Coping with childhood anxiety amid returning to the classroom; new global tracker measures pandemic's impact on education worldwide; Covid-19 drives innovation and evolution in patient care...
Nursing mothers who receive a COVID-19 vaccine may pass protective antibodies to their babies through breast milk for at least 80 days following vaccination, suggests new research from Washington University School of Medicine in St. Louis.
Researchers at the Bloomberg Kimmel Institute for Caner Immunotherapy at the Johns Hopkins Kimmel Cancer Center have developed DeepTCR, a software package that employs deep-learning algorithms to analyze T-cell receptor (TCR) sequencing data. T-cell receptors are found on the surface of immune T cells. These receptors bind to certain antigens, or proteins, found on abnormal cells, such as cancer cells and cells infected with a virus or bacteria, to guide the T cells to attack and destroy the affected cells.
Eczema, or atopic dermatitis (AD), is sometimes called "the itch that rashes." Often, the itch begins before the rash appears, and, in many cases, the itchiness of the skin condition never really goes away.
Women who were vaccinated for COVID-19 earlier in their third trimester had a higher likelihood of passing protective antibodies to their newborn babies than women who received their vaccination closer to delivery, a new study from Northwestern Medicine and Ann & Robert H. Lurie Children’s Hospital of Chicago has found.
UC San Diego students will participate in nationwide clinical trial to assess if COVID-19 vaccination prevents infection and reduces risk of transmission.
A research team led by Donny Hanjaya-Putra is building new lymphatic cord-like structures, which help restore normal behavior to dysfunctional lymphatic systems and allow the body to fight the disease.
"SARS-CoV-2 and SARS-CoV are highly similar genetically, generate a homologous repertoire of viral proteins, and use the same receptor to infect human cells.
Researchers have mapped the distribution of SARS-CoV-2, the virus that causes COVID-19, in deceased patients with the disease, and shed new light on how viral load relates to tissue damage.
New immunotherapy approach to treating cancer patients with COVID-19 aims to reduce risk of severe COVID-19 symptoms by reinvigorating patients' cellular immune responses
A new study out of the University of Chicago and the University of Illinois Urbana-Champaign in humans, chimpanzees, rhesus macaques and baboons has found key differences in early gene expression in response to pathogen exposure, highlighting the importance of choosing the right animal model for the right questions.
Picture viral RNA as a single component that you can break into one million pieces. Now imagine reassembling those pieces together, literally like a jigsaw puzzle. If there’s a chipped corner or if a piece won’t fit snugly as it should, consider that a virus mutation or variant. That’s genomic sequencing, in a nutshell, when it comes to identifying variants of COVID-19, according to Peter Stoilov, associate professor of biochemistry at the West Virginia University School of Medicine.
Humans are born with tens of thousands of hematopoietic stem cells (HSCs) that collectively ensure lifelong production of blood and immune cells that protect us from infections.
Researchers at the Pritzker School of Molecular Engineering at the University of Chicago have developed a new therapeutic vaccine that uses a patient’s own tumor cells to train their immune system to find and kill cancer.
The eighth annual Harrington Prize for Innovation in Medicine has been jointly awarded to Warren J. Leonard, MD, NHLBI, NIH Distinguished Investigator, and John J. O’Shea, MD, Scientific Director, NIAMS, NIH, for their respective contributions to the field of immunology, from fundamental discovery to therapeutic impact.
Wistar is pleased to announce the appointment of Richard M. Horowitz as chair of its Board of Trustees.
Igor Stagljar made his career building molecular tools to combat cancer. But when the pandemic hit last March, he aimed his expertise at a new adversary, SARS-CoV-2.
Most people with cancer who are infected by the novel coronavirus produce antibodies at a rate comparable to the rest of the population—but their ability to do so depends on their type of cancer and the treatments they’ve received, according to a new study by researchers at Montefiore Health System and Albert Einstein College of Medicine. The findings, published online today in Nature Cancer, may lead to better care for cancer patients, who face a heightened risk of dying from COVID-19, and suggests that cancer patients should respond well to COVID-19 vaccines.
A new research study at the University of Chicago Medicine has found that when it comes to COVID-19, having vitamin D levels above those traditionally considered sufficient may lower the risk of infection, especially for Black people.
Research from the University of Kent's School of Biosciences has revealed that a molecule produced by the human immune system can severely diminish the potency of certain antibiotics.
Erica Ollmann Saphire, Ph.D., has been appointed President and CEO of La Jolla Institute for Immunology (LJI), the Institute announced today. Dr. Saphire will become La Jolla Institute’s fifth president when she formally begins her term on September 1, 2021. She will succeed current LJI President Mitchell Kronenberg, who has successfully led the organization for the past 18 years.
Research reveals how mutated SARS-CoV-2 evades immune system defenses In lab-dish experiments, the mutant virus escaped antibodies from the plasma of COVID-19 survivors as well as pharmaceutical-grade antibodies Mutations arose in an immunocompromised patient with chronic SARS-CoV-2 infection Patient-derived virus harbored structural changes now seen cropping up independently in samples across the globe Findings underscore the need for better genomic surveillance to keep track of emerging variants Results highlight importance of therapies aimed at multiple targets on SARS-CoV-2 to minimize risk of resistance
Researchers found two simultaneous conditions in pregnancy's response to stress that made them realize just how complex the cross-talk between mom and baby is during gestation: Immune cells in the placenta and uterus were not activated, but significant inflammation was detected in the fetal brain.
Researchers at the University of Illinois Chicago have discovered that heparanase, HPSE, a poorly understood protein, is a key regulator of cells’ innate defense mechanisms.
Four months after launching the nation’s largest COVID-19 serological testing assessment, Texas CARES, researchers at The University of Texas Health Science Center at Houston (UTHealth) and the Texas Department of State Health Services (DSHS) have compiled preliminary data estimating that 14% to 24% of Texans have COVID-19 antibodies.
Nick Pullen, Ph.D., an associate professor of Biological Sciences at the University of Northern Colorado, shares his expertise on the COVID-19 vaccines and debunks some of the myths surrounding them.
Scientists at Washington University School of Medicine in St. Louis have implicated a type of immune cell in the development of chronic lung disease that sometimes is triggered following a respiratory viral infection. The evidence suggests that activation of this immune cell serves as an early switch that, when activated, drives progressive lung diseases, including asthma and chronic obstructive pulmonary disease (COPD).
The body's immune response plays a crucial role in the course of a SARS-CoV-2 infection.
The March 2021 issue of Toxicological Sciences includes exciting toxicology research in biotransformation, toxicokinetics, and pharmacokinetics; genetic and epigenetic toxicology; neurotoxicology; and more.
At the beginning of an immune response, a molecule known to mobilize immune cells into the bloodstream, where they home in on infection sites, rapidly shifts position, a new study shows. Researchers say this indirectly amplifies the attack on foreign microbes or the body’s own tissues.
Lymph nodes in the armpit area can become swollen after a COVID-19 vaccination, and this is a normal reaction that typically goes away with time.
By analyzing blood samples from individuals infected with SARS-CoV-2, researchers in Singapore have begun to unpack the different responses by the body’s T cells that determine whether or not an individual develops COVID-19. The study, published today in the Journal of Experimental Medicine (JEM), suggests that clearing the virus without developing symptoms requires T cells to mount an efficient immune response that produces a careful balance of pro- and anti-inflammatory molecules.
Discovery of a metabolic pathways that inhibit memory T cell production has potential for enhancing the immune system’s ability to fight infections and cancers.
Medical researchers have long understood that a pregnant mother’s diet has a profound impact on her developing fetus’s immune system and that babies — especially those born prematurely — who are fed breast milk have a more robust ability to fight disease, suggesting that even after childbirth, a mother’s diet matters. However, the biological mechanisms underlying these connections have remained unclear.
ROCKVILLE, MD – The Zika outbreak of 2015 and 2016 is having lasting impacts on children whose mothers became infected with the virus while they were pregnant.
St. Jude Children’s Research Hospital has discovered a mechanism that tumors use to switch on protective regulatory T cells, raising the potential for drug treatments that render tumors more vulnerable to cancer immunotherapy.
Scientists at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have identified the specialized environment, known as a niche, in the bone marrow where new bone and immune cells are produced. The study, published in Nature, also shows that movement-induced stimulation is required for the maintenance of this niche, as well as the bone and immune-forming cells that it contains. Together, these findings identify a new way that exercise strengthens bones and immune function.
HSE University researchers have become the first in the world to discover genetic predisposition to severe COVID-19. The results of the study were published in the journal Frontiers in Immunology.
La Jolla Institute for Immunology (LJI), one of the leading research organizations dedicated to studying the immune system announced today that it has signed a licensing agreement with Leinco Technologies, Inc., a premier developer and manufacturer of leading-edge recombinant proteins, antibodies, and conjugates.
In patients with severe COVID-19, the innate immune system overreacts.
The course and severity of COVID-19 in individual patients is largely influenced by the interaction between the SARS-CoV-2 coronavirus and the human immune system.
Creating “super soldiers” of specific white blood cells to boost an anti-tumour response has been shown in a series of elegant experiments by Princess Margaret researchers.
A child’s first influenza infection shapes their immunity to future airborne flu viruses – including emerging pandemic strains. But not all flu strains spur the same initial immune defense, according to new findings published today by University of Pittsburgh virologists.
Extending the symptoms that trigger a PCR test for COVID-19 could help detect around a third more cases of the disease.
UC San Diego researchers report that individual immune response to SARS-CoV-2 may be limited by a set of variable genes that code for cell surface proteins essential for the adaptive immune system. The finding may help explain why COVID-19 immunity varies by individual.
Un estudio dirigido por investigadores de Mayo Clinic y publicado en Kidney International Reports (Informes Internacionales sobre el Riñón) descubrió que los inhibidores de los puntos de control inmunitario pueden tener consecuencias negativas en algunos pacientes, incluida una inflamación aguda del riñón conocida como nefritis intersticial.
A paper published today in Nature shows how chemicals in the areas surrounding tumors – known as the tumor microenvironment – subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy.
The healthy human oral microbiome consists of not just clean teeth and firm gums, but also bacteria living in an environment where they constantly communicate with the immune system. A growing body of evidence has shown that this system is highly influential on, and influenced by, our overall health.
DALLAS – Feb. 8, 2021 – A new nanoparticle-based drug can boost the body’s innate immune system and make it more effective at fighting off tumors, researchers at UT Southwestern have shown. Their study, published in Nature Biomedical Engineering, is the first to successfully target the immune molecule STING with nanoparticles about one millionth the size of a soccer ball that can switch on/off immune activity in response to their physiological environment.
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