A cancer therapy model in which existing medication can be used to degrade for only a required period of time and reduce the protein responsible for programmed cell death has been developed. The team utilizes the small-molecule-assisted shutoff -- or SMASh -- degron system in both cultured cells and mice in vivo. Cancer cell growth was suppressed in wild-type mice.
We rate this claim as mostly true. Among the ways monkeypox can spread is by "Touching objects, fabrics (clothing, bedding, or towels), and surfaces that have been used by someone with monkeypox," according to the Centers for Disease Control and Protection.
A specific group of bacteria-killing proteins inside the immune system could hold the key to developing smarter and more effective drugs capable of eliminating certain infectious diseases including meningitis, pneumonia and sepsis, according to scientists from The Australian National University (ANU).
A research team, comprised of Associate Professor Tomonari Sumi of the Research Institute for Interdisciplinary Science at Okayama University and Associate Professor Kouji Harada of the Center for IT-based Education (CITE) at Toyohashi University of Technology, has developed a mathematical model of the immune response within infected hosts that considers systemic infection of a novel coronavirus (SARS-CoV-2), and demonstrated by conducting experimental computer simulations that persistent viral infections within hosts potentially cause long COVID or post-acute sequelae of COVID-19.
The COVID-19 pandemic has wreaked havoc worldwide. While most infected individuals experience mild symptoms, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus may cause severe pneumonia, acute respiratory distress syndrome, and organ damage in some patients, particularly those with comorbidities.
Griffith University researchers have discovered a genetic switch in a common bacterium that helps defend itself against the human body’s natural immune system.
JMIR Publications recently published "COVID-19 and Vitamin D Misinformation on YouTube: Content Analysis" in JMIR Infodemiology, which reported that although social media platforms, such as YouTube, can be an inexpensive and effective method of sharing accurate health information, inaccurate and misleading information shared on YouTube can be dangerous for viewers.
Carterra, Inc., the world leader in innovative technologies enabling high-throughput biology, and La Jolla Institute for Immunology (LJI), a globally recognized non-profit research organization dedicated to understanding the power of the immune system to promote human health, announced today that LJI has acquired a Carterra LSA instrument to enhance its antibody screening and characterization work.
Cells in the gut send secret messages to the immune system. Thanks to new research from La Jolla Institute for Immunology (LJI) scientists, we can finally get a look at what they're saying.
Wake Forest Institute for Regenerative Medicine (WFIRM) researchers are using a tumor organoid system to examine the effects of metabolites secreted by bacteria on a specialized immunotherapy – immune checkpoint blockage, a promising cancer treatment development – to determine why some patients don’t respond or develop a resistance to the treatment over time.
Researchers at Canada's McMaster University have discovered a significant and previously unknown mechanism that many bacteria use to resist antibiotics.
When we fall ill, we often lose our appetite. This also has an effect on our metabolism: since it is no longer as well supplied with carbohydrates, it switches to burning fat.
New research has advanced COVID-19 vaccine work in several ways: using a modified live attenuated mumps virus for delivery, showing that a more stable coronavirus spike protein stimulates a stronger immune response, and suggesting a dose up the nose has an advantage over a shot.
One of the deadliest forms of cancer is biliary tract cancer. Only one in three patients diagnosed with the disease is operable. The rest must settle for life-sustaining treatment.
In a presentation today at AIDS 2022, the 24th International AIDS Conference in Montreal, scientists with the National Institute of Allergy and Infectious Diseases’ (NIAID) Vaccine Research Center (VRC) and their collaborators described how their use of cutting-edge technology revealed new insights into cellular reservoirs of HIV and what those observations could mean for the next steps in HIV cure research. NIAID is part of the National Institutes of Health.
The study findings suggest possibilities for developing new drugs that replicate or build on A. muciniphila’s immuno-modulatory activity.
The work provides a model for using traditional techniques to pinpoint how other members of the gut microbiome act on the body.
Moderna vaccines are better than Pfizer in protecting residents of long-term care (LTC) homes from COVID-19 Omicron infections, say McMaster University researchers.
Two studies presented today at the 2022 AACC Annual Scientific Meeting & Clinical Lab Expo reveal how SARS-CoV-2 antibody levels vary among recipients of COVID-19 vaccines and naturally infected individuals. These findings add to a growing body of knowledge that is essential for guiding public health initiatives, and that might one day enable clinicians to assess individuals’ immunity to SARS-CoV-2.
In a new article published in the Journal for ImmunoTherapy of Cancer, Moffitt Cancer Center researchers demonstrate how mathematical modeling can be used to analyze the impact of different cancer treatments on tumor and immune cell dynamics and help predict outcomes to therapy and personalize cancer treatment.
مدينة روتشستر، ولاية مينيسوتا: يعد تموز/يوليو هو شهر التوعية بالساركوما وللفت الانتباه لمجموعة من السرطانات التي تبدأ في العظام أو الأنسجة الرخوة في الجسم. هناك أكثر من 70 نوعاً من الساركوما، منها سرطان العظام. وتشمل طرق علاج سرطان العظام الجراحة والعلاج الكيميائي والعلاج الإشعاعي والعلاج الإشعاعي بحزم البروتونات الذي يستهدف الخلايا السرطانية.
Julio es el mes para concienciar sobre el sarcoma y llamar la atención sobre aquel grupo de cánceres que empiezan en los huesos o en los tejidos blandos del cuerpo. Hay más de 70 tipos de sarcoma, entre ellos, el cáncer de hueso.
Julho é o Mês da Conscientização do Sarcoma, chamando a atenção para um grupo de cânceres que começa nos ossos ou nos tecidos moles do corpo. Existem mais de 70 tipos de sarcoma, incluindo o câncer ósseo.
Cytovale®, a medical diagnostics company focused on providing rapid and insightful tools to improve early detection of fast-moving and immune-mediated diseases, will reveal its 510(k) pending Cytovale system and 10-minute IntelliSep® sepsis risk stratification test at the American Association for Clinical Chemistry (AACC) annual meeting, where new data featuring the test will also be shared. The instrument can be seen in the Cytovale booth, no. 5045, in the exhibit hall during Clinical Lab Expo hours. The IntelliSep test was recently named an AACC Disruptive Technology Award Semifinalist and is also being featured in the Disruptive Tech area of the exhibit hall during the meeting.
Researchers at Mayo Clinic's Center for Individualized Medicine have discovered key human genomic signatures that could help explain why COVID-19 is severe in some people and mild in others. After analyzing volumes of diverse worldwide DNA sequence data, the scientists identified mutations in two human proteins that might sway the course of SARS-CoV-2 — the virus responsible for COVID-19.
The Omicron variant of the SARS-CoV-2 virus was first detected in South Africa in November 2021. The high level of infectiousness of the virus and its ability to quickly spawn additional variants has also been observed in Germany: Since January 2022 the Omicron variant BA.1 has dominated here, followed in subsequent months by the variant BA.2.
For patients with lymphoma, multiple myeloma, or certain types of leukemia, treatment with chimeric antigen receptor T cells (CAR T cells) is sometimes the last chance of overcoming the cancer.
For a glimpse into the future of SARS-CoV-2 immunity, scientists at La Jolla Institute for Immunology (LJI) are investigating how the immune system builds its defenses against common cold coronaviruses (CCCs).
Cancer cells produce small amounts of their own form of collagen, creating a unique extracellular matrix that affects the tumor microbiome and protects against immune responses, according to a new study by researchers at The University of Texas MD Anderson Cancer Center. This abnormal collagen structure is fundamentally different from normal collagen made in the human body, providing a highly specific target for therapeutic strategies.
Protection against severe COVID-19 by two doses of Pfizer-BioNTech and AstraZeneca COVID-19 vaccines remained high up to six months after second doses, finds new research which analysed NHS health record data on over seven million adults. Reassuringly, the University of Bristol-led study published in The BMJ today [July 20], found protection in older adults aged over 65 years, and in clinically vulnerable adults.
Paramyxoviruses have the potential to trigger a devastating pandemic. This family of viruses includes measles, Nipah virus, mumps, Newcastle disease and canine distemper. An international team of collaborators has published the first-ever look at a key stage in the life cycles of measles and Nipah viruses. It reveals how future therapies might stop these viruses in their tracks.
Tufts University School of Medicine immunologist Pilar Alcaide explains what autoimmune diseases are, what causes them, who gets them the most, and what can be done about them.
Those widely available COVID-19 vaccinations keeping the majority of the population free from serious illness will not be enough to stop the spread of the virus and its variants, new University of Virginia collaborative research indicates.
Although COVID-19 booster vaccinations in adults elicit high levels of neutralizing antibodies against the Omicron variant of SARS-CoV-2, antibody levels decrease substantially within 3 months, according to new clinical trial data.
In a new study, researchers show how a critical Lassa virus protein, called polymerase, drives infection by harnessing a cellular protein in human hosts. Their work suggests future therapies could target this interaction to treat patients.
As new Omicron subvariants of COVID-19 continue to sweep across the United States, researchers at the University of Missouri have identified specific mutations within the virus’ spike protein that help Omicron subvariants evade existing antibodies humans have from either vaccines or previous COVID-19 infections.
Adding immunotherapy to standard anti-rejection medication could change the lives of thousands of kidney transplant patients with incurable cancer, as new research shows it can reduce this risk of organ rejection and eliminate cancer in a quarter of patients.