the first to identify a specific fungus in humans that interacted with bacteria in the development of the disease. Now, to learn precisely how that fungus interacts with bacteria to trigger CD, Ghannoum has received a five-year, $3M grant from the National Institutes of Health. His investigation will involve innovative molecular and cellular technologies, to delete specific genes in the fungus and note the effects on the inflammation that is a marker for CD using powerful microscopic analysis.
A specific class of bacteria from the gut prevents mice from becoming obese, suggesting these same microbes may similarly control weight in people, a new study reports. The beneficial bacteria, called Clostridia, are part of the microbiome — collectively trillions of bacteria and other microorganisms that inhabit the intestine. University of Utah Health investigators led the study which publishes online in the journal Science on July 25.
A report from St. Jude Children’s Research Hospital links inherited mutations in the BRCA2 gene with an increased risk of developing non-Hodgkin lymphoma in children and adolescents. The work appears as an advance online publication today in JAMA Oncology.
A team of scientists have designed and tested in mice a novel and promising therapeutic strategy for treating Lafora Disease (LD), a fatal form of childhood epilepsy. This new type of drug is a first-in-class therapy for LD and an example of precision medicine that has potential for treating other types of aggregate-based neurological diseases.
Researchers describe a new way to form an essential part of an artificial chromosome, called the centromere, by bypassing the biological requirements needed to form a natural one.
Delivering two federally approved immunity-altering drugs together significantly extended the lives of mice injected with human ovarian cancer cells, an early proof-of-concept experiment that may advance treatment for the most deadly — although rare — gynecologic malignancy in humans, according to scientists at the Johns Hopkins Kimmel Cancer Center who performed the research.
Scientists studying poison ivy rashes in mice have identified two proteins and a neurotransmitter involved in poison ivy itch in mice. They could be potential drug targets that could lead to treating the aggravating itch in people.
A research team led by Tufts University engineers has developed a 3D printed pill that samples bacteria found in the gut -- known as the microbiome -- as it passes through the gastrointestinal tract (GI). The ability to profile bacterial species throughout the GI tract could have important implications for the diagnosis and treatment of many diseases.
Investigators at St. Jude Children’s Research Hospital and Massachusetts General Hospital, alongside others, have revealed the cells of origin for specific subtypes of medulloblastoma, the most common malignant pediatric brain tumor. The work also has implications for how medulloblastoma is classified, which may eventually shape clinical care. The work appears as an advance online publication today in Nature.
Paralyzing damage in spinal cord injury is often caused by the zealous immune response to the injury. NIBIB-funded engineers have developed nanoparticles that lure immune cells away from the spinal cord, allowing regeneration that restored spinal cord function in mice.
A team of scientists led by Texas Biomed’s Assistant Professor Smita Kulkarni, Ph.D. and Mary Carrington, Ph.D., at the Frederick National Laboratory for Cancer Research, published results of a study that pinpointed a long noncoding RNA molecule which influences a key receptor involved in HIV infection and progression of the disease.
A team led by Johns Hopkins Kimmel Cancer Center investigators reports that a new laboratory test they developed to identify chemical changes to a group of cancer-related genes can accurately detect which breast tumors are cancerous or benign, and do it in far less time than gold-standard tests on biopsied breast tissue.
A de novo gene mutation that encodes a brain protein in a child with autism has been placed into the brains of mice. These mice then showed severe alterations of specific behaviors that closely resemble those seen in human autism spectrum disorder, or ASD.
Mammal brains — including those of humans — store and recall impressive amounts of information based on our good and bad decisions and interactions in an ever-changing world. Now, in a series of new experiments with mice, scientists at Johns Hopkins Medicine report they have added to evidence that such “decision-based” memories are stored in very particular parts of the brain.
A new spectroscopic technique reveals that glucose use in live cells provides valuable information about the functional status of cells, tissues, and organs. Shifts in a cell’s use of glucose can signal changes in health and progress of disease.
A University of Vermont study offers a novel framework to test strategies for managing invasive pests. Applying the framework to swede midge, a new invasive fly causing 100% crop losses for organic broccoli growers, the researchers have uncovered which odors are most effective at repelling the pest.
American teenagers and adults are more likely to try illegal or recreational drugs for the first time in the summer, a new study shows.
Bacteria in the bloodstream can trigger an overwhelming immune response that causes sepsis. Now, researchers at Washington University School of Medicine in St. Louis have found genes that help protect the body's cells from dying during sepsis, which could lead to new treatments for the life-threatening condition.
Herbs, including cilantro, have a long history of use as folk medicine anticonvulsants. Until now, many of the underlying mechanisms of how the herbs worked remained unknown. In a new study, researchers uncovered the molecular action that enables cilantro to effectively delay certain seizures common in epilepsy and other diseases.
Using single-molecule imaging, researchers witness how molecules find and fix damaged DNA
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