Some vegetable oils that claim to be healthy may actually increase the risk of heart disease, and Health Canada should reconsider cholesterol-lowering claims on food labelling, states an analysis in CMAJ (Canadian Medical Association Journal) http://www.cmaj.ca/lookup/doi/10.1503/cmaj.130253.
• In patients with chronic kidney disease who lowered their salt intake for two weeks, excess extracellular fluid volume, blood pressure, and protein excretion in the urine all dropped considerably. • If maintained long-term, the effects could reduce a patient’s risk of progressing to kidney failure by 30%.
Current medical guidelines use a one-size-fits-all treatment approach that leads to some patients being on too many medications and others being on too little.
Results of a Johns Hopkins study published today in the journal Diabetes Care found that young and middle-aged women with type 2 diabetes are at much greater risk of coronary artery disease than previously believed.
Among patients with early stages of breast cancer, those whose hearts were more directly irradiated with radiation treatments on the left side in a facing-up position had higher risk of heart disease, according to research letter by David J. Brenner, Ph.D, D.Sc, of Columbia University Medical Center, New York, and colleagues.
Body temperature follows a 24-hour rhythm, peaking during the day, low at night. The benefit might be the conservation of energy while sleeping. It is also critical to be able to adapt to changes in ambient temperature regardless of the time of day. A new mouse study shows how body temperature rhythms are synchronized while maintaining the ability to adapt to changes in environmental temperature day or night.
People with rheumatoid arthritis and other chronic inflammatory conditions are at higher risk of heart disease. Who is in the most danger, why and how best to prevent and detect cardiovascular complications are important questions for physicians and researchers.
Obstructive sleep apnea is known to be associated with an increased incidence of cardiovascular disease. Now a new study indicates that OSA is associated with subclinical myocardial injury, as indicated by increased high sensitivity troponin T (hs-TnT) levels. Elevated hs-TnT levels are predictive of both coronary heart disease (CHD) and heart failure (HF) in the general population. This is the first study to demonstrate an independent association between sleep apnea severity and this marker of early myocardial injury.
There is an association between the influenza virus and cardiovascular events like heart disease and stroke; those with cardiovascular disease should protect themselves against the flu.
Researchers at the University of Illinois at Chicago have identified a protein expressed by human bone marrow stem cells that guides and stimulates the formation of blood vessels. Their findings, which could help improve the vascularization of engineered tissues, were reported online on October 12 in the Journal of Molecular and Cellular Cardiology.
The incidence of chronic pain following cardiac surgery can be reduced in patients when the drug pregabalin is used before surgery and for 14 days post-surgery, according to a study presented at the ANESTHESIOLOGY™ 2013 annual meeting. The study also found that patients at risk of developing long-term post-operative persistent pain can be predicted by conducting pain sensitivity tests at the time of surgery.
Long-term memory loss, difficulty understanding verbal or written communication or impaired ability to pay attention may still occur five years after heart surgery if a patient has a certain gene variation, according to a study presented at the ANESTHESIOLOGY™ 2013 annual meeting. This gene was found to be related to a decline in cognitive capabilities compared to those who do not have the variation.
University of Utah researchers have found that deficiency of an antioxidant response protein called nuclear erythroid-2 like factor-2 (Nrf2) delays or prevents hypertrophic cardiomyopathy.
A global hunt for genes that influence heart disease risk has uncovered 157 changes in human DNA that alter the levels of cholesterol and other blood fats – a discovery that could lead to new medications.
Mitochondria are the power plants of cells, manufacturing fuel so a cell can perform its many tasks. These cellular power plants also are well known for their role in cell suicide. Now, researchers at Washington University School of Medicine in St. Louis and the University of Padua-Dulbecco Telethon Institute in Italy have shown that mitochondria remarkably also orchestrate events that determine a cell’s future, at least in the embryonic mouse heart. The new study identifies new potential genetic culprits in the origins of some congenital heart defects.
Johns Hopkins University School of Nursing joins worldwide effort to increase awareness and seek a cure for cardiovascular disease.
Genes in mitochondria, the “powerhouses” that turn sugar into energy in human cells, shape each person’s risk for heart disease and diabetes.
A biological ability to compensate for the body’s reduced response to insulin may explain why women typically develop heart disease 10 years later than men, according to a recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM).
University at Buffalo translational researchers are developing a richer understanding of atherosclerosis in humans, revealing a key role for stem cells that promote inflammation.
Two treatments that slow the development of diabetes also may protect people from heart disease, according to a recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM).
Evidence from people with heart disease strongly supports the existence of the molecular link first discovered in laboratory mice between the body’s natural circadian rhythms and cardiac arrest or sudden cardiac death — the No. 1 cause of death in heart attacks, a scientist said here today at the 246th National Meeting & Exposition of the American Chemical Society, the world’s largest scientific society.
The small size and abnormal anatomy of children born with heart defects often force doctors to place lifesaving defibrillators entirely outside the heart, rather than partly inside — a less-than-ideal solution to dangerous heart rhythms that involves a degree of guesstimating and can compromise therapy.
Older heart patients present unique challenges for determining the optimal dosages of medications, so a new study from researchers at Duke Medicine offers some rare clarity about the use of drugs that are used to treat patients with heart attacks.
Researchers from Case Western Reserve University School of Medicine and the Dana-Farber Cancer Institute have discovered a new molecular pathway responsible for causing heart failure and showed that a first-in-class prototype drug, JQ1, blocks this pathway to protect the heart from damage.
Vanderbilt Heart and Vascular Institute is participating in the VELOCITY study, a randomized controlled clinical study to assess the safety and feasibility of a rapid cooling system for heart attack patients that could minimize damage to the heart.
American Association of Physicians of Indian Origin (AAPI) has launched educational ”Networks” of renowned thought leaders in the areas of Cardiology, Diabetes, and Stroke to foster high quality medical education of physicians of Asian Indian origin in the US.
An analysis of data from three studies that involved a total of more than 240,000 participants found that a self-reported history of kidney stones was associated with a statistically significant increased risk of coronary heart disease among women but no significant association was evident for men, according to a study in the July 24/31 issue of JAMA.
A Johns Hopkins study finds that healthy people who carry a genetic mutation for arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) are at much higher risk of developing the symptoms of the life-threatening heart disease if they participate in endurance sports and frequent exercise. The study also suggests that those carriers who significantly cut back on their exercise regimen may reduce their risk or delay the onset of symptoms.
St. Jude Children’s Research Hospital scientists have discovered that a protein used by cancer cells to evade death also plays a vital role in heart health.
Drugs that help millions of people cope with acid reflux may also cause cardiovascular disease. It is the first time researchers have shown how proton pump inhibitors, or PPIs, might cause cardiovascular problems.
Programs to address multiple health behaviors, such as diet and exercise, significantly lowered the risk of a fatal heart attack, stroke or other cardiovascular event in people with coronary heart disease, finds a new study in the American Journal of Preventive Medicine.
Researchers led by M. Mahmood Hussain, PhD, found that a regulatory RNA molecule interferes with the production of lipoproteins and, in a mouse model, reduces hyperlipidemia and atherosclerosis.
A new heart valve that can be implanted inside an existing valve will help adults with congenital heart disease avoid open heart surgeries.
Too much sugar can set people down a pathway to heart failure, according to a study led by researchers at The University of Texas Health Science Center at Houston (UTHealth).
Mayo Clinic has announced the first U.S. stem cell clinical trial for pediatric congenital heart disease. The trial aims to determine how stem cells from autologous umbilical cord blood can help children with hypoplastic left heart syndrome (HLHS), a rare defect in which the left side of the heart is critically underdeveloped.
Mice suffering from age-related heart disease saw a significant improvement in cardiac function after treatment with the FDA-approved drug rapamycin for just three months. Research at the Buck Institute shows how rapamycin impacts mammalian tissues, providing functional insights and possible benefits for a drug that can extend lifespan in mice as much as 14 percent. Researchers at the Mayo clinic are now recruiting seniors with cardiac artery disease for a clinical trial involving the drug.
Pulse oximetry test, already used at UCLA, will be mandatory statewide July 1.
Two biomarkers being investigated as predictors of heart and vascular disease appear to indicate risk for "silent" strokes and other causes of mild brain damage that present no symptoms, report researchers in an upcoming issue of Stroke.
The more heart attack-induced PTSD symptoms a patient has, the worse their sleep likely was in the month following their heart attack. New findings from a research team at Columbia University Medical Center’s Center for Behavioral Cardiovascular Health, published in the Annals of Behavioral Medicine.
UCLA researchers examining outcomes for advanced heart-failure patients over the past two decades have found that, coinciding with the increased availability and use of new therapies, overall mortality has decreased and sudden cardiac death, caused by the rapid onset of severe abnormal heart rhythms, has declined. However, the team found that even today, with these significant improvements, one-third of patients don’t survive more than three years after being diagnosed with advanced disease.
Patients with underlying heart failure are more likely to experience adverse outcomes from mild hypothyroidism, according to a recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM).
Why is fish oil good for the heart? A new study suggests that this omega 3 fatty acid-rich nutrient could blunt some cardiovascular effects of mental stress.
Scientists at the Texas Biomedical Research Institute in San Antonio have identified four genes in baboons that influence levels of “bad” cholesterol. This discovery could lead to the development of new drugs to reduce the risk of heart disease.
Although genetic factors contribute to congenital heart disease, many children born with heart defects have healthy parents and siblings, suggesting that new mutations that arise spontaneously—known as de novo mutations—might contribute to the disease. New research shows that about 10 percent of these defects are caused by genetic mutations that are absent in the parents of affected children.
A commentary and review provides clinicians with the optimal utilization of aspirin to treat and prevent heart attacks, and advice on aspirin in the prevention of colorectal and other cancers.
Type 1 (insulin-dependent) diabetes appears to increase the risk of heart disease, the leading cause of death among people with high blood sugar, partly by stimulating the production of calprotectin, a protein that sparks an inflammatory process that fuels the buildup of artery-clogging plaque.
Your genetic makeup can help determine how well your body will respond to weight loss efforts aimed at controlling high blood pressure, a new study confirms. The multi-institutional study, led by researchers at The Cardiovascular Institute, part of the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, may help clarify how hypertension develops and progresses in certain individuals and also identify people for whom weight loss programs are most likely to help reduce blood pressure.
Findings pinpoint 14 genetic targets in humans that may provide insight for the treatment of cardiovascular disease.
Mayo Clinic physicians in Arizona have shown that tablet computers can be used to analyze electroencephalogram or EEG results outside of the clinic or hospital. Their study findings were recently presented at the American Academy of Neurology conference in San Diego.
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